Dangers, and benefits of the cytokine mediated response to injury and infection

Clinical Nutrition

Volumn 28, Issue 6, 2009, Pages 583-596

  Soeters, Peter B ^a   Grimble, Robert F ^b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Acute phase response; Ageing; Albumin; Chronic disease; Cytokines; Gender; Genotype; Immunonutrition; Inflammation; Insulin sensitivity; Malnutrition; Obesity; Plasma lipids; Protein kinetics

Indexed keywords

CYTOKINE;

ATHEROSCLEROSIS; CHRONIC DISEASE; DIET RESTRICTION; ENVIRONMENTAL EXPOSURE; GENDER; GENOTYPE; HAZARD; HUMAN; INFECTION; INFLAMMATION; INJURY; INTOXICATION; MALNUTRITION; NUTRIENT; REVIEW; SURVIVAL;

ANIMALS; CHRONIC DISEASE; CYTOKINES; HUMANS; INFECTION; INFLAMMATION; NUTRITIONAL STATUS; WOUNDS AND INJURIES;

EID: 71549124653     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2009.05.014     Document Type: Review

References (174)

1. Plank L.D., and Hill G.L. Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma. World J Surg 24 6 (2000) 630-638
2. Plank L.D., and Hill G.L. Similarity of changes in body composition in intensive care patients following severe sepsis or major blunt injury. Ann N Y Acad Sci 904 (2000) 592-602
3. Ishibashi N., Plank L.D., Sando K., and Hill G.L. Optimal protein requirements during the first 2 weeks after the onset of critical illness. Crit Care Med 26 9 (1998) 1529-1535
4. Clowes Jr. G.H., Randall H.T., and Cha C.J. Amino acid and energy metabolism in septic and traumatized patients. J Parenter Enteral Nutr 4 2 (1980) 195-205
5. Burkly L.C., Michaelson J.S., Hahm K., Jakubowski A., and Zheng T.S. TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine 40 1 (2007) 1-16
6. Chicheportiche Y., Bourdon P.R., Xu H., Hsu Y.M., Scott H., Hession C., et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 272 51 (1997) 32401-32410
7. Singer A.J., and Clark R.A. Cutaneous wound healing. N Engl J Med 341 10 (1999) 738-746
8. Kim K.-J., and Malik A.B. Protein transport across the lung epithelial barrier. Am J Physiol Lung Cell Mol Physiol 284 2 (2003) L247-259
9. Healy J., and Tipton K. Ceruloplasmin and what it might do. J Neural Transm 114 6 (2007) 777-781
10. Era S., Kuwata K., Imai H., Nakamura K., Hayashi T., and Sogami M. Age-related change in redox state of human serum albumin. Biochim Biophys Acta 1247 1 (1995) 12-16
11. Droge W., Kinscherf R., Hildebrandt W., and Schmitt T. The deficit in low molecular weight thiols as a target for antiageing therapy. Curr Drug Targets 7 11 (2006) 1505-1512
12. Hack V., Breitkreutz R., Kinscherf R., Rohrer H., Bartsch P., Taut F., et al. The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention. Blood 92 1 (1998) 59-67
13. Imai H., Hayashi T., Negawa T., Nakamura K., Tomida M., Koda K., et al. Strenuous exercise-induced change in redox state of human serum albumin during intensive kendo training. Jpn J Physiol 52 2 (2002) 135-140
14. Quinlan G.J., Mumby S., Martin G.S., Bernard G.R., Gutteridge J.M., and Evans T.W. Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury. Crit Care Med 32 3 (2004) 755-759
15. Hargreaves I.P., Lee P.J., and Briddon A. Homocysteine and cysteine - albumin binding in homocystinuria: assessment of cysteine status and implications for glutathione synthesis?. Amino Acids 22 2 (2002) 109-118
16. Cheng A.T.H., Plank L.D., and Hill G.L. Prolonged overexpansion of extracellular water in elderly patients with sepsis. Arch Surg (1998) 745-751
