Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus

Epilepsia

Volumn 49, Issue 5, 2008, Pages 888-897

  Lee, Chun Yao ^a   Fu, Wen Mei ^a   Chen, Chih Chuan ^b   Su, Ming Jai ^a   Liou, Horng Huei ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

AMPA receptor; Dentate gyrus; Epilepsy; EPSC; Lamotrigine

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; BICUCULLINE METHIODIDE; GLUTAMIC ACID; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DENTATE GYRUS; DRUG MECHANISM; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; MALE; NONHUMAN; PATCH CLAMP; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTICONVULSANTS; DENTATE GYRUS; DISEASE MODELS, ANIMAL; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMATES; MALE; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; TRIAZINES;

EID: 43249100266     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01526.x     Document Type: Article

References (41)

1. Abrahamsson T, Gustafsson B, Hanse E 2005) Synaptic fatigue at the naïve perforant path-dentate granule cell synapse in the rat. J Physiol 569 : 737 750.
2. Anderson P, Bliss TVP, Skrede KK 1971) Lamellar organization of the hippocampal excitatory pathways. Exp Brain Res 13 : 222 238.
3. Andreasen M, Hablitz JJ 1994) Paired-pulse facilitation in the dentate gyrus: a patch-clamp study in rat hippocampus in vitro. J Neurophysiol 72 : 326 336.
4. 2+ transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures. J Neurochem 94 : 1124 1130.
5. Bekkers JM, Clements JD 1999) Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons. J Physiol 516 : 227 248.
6. Bowden CL 1998) New concepts in mood stabilization: evidence for the effectiveness of valproate and lamotrigine. Neuropsychopharmacology 19 : 194 199.
7. Calabresi P, Centonze D, Marfia GA, Pisani A, Bernardi G 1999) An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. Br J Pharmacol 126 : 689 696.
8. Carunchio I, Pieri M, Ciotti MT, Albo F, Zona C 2007) Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam. Epilepsia 48 : 654 662.
9. Collins RC, Tearse RG, Lothman EW 1983) Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat. Brain Res 280 : 25 40.
10. Craig AM, Boudin H 2001) Molecular heterogeneity of central synapses: afferent and target regulation. Nat Neurosci 4 : 569 578.
11. Cunningham MO, Jones RS 2000) The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. Neuropharmacology 39 : 2139 2146.
12. Cunningham MO, Dhillon A, Wood SJ, Jones RS 2000) Reciprocal modulation of glutamate and GABA release may underlie the anticonvulsant effect of phenytoin. Neuroscience 95 : 343 351.
13. Du J, Suzuki K, Wei Y, Wang Y, Blumenthal R, Chen Z, Falke C, Zarate CA Jr., Manji HK 2006) The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders. Neurophycopharmacology 32 : 793 802.
14. Epsztein J, Represa A, Jorquera I, Ben-Ari Y, Crepel V 2005) Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats. J Neurosci 25 : 8229 8239.
15. Frizelle HP, Moriarty DC, O'Connor JJ 1999) The combined effects of halothane and lamotrigine on excitatory postsynaptic potentials and use-dependent block in the rat dentate gyrus in vitro. Anesth Analg 89 : 496 501.
16. Gilbert ME, Burdette LJ 1996) Enhancement of paired-pulse depression in the dentate gyrus in vivo by the NMDA antagonist, MK-801, and electrical kindling. Brain Res 732 : 201 208.
17. Hama H, Hara C, Yamaguchi K, Miyawaki A 2004) PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron 41 : 405 415.
18. Huang CW, Ueno S, Okada M, Kaneko S 2005) Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex. Epilepsy Res 67 : 51 60.
19. Kang TC, Kim DS, Kwak SE, Kim JE, Kim DW, Kang JH, Won MH, Kwon OS, Choi SY 2005) Valproic acid reduces enhanced vesicular glutamate transporter immunoreactivities in the dentate gyrus of the seizure prone gerbil. Neuropharmacology 49 : 912 921.
20. + channels in rat hippocampal neurones. Br J Pharmacol 121 : 1231 1238.
21. Langosch JM, Zhou XY, Frick A, Grunze H, Walden J 2000) Effect of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices. Epilepsia 41 : 1102 1106.
22. Leach MJ, Marden CM, Miller AA 1986) Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 27 : 490 497.
23. Martin ED, Pozo MA 2004) Valproate reduced excitatory postsynaptic currents in hippocampal CA1 pyramidal neurons. Neuropharmacology 46 : 555 561.
24. McNaughton BL, Barnes CA 1997) Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat. J Comp Neurol 175 : 439 454.
25. Mikati MA, Holmes GL 1997) Lamotrigine in absence and primary generalized epilepsies. J Child Neurol 12 (Suppl 1 S29 S37.
26. Onodera K, Hamba M, Takahashi T 2000) Primary afferent synaptic responses recorded from trigeminal caudal neurons in a mandibular nerve-brainstem preparation of neonatal rats. J Physiol 524 : 503 512.
27. Perkel DJ, Nicoll RA 1993) Evidence for all-or-none regulation of neurotransmitter release: implications for long-term potentiation. J Physiol 471 : 481 500.
28. Phillips I, Martin KF, Thompson KSJ, Heal DJ 1997) Weak blockade of AMPA receptor-mediated depolarisations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine. Eur J Pharmacol 337 : 189 195.
29. Pisani F, Pedale S, Macaione V, Torre V, Oteri G, Avanzini G, Ientile R 2001) Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina. Exp Neurol 170 : 162 170.
30. Rambeck B, Jurgens UH, May TW, Pannek HW, Behne F, Ebner A, Gorji A, Straub H, Speckmann EJ, Pohlmann-Eden B, Loscher W 2006) Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy. Epilepsia 47 : 681 694.
31. Redman S 1990) Quantal analysis of synaptic potential in neurons of the central nerve system. Physiol Rev 70 : 165 198.
32. Rogawski MA, Donevan SD 1999) AMPA receptor in epilepsy and as targets for antiepileptic drugs. Adv Neurol 79 : 947 963.
33. Shimoyama M, Shimoyama N, Hori Y 2000) Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 85 : 405 414.
34. Stewart J, Hughes E, Reynolds EH 1992) Lamotrigine for generalized epilepsies. Lancet 340 : 1223.
35. Stringer JL, Williamson JM, Lothman EW 1989) Induction of paroxysmal discharges in the dentate gyrus: frequency dependence and relationship to afterdischarge production. J Neurophysiol 62 : 126 135.
36. Thompson KW 2005) Genetically engineered cells with regulatable GABA production can affect afterdischarges and behavioral seizures after transplantation into the dentate gyrus. Neuroscience 133 : 1029 1037.
37. Wang SJ, Huang CC, Hsu KS, Tsai JJ, Gean PW 1996) Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neurons. Synapse 24 : 248 255.
38. Walker MC, Tong X, Perry H, Alavijeh MS, Patsalos PN 2000) Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine. Br J Pharmacol 130 : 242 248.
39. Wuarin JP, Deduk FE 1996) Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats. J Neurosci 16 : 4438 4448.
40. Yamaguchi S, Donevan SD, Rogawski MA 1993) Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant models. Epilepsy Res 15 : 179 184.
41. Zucker R 1989) Short-term synaptic plasticity. Annu Rev Neurosci 12 : 13 31.