Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus

British Journal of Pharmacology

Volumn 158, Issue 7, 2009, Pages 1753-1762

  Lee, Chun Yao ^a   Chen, Chih Chuan ^b   Liou, Horng Huei ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Dentate gyrus; EPSC; Glutamate; Levetiracetam; Voltage dependent calcium channel

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; ETIRACETAM; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIMODIPINE; OMEGA AGATOXIN; OMEGA CONOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; HIPPOCAMPUS; IN VITRO STUDY; INHIBITION KINETICS; MALE; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT; SEIZURE; SYNAPTIC TRANSMISSION;

ANIMALS; ANTICONVULSANTS; CALCIUM CHANNELS, P-TYPE; CALCIUM CHANNELS, Q-TYPE; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; MALE; PATCH-CLAMP TECHNIQUES; PIRACETAM; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 71249152084     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00463.x     Document Type: Article

References (43)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Augustine GJ (2001). How does calcium trigger neurotransmitter release? Curr Opin Neurobiol 11 : 320 326.
3. 2+ channels. Neuropharmacology 46 : 743 749.
4. Bekkers JM, Clements JD (1999). Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons. J Physiol 516 : 227 248.
5. Carunchio I, Pieri M, Ciotti MT, Albo F, Zona C (2007). Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam. Epilepsia 48 : 654 662.
6. Cereghino JJ, Biton V, Abou-Khalil B, Dreifuss F, Gauer LJ, Leppik I (2000). Levetiracetam for partial seizures. Results of a double-blind, randomized clinical trial. Neurology 55 : 236 242.
7. Craig AM, Boudin H (2001). Molecular heterogeneity of central synapses: Afferent and target regulation. Nat Neurosci 4 : 569 578.
8. Cunningham MO, Woodhall GL, Thompson SE, Dooley DJ, Jones RS (2004). Dual effect of gabapentin and pregabalin on glutamate release at rat entorhinal stnapses in vitro. Eur J Neurosci 20 : 1566 1576.
9. During MJ, Spencer DD (1993). Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341 : 1607 1610.
10. 2+ channels - integration centers for neuronal signaling pathways. Trends Neurosci 29 : 617 624.
11. Gorji A, Hohling JM, Madeja M, Straub H, Kohling R, Tuxhorn I et al. (2002). Effect of levetiracetam on epileptiform discharges in human neocortical slices. Epilepsia 43 : 1480 1487.
12. Inchauspe CG, Forsythe ID, Uchitel OD (2007). Changes in synaptic transmission properties due to the expression of N-type calcium channels at the calyx of Held synapse of mice lacking P/Q-type calcium channels. J Physiol 584 : 835 851.
13. 2+ regulators in neurotransmitter release. Neuron 24 : 1003 1016.
14. Kleckner NW, Glazewski JC, Chen CC, Moscrip TD (1999). Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: Insights into the mechanism of action. J Pharmacol Exp Ther 289 : 886 894.
15. Klitgaard H, Matagne A, Grimee R, Vanneste-Goemaere J, Margineanu DG (2003). Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy. Seizure 12 : 92 100.
16. Lee CH, Lee CY, Tsai TS, Liou HH (2008a). PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharm 76 : 225 235.
17. Lee CY, Fu WM, Chen CC, Su MJ, Liou HH (2008b). Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia 49 : 889 897.
18. Löscher W, Hönack D, Rundfeldt C (1998). Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 284 : 474 479.
19. Lukyanetz EA, Shkryl VM, Kostyuk PG (2002). Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 43 : 9 18.
20. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A et al. (2004). The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 101 : 9861 9866.
21. McNaughton BL, Barnes CA (1997). Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat. J Comp Neurol 175 : 439 454.
22. Madeja M, Margineanu DG, Gorji A, Siep E, Boerrigter P, Klitgaard H et al. (2003). Reduction of voltage-operated potassium currents by levetiracetam: A novel antiepileptic mechanism of action? Neuropharmacology 45 : 661 671.
23. Mori Y, Mikala G, Varadi G, Kobayashi T, Koch S, Wakamori M et al. (1996). Molecular pharmacology of voltage-dependent calcium channels. Jpn J Pharmacol 72 : 83 109.
24. Mula M, Pini S, Cassano GB (2007). The role of anticonvulsant drugs in anxiety disorders: A critical review of the evidence. J Clin Psychopharmacol 27 : 263 272.
25. 2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held. J Physiol 586 : 5503 5520.
26. Muralidharan A, Bhagwagar Z (2006). Potential of levetiracetam in mood disorders: A preliminary review. CNS Drugs 20 : 969 979.
27. Nadler JV (2003). The recurrent mossy fiber pathway of the epileptic brain. Neurochem Res 28 : 1649 1658.
28. Niespodziany I, Klitgaard H, Margineanu DG (2001). Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neurosci Lett 306 : 5 8.
29. Ozawa S, Kamiya H, Tsuzuki K (1998). Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 54 : 581 618.
30. Patsalos PN (2000). Pharmacolkinetic profile of levetiracetam: Toward ideal characteristics. Pharmacol Ther 85 : 77 85.
31. Perkel DJ, Nicoll RA (1993). Evidence for all-or-none regulation of neurotransmitter release: Implications for long-term potentiation. J Physiol 471 : 481 500.
32. Pisani A, Bonsi P, Martella G, De Persis C, Costa C, Pisani F et al. (2004). Intracellular calcium increase in epileptiform activity: Modulation by levetiracetam and lamotrigine. Epilepsia 45 : 719 728.
33. 2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron. J Neurosci 21 : 3721 3728.
34. Redman S (1990). Quantal analysis of synaptic potential in neurons of the central nerve system. Physiol Rev 70 : 165 198.
35. 2+ channels: A functional patchwork. Trends Neurosci 26 : 683 687.
36. Rigo JM, Hans G, Nguyen L, Rocher V, Belachew S, Malgrange B et al. (2002). The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br J Pharmacol 136 : 659 672.
37. 2+ currents in cortical neurons: Functional implications. Eur J Pharmacol 307 : 113 116. (Pubitemid 26226292)
38. Stringer JL, Williamson JM, Lothman EW (1989). Induction of paroxysmal discharges in the dentate gyrus: Frequency dependence and relationship to afterdischarge production. J Neurophysiol 62 : 126 135.
39. Weber S, Beran RG (2004). A pilot study of compassionate use of levetiracetam in patients with generalised epilepsy. J Clin Neurosci 11 : 728 731.
40. Wu LG, Saggau P (1997). Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci 20 : 204 212.
41. Yang XF, Weisenfeld A, Rothman SM (2007). Prolonged exposure of levetiracetam reveals a presynaptic effect on neurotransmission. Epilepsia 48 : 1861 1869.
42. 2+ currents. Seizure 10 : 279 286.
43. Zucker R (1989). Short-term synaptic plasticity. Annu Rev Neurosci 12 : 13 31.