17. Appenheimer M.M., Chen Q., Girard R.A., Wang W.C., and Evans S.S. Impact of fever-range thermal stress on lymphocyte-endothelial adhesion and lymphocyte trafficking. Immunol Invest 34 3 (2005) 295-323
18. Carli F., and Schricker T. Modulation of the catabolic response to surgery. Nutrition 16 9 (2000) 777-780
19. 14C]-leucine. Surgery 88 2 (1980) 294-300
20. Long C.L., Jeevanandam M., Kim B.M., and Kinney J.M. Whole body protein synthesis and catabolism in septic man. Am J Clin Nutr 30 8 (1977) 1340-1344
21. Coss-Bu J.A., Klish W.J., Walding D., Stein F., Smith E.O., and Jefferson L.S. Energy metabolism, nitrogen balance, and substrate utilization in critically ill children. Am J Clin Nutr 74 5 (2001) 664-669
22. Kien C.L., Young V.R., Rohrbaugh D.K., and Burke J.F. Increased rates of whole body protein synthesis and breakdown in children recovering from burns. Ann Surg 187 4 (1978) 383-391
23. O'Donnel T.F., Clowes Jr. G.H., Blackburn G.L., Ryan N.T., Benotti P.N., and Miller J.D. Proteolysis associated with a deficit of peripheral energy fuel substrates in septic man. Surgery 80 2 (1976) 192-200
24. Biolo G., Toigo G., Ciocchi B., Situlin R., Iscra F., Gullo A., et al. Metabolic response to injury and sepsis: changes in protein metabolism. Nutrition 13 9 Suppl. (1997) 52S-57S
25. Melchior J.C. From malnutrition to refeeding during anorexia nervosa. Curr Opin Clin Nutr Metab Care 1 6 (1998) 481-485
26. Holecek M., Sprongl L., and Tilser I. Metabolism of branched-chain amino acids in starved rats: the role of hepatic tissue. Physiol Res 50 1 (2001) 25-33
27. Bruins M.J., Deutz N.E., and Soeters P.B. Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis. Clin Sci (Lond) 104 2 (2003) 127-141
28. Samuels S.E., and Baracos V.E. Tissue protein turnover is altered during catch-up growth following Escherichia coli infection in weanling rats. J Nutr 125 3 (1995) 520-530
29. Desborough J.P. The stress response to trauma and surgery. Br J Anaesth 85 1 (2000) 109-117
30. Jepson M.M., Pell J.M., Bates P.C., and Millward D.J. The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochem J 235 2 (1986) 329-336
31. Planas M., Schwartz S., Garcia-Arumi E., Andreu A., Farriol M., and Lopez J. Protein synthesis in specific tissues during sepsis. Infusionsther Transfusionsmed 22 2 (1995) 106-109
32. Breuille D., Rose F., Arnal M., Melin C., and Obled C. Sepsis modifies the contribution of different organs to whole-body protein synthesis in rats. Clin Sci (Colch) 86 6 (1994) 663-669
33. Emery P.W., and Ghusain-Choueiri A. Effect of surgical trauma on muscle protein synthesis in the rat. Br J Surg 81 4 (1994) 539-542
34. Emery P.W., and Ghusain-Choueiri A. The local and systemic effects of minor injury on muscle protein synthesis in the rat. Int J Biochem Cell Biol 27 8 (1995) 815-820
35. Rooyackers O.E., Saris W.H., Soeters P.B., and Wagenmakers A.J. Prolonged changes in protein and amino acid metabolism after zymosan treatment in rats. Clin Sci (Colch) 87 5 (1994) 619-626
36. Bruins M.J., Soeters P.B., and Deutz N.E. Endotoxemia affects organ protein metabolism differently during prolonged feeding in pigs. J Nutr 130 12 (2000) 3003-3013
37. Rosenblatt S., Clowes Jr. G.H., George B.C., Hirsch E., and Lindberg B. Exchange of amino acids by muscle and liver in sepsis. Arch Surg 118 2 (1983) 167-175
38. Gabay C., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340 6 (1999) 448-454
39. Wilmore D.W. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr 131 9 Suppl. (2001) 2543S-2549S Discussion 2550S-2541S
