메뉴 건너뛰기




Volumn 23, Issue SUPPL.21, 2009, Pages 26-32

Pathogenesis of tubulointerstitial fibrosis in chronic allograft dysfunction

Author keywords

EMT; Extracellular matrix; Fibroblast

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BONE MORPHOGENETIC PROTEIN; CALVASCULIN; CYCLOSPORIN A; HEAT SHOCK PROTEIN 47; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; ONCOSTATIN M; PROTEIN S 100; RAPAMYCIN; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 70649101510     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01106.x     Document Type: Review
Times cited : (32)

References (51)
  • 1
    • 0029010771 scopus 로고
    • Chronic renal transplant loss
    • Paul LC. Chronic renal transplant loss. Kidney Int 1995, 47:1491.
    • (1995) Kidney Int , vol.47 , pp. 1491
    • Paul, L.C.1
  • 3
    • 2342526558 scopus 로고    scopus 로고
    • The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging
    • Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC. The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging. Kidney Int 2004, 65:1556.
    • (2004) Kidney Int , vol.65 , pp. 1556
    • Joosten, S.A.1    van Kooten, C.2    Sijpkens, Y.W.3    de Fijter, J.W.4    Paul, L.C.5
  • 4
    • 32844454764 scopus 로고    scopus 로고
    • What we CAN do about chronic allograft nephropathy: role of immunosuppressive modulations
    • Afzali B, Taylor AL, Goldsmith DJ. What we CAN do about chronic allograft nephropathy: role of immunosuppressive modulations. Kidney Int 2005, 68:2429.
    • (2005) Kidney Int , vol.68 , pp. 2429
    • Afzali, B.1    Taylor, A.L.2    Goldsmith, D.J.3
  • 5
    • 0032910625 scopus 로고    scopus 로고
    • The Banff 97 working classification of renal allograft pathology
    • Racusen LC, Solez K, Colvin RB. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999, 55:713.
    • (1999) Kidney Int , vol.55 , pp. 713
    • Racusen, L.C.1    Solez, K.2    Colvin, R.B.3
  • 7
    • 33847761900 scopus 로고    scopus 로고
    • Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    • Solez K, Colvin RB, Racusen LC. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007, 7:518.
    • (2007) Am J Transplant , vol.7 , pp. 518
    • Solez, K.1    Colvin, R.B.2    Racusen, L.C.3
  • 8
    • 0033658775 scopus 로고    scopus 로고
    • The importance of tubulointerstitial damage in progressive renal disease
    • Müller GA, Zeisberg M, Strutz F. The importance of tubulointerstitial damage in progressive renal disease. Nephrol Dial Transplant 2000, 15(Suppl. 6):76.
    • (2000) Nephrol Dial Transplant , vol.15 , Issue.SUPPL. 6 , pp. 76
    • Müller, G.A.1    Zeisberg, M.2    Strutz, F.3
  • 10
    • 17644375856 scopus 로고    scopus 로고
    • Kidney allograft fibrosis and atrophy early after living donor transplantation
    • Cosio FG, Grande JP, Larson TS. Kidney allograft fibrosis and atrophy early after living donor transplantation. Am J Transplant 2005, 5:1130.
    • (2005) Am J Transplant , vol.5 , pp. 1130
    • Cosio, F.G.1    Grande, J.P.2    Larson, T.S.3
  • 12
    • 33750712380 scopus 로고    scopus 로고
    • Renal fibroblasts and myofibroblasts in chronic kidney disease
    • Strutz F, Zeisberg M. Renal fibroblasts and myofibroblasts in chronic kidney disease. J Am Soc Nephrol 2006, 17:2992.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2992
    • Strutz, F.1    Zeisberg, M.2
  • 14
    • 0029091682 scopus 로고
    • Identification and characterization of fibroblast-specific protein 1 (FSP1)
    • Strutz F, Okada H, Lo CW. Identification and characterization of fibroblast-specific protein 1 (FSP1). J Cell Biol 1995, 130:393.
