-
1
-
-
0025124447
-
Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas
-
Snoeck A, Remacle C, Reusens B, Hoet JJ. Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biol Neonate 1990; 57: 107-118. (Pubitemid 20041117)
-
(1990)
Biology of the Neonate
, vol.57
, Issue.2
, pp. 107-118
-
-
Snoeck, A.1
Remacle, C.2
Reusens, B.3
Hoet, J.J.4
-
2
-
-
0026316923
-
Islet function in offspring of mothers on low-protein diet during gestation
-
Dahri S, Snoeck A, Reusens-Billen B, Remacle C, Hoet JJ. Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 1991; 40 (Suppl 2): 115-120.
-
(1991)
Diabetes
, vol.40
, Issue.SUPPL. 2
, pp. 115-120
-
-
Dahri, S.1
Snoeck, A.2
Reusens-Billen, B.3
Remacle, C.4
Hoet, J.J.5
-
3
-
-
0033305240
-
A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II
-
Petrik J, Reusens B, Arany E, Remacle C, Coelho C, Hoet JJ, et al. A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II. Endocrinology 1999; 140: 4861-4873. (Pubitemid 30666156)
-
(1999)
Endocrinology
, vol.140
, Issue.10
, pp. 4861-4873
-
-
Petrik, J.1
Reusens, B.2
Arany, E.3
Remacle, C.4
Coelho, C.5
Hoet, J.J.6
Hill, D.J.7
-
4
-
-
35848944102
-
Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet
-
DOI 10.1007/s00125-007-0811-0
-
Dumortier O, Blondeau B, Duvillie B, Reusens B, Breant B, Remacle C. Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet. Diabetologia 2007; 50: 2495-2503. (Pubitemid 350060634)
-
(2007)
Diabetologia
, vol.50
, Issue.12
, pp. 2495-2503
-
-
Dumortier, O.1
Blondeau, B.2
Duvillie, B.3
Reusens, B.4
Breant, B.5
Remacle, C.6
-
5
-
-
0037371645
-
Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase C alpha expression
-
Ferreira F, Filiputti E, Arantes VC, Stoppiglia LF, Araujo EP, Delghingaro-Augusto V, et al. Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase C alpha expression. J Nutr 2003; 133: 695-699. (Pubitemid 36268341)
-
(2003)
Journal of Nutrition
, vol.133
, Issue.3
, pp. 695-699
-
-
Ferreira, F.1
Filiputti, E.2
Arantes, V.C.3
Stoppiglia, L.F.4
Araujo, E.P.5
Delghingaro-Augusto, V.6
Latorraca, M.Q.7
Toyama, M.H.8
Boschero, A.C.9
Carneiro, E.M.10
-
6
-
-
42949098384
-
Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats
-
DOI 10.1016/j.metabol.2007.12.004, PII S0026049508000139
-
Giozzet VA, Rafacho A, Boschero AC, Carneiro EM, Bosqueiro JR. Dexamethasone treatment in vivo counteracts the functional pancreatic islet alterations caused by malnourishment in rats. Metabolism 2008; 57: 617-624. (Pubitemid 351608222)
-
(2008)
Metabolism: Clinical and Experimental
, vol.57
, Issue.5
, pp. 617-624
-
-
Giozzet, V.A.G.1
Rafacho, A.2
Boschero, A.C.3
Carneiro, E.M.4
Bosqueiro, J.R.5
-
7
-
-
0030998522
-
Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
-
Reis MA, Carneiro EM, Mello MA, Boschero AC, Saad MJ, Velloso LA. Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats. J Nutr 1997; 127: 403-410.
-
(1997)
J Nutr
, vol.127
, pp. 403-410
-
-
Reis, M.A.1
Carneiro, E.M.2
Mello, M.A.3
Boschero, A.C.4
Saad, M.J.5
Velloso, L.A.6
-
8
-
-
0026709588
-
Persistent reduction of pancreatic beta-cell mass after a limited period of protein-energy malnutrition in the young rat
-
Swenne I, Borg LA, Crace CJ, Schnell LA. Persistent reduction of pancreatic beta-cell mass after a limited period of protein-energy malnutrition in the young rat. Diabetologia 1992; 35: 939-945.
