-
1
-
-
0024376173
-
ras oncogenes in human cancer: A review
-
Bos,J.L. (1989) ras oncogenes in human cancer: A review. Cancer Res. 49, 4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
2
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward,J. (2003) Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer, 3, 11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
3
-
-
0032584108
-
Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/ vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
-
Okada,F. et al. (1998) Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/ vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA, 95, 3609-3614.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3609-3614
-
-
Okada, F.1
-
4
-
-
0034650744
-
Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
-
Rak,J. et al. (2000) Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res., 60, 490-498.
-
(2000)
Cancer Res
, vol.60
, pp. 490-498
-
-
Rak, J.1
-
5
-
-
7944223098
-
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
-
Sparmann,A. et al. (2004) Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 6, 447-458.
-
(2004)
Cancer Cell
, vol.6
, pp. 447-458
-
-
Sparmann, A.1
-
6
-
-
9444267059
-
The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor
-
Ahuja,S.K. et al. (1996) The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J. Biol. Chem., 271, 20545-20550.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 20545-20550
-
-
Ahuja, S.K.1
-
7
-
-
0036781172
-
Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer
-
Wigmore,S.J. et al. (2002) Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. Int. J. Oncol., 21, 881-886.
-
(2002)
Int. J. Oncol
, vol.21
, pp. 881-886
-
-
Wigmore, S.J.1
-
8
-
-
33750089043
-
Serum vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) levels in small cell lung cancer
-
Tas,F. et al. (2006) Serum vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) levels in small cell lung cancer. Cancer Invest., 24, 492-496.
-
(2006)
Cancer Invest
, vol.24
, pp. 492-496
-
-
Tas, F.1
-
9
-
-
33644841344
-
Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma
-
Brennecke,S. et al. (2005) Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma. Melanoma Res., 15, 515-522.
-
(2005)
Melanoma Res
, vol.15
, pp. 515-522
-
-
Brennecke, S.1
-
10
-
-
34247877774
-
Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: A potential role for interleukin 7
-
Lambeck,A.J. et al. (2007) Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: A potential role for interleukin 7. Clin. Cancer Res., 13, 2385-2391.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2385-2391
-
-
Lambeck, A.J.1
-
11
-
-
33745890935
-
Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer
-
Lokshin,A.E. et al. (2006) Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer. Gynecol. Oncol., 102, 244-251.
-
(2006)
Gynecol. Oncol
, vol.102
, pp. 244-251
-
-
Lokshin, A.E.1
-
12
-
-
6344241445
-
Serum interleukin-8 is elevated in men with prostate cancer and bone metastases
-
Lehrer,S. et al. (2004) Serum interleukin-8 is elevated in men with prostate cancer and bone metastases. Technol. Cancer Res. Treat. 3, 411.
-
(2004)
Technol. Cancer Res. Treat
, vol.3
, pp. 411
-
-
Lehrer, S.1
-
13
-
-
0037372374
-
Elevation of cytokine levels in cachectic patients with prostate carcinoma
-
Pfitzenmaier,J. et al. (2003) Elevation of cytokine levels in cachectic patients with prostate carcinoma. Cancer, 97, 1211-1216.
-
(2003)
Cancer
, vol.97
, pp. 1211-1216
-
-
Pfitzenmaier, J.1
-
14
-
-
34447506658
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
-
Ancrile,B. et al. (2007) Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev., 21, 1714-1719.
-
(2007)
Genes Dev
, vol.21
, pp. 1714-1719
-
-
Ancrile, B.1
-
15
-
-
40849114627
-
Oncogenic ras-induced expression of cytokines: A new target of anti-cancer therapeutics
-
Ancrile,B.B. et al. (2008) Oncogenic ras-induced expression of cytokines: A new target of anti-cancer therapeutics. Mol. Interv., 8, 22-27.
-
(2008)
Mol. Interv
, vol.8
, pp. 22-27
-
-
Ancrile, B.B.1
-
16
-
-
0142250392
-
Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
-
Trikha,M. et al. (2003) Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence. Clin. Cancer Res., 9, 4653-4665.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 4653-4665
-
-
Trikha, M.1
-
17
-
-
12144287282
-
A genetically defined model for human ovarian cancer
-
Liu,J. et al. (2004) A genetically defined model for human ovarian cancer. Cancer Res., 64, 1655-1663.
-
(2004)
Cancer Res
, vol.64
, pp. 1655-1663
-
-
Liu, J.1
-
18
-
-
33750798741
-
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
-
Yang,G. et al. (2006) The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. USA, 103, 16472-16477.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16472-16477
-
-
Yang, G.1
-
19
-
-
0030022829
-
CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct
-
Ahuja,S.K. et al. (1996) CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct. J. Biol. Chem., 271, 225-232.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 225-232
-
-
Ahuja, S.K.1
-
20
-
-
34247855761
-
Chemokine: Receptor structure, interactions, and antagonism
-
Allen,S.J. et al. (2007) Chemokine: Receptor structure, interactions, and antagonism. Annu. Rev. Immunol., 25, 787-820.