40. Boelens P.G., Nijveldt R.J., Houdijk A.P., Meijer S., and van Leeuwen P.A. Glutamine alimentation in catabolic state. J Nutr 131 9 Suppl. (2001) 2569S-2577S Discussion 2590S
41. Reeds P.J., Fjeld C.R., and Jahoor F. Do the differences between the amino acid compositions of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states?. J Nutr 124 6 (1994) 906-910
42. Cayol M., Tauveron I., Rambourdin F., Prugnaud J., Gachon P., Thieblot P., et al. Whole-body protein turnover and hepatic protein synthesis are increased by vaccination in man. Clin Sci (Colch) 89 4 (1995) 389-396
43. Jahoor F., Abramson S., and Heird W.C. The protein metabolic response to HIV infection in young children. Am J Clin Nutr 78 1 (2003) 182-189
44. Preston T., Slater C., McMillan D.C., Falconer J.S., Shenkin A., and Fearon K.C. Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response. J Nutr 128 8 (1998) 1355-1360
45. Fearon K.C., Falconer J.S., Slater C., McMillan D.C., Ross J.A., and Preston T. Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acute-phase protein response [see comments]. Ann Surg 227 2 (1998) 249-254
46. Dahn M.S., Mitchell R.A., Lange M.P., Smith S., and Jacobs L.A. Hepatic metabolic response to injury and sepsis. Surgery 117 5 (1995) 520-530
47. Fuhrman M.P. The albumin-nutrition connection: separating myth from fact. Nutrition 18 2 (2002) 199-200
48. Soeters P.B., and Baracos V.E. Anabolic and catabolic mediators. Curr Opin Clin Nutr Metab Care 2 3 (1999) 195-199
49. Barle H., Gamrin L., Essen P., McNurlan M.A., Garlick P.J., and Wernerman J. Growth hormone does not affect albumin synthesis in the critically ill. Intensive Care Med 27 5 (2001) 836-843
50. Barle H., Januszkiewicz A., Hallstrom L., Essen P., McNurlan M.A., Garlick P.J., et al. Albumin synthesis in humans increases immediately following the administration of endotoxin. Clin Sci (Lond) 103 5 (2002) 525-531
51. Essen P., McNurlan M.A., Gamrin L., Hunter K., Calder G., Garlick P.J., et al. Tissue protein synthesis rates in critically ill patients. Crit Care Med 26 1 (1998) 92-100
52. 13C]leucine. Kidney Int 41 1 (1992) 132-138
53. Ballmer P.E., Reichen J., McNurlan M.A., Sterchi A.B., Anderson S.E., and Garlick P.J. Albumin but not fibrinogen synthesis correlates with galactose elimination capacity in patients with cirrhosis of the liver. Hepatology 24 1 (1996) 53-59
54. Noel J.K., and Hunter M.J. Bovine mercaptalbumin and non-mercaptalbumin monomers. Interconversions and structural differences. J Biol Chem 247 22 (1972) 7391-7406
55. Droge W. Cysteine and glutathione in catabolic conditions and immunological dysfunction. Curr Opin Clin Nutr Metab Care 2 3 (1999) 227-233
56. Arndt T., Hackler R., Muller T., Kleine T.O., and Gressner A.M. Increased serum concentration of carbohydrate-deficient transferrin in patients with combined pancreas and kidney transplantation. Clin Chem 43 2 (1997) 344-351
57. Fleck A., Raines G., Hawker F., Trotter J., Wallace P.I., Ledingham I.M., et al. Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury. Lancet 1 8432 (1985) 781-784
58. Boldt J. Volume therapy in the intensive care patient - we are still confused, but. Intensive Care Med 26 9 (2000) 1181-1192
59. Hirschfield G.M., and Pepys M.B. C-reactive protein and cardiovascular disease: new insights from an old molecule. QJM 96 11 (2003) 793-807
