A pilot study of compassionate use of Levetiracetam in patients with generalised epilepsy

Journal of Clinical Neuroscience

Volumn 11, Issue 7, 2004, Pages 728-731

  Weber, Suzanne ^a   Beran, Roy G ^a  

^a Strategic Health Evaluators   (Australia)

Author keywords

Lennox Gastaut syndrome; levetiracetam; primary generalised epilepsy

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; DIAZEPAM; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; METHYLPHENOBARBITAL; NITRAZEPAM; PARAMETHADIONE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; SULTIAME; TIAGABINE; TRIMETHADIONE; VALPROIC ACID; VIGABATRIN;

ADULT; AGGRESSION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG USE; FEMALE; FOLLOW UP; GENERALIZED EPILEPSY; HUMAN; LENNOX GASTAUT SYNDROME; LONG TERM CARE; MALE; OPEN STUDY; PATIENT COMPLIANCE; PILL; PILOT STUDY; PREGNANCY; PRIORITY JOURNAL; SEIZURE; SIDE EFFECT; TREATMENT OUTCOME;

ADULT; ANTICONVULSANTS; EPILEPSY, GENERALIZED; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PIRACETAM; TREATMENT OUTCOME;

EID: 4444245442     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2004.01.002     Document Type: Article

References (18)

1. Shorvon S.D., Lowenthal A., Janz D., Bielen E., Loiseau P. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia. 41(9):2000;1179-1186
2. Betts T., Waegemans T., Crawford P. A multicentre, double-blind, randomised, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy. Seizure. 9:2000;80-87
3. Cereghino MD, Biton V, Abou-Khalil B, Dreifuss F, Gauer LJ, Leppik I, the United States Levetiracetam Study Group, Levetiracetam for partial seizures: results of a double-blind, randomised clinical trial. Neurology 2000;55:236-242
4. Ben-Menachem E, Falter U. for the European Levetiracetam Study Group, Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy. Epilepsia 2000;41(10):1276-1283
5. Penovich P., Cereghino J., Debrabandere L., Gauer L. Levetiracetam: evaluation of efficacy and safety of different dosages in add-on treatment of partial epilepsy. Epilepsia. 39(Suppl 6):1998;68
6. Beran RG, Berkovic SF, Black AB, Danta G, Schapel GJ, Vajda FJ. Open-label, multi-centre study: evaluation of the efficacy and safety of Levetiracetam with individualised doses up to 3000 mg/day as add-on therapy in adult Australians with uncontrolled partial seizures, Epilepsy Society of Australia Annual Scientific Meeting, Brisbane 2002
7. Commission on Classification and Terminology of the ILAE, Proposal for revised clinical and electro-encephalographic classification of seizures, Epilepsia 1981;22:489-501
8. Parra J., Augustijn P.B., Geerts Y., van Emde Boas W. Classification of epileptic seizures: a comparison of two systems. Epilepsia. 42(4):2001;476-482
9. Kasteleijn-Nolst T., Marescaux C., Stodieck S., Edelbroek P.M., Oosting J. Photosensitive epilepsy: a model to study the effects of antiepileptic drugs. Evaluation of the piracetam analogue, levetiracetam. Epilepsy Res. 25:1996;225-230
10. Beran R.G., Gibson R.J. Aggressive behaviour in intellectually challenged patients with epilepsy, treated with Lamotrigine. Epilepsia. 39(3):1998;280-282
11. Beran R.G., Berkovic S.F., Dunagan F.M., Vajda F.J.E., Danta G., Black A.B., Mackenzie R. Double-blind, placebo-controlled, crossover study of Lamotrigine in treatment-resistant generalised epilepsy. Epilepsia. 39(12):1998;1329-1333
12. Privitera M. Efficacy of Levetiracetam: a review of three pivotal clinical trials. Epilepsia 42(Suppl 4):31-35
13. Krakow K., Walker M., Otoul C., Sander J.W.A.S. Long-term continuation of levetiracetam in patients with refractory epilepsy. Neurology. 56:2001;1772-1774
14. Cramer J.A., Arrigo C., Van Hammee G., Gauer L.J., Cereghino J.J. Effect of levetiracetam on epilepsy-related quality of life. Epilepsia. 41(7):2000;868-874
15. Harden C. Safety profile of levetiracetam. Epilepsia. 42(Suppl 4):2001;36-39
16. Sander J.W., Hart Y.M. Psychiatry and epilepsy. Epilepsy: Questions and Answers. 1999;Merit Publishing International, Hampshire
17. MacDonell R, Berkovic SF, Vajda FJE. Pseudoseizures: adult aspects. In: Vajda FJE, Donnan GA (eds). Grey Areas in Epilepsy: Proceedings of workshop held at the Austin Hospital, Melbourne, Australia, 22nd and 23rd November, 1985, York Press:Melbourne;1985
18. Cortesi F., Giannotti F., Ottaviano S. Sleep problems and daytime behavior in childhood idiopathic epilepsy. Epilepsia. 40(11):1999;1557-1565