Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells

Neurobiology of Disease

Volumn 23, Issue 3, 2006, Pages 725-730

  Linnebank, Michael ^a   Lutz, Holger ^a   Jarre, Eva ^a   Vielhaber, Stefan ^b   Noelker, Carmen ^a   Struys, Eduard ^c   Jakobs, Cornelis ^c   Klockgether, Thomas ^a   Evert, Bernd O ^a   Kunz, Wolfram S ^a   Wüllner, Ullrich ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Copper; COX; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Menkes disease

Indexed keywords

COPPER; CYTOCHROME C OXIDASE; HOMOCYSTEINE; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL LINE; CHELATION; DOSE RESPONSE; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; NERVE CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; CELLS, CULTURED; CHELATING AGENTS; COPPER; CYTOCHROME-C OXIDASE DEFICIENCY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX IV; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MENKES KINKY HAIR SYNDROME; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS;

EID: 33747177842     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.06.010     Document Type: Article

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