Chronic protein undernutrition and an acute inflammatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets

Journal of Nutrition

Volumn 129, Issue 3, 1999, Pages 693-699

  Jahoor, Farook ^a   Wykes, Linda ^b   Del Rosario, Melanie ^a   Frazer, Margaret ^a   Reeds, Peter J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Inflammatory stimulus; Muscle protein; Piglets; Plasma protein; Protein undernutrition; Stable isotope

Indexed keywords

ALBUMIN; FIBRINOGEN; MUSCLE PROTEIN; PLASMA PROTEIN; PROTEIN; TURPENTINE;

ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HYDROCORTISONE BLOOD LEVEL; INFLAMMATION; INSULIN BLOOD LEVEL; MUSCLE; NONHUMAN; PLASMA; PROTEIN DEGRADATION; PROTEIN MALNUTRITION; PROTEIN SYNTHESIS; STRESS; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0032980434     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.3.693     Document Type: Article

References (33)

1. Aldred, A. R. & Schreiber, G. (1993) The negative acute phase proteins. In: Acute Phase Proteins, Molecular Biology, Biochemistry and Clinical Applications (Mackiewicz, A., Kushner, I. & Baumann, H., eds.), pp. 21-38, CRC Press, Boca Raton, FL.
2. Clowes, G.H.A., Randall, H. T. &. Cha, C. J. (1980) Amino acid and energy metabolism in septic and traumatized patients. J. Paren. Enter. Nutr. 4: 195-205.
3. Cuthbertson, D. P. (1932) Observations on the disturbance of metabolism produced by injury to the limbs. Q. J. Med. 1: 233-246.
4. Davies, J.W.L., Ricketts, C. R. & Bull, J. P. (1962) Studies of plasma protein metabolism. Part 1. Albumin in burned and injured patients. Clin. Sci. 23: 411-423.
5. Egusa, G., Brady, D. W., Grundy, S. M. & Howard, B. V. (1983) . Isopropanol precipitation method for the determination of apolipoprotein B specific activity and plasma concentrations during metabolic studies of very low density lipoprotein and low density lipoprotein apolipoprotein. Br. J. Lipid Res. 24: 1261-1267.
6. Fleck, A. (1989) Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc. Nutr. Soc. 48: 347-354.
7. Fleck, A., Hawker, F., Wallace, P. I., Raines, G., Trotters, J., Ledingham, I. M., & Calma, K. C. (1985) Increased vascular permeability: A major cause of hypoalbuminemia in disease and injury. Lancet. 1: 781-784.
8. Garlick, P. J., Millward, D. J., James W.P.T. & Waterlow, J. C. (1975) The effect of protein deprivation and starvation on the rate of protein synthesis in tissues of the rat. Biochimica. et Biophysica. Acta. 414: 71-84.
9. Golden, M.H.N., Waterlow, J. C. & Picou, D. (1977) Protein turnover, synthesis and breakdown before and after recovery from protein-energy malnutrition. Clin. Sci. 53: 473-477.
10. Grossman, J., Yalow, A. A. & Weston, R. E. (1960) Albumin degradation and synthesis as influenced by hydrocortisone, corticotrophin and infection. Metabolism. 9: 528-550.
11. Hardin, T. C. (1993) Cytokine mediators of malnutrition: Clinical implications. Nutr. Clin. Practice. 8: 55-59.
12. 3 into intestinal mucosal protein of protein-deprived rats. J. Clin. Invest. 48: 1224-1229.
13. Jackson, A. A., Doherty, J., DeBenoist, M. H., Hibbert, J. & Persaud, C. (1990) The effect of the level of dietary protein, carbohydrate and fat on urea kinetics in young children during rapid catch-up weight gain. Br. J. Nutr. 64: 371-385.
14. Jahoor, F., Burrin, D. G., Reeds, P. J. & Frazer, M. (1994) Measurement of plasma protein synthesis rate in the infant pig: An investigation of alternative tracer approaches. Am. J. Physiol. 267:R221-R227.
