Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore

Journal of Molecular Biology

Volumn 309, Issue 1, 2001, Pages 267-283

  Tanaka, Toshiyuki ^a   Fukuda Ishisaka, Sumiko ^b   Hirama, Masahiro ^b   Otani, Toshio ^c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

C 1027; Chromoprotein; Molecular recognition; Nuclear magnetic resonance; Three dimensional solution structure

Indexed keywords

APOPROTEIN; BACTERIAL PROTEIN; BENZOXAZINE DERIVATIVE; HYDROGEN; KEDARCIDIN; TYROSINE DERIVATIVE; ZINOSTATIN;

ARTICLE; CHROMATOPHORE; HYDROGEN BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0035946947     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4621     Document Type: Article

References (87)

1. A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity
2. A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties
3. A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity
4. Specific interaction between a novel enediyne chromophore and apoprotein in macromolecular antitumor antibiotic C-1027
5. Structure of an aromatization product of C-1027 chromophore
6. Structure and cycloaromatization of a novel enediyne, C-1027 chromophore
7. Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore
8. C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage
9. A single binding mode of activated enediyne C1027 generates two types of double-strand DNA lesions: Deuterium isotope-induced shuttling between adjacent nucleotide target sites
10. Synthesis and characterization of nine-membered cyclic enediynes, models of C-1027 and kedarcidin chromophore: Equilibration with a p-benzyne biradical and kinetic stabilization
11. Synthesis and chemistry of chromoprotein antitumor antibiotics: Nine-membered enediynes are equilibrated with p-benzyne type biradicals
12. Paramagnetic enediyne antibiotic C-1027: Spin identification and characterization of radical species
13. Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene
14. C-1027 AG, a selective antagonist of the macromolecular antitumor antibiotic, C-1027
15. Purification and primary structure of C-1027-AG, a selective antagonist of antitumor antibiotic C-1027, from Streptomyces globisporus
16. Neocarzinostatin, an antitumor antibiotic of high molecular weight. Isolation, physicochemical properties and biological activities
17. A new antibiotic, macromomycin, exhibiting antitumor and antimicrobial activity
18. Further purification and characterization of macromomycin
19. Studies on auromomycin
20. Physico-chemical and biological studies on actinoxanthin, an antibiotic from Actinomyces globisporus 1131
21. Kedarcidin, a new chromoprotein antitumor antibiotic. I. Taxonomy of producing organism, fermentation and biological activity
22. Kedarcidin, a new chromoprotein antitumor antibiotic. II. Isolation, purification and physico-chemical properties
23. Three-dimensional solution structure of apo-neocarzinostatin from Streptomyces carzinostaticus determined by NMR spectroscopy
24. Three-dimensional solution structure of apo-neocarzinostatin
25. Crystal structure of apo-neocarzinostatin at 0.15-nm resolution
26. Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side-chains to chromophore binding selectivity
27. Three-dimensional structure of actinoxanthin. IV. A 2.5-Å resolution
28. 15N NMR assignments and solution conformation of apokedarcidin
29. Neocarzinostatin: Chemical characterization and partial structure of the nonprotein chromophore
30. Naphthalenecarboxylic acid from neocarzinostatin (NCS)
31. Neocarzinostatin chromophore: Presence of a cyclic carbonate subunit and its modification in the structure of other biologically active forms
32. Neocarzinostatin chromophore: Presence of a highly strained ether ring and its reaction with mercaptan and sodium borohydride
33. Synthesis of the naphthalenecarboxylic acid derivative obtained from neocarzinostatin (NCS): A structure revision
34. The structure of neocarzinostatin chromophore possessing a novel bicyclo[7,3,0]dodecadiyne system
35. Absolute configuration of the amino sugar moiety of the neocarzinostatin chromophore
36. Stereochemical assignment of neocarzinostatin chromophore. Structures of neocarzinostatin chromophore-methyl thioglycolate adducts
37. Kedarcidin chromophore: Structure elucidation of the amino sugar kedarosamine
38. Kedarcidin, a new chromoprotein antitumor antibiotic: Structure elucidation of kedarcidin chromophore
39. Chemistry and structure elucidation of the kedarcidin chromophore
