Down-regulation of PPARγ2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis

Archives of Biochemistry and Biophysics

Volumn 456, Issue 1, 2006, Pages 19-29

  Moon, H S ^a   Lee, H G ^a   Seo, J H ^a   Chung, C S ^b   Kim, T G ^c   Kim, I Y ^a   Lim, K W ^b   Seo, S J ^a   Choi, Y J ^a   Cho, C S ^a  

^a Seoul National University   (South Korea)

^b Chungbuk National University   (South Korea)

^c Agribrands Purina Korea Inc   (South Korea)

Author keywords

Adipocyte differentiation; Anti obesity; Conjugated linoleic acid (CLA); Lipolysis; PEGylation; Poly(ethylene glycol) (PEG); Pro drug

Indexed keywords

ANTIOBESITY AGENT; BIOLOGICAL MARKER; CARBOXYL GROUP; CCAAT ENHANCER BINDING PROTEIN ALPHA; CONJUGATED LINOLEIC ACID; ESTER; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HORMONE SENSITIVE LIPASE; HYDROXYL GROUP; ISOPRENALINE; MACROGOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PRODRUG; DRUG CARRIER; LINOLEIC ACID; MACROGOL DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CATALYST; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG RELEASE; DRUG STABILITY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIPID STORAGE; LIPOLYSIS; MELTING POINT; MOLECULAR MODEL; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DRUG COMBINATION; DRUG EFFECT; LIPID METABOLISM; METABOLIC CLEARANCE RATE; METABOLISM; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; DOWN-REGULATION; DRUG CARRIERS; DRUG COMBINATIONS; LINOLEIC ACID; LIPID METABOLISM; METABOLIC CLEARANCE RATE; MICE; POLYETHYLENE GLYCOLS; PPAR GAMMA; PRODRUGS;

EID: 33751436327     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.10.002     Document Type: Article

References (57)