60. Newsholme P., Costa Rosa L.F., Newsholme E.A., and Curi R. The importance of fuel metabolism to macrophage function. Cell Biochem Funct 14 1 (1996) 1-10
61. Barcia A., and Harris H. Triglyceride-rich lipoproteins as agents of innate immunity. Clin Infect Dis (2005) S498-S503
62. Robinson Y., Hostmann A., Matenov A., Ertel W., and Oberholzer A. Erythropoiesis in multiply injured patients. J Trauma 61 5 (2006) 1285-1291
63. Nikolaisen C., Figenschau Y., and Nossent J.C. Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality. J Rheumatol (2008)
64. McDevitt M.A., Xie J., Gordeuk V., and Bucala R. The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep 3 2 (2004) 97-106
65. Del Vecchio L., Pozzoni P., Andrulli S., and Locatelli F. Inflammation and resistance to treatment with recombinant human erythropoietin. J Ren Nutr 15 1 (2005) 137-141
66. Oppenheimer S. Comments on background papers related to iron, folic acid, malaria and other infections. Food Nutr Bull 28 4 Suppl. (2007) S550-S559
67. Weinberg E.D., and Miklossy J. Iron withholding: a defense against disease. J Alzheimers Dis 13 4 (2008) 451-463
68. Koch C.G., Li L., Sessler D.I., Figueroa P., Hoeltge G.A., Mihaljevic T., et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 358 12 (2008) 1229-1239
69. Mynster T., and Nielsen H.J. The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Danish RANX05 Colorectal Cancer Study Group. Scand J Gastroenterol 35 2 (2000) 212-217
70. Phillips T.F., Soulier G., and Wilson R.F. Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery. J Trauma 27 8 (1987) 903-910
71. Hershko C. Mechanism of iron toxicity. Food Nutr Bull 28 4 Suppl. (2007) S500-509
72. Van den Berghe G., Wilmer A., Hermans G., Meersseman W., Wouters P.J., Milants I., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 354 5 (2006) 449-461
73. Van den Berghe G., Wouters P.J., Bouillon R., Weekers F., Verwaest C., Schetz M., et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 31 2 (2003) 359-366
74. Elenkov I.J., Iezzoni D.G., Daly A., Harris A.G., and Chrousos G.P. Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 12 5 (2005) 255-269
75. Fearon K.C., Ljungqvist O., Von Meyenfeldt M., Revhaug A., Dejong C.H., Lassen K., et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr 24 3 (2005) 466-477
76. Ljungqvist O., Nygren J., and Thorell A. Insulin resistance and elective surgery. Surgery 128 5 (2000) 757-760
77. Cigarran S., Barril G., Cirugeda A., Bernis C., Aguilera A., Sanz P., et al. Hypoalbuminemia is also a marker of fluid excess determined by bioelectrical impedance parameters in dialysis patients 11 2 (2007) 114-120
78. Murray M.J., Murray A.B., Murray N.J., and Murray M.B. Infections during severe primary undernutrition and subsequent refeeding: paradoxical findings. Aust N Z J Med 25 5 (1995) 507-511
79. Clowes Jr. G.H., Hirsch E., George B.C., Bigatello L.M., Mazuski J.E., and Villee Jr. C.A. Survival from sepsis. The significance of altered protein metabolism regulated by proteolysis inducing factor, the circulating cleavage product of interleukin-1. Ann Surg 202 4 (1985) 446-458
80. Tomkins A.M., Garlick P.J., Schofield W.N., and Waterlow J.C. The combined effects of infection and malnutrition on protein metabolism in children. Clin Sci 65 3 (1983) 313-324
81. Pollack M.M., Ruttimann U.E., and Wiley J.S. Nutritional depletions in critically ill children: associations with physiologic instability and increased quantity of care. J Parenter Enteral Nutr 9 3 (1985) 309-313