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 787-820
-
-
Allen, S.J.1
-
21
-
-
0034080318
-
The biology of chemokines and their receptors
-
Rossi,D. et al. (2000) The biology of chemokines and their receptors. Annu. Rev. Immunol., 18, 217-242.
-
(2000)
Annu. Rev. Immunol
, vol.18
, pp. 217-242
-
-
Rossi, D.1
-
22
-
-
0037180757
-
Inflammation and cancer
-
Coussens,L.M. et al. (2002) Inflammation and cancer. Nature, 420, 860-867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
-
23
-
-
0037443760
-
IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
-
Li,A. et al. (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J. Immunol., 170, 3369-3376.
-
(2003)
J. Immunol
, vol.170
, pp. 3369-3376
-
-
Li, A.1
-
24
-
-
27644556527
-
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance
-
Lim,K.H. et al. (2005) Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell, 8, 381-392.
-
(2005)
Cancer Cell
, vol.8
, pp. 381-392
-
-
Lim, K.H.1
-
25
-
-
27544453375
-
A network of genetic events sufficient to convert normal human cells to a tumorigenic state
-
Kendall,S.D. et al. (2005) A network of genetic events sufficient to convert normal human cells to a tumorigenic state. Cancer Res., 65, 9824-9828.
-
(2005)
Cancer Res
, vol.65
, pp. 9824-9828
-
-
Kendall, S.D.1
-
26
-
-
2342526543
-
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
-
Yeh,E. et al. (2004) A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat. Cell Biol., 6, 308-318.
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 308-318
-
-
Yeh, E.1
-
27
-
-
19644366513
-
Genetic modeling of human rhabdomyosarcoma
-
Linardic,C.M. et al. (2005) Genetic modeling of human rhabdomyosarcoma. Cancer Res., 65, 4490-4495.
-
(2005)
Cancer Res
, vol.65
, pp. 4490-4495
-
-
Linardic, C.M.1
-
28
-
-
0037102561
-
Distinct requirements for Ras oncogenesis in human versus mouse cells
-
Hamad,N.M. et al. (2002) Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev., 16, 2045-2057.
-
(2002)
Genes Dev
, vol.16
, pp. 2045-2057
-
-
Hamad, N.M.1
-
29
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn,W.C. et al. (1999) Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
-
30
-
-
27644525734
-
A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro
-
O'Hayer,K. et al. (2006) A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. Methods Enzymol., 407, 637-647.
-
(2006)
Methods Enzymol
, vol.407
, pp. 637-647
-
-
O'Hayer, K.1
-
31
-
-
33750798741
-
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
-
Yang,G. et al. (2006) The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. USA, 103, 16472-16477.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16472-16477
-
-
Yang, G.1
-
32
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens,V. et al. (2001) Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J., 353, 417-439.
-
(2001)
Biochem. J
, vol.353
, pp. 417-439
-
-
Janssens, V.1
-
33
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
Sharpless,N.E. et al. (2006) The mighty mouse: Genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov., 5, 741-754.
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
-
34
-
-
0022527161
-
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
-
Quintanilla,M. et al. (1986) Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature, 322, 78-80.
-
(1986)
Nature
, vol.322
, pp. 78-80
-
-
Quintanilla, M.1
-
35
-
-
0028067339
-
Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog
-
Cacalano,G. et al. (1994) Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science, 265, 682-684.
-
(1994)
Science
, vol.265
, pp. 682-684
-
-
Cacalano, G.1
-
36
-
-
33646255924
-
High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras
-
Wislez,M. et al. (2006) High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res., 66, 4198-4207.
-
(2006)
Cancer Res
, vol.66
, pp. 4198-4207
-
-
Wislez, M.1
-
37
-
-
10044261013
-
Cytokines in pancreatic carcinoma: Correlation with phenotypic characteristics and prognosis
-
Ebrahimi,B. et al. (2004) Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer, 101, 2727-2736.
-
(2004)
Cancer
, vol.101
, pp. 2727-2736
-
-
Ebrahimi, B.1
-
38
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin,L. et al. (1999) Essential role for oncogenic Ras in tumour maintenance. Nature, 400, 468-472.
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
-
39
-
-
0842303173
-
Reversibility of oncogene-induced cancer
-
Felsher,D.W. (2004) Reversibility of oncogene-induced cancer. Curr. Opin. Genet. Dev., 14, 37-42.
-
(2004)
Curr. Opin. Genet. Dev
, vol.14
, pp. 37-42
-
-
Felsher, D.W.1
-
40
-
-
28844509531
-
K-ras as a target for cancer therapy
-
Friday,B.B. et al. (2005) K-ras as a target for cancer therapy. Biochim. Biophys. Acta, 1756, 127-144.
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, pp. 127-144
-
-
Friday, B.B.1
-
41
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams,G.P. et al. (2005) Monoclonal antibody therapy of cancer. Nat. Biotechnol., 23, 1147-1157.
-
(2005)
Nat. Biotechnol
, vol.23
, pp. 1147-1157
-
-
Adams, G.P.1
|