1. Fruhbeck G., Gomez-Ambrosi J., Muruzabal F.J., and Burrel M.A. Am. J. Physiol. Endocrinol. Metab. 280 (2001) E827-E847
2. Lee W.J., Koh E.H., Won J.C., Kim M.S., Park J.Y., and Lee K.U. Int. J. Biochem. Cell Biol. 37 (2005) 2254-2259
3. Kelly D.E., and Goodpaster B.H. Diabetes Care 24 (2001) 933-941
4. Lewis G.F., Carpentier A., Adeli K., and Giacca A. Endocr. Rev. 23 (2002) 201-209
5. Farmer S.R., and Auwerx J. J. Obes. Rev. 5 (2004) 189-196
6. Unger R.H., and Zhou Y.T. Diabetes 50 (2001) S118-S121
7. Park Y., Albright K.J., Liu W., Storlson J.M., Cook M.E., and Pariza M.W. Lipids 32 (1997) 853-858
8. Ha Y.L., Grimm N.K., and Pariza M.W. Carcinogenesis 8 (1997) 1881-1887
9. Liew C., Schut H.A., Chin S.F., Pariza M.W., and Dashwood R.H. Carcinogenesis 16 (1995) 3034-3037
10. Lee K.N., Kritchevsky D., and Pariza M.W. Atherosclerosis 108 (1994) 19-25
11. Cook M.E., Miller C.C., Park Y., and Pariza M.W. Poult. Sci. 72 (1993) 1301-1305
12. Miller C.C., Park Y., Pariza M.W., and Cook M.E. Biochem. Biophys. Res. Commun. 198 (1994) 1107-1112
13. Park Y., Storkson J.M., Albright K.J., Liu W., and Pariza M.W. Lipids 34 (1999) 235-241
14. Evans M., Geigerman C., Cook J., Curtis L., Kuebler B., and Mclntosh M. Lipids 35 (2000) 899-910
15. Choi Y., Kim Y., Han Y., Park Y., and Pariza M.W. J. Nutr. 130 (1999) 1920-1924
16. Allen T.M. Trends Pharmacol. Sci. 15 (1994) 215-220
17. Greenwald R.B., Choe Y.H., Mcguire J., and Conover C.D. Adv. Drug Deliv. Rev. 55 (2003) 217-250
18. Tobio M., Sanchez A., Vila A., Soriano I., Evora C., Vila-Jato J.L., and Alonso M.J. Colloids Surf. B Biointerfaces 18 (2000) 315-323
19. Abuchowski A., McCoy J.R., Palczuk N.C., van Es T., and Davis F.F. J. Biol. Chem. 252 (1997) 3582-3586
20. Abuchowski A., van Es T., Palczuk N.C., and Davis F.F. J. Biol. Chem. 252 (1997) 3578-3581
21. Li C., Yu D., Inoue T., Yang D.J., Milas L., Hunter N.R., Kim E.E., and Wallace S. Anticancer Drugs 7 (1996) 642-648
22. Teske E., Rutterman G.R., van Heere P., and Misdorp W. Eur. J. Cancer 26 (1990) 891-895
23. Scott M.D., and Chen A.M. Transfus. Clin. Biol. 11 (2004) 40-46
24. DiRamio J.A., Kisaalita W.S., Majectich G.F., and Shimkus J.M. Biotechnol. Prog. 21 (2005) 1281-1288
25. Wise L.S., and Green H. J. Biol. Chem. 254 (1979) 273-275
26. Bradford M.M. Anal Biochem. 72 (1976) 248-254
27. Suryawan A., and Hu C.Y. Comp. Biochem. Physiol. Comp. Physiol. 105 (1993) 485-492
28. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., and Hadjiargyrou M. J. Control. Release 98 (2004) 47-56
29. Greenwald R.B. J. Control. Release 74 (2001) 159-171
30. Sipahigil O., Gursoy A., Cakalagaoglu F., and Okar I. Int. J. Pharm. 311 (2006) 130-138
31. Kaul G., and Amiji M. Pharm. Res. 19 (2002) 1061-1067
32. Scavo L.M., Karas M., Murray M., and Leroith D. J. Clin. Endocrinol. Metab. 89 (2004) 3543-3553
33. Moussalli C., Downs R.W., and May J.M. Diabetes 35 (1986) 759-763
34. Wang Y.W., and Jones P.J. Int. J. Obes. Relat. Metab. Disord. 28 (2004) 941-955
35. Shao D., and Lazar M.A. J. Biol. Chem. 272 (1997) 21473-21478
36. Durgam V.R., and Fernandes G. Cancer Lett. 116 (1997) 121-130
37. Shirui M., Xintao S., Florian U., Mittmar W., Xiulan X., and Thomas K. Biomaterials 26 (2005) 6343-6356
38. Kichler A. J. Gene Med. 6 (2004) S3-S10
39. Claudia F.P. Toxicology 214 (2005) 1-38
40. Brown M., Evans M., and McIntosh M. J. Nutr. Biochem. 12 (2001) 381-387
41. Stangl G. J. Nutr. 130 (2000) 1140-1146
42. Eggert J.M., Belury M.A., Kempa-Steczko A., Mills S.E., and Schinckel A.P. J. Anim. Sci. 79 (2001) 2866-2872
43. Szkudelski T., and Szkudelska K. Physiol. Res. 49 (2000) 213-217
44. Park Y., Albright K., Liu W., Storkson J., Cook M., and Pariza M. Lipids 32 (1997) 853-858
45. Park Y., Albright K., Storkson J., Liu W., Cook M., and Pariza M. Lipids 34 (1999) 243-248
46. Evans M., Lin X., Odle J., and McIntosh M. J. Nutr. 132 (2002) 450-455
47. Clifford G., Londos C., Kraemer F., and Vernon R. J. Biol. Chem. 275 (2000) 5011-5015
48. Okazaki H., Osuga J., Tamura Y., Yahagi N., Tomita S., Shionoiri F., Iizuka-Ohashi Y., Harada K., Kimura S., Gotoda T., Shimano H., Nobuhiro Y., and Ishibashi S. Diabetes 51 (2002) 3368-3375
49. Soni K., Lehner R., Metalnikov R., O'Donnell P., Semache M., Gao W., Ashman K., Pshezhetsky A., and Mitchell G. J. Biol. Chem. 279 (2004) 40683-40689
50. Cantwell H., Devery R., Stanton C., and Lawless F. Biochem. Soc. Trans. 26 (1998) 69
51. Brodie A., Manning V., Ferguson K., Jewell D., and Hu C.Y. J. Nutr. 129 (1999) 602-606
52. Pariza M.W., Park Y., and Cook M.E. Proc. Soc. Exp. Biol. Med. 223 (2000) 8-13
53. Bhattacharya A., Rahman M.M., Sun D., Lawrence R., Mejia W., McCarter R., O'Shea M., and Fernandes G. J. Nutr. 135 (2005) 1124-1130
54. Brown J.M., Halvorsen Y.D., Lea-Currie Y.R., Geigerman C., and McIntosh M. J. Nutr. 131 (2001) 2316-2321
55. Kawada T., Kamei Y., Fujita A., Hida Y., Takahashi N., Sugimoto E., and Fushiki T. Biofactors 13 (2000) 103-109
56. Chu R., Madison L.D., Lin Y., Kopp P., Rao M.S., Jameson J.L., and Reddy J.K. Proc. Natl. Acad. Sci. USA 92 (1995) 11593-11597
57. Dalei S., and Lazar M.A. J. Biol. Chem. 272 (1997) 21473-21478