Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc-

Toxicology and Applied Pharmacology

Volumn 242, Issue 2, 2010, Pages 209-223

  Gu, Li ^a   Hu, Xiaoling ^a   Xue, Zhanxia ^a   Yang, Jun ^a   Wan, Lishu ^a   Ren, Yan ^a   Hertz, Leif ^a   Peng, Liang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cystine; ERK1 2; Glutamate; Homocysteine; Quis sensitization; Transactivation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTIPORTER; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; GLUTAMINE; HOMOCYSTEINE; IONOTROPIC RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SYSTEM XC; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GRANULE; CEREBELLUM CORTEX; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HYPERHOMOCYSTEINEMIA; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN SECRETION; SENSITIZATION; TRANSACTIVATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYSTINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMINE; HOMOCYSTEINE; MICE; NEURONS; PHOSPHORYLATION; ZINC;

EID: 71049123904     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.10.010     Document Type: Article

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