Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons

Journal of Physiology

Volumn 516, Issue 1, 1999, Pages 227-248

  Bekkers, John M ^a   Clements, John D ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

STRONTIUM; CALCIUM ION;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIAL; FILTRATION; GRANULE CELL; LATENT PERIOD; NERVE CELL; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION; SYSTEM ANALYSIS; VARIANCE; ASYNCHRONOUS EXCITATORY POSTSYNAPTIC CURRENT; BRAIN SLICE; CELL STIMULATION; DENDRITIC CELL; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; MONTE CARLO METHOD; NERVE POTENTIAL; QUANTAL AMPLITUDE; QUANTAL VARIANCE; SYNAPSE; SYNAPTIC TRANSMISSION;

EID: 0033119168     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.227aa.x     Document Type: Article

References (55)

1. 2+ and quantal events at excitatory synapses between mouse hippocampal neurons in culture. Journal of Physiology 495, 113-125.
2. AMARAL, D. G., ISHIZUKA, N. & CLAIBORNE, B. (1990). Neurons, numbers and the hippocampal network, In Progress in Brain Research, ed. STORM-MATHISON, J., ZIMMER, J. & OTTERSEN, O. P., pp. 1-11. Elsevier, New York.
3. AUGUSTINE, G. J. & ECKERT, R. (1984). Divalent cations differentially support transmitter release at the squid giant synapse. Journal of Physiology 346, 257-271.
4. BARRETT, E. F. & STEVENS, C. F. (1972). The kinetics of transmitter release at the frog neuromuscular junction. Journal of Physiology 227, 691-708.
5. BEKKERS, J. M. (1994). Quantal analysis of synaptic transmission in the central nervous system. Current Opinion in Neurobiology 4, 300-365.
6. BEKKERS, J. M. (1995). Synchronous and asynchronous EPSCs evoked in hippocampal slices: A test of the quantal model of neurotransmission. Society for Neuroscience Abstracts 21, 1091.
7. BEKKERS, J. M. (1998). Strontium-evoked mEPSCs reveal large quantal variance at central glutamate synapses. In Central Synapses: Quantal Mechanisms and Plasticity, ed. FABER, D. S., KORN, H., REDMAN, S. J., THOMPSON, S. M. & ALTMAN, J. S., pp. 115-123. HFSP, Strasbourg.
8. BEKKERS, J. M., RICHERSON, G. B. & STEVENS, C. F. (1990). Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices. Proceedings of the National Academy of Sciences of the USA 87, 5359-5362.
9. BEKKERS, J. M. & STEVENS, C. K. (1995). Quantal analysis of EPSCs recorded from small numbers of synapses in hippocampal cultures. Journal of Neurophysiology 73, 1 145-1 156.
10. BEKKERS, J. M. & STEVENS, C. F. (1996). Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. Journal of Neurophysiology 75, 1250-1255.
11. CHOI, S. & LOVINGER, D. M. (1997). Decreased frequency but not amplitude of quantal synaptic responses associated with expression of corticostriatal long-term depression. Journal of Neuroscience 17, 8613-8620.
12. CLEMENTS, J. D. (1996). Transmitter time course in the synaptic cleft: Its role in central synaptic function. Trends in Neurosciences 19, 163-171.
13. CLEMENTS, J. D. & BEKKERS, J. M. (1997). Detection of spontaneous synaptic events using an optimally scaled template. Biophysical Journal 73, 220-229.
14. DEL CASTILLO, J. & KATZ, B. (1954). Quantal components of the end-plate potential. Journal of Physiology 124, 560-573.
15. DODGE, J. F. A., MILEDI, R. & RAHAMIMOFF, R. (1969). Strontium and quantal release of transmitter at the neuromuscular junction. Journal of Physiology 200, 207-283.
16. FATT, P. & KATZ, B. (1952). Spontaneous subthreshold activity at motor nerve endings. Journal of Physiology 117, 109-128.
17. FORTI, L., BOSSI, M., BERGAMASCHI, A., VILLA, A. & MALGAROLI, A. (1997). Loose-patch recordings of single quanta at individual hippocampal synapses. Nature 388, 874-878.
18. FRERKING, M., BORGES, S. & WILSON, M. (1995). Variation in GABA mini amplitude is the consequence of variation in transmitter concentration, Neuron 15, 885-895.
19. FRERKING, M. & WILSON, M. (1996a). Effects of variance in mini amplitude on stimulus-evoked release: A comparison of two models. Biophysical Journal 70, 2078-2091.
20. FRERKING, M. & WILSON, M. (1996b). Saturation of postsynaptic receptors at central synapses? Current Opinion in Neurobiology 6, 395-403.
21. GHAMARI-LANGROUDI, M. & GLAVINOVIĆ, M. I. (1998). Changes of spontaneous miniature postsynaptic currents in rat hippocampal pyramidal cells induced by aniracetam. Pflügers Archiv 435, 185-192.
22. GODA, Y. & STEVENS, C. F. (1994). TWO components of transmitter release at a central synapse. Proceedings of the National Academy of Sciences of the USA 91, 12942-12946.
23. GULYÁS, A. I., MILES, R., SIK, A., TÓTH, K., TAMAMAKI, N. & FREUND, T. F. (1993). Hippocampal pyramidal cells excite inhibitory neurons through a single release site. Nature 366, 683-687.
24. ISAACSON, J. S. & WALMSLEY, B. (1995). Counting quanta: Direct measurements of transmitter release at a central synapse. Neuron 15, 870-884.
