Disruption of cagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore

FEMS Microbiology Letters

Volumn 301, Issue 1, 2009, Pages 57-68

  Cui, Zhihui ^a   Wang, Lifei ^a   Wang, Songmei ^a   Li, Guangwei ^a   Hong, Bin ^a  

^a BEIJING HOSPITAL   (China)

Author keywords

Apoprotein; C 1027; Enediyne; Gene disruption

Indexed keywords

ANTIBIOTIC C 1027; APOPROTEIN;

ARTICLE; CAGA GENE; CHROMATOPHORE; ELECTROSPRAY MASS SPECTROMETRY; GENE; GENE CLUSTER; GENE CONTROL; GENE DISRUPTION; GENE OVEREXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SGCA1 GENE; SGCC4 GENE; SGCD6 GENE; SGCE GENE; SGCR3 GENE; STREPTOMYCES; STREPTOMYCES GLOBISPORUS; WILD TYPE;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; APOPROTEINS; BIOSYNTHETIC PATHWAYS; ENEDIYNES; GENE EXPRESSION REGULATION, BACTERIAL; GENE KNOCKOUT TECHNIQUES; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STREPTOMYCES;

EID: 71049136512     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2009.01800.x     Document Type: Article

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