Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet

Diabetologia

Volumn 50, Issue 12, 2007, Pages 2495-2503

  Dumortier, O ^a   Blondeau, B ^b,c   Duvillie B ^d   Reusens, B ^a   Breant B ^b,c   Remacle, C ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Beta cell; Low calorie; Low energy; Low protein; Metabolic programming; Neurogenin 3; Pancreas development; PDX 1; Proliferation; Vascularisation

Indexed keywords

CORTICOSTERONE; GLUCOSE; INSULIN; NEUROGENIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; DIET RESTRICTION; FEMALE; FETUS; FETUS CELL; GESTATION PERIOD; MALE; MALNUTRITION; MATERNAL NUTRITION; MORPHOMETRICS; NONHUMAN; ORGAN WEIGHT; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PREGNANCY; PRIORITY JOURNAL; PROTEIN RESTRICTION; RAT; VASCULARIZATION;

ANIMALS; BLOOD GLUCOSE; CALORIC RESTRICTION; CORTICOSTERONE; DIET, PROTEIN-RESTRICTED; DIET, REDUCING; ENERGY INTAKE; FEMALE; FETAL WEIGHT; GESTATIONAL AGE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MATERNAL-FETAL EXCHANGE; ORGAN SIZE; PANCREAS, EXOCRINE; PREGNANCY; PROTEIN-ENERGY MALNUTRITION; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 35848944102     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0811-0     Document Type: Article

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