82. Jahoor F., Wykes L., Del Rosario M., Frazer M., and Reeds P.J. Chronic protein undernutrition and an acute inflammatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets. J Nutr 129 3 (1999) 693-699
83. Jahoor F., Badaloo A., Reid M., and Forrester T. Protein kinetic differences between children with edematous and nonedematous severe childhood undernutrition in the fed and postabsorptive states. Am J Clin Nutr 82 4 (2005) 792-800
84. Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8 3 (2003) 223-246
85. Tappy L., Berger M.M., and Chiolero R.L. [Nutrition and stress]. Ann Med Interne (Paris) 151 7 (2000) 584-593
86. Takala J., Ruokonen E., Webster N.R., Nielsen M.S., Zandstra D.F., Vundelinckx G., et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 341 11 (1999) 785-792
87. Jeschke M.G., Wolf S.E., DebRoy M.A., Jarrar D., and Herndon D.N. Recombinant human growth hormone (rhGH) downregulates hepatocyte growth factor (HGF) in burns. J Surg Res 76 1 (1998) 11-16
88. Ruokonen E., and Takala J. Dangers of growth hormone therapy in critically ill patients. Curr Opin Clin Nutr Metab Care 5 2 (2002) 199-209
89. Vara-Thorbeck R., Guerrero J.A., Rosell J., Ruiz-Requena E., and Capitan J.M. Exogenous growth hormone: effects on the catabolic response to surgically produced acute stress and on postoperative immune function. World J Surg 17 4 (1993) 530-537 Discussion 537-538
90. Kaneko A., Kido T., Yamamoto M., Kase Y., Washizawa N., Aburada M., et al. Intestinal anastomosis surgery with no septic shock primes for a dysregulatory response to a second stimulus. J Surg Res 134 2 (2006) 215-222
91. Reikerås O., JSJ, EWA, and OA. Postoperative serum attenuates LPS-induced release of TNF-? in orthopaedic surgery. J Orthopaed Res (2007) 1395-1400
92. Amar D., Zhang H., Park B., Heerdt P.M., Fleisher M., and Thaler H.T. Inflammation and outcome after general thoracic surgery. Eur J Cardiothorac Surg 32 3 (2007) 431-434
93. Lohsiriwat V., Chinswangwatanakul V., Lohsiriwat S., Akaraviputh T., Boonnuch W., Methasade A., et al. Hypoalbuminemia is a predictor of delayed postoperative bowel function and poor surgical outcomes in right-sided colon cancer patients. Asia Pac J Clin Nutr 16 2 (2007) 213-217
94. Engelman D.T., Adams D.H., Byrne J.G., Aranki S.F., Collins Jr. J.J., Couper G.S., et al. Impact of body mass index and albumin on morbidity and mortality after cardiac surgery. J Thorac Cardiovasc Surg 118 5 (1999) 866-873
95. Graham S.M., Baeten J.M., Richardson B.A., Wener M.H., Lavreys L., Mandaliya K., et al. Short communication: a decrease in albumin in early HIV type 1 infection predicts subsequent disease progression. AIDS Res Hum Retroviruses 23 10 (2007) 1197-1200
96. Horowitz I.N., and Tai K. Hypoalbuminemia in critically ill children. Arch Pediatr Adolesc Med (2007) 1048-1052
97. Iwata M., Kuzuya M., Kitagawa Y., and Iguchi A. Prognostic value of serum albumin combined with serum C-reactive protein levels in older hospitalized patients: continuing importance of serum albumin. Aging Clin Exp Res 18 4 (2006) 307-311
98. Kudsk K.A., Tolley E.A., DeWitt R.C., Janu P.G., Blackwell A.P., Yeary S., et al. Preoperative albumin and surgical site identify surgical risk for major postoperative complications. J Parenter Enteral Nutr 27 1 (2003) 1-9
99. Schwartz S.R., Yueh B., Maynard C., Daley J., Henderson W., and Khuri S.F. Predictors of wound complications after laryngectomy: a study of over 2000 patients. Otolaryngol Head Neck Surg 131 1 (2004) 61-68