-
(1992)
Diabetologia
, vol.35
, pp. 939-945
-
-
Swenne, I.1
Borg, L.A.2
Crace, C.J.3
Schnell, L.A.4
-
9
-
-
0031264027
-
Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats
-
Tse EO, Gregoire FM, Reusens B, Remacle C, Hoet JJ, Johnson PR, et al. Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats. Obes Res 1997; 5: 563-571.
-
(1997)
Obes Res
, vol.5
, pp. 563-571
-
-
Tse, E.O.1
Gregoire, F.M.2
Reusens, B.3
Remacle, C.4
Hoet, J.J.5
Johnson, P.R.6
-
10
-
-
0037131246
-
Beta-cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
-
Liu YQ, Jetton TL, Leahy JL. Beta-cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem 2002; 277: 39163-39168.
-
(2002)
J Biol Chem
, vol.277
, pp. 39163-39168
-
-
Liu, Y.Q.1
Jetton, T.L.2
Leahy, J.L.3
-
11
-
-
33745863033
-
Islet beta cell failure in type 2 diabetes
-
DOI 10.1172/JCI29103
-
Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006; 116: 1802-1812. (Pubitemid 44033300)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
12
-
-
41149165411
-
Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance
-
Rafacho A, Giozzet VA, Boschero AC, Bosqueiro JR. Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance. Pancreas 2008; 36: 284-293.
-
(2008)
Pancreas
, vol.36
, pp. 284-293
-
-
Rafacho, A.1
Giozzet, V.A.2
Boschero, A.C.3
Bosqueiro, J.R.4
-
13
-
-
41649099891
-
Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion
-
Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, et al. Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion. Am J Physiol Endocrinol Metab 2008; 294: E679-E687.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Jetton, T.L.1
Everill, B.2
Lausier, J.3
Roskens, V.4
Habibovic, A.5
LaRock, K.6
-
14
-
-
0020065416
-
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor
-
Kasuga M, Karlsson FA, Kahn CR. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science 1982; 215: 185-187. (Pubitemid 12178108)
-
(1982)
Science
, vol.215
, Issue.4529
, pp. 185-187
-
-
Kasuga, M.1
Karlsson, F.A.2
Kahn, C.R.3
-
15
-
-
0021985413
-
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
-
DOI 10.1038/313756a0
-
Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ, et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 1985; 313: 756-761. (Pubitemid 15130823)
-
(1985)
Nature
, vol.313
, Issue.6005
, pp. 756-761
-
-
Ullrich, A.1
Bell, J.R.2
Chen, E.Y.3
-
16
-
-
0026660653
-
Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
-
Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, et al. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 1992; 11: 3469-3479.
-
(1992)
EMBO J
, vol.11
, pp. 3469-3479
-
-
Backer, J.M.1
Myers Jr., M.G.2
Shoelson, S.E.3
Chin, D.J.4
Sun, X.J.5
Miralpeix, M.6
-
17
-
-
0028270049
-
Molecular mechanisms of insulin resistance
-
Saad MJ. Molecular mechanisms of insulin resistance. Braz J Med Biol Res 1994; 27: 941-957.