    • (1995) J Cell Biol , vol.130 , pp. 393
    • Strutz, F.1    Okada, H.2    Lo, C.W.3
  • 15
    • 0031816584 scopus 로고    scopus 로고
    • Identification of a novel cis-acting element for fibroblast-specific transcription of the FSP1 gene
    • Okada H, Danoff TM, Fischer A, Lopez-Guisa JM, Strutz F, Neilson EG. Identification of a novel cis-acting element for fibroblast-specific transcription of the FSP1 gene. Am J Physiol 1998, 275(2 Pt 2):F306.
    • (1998) Am J Physiol , vol.275 , Issue.2 PT 2
    • Okada, H.1    Danoff, T.M.2    Fischer, A.3    Lopez-Guisa, J.M.4    Strutz, F.5    Neilson, E.G.6
  • 16
    • 0034981126 scopus 로고    scopus 로고
    • Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt dna replication in transgenic fibroblasts
    • Iwano M, Fischer A, Okada H. Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt dna replication in transgenic fibroblasts. Mol Ther 2001, 3:149.
    • (2001) Mol Ther , vol.3 , pp. 149
    • Iwano, M.1    Fischer, A.2    Okada, H.3
  • 18
    • 4444383533 scopus 로고    scopus 로고
    • Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
    • Ikeda Y, Jung YO, Kim H. Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria. Nephron Exp Nephrol 2004, 97:e123.
    • (2004) Nephron Exp Nephrol , vol.97
    • Ikeda, Y.1    Jung, Y.O.2    Kim, H.3
  • 19
    • 27544515448 scopus 로고    scopus 로고
    • Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis
    • Faulkner JL, Szcykalski LM, Springer F, Barnes JL. Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis. Am J Pathol 2005, 167:1193.
    • (2005) Am J Pathol , vol.167 , pp. 1193
    • Faulkner, J.L.1    Szcykalski, L.M.2    Springer, F.3    Barnes, J.L.4
  • 20
    • 0033865917 scopus 로고    scopus 로고
    • Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation
    • Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG. Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 2000, 58:587.
    • (2000) Kidney Int , vol.58 , pp. 587
    • Okada, H.1    Ban, S.2    Nagao, S.3    Takahashi, H.4    Suzuki, H.5    Neilson, E.G.6
  • 21
    • 0036854980 scopus 로고    scopus 로고
    • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    • Yang J, Shultz RW, Mars WM. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 2002, 110:1525.
    • (2002) J Clin Invest , vol.110 , pp. 1525
    • Yang, J.1    Shultz, R.W.2    Mars, W.M.3
  • 22
    • 36048949007 scopus 로고    scopus 로고
    • Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling
    • Pollack V, Sarkozi R, Banki Z. Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling. Am J Physiol Renal Physiol 2007, 293:F1714.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Pollack, V.1    Sarkozi, R.2    Banki, Z.3
  • 23
    • 20544462075 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis
    • Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 2005, 5:1367.
    • (2005) Am J Transplant , vol.5 , pp. 1367
    • Vongwiwatana, A.1    Tasanarong, A.2    Rayner, D.C.3    Melk, A.4    Halloran, P.F.5
  • 24
    • 0942276287 scopus 로고    scopus 로고
    • Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition
    • Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA. Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol 2004, 15:390.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 390
    • Robertson, H.1    Ali, S.2    McDonnell, B.J.3    Burt, A.D.4    Kirby, J.A.5
  • 25
    • 33751184559 scopus 로고    scopus 로고
    • Risk factors for early epithelial to mesenchymal transition in renal grafts
    • Hertig A, Verine J, Mougenot B. Risk factors for early epithelial to mesenchymal transition in renal grafts. Am J Transplant 2006, 6:2937.