100. Steinman T.I. Serum albumin: its significance in patients with ESRD. Semin Dial (2000) 404-408
101. Visschers R.G., Olde Damink S.W., Winkens B., Soeters P.B., and van Gemert W.G. Treatment strategies in 135 consecutive patients with enterocutaneous fistulas. World J Surg 32 3 (2008) 445-453
102. Corti M.C., Guralnik J.M., Salive M.E., and Sorkin J.D. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA 272 13 (1994) 1036-1042
103. Greenberg B.M., Atmar R.L., Stager C.E., and Greenberg S.B. Bacteraemia in the elderly: predictors of outcome in an urban teaching hospital. J Infect 50 4 (2005) 288-295
104. Lang J.D., and Hickman-Davis J.M. One-hit, two-hit... is there really any benefit?. Clin Exp Immunol 141 2 (2005) 211-214
105. Patel N.J., Zaborina O., Wu L., Wang Y., Wolfgeher D.J., Valuckaite V., et al. Recognition of intestinal epithelial HIF-1{alpha} activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol (2007) G134-G142
106. Laughlin R.S., Musch M.W., Hollbrook C.J., Rocha F.M., Chang E.B., and Alverdy J.C. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Ann Surg 232 1 (2000) 133-142
107. Alverdy J., Holbrook C., Rocha F., Seiden L., Wu R.L., Musch M., et al. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg 232 4 (2000) 480-489
108. Wu L.R., Zaborina O., Zaborin A., Chang E.B., Musch M., Holbrook C., et al. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg Infect (Larchmt) 6 2 (2005) 185-195
109. Wu L., Estrada O., Zaborina O., Bains M., Shen L., Kohler J.E., et al. Recognition of host immune activation by Pseudomonas aeruginosa. Science 309 5735 (2005) 774-777
110. Van Goor H. Interventional management of abdominal sepsis: when and how. Langenbecks Arch Surg 387 5-6 (2002) 191-200
111. Wellen K.E., and Hotamisligil G.S. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112 12 (2003) 1785-1788
112. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., and Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95 5 (1995) 2409-2415
113. Engeli S., Feldpausch M., Gorzelniak K., Hartwig F., Heintze U., Janke J., et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes 52 4 (2003) 942-947
114. Wolf A.M., Wolf D., Rumpold H., Enrich B., and Tilg H. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 323 2 (2004) 630-635
115. El-Solh A., Sikka P., Bozkanat E., Jaafar W., and Davies J. Morbid obesity in the medical ICU. Chest 120 6 (2001) 1989-1997
116. Yaegashi M., Jean R., Zuriqat M., Noack S., and Homel P. Outcome of morbid obesity in the intensive care unit. J Intensive Care Med 20 3 (2005) 147-154
117. Hotamisligil G.S., Budavari A., Murray D., and Spiegelman B.M. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94 4 (1994) 1543-1549
118. Hotamisligil G.S., and Spiegelman B.M. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 43 11 (1994) 1271-1278
119. Kern P.A., Saghizadeh M., Ong J.M., Bosch R.J., Deem R., and Simsolo R.B. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95 5 (1995) 2111-2119
120. Neels J.G., and Olefsky J.M. Inflamed fat: what starts the fire?. J Clin Invest 116 1 (2006) 33-35
121. Fasol R., Schindler M., Schumacher B., Schlaudraff K., Hannes W., Seitelberger R., et al. The influence of obesity on perioperative morbidity: retrospective study of 502 aortocoronary bypass operations. Thorac Cardiovasc Surg 40 3 (1992) 126-129
122. Shor R, Wainstein J, Oz D, Boaz M, Matas Z, Fux A, et al Low HDL levels and the risk of death, sepsis and malignancy. Clin Res Cardiol.
