Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker rats

Experimental Biology and Medicine

Volumn 231, Issue 10, 2006, Pages 1602-1609

  Burr, Laura L ^a   Taylor, Carla G ^b   Weiler, Hope A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Bone mass; Conjugated linoleic acid; Hyperinsulinemia; Obesity; Zucker rat

Indexed keywords

CONJUGATED LINOLEIC ACID;

ANIMAL MODEL; ARTICLE; BODY HEIGHT; BODY SIZE; BONE DENSITY; BONE MASS; BONE MINERAL; CONTROLLED STUDY; DIET; DIET RESTRICTION; FACTORIAL ANALYSIS; FEMUR; FOOD INTAKE; GENOTYPE; HYPERINSULINEMIA; ISOMER; MALE; MORPHOMETRICS; NONHUMAN; OBESITY; RAT; RAT STRAIN; SPINE;

ANIMALIA;

EID: 33751336339     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/153537020623101004     Document Type: Article

References (60)

1. Watkins BA, Li Y, Allen KG, Hoffmann WE, Seifert MF. Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats. J Nutr 130:2274-2284, 2000.
2. Yamasaki M, Ikeda A, Oji M, Tanaka Y, Hirao A, Kasai M, Iwata T, Tachibana H, Yamada K. Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition 19:30-35, 2003.
3. Baumgard LH, Corl BA, Dwyer DA, Saebo A, Bauman DE. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am J Physiol Regul Integr Comp Physiol 278:R179-R184, 2000.
4. Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc 36:814-820, 2004.
5. Song HJ, Grant I, Rotondo D, Mohede I, Sattar N, Heys SD, Wahle KW. Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr 59:508-517, 2005.
6. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34:235-241, 1999.
7. Li Y, Seifert MF, Ney DM, Grahn M, Grant AL, Allen KG, Watkins BA. Dietary conjugated linoleic acids alter serum IGF-I and IGF-binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. J Bone Miner Res 14:1153-1162, 1999.
8. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34:243-248, 1999.
9. Thiel-Cooper RL, Parrish FC Jr, Sparks JC, Wiegand BR, Ewan RC. Conjugated linoleic acid changes swine performance and carcass composition. J Anim Sci 79:1821-1828, 2001.
10. 2 production, insulin-like growth factor-I concentration and formation rate in chicks. J Nutr 127:1084-1091,1997.
11. Terpestra AH, Everts H, Kocsis S, Katan MB, Zock PL. The decrease in body fat in mice fed conjugated linoleic acid is due to the increases in energy expenditure and energy loss in the excreta. J Nutr 132:940-945, 2002.
12. Demaree SR, Gilbert CD, Mersmann HJ, Smith SB. Conjugated linoleic acid differentially modifies fatty acid composition in subcellular fractions of muscle and adipose tissue but not adiposity of post-weaning pigs. J Nutr 132:3272-3279, 2002.
13. 2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 33:417-425, 1998.
14. Swan JE, Parrish FC Jr, Wiegand BR, Larsen ST, Baas TJ, Berg EP. Total body electrical conductivity (TOBEC) measurement of compositional differences in hams, loins, and bellies from conjugated linoleic acid (CLA)-fed stress-genotype pigs. J Anim Sci 79:1475-1482, 2001.
15. Ostrowska E, Suster D, Muralitharan M, Cross RF, Leury BJ, Bauman DE, Dunshea FR. Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy x-ray absorptiometry. Br J Nutr 89:219-229, 2003.
16. Brownbill RA, Petrosian M, Ilich JZ. Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women. J Am Coll Nutr 24:177-181, 2005.
17. Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 16:325-334, 2002.
18. Doyle L, Jewell C, Mullen A, Nugent AP, Roche HM, Cashman KD. Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men. Eur J Clin Nutr 59:432-440, 2005.
19. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135:778-784, 2005.
20. Barker DJ. In utero programming of chronic disease. Clin Sci (Lond) 95:115-128, 1998.
21. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 288:1728-1732, 2002.
22. Jolliffe D. Extent of overweight among US children and adolescents from 1971 to 2000. Int J Obes Relat Metab Disord 28:4-9, 2004.
23. Willms JD, Tremblay MS, Katzmarzyk PT. Geographic and demographic variation in the prevalence of overweight Canadian children. Obes Res 11:668-673, 2003.
24. Mazess RB, Barden HS. Bone density in premenopausal women: effects of age, dietary intake, physical activity, smoking, and birth-control pills. Am J Clin Nutr 53:132-142, 1991.
25. Nguyen TV, Center JR, Eisman JA. Osteoporosis in elderly men and women: effects of dietary calcium, physical activity, and body mass index. J Bone Miner Res 15:322-331, 2000.
26. De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey E, Mellstrom D, Melton LJ, Meunier PJ, Pols HAP, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330-1338, 2005.
27. Goulding A, Taylor RW, Jones IE, McAuley KA, Manning PJ, Williams SM. Overweight and obese children have low bone mass and area for their weight. Int J Obes Relat Metab Disord 24:627-632, 2000.
28. Specker BL, Johannsen N, Binkley T, Finn K. Total body bone mineral content and tibial cortical bone measures in preschool children. J Bone Miner Res 16:2298-2305, 2001.