-
(1994)
Braz J Med Biol Res
, vol.27
, pp. 941-957
-
-
Saad, M.J.1
-
18
-
-
0034810894
-
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
-
DOI 10.1096/fj.01-0009rev
-
Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 2001; 15: 2099-2111. (Pubitemid 32927927)
-
(2001)
FASEB Journal
, vol.15
, Issue.12
, pp. 2099-2111
-
-
Sesti, G.1
Federici, M.2
Hribal, M.L.3
Lauro, D.4
Sbraccia, P.5
Lauro, R.6
-
19
-
-
34548173724
-
Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets
-
DOI 10.1139/Y07-037
-
Rafacho A, Roma LP, Taboga SR, Boschero AC, Bosqueiro JR. Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets. Can J Physiol Pharmacol 2007; 85: 536-545. (Pubitemid 47309800)
-
(2007)
Canadian Journal of Physiology and Pharmacology
, vol.85
, Issue.5
, pp. 536-545
-
-
Rafacho, A.1
Roma, L.P.2
Taboga, S.R.3
Boschero, A.C.4
Bosqueiro, J.R.5
-
20
-
-
47649101647
-
2 protein levels in insulin-resistant rats
-
DOI 10.1111/j.1365-2613.2008.00588.x
-
Rafacho A, Ribeiro DL, Boschero AC, Taboga SR, Bosqueiro JR. Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats. Int J Exp Pathol 2008; 89: 264-275. (Pubitemid 352019179)
-
(2008)
International Journal of Experimental Pathology
, vol.89
, Issue.4
, pp. 264-275
-
-
Rafacho, A.1
Ribeiro, D.L.2
Boschero, A.C.3
Taboga, S.R.4
Bosqueiro, J.R.5
-
21
-
-
65649099155
-
High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets
-
Rafacho A, Cestari TM, Taboga SR, Boschero AC, Bosqueiro JR. High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab 2009; 296: E681-E689.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Rafacho, A.1
Cestari, T.M.2
Taboga, S.R.3
Boschero, A.C.4
Bosqueiro, J.R.5
-
22
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
DOI 10.1038/414799a
-
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806. (Pubitemid 34000783)
-
(2001)
Nature
, vol.414
, Issue.6865
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
23
-
-
0036549647
-
Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function
-
Kulkarni RN. Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans 2002; 30: 317-322.
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 317-322
-
-
Kulkarni, R.N.1
-
24
-
-
34547482573
-
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
-
DOI 10.1073/pnas.0608703104
-
Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, et al. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A 2007; 104: 8977-8982. (Pubitemid 47175422)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.21
, pp. 8977-8982
-
-
Okada, T.1
Chong, W.L.2
Hu, J.3
Hinault, C.4
Michael, M.D.5
Krutzfeldt, J.6
Yin, C.7
Holzenberger, M.8
Stoffel, M.9
Kulkarni, R.N.10
-
25
-
-
0032587076
-
The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells
-
Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R, et al. The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J Clin Invest 1999; 104: 357-364.
-
(1999)
J Clin Invest
, vol.104
, pp. 357-364
-
-
Porzio, O.1
Federici, M.2
Hribal, M.L.3
Lauro, D.4
Accili, D.5
Lauro, R.6
-
26
-
-
0033379267
-
Altered function of insulin receptor substrate 1-deficient mouse islets and cultured beta-cell lines
-
Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D, et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999; 104: R69-R75. (Pubitemid 30053195)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.12
-
-
Kulkarni, R.N.1
Winnay, J.N.2
Daniels, M.3
Bruning, J.C.4
Flier, S.N.5
Hanahan, D.6
Kahn, C.R.7
-
27
-
-
23044446704
-
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells
-
DOI 10.1152/ajpendo.00032.2004
-
Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, et al. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 2005; 289: E337-E346. (Pubitemid 41076637)
-
(2005)
American Journal of Physiology - Endocrinology and Metabolism
, vol.289
, Issue.2
-
-
Hennige, A.M.1
Ozcan, U.2
Okada, T.3
Jhala, U.S.4
Schubert, M.5
White, M.F.6
Kulkarni, R.N.7
-
28
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
DOI 10.1038/36116
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998; 391: 900-904. (Pubitemid 28157668)
-
(1998)
Nature
, vol.391
, Issue.6670
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.-M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