123. Benzie I.F. Evolution of antioxidant defence mechanisms. Eur J Nutr 39 2 (2000) 53-61
124. Soeters P.B., Reijven P.L., van Bokhorst-de van der Schueren M.A., Schols J.M., Halfens R.J., Meijers J.M., et al. A rational approach to nutritional assessment. Clin Nutr 27 5 (2008) 706-716
125. Kirkwood T.B. Understanding the odd science of aging. Cell 120 4 (2005) 437-447
126. Schaap L.A., Pluijm S.M., Deeg D.J., and Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 119 6 (2006) p. 526e9-17
127. Schalk B.W.M., Deeg D.J.H., Penninx B.W.J.H., Bouter L.M., and Visser M. Serum albumin and muscle strength: a longitudinal study in older men and women. J Am Geriatr Soc (2005) 1331-1338
128. Schrager M.A., Metter E.J., Simonsick E., Ble A., Bandinelli S., Lauretani F., et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol 102 3 (2007) 919-925
129. Visser M., Pahor M., Taaffe D.R., Goodpaster B.H., Simonsick E.M., Newman A.B., et al. Relationship of interleukin-6 and tumor necrosis factor-{alpha} with muscle mass and muscle strength in elderly men and women: the Health ABC study. J Gerontol 57 5 (2002) M326-332
130. Zuliani G., Romagnoni F., Volpato S., Soattin L., Leoci V., Bollini M.C., et al. Nutritional parameters, body composition, and progression of disability in older disabled residents living in nursing homes. J Gerontol A Biol Sci Med Sci 56 4 (2001) M212-216
131. Fernando M.M., Stevens C.R., Walsh E.C., De Jager P.L., Goyette P., Plenge R.M., et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 4 4 (2008) e1000024
132. Jacob C.O., Fronek Z., Lewis G.D., Koo M., Hansen J.A., and McDevitt H.O. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A 87 3 (1990) 1233-1237
133. Paoloni-Giacobino A., Grimble R., and Pichard C. Genomic interactions with disease and nutrition. Clin Nutr 22 6 (2003) 507-514
134. Dahmer M.K., Randolph A., Vitali S., and Quasney M.W. Genetic polymorphisms in sepsis. Pediatr Crit Care Med 6 3 Suppl. (2005) S61-73
135. Jofre-Monseny L., Minihane A.M., and Rimbach G. Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 52 1 (2008) 131-145
136. Fazekas F., Enzinger C., Ropele S., Schmidt H., Schmidt R., and Strasser-Fuchs S. The impact of our genes: consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis. J Neurol Sci 245 1-2 (2006) 35-39
137. Olivieri F., Antonicelli R., Cardelli M., Marchegiani F., Cavallone L., Mocchegiani E., et al. Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly. Mech Ageing Dev 127 6 (2006) 552-559
138. Schroder J., Kahlke V., Book M., and Stuber F. Gender differences in sepsis: genetically determined?. Shock 14 3 (2000) 307-310 Discussion 310-303
139. Grimble R., Thorell A., Nygren J., Ljungqvist O., Barber N., Grant S.W., et al. Cytokine genotype and gender influence the inflammatory response to surgery. Clin Nutr 22 (2003) S45
140. Grimble R.F. Inflammatory status and insulin resistance. Curr Opin Clin Nutr Metab Care 5 5 (2002) 551-559
141. Cederholm T., Persson M., Andersson P., Stenvinkel P., Nordfors L., Madden J., et al. Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients. J Intern Med 262 2 (2007) 215-223
142. Nilsson J., Jovinge S., Niemann A., Reneland R., and Lithell H. Relation between plasma tumor necrosis factor-alpha and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 18 8 (1998) 1199-1202
143. Yaqoob P., Newsholme E.A., and Calder P.C. Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells. Cytokine 11 8 (1999) 600-605
144. Blackwell J.M., Barton C.H., White J.K., Searle S., Baker A.M., Williams H., et al. Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol Med 1 2 (1995) 194-205
145. England A., Slater-Jefferies J., Miles L., Browning L., Browning L., Grimaldi K., et al. RRR-alpha tocopherol supplementation has pro- and anti-inflammatory and pro- and anti-oxidant effects in PBMCs in healthy middle aged men, depending upon dosage and genotype for xenobitoic metabolising enzymes. Proc Nutr Soc 65 (2006) 69A
146. Reiner A.P., Diehr P., Browner W.S., Humphries S.E., Jenny N.S., Cushman M., et al. Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study. Atherosclerosis 181 1 (2005) 175-183
147. Albers R., Antoine J.M., Bourdet-Sicard R., Calder P.C., Gleeson M., Lesourd B., et al. Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 94 3 (2005) 452-481
148. Caruso C., Lio D., Cavallone L., and Franceschi C. Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci 1028 (2004) 1-13