40. Mechanism of the effect of organic solvents and other protein denaturants on neocarzinostatin activity
41. Stabilization of neocarzinostatin nonprotein chromophore activity by interaction with apoprotein and with HeLa cells
42. Binding of the nonprotein chromophore of neocarzinostatin to deoxyribonucleic acid
43. An antitumor polypeptide antibiotic neocarzinostatin: The mode of apo-protein-chromophore interaction
44. Strand scission of deoxyribonucleic acid by neocarzinostatin, auromomycin, and bleomycin: Studies on base release and nucleotide sequence specificity
45. Proposed structure of the neocarzinostatin chromophore-methyl thioglycolate adduct; a mechanism for the nucleophilic activation of neocarzinostatin
46. Oxidative triggering for aromatization of the neocarzinostatin chromophore
47. Photoactivation of neocarzinostatin chromophore: Photo-induced cycloaromatization via naphthoate participation
48. Solution structure of the antitumour antibiotic neocarzinostatin, a chromophoreprotein complex
49. Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex
50. AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
51. β-sheet topology and the relatedness of proteins
52. The anatomy and taxonomy of protein structure
53. The interpretation of protein structures: Estimation of static accessibility
54. Neocarzinostatin chromophore: Assignment of spectral properties and structural requirements for binding to DNA
55. Structural basis for reaction mechanism and drug delivery system of chromoprotein antitumor antibiotic C-1027
56. Requirement for reducing agents in deoxyribonucleic acid strand scission by the purified chromophore of auromomycin
57. Remarkable kinetic solvent isotope effect on the cycloaromatization of C-1027 chromophore, a 9-membered enediyne, and the thermochemistry
58. Ab Initio calculation of hydrogen abstraction reactions of phenyl radical and p-benzyne
59. On the conformation of Phe78 of a chromoprotein antibiotic, neocarzinostatin
60. Monoclonal antibody raised against apoprotein of C-1027: Effect on biochemical and biological activities of the holoantibiotic
61. Subcellular fate of protein antibiotic neocarzinostatin in culture of a lymphoid cell line from Burkitt's lymphoma
62. An uptake of fluorescein isothiocyanate labeled neocarzinostatin into the cancer and normal cells
63. Subcellular action of neocarzinostatin. Intracellular incorporation, DNA breakdown and cytotoxicity
64. Uptake and distribution of neocarzinostatin (NCS) studied with fluorescent antibody in experimental glioma models
65. Quadrature Fourier NMR detection: Simple multiplex for dual detection and discussion
66. Multiple quantum spin-echo spectroscopy
67. 1H spin-spin coupling constants in proteins
68. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
69. Homonuclear Hartmann-Hahn Experiments
70. Investigation of exchange processes by two-dimensional NMR spectroscopy
71. Separation and suppression of coherent transfer effects in two-dimensional NOE and chemical exchange spectroscopy
72. 1H-NMR methyl lines and conformation of valyl residues in the lac repressor headpiece
73. Determination of the complete three-dimensional structure of the α-amylase inhibitor tendamistat in aqueous solution by nuclear magnetic resonance and distance geometry
74. Pseudo-structures for the 20 common amino acids for use in studies of protein conformations by measurements of intramolecular proton-proton distance constraints with nuclear magnetic resonance
75. Three-dimensional structure of potato carboxypeptidase inhibitor in solution. A study using nuclear magnetic resonance, distance geometry, and restrained molecular dynamics
76. Protein structures in solution by nuclear magnetic resonance and distance geometry. The polypeptide fold of the basic pancreatic trypsin inhibitor determined using two different algorithms, DISGEO and DISMAN
77. 1H nuclear magnetic resonance and distance geometry
78. Chemical shifts as a tool for structure determination
79. Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2
80. NMR-derived three-dimensional solution structure of protein S complexed with calcium
81. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
82. Raster3D: Photo-realistic molecular graphics
83. The amino acid sequence of actinoxanthin apoprotein deduced from the base sequence of the gene
84. The amino acid sequence of neocarzinostatin apoprotein deduced from the base sequence of the gene
85. Nucleotide sequence of the macromomycin apoprotein gene and its expression in Streptomyces macromomyceticus