    • (2006) Am J Transplant , vol.6 , pp. 2937
    • Hertig, A.1    Verine, J.2    Mougenot, B.3
  • 26
    • 0036233764 scopus 로고    scopus 로고
    • Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis
    • Shimizu A, Yamada K, Sachs DH, Colvin RB. Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis. Kidney Int 2002, 61:1867.
    • (2002) Kidney Int , vol.61 , pp. 1867
    • Shimizu, A.1    Yamada, K.2    Sachs, D.H.3    Colvin, R.B.4
  • 27
    • 0033736302 scopus 로고    scopus 로고
    • Acute rejection-associated tubular basement membrane defects and chronic allograft nephropathy
    • Bonsib SM, Abul-Ezz SR, Ahmad I. Acute rejection-associated tubular basement membrane defects and chronic allograft nephropathy. Kidney Int 2000, 58:2206.
    • (2000) Kidney Int , vol.58 , pp. 2206
    • Bonsib, S.M.1    Abul-Ezz, S.R.2    Ahmad, I.3
  • 28
    • 20044392827 scopus 로고    scopus 로고
    • Functionally significant renal allograft rejection is defined by transcriptional criteria
    • Hoffmann SC, Hale DA, Kleiner DE. Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 2005, 5:573.
    • (2005) Am J Transplant , vol.5 , pp. 573
    • Hoffmann, S.C.1    Hale, D.A.2    Kleiner, D.E.3
  • 29
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007, 282:23337.
    • (2007) J Biol Chem , vol.282 , pp. 23337
    • Zeisberg, M.1    Yang, C.2    Martino, M.3
  • 30
    • 38549143883 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
    • Rygiel KA, Robertson H, Marshall HL. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab Invest 2008, 88:112.
    • (2008) Lab Invest , vol.88 , pp. 112
    • Rygiel, K.A.1    Robertson, H.2    Marshall, H.L.3
  • 31
    • 34548411746 scopus 로고    scopus 로고
    • TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
    • Willis BC, Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 2007, 293:L525.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Willis, B.C.1    Borok, Z.2
  • 32
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg EM, Tarnavski O, Zeisberg M. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007, 13:952.
    • (2007) Nat Med , vol.13 , pp. 952
    • Zeisberg, E.M.1    Tarnavski, O.2    Zeisberg, M.3
  • 34
    • 57149094066 scopus 로고    scopus 로고
    • How many different roads may a cell walk down in order to become a fibroblast?
    • Strutz F. How many different roads may a cell walk down in order to become a fibroblast?. J Am Soc Nephrol 2008, 19:2246.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2246
    • Strutz, F.1
  • 35
    • 0028944542 scopus 로고
    • Myofibroblast differentiation during fibrosis
    • Desmoulière A, Gabbiani G. Myofibroblast differentiation during fibrosis. Exp Nephrol 1995, 3:134.
    • (1995) Exp Nephrol , vol.3 , pp. 134
    • Desmoulière, A.1    Gabbiani, G.2
  • 36
    • 38049100595 scopus 로고    scopus 로고
    • Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis
    • Wallach-Dayan SB, Golan-Gerstl R, Breuer R. Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis. Proc Natl Acad Sci USA 2007, 104:20460.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20460
    • Wallach-Dayan, S.B.1    Golan-Gerstl, R.2    Breuer, R.3
  • 37
    • 0033788161 scopus 로고    scopus 로고
    • Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis
    • Jelaska A, Korn JH. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum 2000, 43:2230.
    • (2000) Arthritis Rheum , vol.43 , pp. 2230
    • Jelaska, A.1    Korn, J.H.2
  • 38
    • 33745818408 scopus 로고    scopus 로고
    • Primer: histopathology of calcineurin-inhibitor toxicity in renal allografts
    • Liptak P, Ivanyi B. Primer: histopathology of calcineurin-inhibitor toxicity in renal allografts. Nat Clin Pract Nephrol 2006, 2:398.
