메뉴 건너뛰기




Volumn 9, Issue 8, 2000, Pages 1145-1159

(Over)correction of FMR1 deficiency with YAC transgenics: Behavioral and physical features

Author keywords

[No Author keywords available]

Indexed keywords

RNA BINDING PROTEIN;

EID: 0034194228     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.8.1145     Document Type: Article
Times cited : (233)

References (75)
  • 3
    • 0028799833 scopus 로고
    • Prevalence of carriers of premutation-size alleles of the FMRI gene and implications for the population genetics of the fragile X syndrome
    • Rousseau, F., Rouillard, P., Morel, M.L., Khandjian, E.W. and Morgan, K. (1995) Prevalence of carriers of premutation-size alleles of the FMRI gene and implications for the population genetics of the fragile X syndrome. Am. J. Hum. Genet., 57, 1006-1018.
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 1006-1018
    • Rousseau, F.1    Rouillard, P.2    Morel, M.L.3    Khandjian, E.W.4    Morgan, K.5
  • 6
    • 0025905795 scopus 로고
    • Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk, A.J., Pieretti, M., Sutcliffe, J.S., Fu, Y.H., Kuhl, D.P., Pizzuti, A., Reiner, O., Richards, S., Victoria, M.F., Zhang, F.P. et al. (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905-914.
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.1    Pieretti, M.2    Sutcliffe, J.S.3    Fu, Y.H.4    Kuhl, D.P.5    Pizzuti, A.6    Reiner, O.7    Richards, S.8    Victoria, M.F.9    Zhang, F.P.10
  • 9
    • 0029123145 scopus 로고
    • Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome
    • Lugenbeel, K.A., Peier, A.M., Carson, N.L., Chudley, A.E. and Nelson, D.L. (1995) Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome. Nature Genet., 10, 483-485.
    • (1995) Nature Genet. , vol.10 , pp. 483-485
    • Lugenbeel, K.A.1    Peier, A.M.2    Carson, N.L.3    Chudley, A.E.4    Nelson, D.L.5
  • 11
    • 0027300283 scopus 로고
    • Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain
    • Abitbol, M., Menini, C., Delezoide, A.L., Rhyner, T., Vekemans, M. and Mallet, J. (1993) Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain. Nature Genet., 4, 147-153.
    • (1993) Nature Genet. , vol.4 , pp. 147-153
    • Abitbol, M.1    Menini, C.2    Delezoide, A.L.3    Rhyner, T.4    Vekemans, M.5    Mallet, J.6
  • 12
    • 0027176361 scopus 로고
    • The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
    • Devys, D., Lutz, Y., Rouyer, N., Bellocq, J.P. and Mandel, J.L. (1993) The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nature Genet., 4, 335-340.
    • (1993) Nature Genet. , vol.4 , pp. 335-340
    • Devys, D.1    Lutz, Y.2    Rouyer, N.3    Bellocq, J.P.4    Mandel, J.L.5
  • 16
    • 0027715424 scopus 로고
    • Enhanced expression of the murine FMR1 gene during germ cell proliferation suggests a special function in both the male and the female gonad
    • Bachner, D., Manca, A., Steinbach, P., Wohrle, D., Just, W., Vogel, W., Hameister, H. and Poustka, A. (1993) Enhanced expression of the murine FMR1 gene during germ cell proliferation suggests a special function in both the male and the female gonad. Hum. Mol. Genet., 2, 2043-2050.
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 2043-2050
    • Bachner, D.1    Manca, A.2    Steinbach, P.3    Wohrle, D.4    Just, W.5    Vogel, W.6    Hameister, H.7    Poustka, A.8
  • 18
    • 0030051618 scopus 로고    scopus 로고
    • Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms
    • Sittler, A., Devys, D., Weber, C. and Mandel, J.L. (1996) Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms. Hum. Mol. Genet., 5, 95-102.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 95-102
    • Sittler, A.1    Devys, D.2    Weber, C.3    Mandel, J.L.4
  • 19
    • 0027327486 scopus 로고
    • The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
    • Siomi, H., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. (1993) The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell, 74, 291-298.
    • (1993) Cell , vol.74 , pp. 291-298
    • Siomi, H.1    Siomi, M.C.2    Nussbaum, R.L.3    Dreyfuss, G.4
  • 20
    • 0030059545 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is associated with ribosomes
    • Khandjian, E.W., Corbin, F., Woerly, S. and Rousseau, F. (1996) The fragile X mental retardation protein is associated with ribosomes. Nature Genet., 12, 91-93.