25. JACK, J. J. B., REDMAN, S. J. & WONG, K. (1981). The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group Ia afferents. Journal of Physiology 321, 65-96.
26. JONAS, P., MAJOR, G. & SAKMANN, B. (1993). Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology 472, 615-663.
27. KELLER, B. U., KONNERTH, A. & YAARI, Y. (1991). Patch clamp analysis of excitatory synaptic currents in granule cells of rat hippocampus. Journal of Physiology 435, 275-293.
28. KONDO, S. & MARTY, A. (1998). Synaptic currents at individual connections among stellate cells in rat cerebellar slices. Journal of Physiology 509, 221-232.
29. KORN, H. & FABER, D. S. (1991). Quantal analysis and synaptic efficacy in the CNS. Trends in Neurosciences 14, 439-445.
30. KULLMANN, D. M. & NICOLL, R. A. (1992). Long-term potentiation is associated with increases in quantal content and quantal amplitude. Nature 357, 240-244.
31. LAATSCH, R. H. & COWAN, W. M. (1966). Electron microscopic studies of the dentate gyrus of the rat. I. Normal structure with special reference to synaptic organization. Journal of Comparative Neurology 128, 359-390.
32. LARKMAN, A., STRATFORD, K. & JACK, J. (1991). Quantal analysis of excitatory synaptic action and depression in hippocampal slices. Nature 350, 344-347.
33. LARKMAN, A. U., JACK, J. J. B. & STRATFORD, K. J. (1997). Quantal analysis of excitatory synapses in rat hippoammpal CA1 in vitro during low-frequency depression. Journal of Physiology 505, 457-471.
34. LIAO, D., JONES, A. & MALINOW, R. (1992). Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus. Neuron 9, 1089-1097.
35. LIU, G. & TSIEN, R. W. (1995). Properties of synaptic transmission at hippocampal synaptic boutons. Nature 375, 404 408.
36. MCLACHLAN, E. M. (1978). The statistics of transmitter release at chemical synapses, International Reviews of Physiology 17, 49-117.
37. MENNERICK, S., QUE, J., BENZ, A. & ZORUMSKI, C. F. (1995). Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures. Journal of Neurophysiology 73, 320-332.
38. MILEDI, R. (1966). Strontium as a substitute for calcium in the process of transmitter release at the neuromuscular junction. Nature 212, 1233-1234.
39. OLIET, S. H. R., MALENKA, R. C. & NICOLL, R. A. (1996). Bidirectional control of quantal size by synaptic activity in the hippocampus. Science 271, 1294-1297.
40. OTIS, T., ZHANG, S. & TRUSSELL, L. O. (1996). Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission. Journal of Neuroscience 16, 7496-7504.
41. PAULSEN, O. & HEGGELUND, P. (1994). The quantal size at retinogeniculate synapses determined from spontaneous and evoked EPSC's in guinea-pig thalamic slices. Journal of Physiology 480, 505-511.
42. PAULSEN, O. & HEGGELUND, P. (1996). Quantal properties of spontaneous EPSCs in neurons of the guinea-pig dorsal lateral geniculate nucleus. Journal of Physiology 496, 759-772.
43. RAASTAD, M. (1995). Extracellular activation of unitary excitatory synapses between hippocampal CA3 and CA1 pyramidal cells. European Journal of Neuroscience 7, 1882-1888.
44. RAASTAD, M., STORM, J. F. & ANDERSEN, P. (1992). Putative single quantum and single libre excitatory postsynaptic currents show similar amplitude range and variability in rat hippocampal slices. European Journal of Neuroscience 4, 113-117.
45. REDMAN, S. J. (1990). Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiological Reviews 70, 165-198.
46. ROSENMUND, C., CLEMENTS, J. D. & WESTBKOOK, G. L. (1993). Nonuniform probability of glutamate release at a hippocampal synapse. Science 262, 754-757.
47. SIGWORTH, F. J. & SINE, S. M. (1987). Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal 52, 1047-1054.
48. SILVER, R. A., CULL-CANDY, S. G. & TAKAHASHI, T. (1996). Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. Journal of Physiology 494, 231-250.
49. SILVER, R. A., MOMIYAMA, A. & CULL-CANDAY, S. G. (1998). Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses. Journal of Physiology 510, 881-902.
50. SPRUSTON, N. & JOHNSTON, D. (1992). Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons. Journal of Neurophysiology 67, 508-529.
51. STEVENS, C. F. & WANG, Y. (1994). Changes in reliability of synaptic function as a mechanism for plasticity. Nature 371, 704-707.
52. STEVENS, C. F. & WANG, Y. (1995). Facilitation and depression at single central synapses. Neuron 14, 795-802.
53. STRICKER, C., FIELD, A. C. & REDMAN, S. J. (1996). Statistical analysis of amplitude fluctuations in EPSCs evoked in rat CA1 pyramidal neurones in vitro. Journal of Physiology 490, 419-441.
54. VAN DER KLOOT, W. (1994). Quantal acetylcholine release at the vertebrate neuromuscular junction. Physiological Reviews 74, 899-991.
55. WALMSLEY, B. (1993). Quantal analysis of synaptic transmission. In Electrophysiology - A Practical Approach, ed. WALLIS, D. I., pp. 110 141. Oxford University Press.