29. Goulding A, Jones IE, Taylor RW, Williams SM, Manning PJ. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study. J Pediatr 139:509-515, 2001.
30. Skaggs DL, Loro ML, Pitukcheewanont P, Tolo V, Gilsanz V. Increased body weight and decreased radial cross-sectional dimensions in girls with forearm fractures. J Bone Miner Res 16:1337-1342, 2001.
31. Taylor CG, Zahradka P. Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models. Am J Clin Nutr 79:1164S-1168S, 2004.
32. Ball GML. Childhood obesity in Canada: a review of prevalence estimates and risk factors for cardiovascular disease and type 2 diabetes. Can J Appl Physiol 28:117-140, 2003.
33. Molnar D. The prevalence of the metabolic syndrome and type 2 diabetes mellitus in children and adolescents. Int J Obes Relat Metab Disord 28(Suppl 3):S70-S74, 2004.
34. Barrett-Connor E, Holbrook TL. Sex differences in osteoporosis in older adults with non-insulin-dependent diabetes mellitus. JAMA 268:3333-3337, 1992.
35. Abrahamsen B, Rohold A, Henriksen JE, Beck-Nielsen H. Correlations between insulin sensitivity and bone mineral density in non-diabetic men. Diabet Med 17:124-129, 2000.
36. Zucker LM, Antoniades HN. Insulin and obesity in the Zucker genetically obese rat "fatty." Endocrinology 90:1320-1330, 1972.
37. Foldes J, Shih MS, Levy J. Bone structure and calcium metabolism in obese Zucker rats. Int J Obes Relat Metab Disord 16:95-102, 1992.
38. Cifuentes M, Morano AB, Chowdhury HA, Shapses SA. Energy restriction reduces fractional calcium absorption in mature obese and lean rats. J Nutr 132:2660-2666, 2002.
39. Mathey J, Horcajada-Molteni MN, Chanteranne B, Picherit C, Puel C, Lebecque P, Cubizoles C, Davicco MJ, Coxam V, Barlet JP. Bone mass in obese diabetic Zucker rats: influence of treadmill running. Calcif Tissue Int 70:305-311, 2002.
40. Wahle KW, Heys SD, Rotondo D. Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res 43:553-587, 2004.
41. Tricon S, Burdge GC, Williams CM, Calder PC, Yaqoob P. The effects of conjugated linoleic acid on human health-related outcomes. Proc Nutr Soc 64:171-182, 2005.
42. Canadian Council on Animal Care. Guide to the Care and Use of Experimental Animals (2nd ed.). Ottawa: Bradda Printing Services, 1993.
43. Reeves PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127:838S-841S, 1997.
44. Noto A, Zahradka P, Yurkova N, Xie X, Nitschmann E, Ogborn M, Taylor C. Conjugated linoleic acid (CLA) reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin resistant rats. Lipids 41(in press), 2006.
45. Bertin E, Ruiz JC, Mourot J, Peiniau P, Portha B. Evaluation of dual-energy x-ray absorptiometry for body-composition assessment in rats. J Nutr 128:1550-1554, 1998.
46. Nagy TR, Clair AL. Precision and accuracy of dual-energy x-ray absorptiometry for determining in vivo body composition of mice. Obes Res 8:392-398, 2000.
47. Engelbregt MJT, Tromp AM, van Lingen A, Lips P, Popp-Snijders C, Delemarre-van de Waal HA. Validation of whole-body DXA in young and adult rats. Horm Res 51:248, 1999.
48. Grier SJ, Turner AS, Alvis MR. The use of dual-energy x-ray absorptiometry in animals. Invest Radiol 31:50-62, 1996.
49. Reichling TD, German RZ. Bones, muscles, and visceral organs of protein-malnourished rats (Rattus norvegicus) grow more slowly but for longer durations to reach normal final size. J Nutr 130:2326-2332, 2000.
50. 2 from bone but do not affect bone mass in obese (fa/fa) and lean Zucker rats. J Nutr 135:499-504, 2005.
51. Kastl S, Sommer T, Klein P, Hohenberger W, Engelke K. Accuracy and precision of bone mineral density and bone mineral content in excised rat humeri using fan beam dual-energy x-ray absorptiometry. Bone 30:243-246, 2002.
52. Clegg M KC, Lonnerdal B, Hurley L. Influence of ashing techniques on the analysis of trace elements in animal tissues. I. Wet ashing. Biol Trace Elem Res 3:107-115, 1981.
53. Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 167:S1-S34, 2002.
54. Weiler HA, Janzen L, Green K, Grabowski J, Seshia MM, Yuen KC. Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone 27:203-207, 2000.
55. Leonard MB, Shults J, Wilson BA, Tershakovec AM, Zemel BS. Obesity during childhood and adolescence augments bone mass and bone dimensions. Am J Clin Nutr 80:514-523, 2004.
56. Tamasi JA, Arey BJ, Bertolini DR, Feyen JH. Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats. J Bone Miner Res 18:1605-1611, 2003.
57. Picherit C, Horcajada MN, Mathey J, Chanteranne B, Puel C, Lebecque P, Davicco MJ, Coxam V, Barlet JP. Isoflavone consumption does not increase the bone mass in osteopenic obese female Zucker rats. Ann Nutr Metab 47:70-77, 2003.
58. Kelly O, Cusack S, Jewell C, Cashman KD. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. Br J Nutr 90:743-750, 2003.
59. Kelly O, Cashman KD. The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomized rats. Prostaglandins Leukot Essent Fatty Acids 71:295-301, 2004.
60. Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr 70:560S-569S, 1999.