    • (1996) Nature Genet. , vol.12 , pp. 91-93
    • Khandjian, E.W.1    Corbin, F.2    Woerly, S.3    Rousseau, F.4
  • 21
    • 0029816723 scopus 로고    scopus 로고
    • The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
    • Eberhart, D.E., Malter, H.E., Feng, Y. and Warren, S.T. (1996) The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum. Mol. Genet., 5, 1083-1091.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1083-1091
    • Eberhart, D.E.1    Malter, H.E.2    Feng, Y.3    Warren, S.T.4
  • 22
    • 0031046778 scopus 로고    scopus 로고
    • Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes
    • Feng, Y., Gutekunst, C.A., Eberhart, D.E., Yi, H., Warren, S.T. and Hersch, S.M. (1997) Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J. Neurosci., 17, 1539-1547.
    • (1997) J. Neurosci. , vol.17 , pp. 1539-1547
    • Feng, Y.1    Gutekunst, C.A.2    Eberhart, D.E.3    Yi, H.4    Warren, S.T.5    Hersch, S.M.6
  • 23
    • 0031445652 scopus 로고    scopus 로고
    • Analysis of domains affecting intracellular localization of the FMRP protein
    • Bardoni, B., Sittler, A., Shen, Y. and Mandel, J.L. (1997) Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol. Dis., 4, 329-336.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 329-336
    • Bardoni, B.1    Sittler, A.2    Shen, Y.3    Mandel, J.L.4
  • 24
    • 0029880471 scopus 로고    scopus 로고
    • Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway
    • Fridell, R.A., Bogerd, H.P. and Cullen, B.R. (1996) Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Proc. Natl Acad. Sci. USA, 93, 4421-4424.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4421-4424
    • Fridell, R.A.1    Bogerd, H.P.2    Cullen, B.R.3
  • 25
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium
    • Bakker, C.E. and T.D.-B.F.X. Consortium (1994) Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell, 78, 23-33.
    • (1994) Cell , vol.78 , pp. 23-33
    • Bakker, C.E.1    Consortium, T.D.-B.F.X.2
  • 27
    • 0025720084 scopus 로고
    • Analysis of neocortex in three males with the fragile X syndrome
    • Hinton, V.J., Brown, W.T., Wisniewski, K. and Rudelli, R.D. (1991) Analysis of neocortex in three males with the fragile X syndrome. Am. J. Med. Genet., 41, 289-294.
    • (1991) Am. J. Med. Genet. , vol.41 , pp. 289-294
    • Hinton, V.J.1    Brown, W.T.2    Wisniewski, K.3    Rudelli, R.D.4
  • 28
    • 0026026911 scopus 로고
    • The Fra (X) syndrome: Neurological, electrophysiological, and neuropathological abnormalities
    • Wisniewski, K.E., Segan, S.M., Miezejeski, C.M., Sersen, E.A. and Rudelli, R.D. (1991) The Fra (X) syndrome: neurological, electrophysiological, and neuropathological abnormalities. Am. J. Med. Genet., 38, 476-480.
    • (1991) Am. J. Med. Genet. , vol.38 , pp. 476-480
    • Wisniewski, K.E.1    Segan, S.M.2    Miezejeski, C.M.3    Sersen, E.A.4    Rudelli, R.D.5
  • 30
    • 0031658209 scopus 로고    scopus 로고
    • Exploring gene function: Use of yeast artificial chromosome transgenesis
    • Huxley, C. (1998) Exploring gene function: use of yeast artificial chromosome transgenesis. Methods, 14, 199-210.
    • (1998) Methods , vol.14 , pp. 199-210
    • Huxley, C.1
  • 31
    • 0027443269 scopus 로고
    • Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice
    • Gaensler, K.M., Kitamura, M. and Kan, Y.W. (1993) Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc. Natl Acad. Sci. USA, 90, 11381-11385.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 11381-11385
    • Gaensler, K.M.1    Kitamura, M.2    Kan, Y.W.3
  • 32
    • 0027261194 scopus 로고
    • Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes
    • Peterson, K.R., Clegg, C.H., Huxley, C., Josephson, B.M., Haugen, H.S., Furukawa, T. and Stamatoyannopoulos, G. (1993) Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc. Natl Acad. Sci. USA, 90, 7593-7597.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7593-7597
    • Peterson, K.R.1    Clegg, C.H.2    Huxley, C.3    Josephson, B.M.4    Haugen, H.S.5    Furukawa, T.6    Stamatoyannopoulos, G.7
  • 36
    • 0025819924 scopus 로고
    • Vectors for inserting selectable markers in vector arms and human DNA inserts of yeast artificial chromosomes (YACs)
    • Srivastava, A.K. and Schlessinger, D. (1991) Vectors for inserting selectable markers in vector arms and human DNA inserts of yeast artificial chromosomes (YACs). Gene, 103, 53-59.