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 398
    • Liptak, P.1    Ivanyi, B.2
  • 39
    • 27144507950 scopus 로고    scopus 로고
    • Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells
    • McMorrow T, Gaffney MM, Slattery C, Campbell E, Ryan MP. Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells. Nephrol Dial Transplant 2005, 20:2215.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 2215
    • McMorrow, T.1    Gaffney, M.M.2    Slattery, C.3    Campbell, E.4    Ryan, M.P.5
  • 40
    • 34147176657 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone
    • Copeland JW, Beaumont BW, Merrilees MJ, Pilmore HL. Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone. Transplantation 2007, 83:809.
    • (2007) Transplantation , vol.83 , pp. 809
    • Copeland, J.W.1    Beaumont, B.W.2    Merrilees, M.J.3    Pilmore, H.L.4
  • 41
    • 0038637951 scopus 로고    scopus 로고
    • Minimizing calcineurin inhibitor drugs in renal transplantation
    • Flechner SM. Minimizing calcineurin inhibitor drugs in renal transplantation. Transplant Proc 2003, 35(3 Suppl.):118S.
    • (2003) Transplant Proc , vol.35 , Issue.3 SUPPL.
    • Flechner, S.M.1
  • 42
    • 34247582790 scopus 로고    scopus 로고
    • Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    • Flechner SM, Goldfarb D, Solez K. Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs. Transplantation 2007, 83:883.
    • (2007) Transplantation , vol.83 , pp. 883
    • Flechner, S.M.1    Goldfarb, D.2    Solez, K.3
  • 43
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall MD. Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006, 6:514.
    • (2006) Am J Transplant , vol.6 , pp. 514
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.D.3
  • 44
    • 33845389867 scopus 로고    scopus 로고
    • The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression
    • Rintala JM, Savikko J, Rintala SE, von Willebrand E. The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. Transplant Proc 2006, 38:3239.
    • (2006) Transplant Proc , vol.38 , pp. 3239
    • Rintala, J.M.1    Savikko, J.2    Rintala, S.E.3    von Willebrand, E.4
  • 45
    • 34147139494 scopus 로고    scopus 로고
    • The effect of FK778 on the progression of chronic allograft nephropathy in a rat model
    • Lutz J, Huang H, Deng M. The effect of FK778 on the progression of chronic allograft nephropathy in a rat model. Transplantation 2007, 83:741.
    • (2007) Transplantation , vol.83 , pp. 741
    • Lutz, J.1    Huang, H.2    Deng, M.3
  • 46
    • 17544379605 scopus 로고    scopus 로고
    • Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction
    • Hruska KA, Guo G, Wozniak M. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 2000, 279:F130.
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Hruska, K.A.1    Guo, G.2    Wozniak, M.3
  • 47
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003, 9:964.
    • (2003) Nat Med , vol.9 , pp. 964
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3
  • 48
    • 0242582117 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
    • Zeisberg M, Bottiglio C, Kumar N. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Renal Physiol 2003, 285:F1060.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Zeisberg, M.1    Bottiglio, C.2    Kumar, N.3
  • 49
    • 33745819270 scopus 로고    scopus 로고
    • Chronic allograft nephropathy: intraepithelial signals generated by transforming growth factor-beta and bone morphogenetic protein-7
    • Tyler JR, Robertson H, Booth TA, Burt AD, Kirby JA. Chronic allograft nephropathy: intraepithelial signals generated by transforming growth factor-beta and bone morphogenetic protein-7. Am J Transplant 2006, 6:1367.
    • (2006) Am J Transplant , vol.6 , pp. 1367
    • Tyler, J.R.1    Robertson, H.2    Booth, T.A.3    Burt, A.D.4    Kirby, J.A.5
  • 50
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Yang J, Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 2002, 13:96.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 96
    • Yang, J.1    Liu, Y.2
  • 51
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • Croce CM. Oncogenes and cancer. N Engl J Med 2008, 358:502.
    • (2008) N Engl J Med , vol.358 , pp. 502
    • Croce, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.