15. Jahoor, F., Desai, M., Herndon, D. N. & Wolfe, R. R. (1988) Dynamics of the protein metabolic response to bum injury. Metabolism 37: 330-337.
16. Jahoor, F., Sivakumar, B., Wykes, L., Burrin, D., DelRosario, M. & Frazer, M. E. (1996) Chronic protein deficiency differentially affects the rates of synthesis of plasma proteins in young pigs. J. Nutr. 126: 1489-1495.
17. Jahoor, F., Wykes, L., Reeds, P. J., Henry, J., DelRosario, M. & Frazer, M. E. (1995) Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J. Nutr. 125: 1462-1472.
18. Kushner, I. (1982) The phenomenon of the acute phase response. In: C-Reactive Protein and the Plasma Protein Response to Tissue Injury. (Kushner, I., Volanakis, J. E., Gewurz, H., eds.) Ann. NY Acad. Sci. 389: 39-48.
19. Mansoor, O., Cayol, M., Gachon, P., Boirie, Y., Schoeffler, P., Obled, C. & Beaufrere, B. (1997) Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients. Am. J. Physiol. 273: E898-E902.
20. McNurlan, M. A. & Garlick, P. J. (1981) Protein synthesis in liver and small intestine in protein deprivation and diabetes. Am. J. Physiol. 241 : E238-E245.
21. McNurlan, M. A., Fern, E. B. & Garlick, P. J. (1982) Failure of leucine to stimulate protein synthesis in vivo. Biochem. J. 204: 831-838.
22. Millward, D. J. (1990) The hormonal control of protein turnover. Clin. Nutr. 9: 115-126.
23. Morlese, J. F., Forrester, T., Badaloo, A., DelRosario, M., Frazer, M. & Jahoor, F. (1996) Albumin kinetics in edematous and non-edematous protein-energy malnourished children. Am. J. Clin. Nutr. 64: 952-959.
24. Morlese, J. F., Forrester, T. & Jahoor, F. (1998) The acute-phase protein response to infection does not include fibrinogen, and is mediated by different mechanisms in severe malnutrition. Am J. Physiol. 257: E112-E117.
25. Picou, D. & Phillips, M. (1972) Urea metabolism in malnourished and recovered children receiving a high or low protein diet. Am. J. Clin. Nutr. 25: 1261-1266.
26. Ramirez, C. G., Miller, E. R., Ullrey, D. E. & Hoffer, J. A. (1963) Swine hematology from birth to maturity. III. Blood volume of the nursing pig. J. Anim. Sci. 22: 1068-1074.
27. Reeds, P. J., Fjeld, C. R. & Jahoor, F. (1994) Do the differences in the amino acid composition of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states. J. Nutr. 124: 906-910.
28. Schelp, F. P., Thanangkul, O., Supawan, V., Suttajit, M., Meyers, C., Pimpantha, R., Pongpaew, P. & Migasena, P. (1979) Serum proteinase inhibitors and acute phase reactants from protein-energy malnutrition children during treatment. Am. J. Clin. Nutr. 32: 1415-1422.
29. Schreiber, G. (1988) Synthesis, processing, and secretion of plasma proteins by the liver and other organs and their regulation. In: The Plasma Proteins (Putnam, F. W., ed.), pp. 361-399, Academic Press, New York, NY.
30. Tawa N. E., Jr, & Goldberg, A. L. (1992) Suppression of muscle protein turnover and amino acid degradation by dietary protein deficiency. Am. J. Physiol. 263: E317-E325.
31. Tomkins, A. M., Garlick, P. J., Schofield, W. N. & Waterlow, J. C. (1983) The combined effects of infection and malnutrition on protein metabolism in children. Clin. Sci. 65: 313-324.
32. 14C]lysine. Clin. Sci. 35: 287-305.
33. Wykes, L., Burrin, D. G., Fiorotto, M., Pond, W., Fraser, M. E., DelRosario, M. & Jahoor, F. (1996) Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition. J. Nutr. 126: 1481-1488.