    • (1991) Gene , vol.103 , pp. 53-59
    • Srivastava, A.K.1    Schlessinger, D.2
  • 37
    • 0032546976 scopus 로고    scopus 로고
    • Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein
    • Brown, V., Small, K., Lakkis, L., Feng, Y., Gunter, C., Wilkinson, K.D. and Warren, S.T. (1998) Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein. J. Biol. Chem., 273, 15521-15527.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15521-15527
    • Brown, V.1    Small, K.2    Lakkis, L.3    Feng, Y.4    Gunter, C.5    Wilkinson, K.D.6    Warren, S.T.7
  • 38
    • 0021932863 scopus 로고
    • Immunological detection of the messenger RNA cap-binding protein
    • Hiremath, L.S., Webb, N.R. and Rhoads, R.E. (1985) Immunological detection of the messenger RNA cap-binding protein. J. Biol. Chem., 260, 7843-7849.
    • (1985) J. Biol. Chem. , vol.260 , pp. 7843-7849
    • Hiremath, L.S.1    Webb, N.R.2    Rhoads, R.E.3
  • 39
    • 0021099528 scopus 로고
    • Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis
    • Duncan, R. and Hershey, J.W. (1983) Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis. J. Biol. Chem., 258, 7228-7235.
    • (1983) J. Biol. Chem. , vol.258 , pp. 7228-7235
    • Duncan, R.1    Hershey, J.W.2
  • 40
    • 0023124676 scopus 로고
    • Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F
    • Duncan, R., Milburn, S.C. and Hershey, J.W. (1987) Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J. Biol. Chem., 262, 380-388.
    • (1987) J. Biol. Chem. , vol.262 , pp. 380-388
    • Duncan, R.1    Milburn, S.C.2    Hershey, J.W.3
  • 41
    • 0028908587 scopus 로고
    • Protein synthesis initiation factor eIF-1A is a moderately abundant RNA-binding protein
    • Wei, C.L., MacMillan, S.E. and Hershey, J.W. (1995) Protein synthesis initiation factor eIF-1A is a moderately abundant RNA-binding protein. J. Biol. Chem., 270, 5764-5771.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5764-5771
    • Wei, C.L.1    MacMillan, S.E.2    Hershey, J.W.3
  • 42
    • 0032216670 scopus 로고    scopus 로고
    • Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice
    • Paylor, R., Nguyen, M., Crawley, J.N., Patrick, J., Beaudet, A. and Orr-Urtreger, A. (1998) Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn. Mem., 5, 302-316.
    • (1998) Learn. Mem. , vol.5 , pp. 302-316
    • Paylor, R.1    Nguyen, M.2    Crawley, J.N.3    Patrick, J.4    Beaudet, A.5    Orr-Urtreger, A.6
  • 43
    • 0033600662 scopus 로고    scopus 로고
    • Testing the genetics of behavior in mice
    • Dawson, G.R., Flint, J. and Wilkinson, L.S. (1999) Testing the genetics of behavior in mice. Science, 285, 2068-2070.
    • (1999) Science , vol.285 , pp. 2068-2070
    • Dawson, G.R.1    Flint, J.2    Wilkinson, L.S.3
  • 44
    • 0024918146 scopus 로고
    • Animal models of anxiety
    • Crawley, J.N. (1989) Animal models of anxiety. Curr. Opin. Psychiatry, 2, 773-776.
    • (1989) Curr. Opin. Psychiatry , vol.2 , pp. 773-776
    • Crawley, J.N.1
  • 45
    • 0019199013 scopus 로고
    • Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
    • Crawley, J. and Goodwin, F.K. (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav., 13, 167-170.
