Streptomycin production by Streptomyces griseus can be modulated by a mechanism not associated with change in the adpA component of the A-factor cascade

Biotechnology Letters

Volumn 29, Issue 1, 2007, Pages 57-64

  Hong, Bin ^b   Phornphisutthimas, Somkiat ^c   Tilley, Emma ^d   Baumberg, Simon ^a   McDowall, Kenneth J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Actinorhodin; S. coelicolor; S. griseus; Secondary metabolite production; Streptomyces gene regulation; Streptomycin

Indexed keywords

DNA; GENES; METABOLISM; METABOLITES; REDUCTION;

ACTINORHODIN; S. COELICOLOR; S. GRISEUS; SECONDARY METABOLITE PRODUCTION; STREPTOMYCES GENE REGULATION; STREPTOMYCIN;

ANTIBIOTICS;

A FACTOR (STREPTOMYCES); A-FACTOR (STREPTOMYCES); ADPA PROTEIN, STREPTOMYCES GRISEUS; BACTERIAL PROTEIN; DNA BINDING PROTEIN; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; STREPTOMYCIN; TRANSACTIVATOR PROTEIN;

ARTICLE; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; STREPTOMYCES GRISEUS;

4-BUTYROLACTONE; BACTERIAL PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENHANCEMENT; STREPTOMYCES GRISEUS; STREPTOMYCIN; TRANS-ACTIVATORS;

ATRA; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS;

EID: 33845601336     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-006-9216-2     Document Type: Article

References (38)

1. Bibb M (1996) The regulation of antibiotic production in Streptomyces coelicolor A3 (2). Microbiology 142:1335-1344
2. Bibb MJ, White J, Ward JM, Janssen GR (1994) The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site. Mol Microbiol 14:533-545
3. Bibb MJ (2005) Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8:208-215
4. Browning DF, Busby SJ (2004) The regulation of bacterial transcription initiation. Nat Rev Microbiol 2:57-65
5. Challis GL, Hopwood DA (2003) Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc Natl Acad Sci USA 2:14555-14561
6. Chater KF, Bibb MJ (1997) Regulation of bacterial antibiotic production. In: Kleinkauf H, Von Doehren H.v. (eds) Products of secondary metabolism. VCH Press, Germany
7. Chater KF, Horinouchi S (2003) Signalling early developmental events in two highly diverged Streptomyces species. Mol Microbiol 48:9-15
8. Combes P, Till R, Bee S, Smith MC (2002) The streptomyces genome contains multiple pseudo-attB sites for the (phi)C31-encoded site-specific recombination system. J Bacteriol 184:5746-5752
9. Demain AL, Fang A (2000) The natural functions of secondary metabolites. Adv Biochem Eng Biotechnol 69:1-39
10. Demain AL (1999) Pharmaceutically active secondary metabolites of microorganisms. Appl Microbiol Biotechnol 52:455-463
11. Embley TM, Stackebrandt E (1994) The molecular phylogeny and systematics of the actinomycetes. Ann Rev Microbiol 48:257-289
12. Flett F, Mersinias V, Smith CP (1997) High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol Lett 155:223-229
13. Gramajo HC, Takano E, Bibb MJ (1993) Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol Microbiol 7:837-845
14. Hesketh A, Sun J, Bibb M (2001) Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis. Mol Microbiol 39:136-144
15. Jin W, Ryu YG, Kang SG, Kim SK, Saito N, Ochi K, Lee SH, Lee KJ (2004) Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus. Microbiology 150:1485-1493
16. Hopwood DA, Chater KF, Bibb MJ (1995) Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete. Biotechnology 28:65-102
17. Horinouchi S, Kumada Y, Beppu T (1984) Unstable genetic determinant of A-factor biosynthesis in streptomycin-producing organisms: cloning and characterization. J Bacteriol 158:481-487
18. Horinouchi S (2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Frontiers Biosci 7:2045-2057
19. Kato JY, Suzuki A, Yamazaki H, Ohnishi Y, Horinouchi S (2002) Control by A-factor of a metalloendopeptidase gene involved in aerial mycelium formation in Streptomyces griseus. J Bacteriol 184:6016-6025
20. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA (2000) Practical streptomyces genetics. The John Innes Foundation, Norwich
21. Lloyd G, Landini P, Busby S (2001) Activation and repression of transcription initiation in bacteria. Essays Biochem 37:17-31
22. Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
23. Martin JF, Demain AL (1980) Control of antibiotic biosynthesis. Microbiol Rev 44:230-251
24. Ohnishi Y, Kameyama S, Onaka H, Horinouchi S (1999) The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 34:102-111
25. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S (2005) AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci Biotechnol Biochem 69:431-439
26. Retzlaff L, Distler J (1995) The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol Microbiol 18:151-162
27. Schmitt-John T, Engels JW (1992) Promoter constructions for efficient secretion expression in Streptomyces lividans. Appl Microbiol Biotechnol 36:493-498
28. Takano E, Gramajo HC, Strauch E, Andres N, White J, Bibb MJ (1992) Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2). Mol Microbiol 6:2797-2804
29. Tilley E (2005) The metabolic engineering of Streptomyces sp. PhD Thesis. Department of Pharmaceutical Sciences, University of Strathclyde, Gaosgow, UK
30. Tomono A, Tsai Y, Yamazaki H, Ohnishi Y, Horinouchi S (2005) Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 187:5595-5604
31. Uguru GC, Stephens KE, Stead JA, Towle JE, Baumberg S, McDowall KJ (2005) Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol Microbiol 58:131-150
32. van Wezel GP, White J, Hoogvliet G, Bibb MJ (2000) Application of redD, the transcriptional activator gene of the undecylprodigiosin biosynthetic pathway, as a reporter for transcriptional activity in Streptomyces coelicolor A3(2) and Streptomyces lividans. J Mol Microbiol Biotech 2:551-556
33. Vallins WJ, Baumberg S (1985) Cloning of a DNA fragment from Streptomyces griseus which directs streptomycin phosphotransferase activity. J Gen Microbiol 131:1657-1669
34. Vujaklija D, Horinouchi S, Beppu T (1993) Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 175:2652-2661
35. Vujaklija D, Ueda K, Hong SK, Beppu T, Horinouchi S (1991) Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus. Mol Gen Genet 229:119-128
36. Yamazaki H, Ohnishi Y, Horinouchi S (2000) An A-factor-dependent extracytoplasmic function sigma factor (sigma(AdsA)) that is essential for morphological development in Streptomyces griseus. J Bacteriol 182:4596-4605
37. Yamazaki H, Ohnishi Y, Horinouchi S (2003a) Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus. J Bacteriol 185:1273-1283
38. Yamazaki H, Takano Y, Ohnishi Y, Horinouchi S (2003b) AmfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus. Mol Microbiol 50:1173-1187