149. Giacconi R., Cipriano C., Albanese F., Boccoli G., Saba V., Olivieri F., et al. The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. Exp Gerontol 39 4 (2004) 621-628
150. Franceschi C., Motta L., Valensin S., Rapisarda R., Franzone A., Berardelli M., et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging (Milano) 12 2 (2000) 77-84
151. Bonafe M., Olivieri F., Cavallone L., Giovagnetti S., Mayegiani F., Cardelli M., et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 31 8 (2001) 2357-2361
152. Lio D., Scola L., Crivello A., Colonna-Romano G., Candore G., Bonafe M., et al. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun 3 1 (2002) 30-33
153. Calder P.C. Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36 9 (2001) 1007-1024
154. Endres S., Ghorbani R., Kelley V.E., Georgilis K., Lonnemann G., van der Meer J.W., et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320 5 (1989) 265-271
155. Grimble R.F., Howell W.M., O'Reilly G., Turner S.J., Markovic O., Hirrell S., et al. The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 76 2 (2002) 454-459
156. Madden J., Carrero J.J., Brunner A., Dastur N., Shearman C.P., Calder P.C., et al. Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men. Prostaglandins Leukot Essent Fatty Acids 78 6 (2008) 327-335
157. Mol M.J., de Rijke Y.B., Demacker P.N., and Stalenhoef A.F. Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. Atherosclerosis 129 2 (1997) 169-176
158. van Tits L.J., Demacker P.N., de Graaf J., Hak-Lemmers H.L., and Stalenhoef A.F. Alpha-tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am J Clin Nutr 71 2 (2000) 458-464
159. Devaraj S., and Jialal I. Low-density lipoprotein postsecretory modification, monocyte function, and circulating adhesion molecules in type 2 diabetic patients with and without macrovascular complications: the effect of alpha-tocopherol supplementation. Circulation 102 2 (2000) 191-196
160. Massarenti P., Biasi F., De Francesco A., Pauletto D., Rocca G., Silli B., et al. 4-Hydroxynonenal is markedly higher in patients on a standard long-term home parenteral nutrition. Free Radic Res 38 1 (2004) 73-80
161. Di Iorio A., Cherubini A., Volpato S., Sparvieri E., Lauretani F., Franceschi C., et al. Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study. Neurobiol Aging 27 9 (2006) 1280-1288
162. Krabbe K.S., Pedersen M., and Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 39 5 (2004) 687-699
163. Mandavilli B.S., Santos J.H., and Van Houten B. Mitochondrial DNA repair and aging. Mutat Res 509 1-2 (2002) 127-151
164. Tsirpanlis. Cellular senescence, cardiovascular risk, and CKD: a review of established and hypothetical interconnections. Am J Kidney Dis 51 1 (2008) 131-144
165. Candore G., Balistreri C.R., Listi F., Grimaldi M.P., Vasto S., Colonna-Romano G., et al. Immunogenetics, gender, and longevity. Ann N Y Acad Sci 1089 (2006) 516-537
166. Naranjo A., Sokka T., Descalzo M., Calvo-Alen J., Horslev-Petersen K., Luukkainen R., et al. Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study. Arthritis Res Ther (2008) R30
167. van Vollenhoven R. Rheumatologists, take heart! We may be doing something right. Arthritis Res Ther (2008) 105
168. Aslam S. Cardiovascular disease in dialysis patients: do some antihypertensive drugs have specific antioxidant effects or is it just blood pressure reduction? Does antioxidant treatment reduce the risk for cardiovascular disease?. Curr Opin Nephrol Hypertens 17 1 (2008) 99-105
169. Zoccali C., Mallamaci F., and Tripepi G. Traditional and emerging cardiovascular risk factors in end-stage renal disease. Kidney Int Suppl 85 (2003) S105-S110
170. Kimball AB, Robinson JD, Wu Y, Guzzo C, Yeilding N, Paramore C, et al. Cardiovascular disease and risk factors among psoriasis patients in two us healthcare databases; 2001-2002.
171. Brown S.L., Greene M.H., Gershon S.K., Edwards E.T., and Braun M.M. Tumor necrosis factor antagonist therapy and lymphoma development: twenty-six cases reported to the Food and Drug Administration. Arthritis Rheum 46 12 (2002) 3151-3158
172. Askling J., and Dixon W. The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis. Curr Opin Rheumatol 20 2 (2008) 138-144
173. Luiking Y.C., Poeze M., Ramsay G., and Deutz N.E.P. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 89 1 (2009) 142-152
174. Stulc T., Melenovsky V., Grauova B., Kozich V., and Ceska R. Folate supplementation prevents plasma homocysteine increase after fenofibrate therapy. Nutrition 17 9 (2001) 721-723