    • (1980) Pharmacol. Biochem. Behav. , vol.13 , pp. 167-170
    • Crawley, J.1    Goodwin, F.K.2
  • 47
    • 0023600009 scopus 로고
    • Startle habitation and sensorimotor gating in schizophrenia and related animal models
    • Geyer, M.A. and Braff, D.L. (1987) Startle habitation and sensorimotor gating in schizophrenia and related animal models. Schizophr. Bull., 13, 643-668.
    • (1987) Schizophr. Bull. , vol.13 , pp. 643-668
    • Geyer, M.A.1    Braff, D.L.2
  • 48
    • 0028016082 scopus 로고
    • DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning
    • Paylor, R., Tracy, R., Wehner, J. and Rudy, J.W. (1994) DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behav. Neurosci., 108, 810-817.
    • (1994) Behav. Neurosci. , vol.108 , pp. 810-817
    • Paylor, R.1    Tracy, R.2    Wehner, J.3    Rudy, J.W.4
  • 49
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris, R. (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods, 11, 47-60.
    • (1984) J. Neurosci. Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 50
    • 0026542671 scopus 로고
    • The role of the amygdala in fear-potentiated startle: Implications for animal models of anxiety
    • Davis, M. (1992) The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety. Trends Pharmacol. Sci., 13, 35-41.
    • (1992) Trends Pharmacol. Sci. , vol.13 , pp. 35-41
    • Davis, M.1
  • 51
    • 0031590583 scopus 로고    scopus 로고
    • Amygdala and bed nucleus of the stria terminalis: Differential roles in fear and anxiety measured with the acoustic startle reflex
    • Davis, M., Walker, D.L. and Lee, Y. (1997) Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex. Philos. Trans R. Soc. Lond. B Biol. Sci., 352, 1675-1687.
    • (1997) Philos. Trans R. Soc. Lond. B Biol. Sci. , vol.352 , pp. 1675-1687
    • Davis, M.1    Walker, D.L.2    Lee, Y.3
  • 52
    • 0022374863 scopus 로고
    • Validation of open:Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow, S., Chopin, P., File, S.E. and Briley, M. (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14, 149-167.
    • (1985) J. Neurosci. Methods. , vol.14 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 53
    • 0025014631 scopus 로고
    • Latency to enter a mirrored chamber: A novel behavioral assay for anxiolytic agents
    • Toubas, P.L., Abla, K.A., Cao, W., Logan, L.G. and Scale, T.W. (1990) Latency to enter a mirrored chamber: a novel behavioral assay for anxiolytic agents. Pharmacol. Biochem. Behav., 35, 121-126.
    • (1990) Pharmacol. Biochem. Behav. , vol.35 , pp. 121-126
    • Toubas, P.L.1    Abla, K.A.2    Cao, W.3    Logan, L.G.4    Scale, T.W.5
  • 54
    • 0032881856 scopus 로고    scopus 로고
    • Fragile X mouse: Strain effects of knockout phenotype and evidence suggesting deficient amygdala function
    • Paradee, W., Melikian, H.E., Rasmussen, D.L., Kenneson, A., Conn, P.J. and Warren, S.T. (1999) Fragile X mouse: Strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience, 94, 185-192.
    • (1999) Neuroscience , vol.94 , pp. 185-192
    • Paradee, W.1    Melikian, H.E.2    Rasmussen, D.L.3    Kenneson, A.4    Conn, P.J.5    Warren, S.T.6
  • 55
    • 0027403446 scopus 로고
    • Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis
    • Paylor, R., Baskall, L. and Wehner, J.M. (1993) Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis. Psychobiology, 21, 11-26.
    • (1993) Psychobiology , vol.21 , pp. 11-26
    • Paylor, R.1    Baskall, L.2    Wehner, J.M.3
  • 56
    • 0015253206 scopus 로고
    • The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation)
    • Lifschytz, E. and Lindsley, D.L. (1972) The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation). Proc. Natl Acad. Sci. USA, 69, 182-186.
    • (1972) Proc. Natl Acad. Sci. USA , vol.69 , pp. 182-186
    • Lifschytz, E.1    Lindsley, D.L.2
  • 60
    • 0029949942 scopus 로고    scopus 로고
    • X chromosome inactivation and X-linked mental retardation
    • Willard, H.F. (1996) X chromosome inactivation and X-linked mental retardation. Am. J. Med. Genet, 64, 21-26.