29
-
-
33748675684
-
On the role of IRS2 in the regulation of functional beta-cell mass
-
DOI 10.1080/13813450600711409, PII N0HRTV1317M65040
-
Niessen M. On the role of IRS2 in the regulation of functional beta-cell mass. Arch Physiol Biochem 2006; 112: 65-73. (Pubitemid 44384774)
-
(2006)
Archives of Physiology and Biochemistry
, vol.112
, Issue.2
, pp. 65-73
-
-
Niessen, M.1
-
30
-
-
0032053709
-
Mechanisms and consequences of activation of protein kinase B/Akt
-
DOI 10.1016/S0955-0674(98)80149-X
-
Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 1998; 10: 262-267. (Pubitemid 28174769)
-
(1998)
Current Opinion in Cell Biology
, vol.10
, Issue.2
, pp. 262-267
-
-
Downward, J.1
-
31
-
-
0035914388
-
Akt1/PKBalpha Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice
-
DOI 10.1074/jbc.C100462200
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001; 276: 38349-38352. (Pubitemid 37371183)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.42
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
32
-
-
34548670709
-
Role of FoxO proteins in pancreatic beta cells
-
DOI 10.1507/endocrj.KR-109
-
Kitamura T, Ido Kitamura Y. Role of FoxO proteins in pancreatic beta cells. Endocr J 2007; 54: 507-515. (Pubitemid 47414596)
-
(2007)
Endocrine Journal
, vol.54
, Issue.4
, pp. 507-515
-
-
Kitamura, T.1
Ido Kitamura, Y.2
-
33
-
-
0242584873
-
+/- mice
-
DOI 10.1172/JCI200316537
-
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, et al. Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 2003; 111: 1147-1160. (Pubitemid 36519932)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.8
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
34
-
-
4043106461
-
Transgenic rescue of insulin receptor-deficient mice
-
DOI 10.1172/JCI200421645
-
Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D. Transgenic rescue of insulin receptor-deficient mice. J Clin Invest 2004; 114: 214-223. (Pubitemid 39071626)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.2
, pp. 214-223
-
-
Okamoto, H.1
Nakae, J.2
Kitamura, T.3
Park, B.-C.4
Dragatsis, I.5
Accili, D.6
-
35
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
DOI 10.1172/JCI200216857
-
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH III, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002; 110: 1839-1847. (Pubitemid 36076491)
-
(2002)
Journal of Clinical Investigation
, vol.110
, Issue.12
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.E.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
36
-
-
0027813823
-
MAP kinase kinase: A node connecting multiple pathways
-
DOI 10.1016/0248-4900(93)90138-5
-
Mordret G. MAP kinase kinase: a node connecting multiple pathways. Biol Cell 1993; 79: 193-207. (Pubitemid 24110555)
-
(1993)
Biology of the Cell
, vol.79
, Issue.3
, pp. 193-207
-
-
Mordret, G.1
-
37
-
-
0028152333
-
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
-
Marshall CJ. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 1994; 4: 82-89.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 82-89
-
-
Marshall, C.J.1
-
38
-
-
0028231105
-
Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
-
DOI 10.1111/j.1432-1033.1994.tb18983.x
-
Giorgetti S, Pelicci PG, Pelicci G, Van Obberghen E. Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor. Eur J Biochem 1994; 223: 195-202. (Pubitemid 24221663)
-
(1994)
European Journal of Biochemistry
, vol.223
, Issue.1
, pp. 195-202
-
-
Giorgetti, S.1
Pelicci, P.G.2
Pelicci, G.3
Von Obberghen, E.4
-
39
-
-
0030030357
-
Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase
-
Holt KH, Kasson BG, Pessin JE. Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase. Mol Cell Biol 1996; 16: 577-583. (Pubitemid 26029096)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.2
, pp. 577-583
-
-
Holt, K.H.1
Kasson, B.G.2
Pessin, J.E.3
-
40
-
-
0036224165
-
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation
-
Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ. Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes 2002; 51: 966-976.
-
(2002)
Diabetes
, vol.51
, pp. 966-976
-
-
Lingohr, M.K.1
Dickson, L.M.2
McCuaig, J.F.3
Hugl, S.R.4
Twardzik, D.R.5
Rhodes, C.J.6
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