Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acute-phase protein response

Annals of Surgery

Volumn 227, Issue 2, 1998, Pages 249-254

  Fearon, Kenneth C H ^a   Stuart Falconer, J ^a   Slater, Christine ^b   McMillan, Donald C ^c   Ross, James A ^a   Preston, Tom ^b  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b SCOTTISH UNIVERSITIES ENVIRONMENTAL RESEARCH CENTRE   (United Kingdom)

^c GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ADULT; ARTICLE; CACHEXIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPOALBUMINEMIA; NORMAL HUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN SYNTHESIS; WEIGHT REDUCTION;

EID: 0344765509     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199802000-00015     Document Type: Article

References (30)

1. Fearon KCH. The mechanisms and treatment of weight loss in cancer. Proc Nutr Soc 1992;51:251-265.
2. Costelli P, Carbo N, Tessitore L, et al. Tumour necrosis factor mediates changes in tissue protein turnover in a rat cancer cachexia model. J Clin Invest 1993;92:2783-2789.
3. Strassmann G, Masui Y, Chizzonite R, Fong M. Mechanism of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumour. J Immunol 1993;150:2341-2345.
4. Yasumoto K, Mukaida N, Harada, A. Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice. Cancer Res 1995;55:921-927.
5. Cooper EA. Acute-phase reactant proteins in cancer. In Klein G, Winehouse S, eds. Advances in Cancer Research. New York: Academic Press. 1979:1-44.
6. Falconer JS, Fearon KCH, Plester CE, et al. Cytokines, the acute-phase response and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 1994;219:325-331.
7. Falconer JS, Fearon KCH, Ross JA, et al. Acute-phase protein response and survival duration of patients with pancreatic cancer. Cancer 1995;75:2077-2082.
8. Sirott MN, Bagordin N, Wong GY, et al. Prognostic factors in patients with metastatic malignant melanoma: a multivariate analysis. Cancer 1993;302:3091-3098.
9. Castell JV, Gomez-Lechon J, David M, et al. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990;12:1179-1186.
10. Kowalski-Saunders PWJ, Winwood PJ, Arthur MJP, Wright R. Reversible inhibition of albumin production by rat hepatocytes maintained in a Laminin-rich gel (Engdbroh-Holm-Susarm) in response to secretory products of Kupffer cells and Cytokines. Hepatology 1992;16:733-741.
11. O'Riordain MG, Ross JA, Fearon KCH, et al. Insulin and counter-regulatory hormones influence acute-phase protein production in human hepatocytes. Am J Physiol 1995;269:E323-E330.
12. Fearon KCH, McMillan DC, Preston T, et al. Elevated circulating interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. Ann Surg 1991;213:26-31.
13. Gibson JG, Evans WA. Clinical studies of the blood volume. I. Clinical application of a method employing the azo dye Evans Blue" and the spectrophotometer. J Clin Invest 1937;16:301-316.
14. Ballmer PE, Ochsenbein AF, Schutz-Hofmann S. Transcapillary escape rate of albumin positively correlates with plasma albumin concentration in acute but not in chronic inflammatory disease. Metabolism 1994;43:697-705.
15. Goldie AS, Fearon KCH, Ross JA, et al. Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. JAMA 1995;274:172-177.
16. Doumas BT, Watson W, Biggs HG. Albumin standards and the measurement of serum albumin with bromocresol green. Clin Chim Acta 1971;31:87-96.
17. Slater C, Preston T, McMillan DC, et al. GC MS analysis of 2H5-phenylalanine at very low enrichment: measurement of protein synthesis in health and disease. J Mass Spectrom 1995;30:1325-1332.
18. Korner A, Debro JR. Solubility of albumin after precipitation by trichloroacetic acid: a simplified procedure for separation of albumin. Nature 1956;10:1067.
19. Maguire GF, Lee M, Connelly PW. Sodium dodecyl-sulfate-glycerol polyacrylamide slab gel electrophoresis for the resolution of apolipoproteins. J Lipid Res 1989;30:757-761.
20. McMillan DC, Preston T, Fearon KCH, et al. Protein synthesis in cancer patients with an inflammatory response: investigations using [15N] glycine. Nutrition 1994;10:232-240.
21. Ballmer PE, McNurlan MA, Milne E, et al. Measurement of albumin synthesis in humans: a novel approach employing stable isotopes. Am J Physiol 1990;259:E797-E803.
22. Fleck A, Hawker F, Wallace PI, et al. Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury. Lancet 1985;i:781-784.
23. Preston T, Fearon KCH, Robertson I, et al. Tissue lost during severe wasting in lung cancer patients. In Ellis KJ, Yasumuru S, Morgan WD, eds. In Vivo Body Composition Studies. Inst Phys Sci Med 1987:60-69.
24. Rothschild MA, Orate M, Schreiber SS. Albumin synthesis. N Engl J Med 1972;286:816-821.
25. Steinfeld JL. Albumin breakdown in patients with neoplastic diseases. Cancer 1960;13:974-984.
26. Van Zee KJ, Kohno T, Fischner E, et al. Tumour necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumour necrosis factor alpha in vitro and in vivo. Proc Nat Acad Sci USA 1992;89:4845-4849.
27. Brenner DA, Buck F, Beitelberg SP, Chojkier N. Tumour necrosis factor alpha inhibits albumin gene expression in a murine model of cachexia. J Clin Invest 1990;85:248-255.
28. Pietrangelo A, Shafritz DA. Homeostatic regulation of hepatocyte nuclear transcription factor 1 expressed in cultured hepatoma cells. Proc Nat Acad Sei USA 1994;91:182-186.
29. Dahn MS, Hsu CJ, Lange L, Jefferson LS. Effects of tumour necrosis factor α on glucose and albumin production in primary cultures of rat hepatocytes. Metabolism 1994;43:476-480.
30. Reeds PJ, Fjeld CR, Jahoor F. Do the differences between the amino acid compositions of acute phase and muscle proteins have a bearing on nitrogen loss in traumatic states? J Nutr 1994;124:906-910.