    • (1996) Am. J. Med. Genet , vol.64 , pp. 21-26
    • Willard, H.F.1
  • 61
    • 0032837516 scopus 로고    scopus 로고
    • Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: An animal model of Down's syndrome
    • Ema, M., Ikegami, S., Hosoya, T., Mimura, J., Ohtani, H., Nakao, K., Inokuchi, K., Katsuki, M. and Fujii-Kuriyama, Y. (1999) Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. Hum. Mol. Genet., 8, 1409-1415.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1409-1415
    • Ema, M.1    Ikegami, S.2    Hosoya, T.3    Mimura, J.4    Ohtani, H.5    Nakao, K.6    Inokuchi, K.7    Katsuki, M.8    Fujii-Kuriyama, Y.9
  • 63
    • 0032192481 scopus 로고    scopus 로고
    • Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation
    • Jiang, Y.H., Armstrong, D., Albrecht, U., Atkins, C.M., Noebels, J.L., Eichele, G., Sweatt, J.D. and Beaudet, A.L. (1998) Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation [see comments]. Neuron, 21, 799-811.
    • (1998) Neuron , vol.21 , pp. 799-811
    • Jiang, Y.H.1    Armstrong, D.2    Albrecht, U.3    Atkins, C.M.4    Noebels, J.L.5    Eichele, G.6    Sweatt, J.D.7    Beaudet, A.L.8
  • 64
    • 0029687570 scopus 로고    scopus 로고
    • YAC transfer into mammalian cells by cell fusion
    • Davies, N.P. and Huxley, C. (1996) YAC transfer into mammalian cells by cell fusion. Methods Mol. Biol., 54, 281-292.
    • (1996) Methods Mol. Biol. , vol.54 , pp. 281-292
    • Davies, N.P.1    Huxley, C.2
  • 65
    • 0033499661 scopus 로고    scopus 로고
    • Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex
    • Ceman, S., Brown, V. and Warren, S.T. (1999) Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex. Mol. Cell. Biol., 19, 7925-7932.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7925-7932
    • Ceman, S.1    Brown, V.2    Warren, S.T.3
  • 66
    • 0031310667 scopus 로고    scopus 로고
    • FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
    • Feng, Y., Absher, D., Eberhart, D.E., Brown, V., Malter, H.E. and Warren, S.T. (1997) FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell, 1, 109-118.
    • (1997) Mol. Cell , vol.1 , pp. 109-118
    • Feng, Y.1    Absher, D.2    Eberhart, D.E.3    Brown, V.4    Malter, H.E.5    Warren, S.T.6
  • 68
    • 25944462578 scopus 로고    scopus 로고
    • Dendritic spine maturation is delayed in cultured hippocampal neurons of the Fmr1 knockout mouse
    • Torre, E.R. and Warren, S.T. (1999) Dendritic spine maturation is delayed in cultured hippocampal neurons of the Fmr1 knockout mouse. Am. J. Hum. Genet., 65, 2670(a).
    • (1999) Am. J. Hum. Genet. , vol.65
    • Torre, E.R.1    Warren, S.T.2
  • 69
    • 0029075809 scopus 로고
    • Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2
    • Smith, D.J., Zhu, Y., Zhang, J., Cheng, J.F. and Rubin, E.M. (1995) Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics, 27, 425-434.
    • (1995) Genomics , vol.27 , pp. 425-434
    • Smith, D.J.1    Zhu, Y.2    Zhang, J.3    Cheng, J.F.4    Rubin, E.M.5
  • 72
    • 0026781016 scopus 로고
    • A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome
    • Wohrle, D., Kotzot, D., Hirst, M.C., Manca, A., Korn, B., Schmidt, A., Barbi, G., Rott, H.D., Poustka, A., Davies, K.E. et al. (1992) A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome. Am. J. Hum Genet., 51, 299-306.
    • (1992) Am. J. Hum Genet. , vol.51 , pp. 299-306
    • Wohrle, D.1    Kotzot, D.2    Hirst, M.C.3    Manca, A.4    Korn, B.5    Schmidt, A.6    Barbi, G.7    Rott, H.D.8    Poustka, A.9    Davies, K.E.10
  • 74
    • 0033566226 scopus 로고    scopus 로고
    • Alternative splicing in the murine and human FXR1 genes
    • Kirkpatrick, L.L., McIlwain, K.A. and Nelson, D.L. (1999) Alternative splicing in the murine and human FXR1 genes. Genomics, 59, 193-202.
    • (1999) Genomics , vol.59 , pp. 193-202
    • Kirkpatrick, L.L.1    McIlwain, K.A.2    Nelson, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.