Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis

Kidney International

Volumn 61, Issue 5, 2002, Pages 1867-1879

  Shimizu, Akira ^a,b   Yamada, Kazuhiko ^a,b   Sachs, David H ^a,b   Colvin, Robert B ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Acute rejection; Interstitial fibrosis; Organ rejection; Peritubular capillary; Tubular basement membrane; Tubulitis

Indexed keywords

ALPHA ACTIN; CD3 ANTIGEN;

ANIMAL TISSUE; ARTICLE; ATROPHY; BASEMENT MEMBRANE; CAPILLARY; CELL ASSAY; CELL DEATH; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIUM CELL; EPITHELIUM CELL; FIBROSING ALVEOLITIS; IMMUNOHISTOCHEMISTRY; INTERSTITIUM; KIDNEY BIOPSY; KIDNEY TUBULE; KIDNEY TUBULE EPITHELIUM; MORPHOMETRICS; MYOFIBROBLAST; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; TIME;

EID: 0036233764     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00309.x     Document Type: Article

References (46)

1. Chronic allograft rejection
2. Chronic graft rejection
3. Clinical correlates to chronic renal allograft rejection
4. Renal transplant pathology
5. On the progression of chronic renal disease
6. Significance of postglomerular capillaries in the pathogenesis of chronic renal failure
7. Tubulo-interstitial damage in glomerular disease: Its role in the progression of renal damage
8. Peritubular capillary injury during the progression of experimental glomerulonephritis in rat
9. Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporin
10. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts
11. Role of the thymus in transplantation tolerance in miniature swine. III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I mismatched renal allografts
12. Intragraft events preceding chronic renal allograft rejection in a modified tolerance protocol
13. The acceptance reaction: Intragraft events associated with tolerance to renal allografts in miniature swine
14. The biology of myofibroblasts
15. Human renal cortical interstitial cells with some features of smooth muscle cells participate in tubulointerstitial and crescentic glomerular injury
16. α-smooth muscle actin and collagen deposition in dysfunctional renal transplants
17. Myofibroblast involvement in chronic transplant rejection
18. A novel, simple, reliable and sensitive method of multiple immunoenzymic staining: Use of microwave oven heating to block antibody cross-reactivity and retrieve antigens
19. Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method. A study of pituitary glands of the rat
20. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
21. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury
22. Tubulointerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia
23. Can graft endothelial cells initiate a host anti-graft immune response?
24. Adhesion molecules and rejection of renal allografts
25. Mechanisms of allograft rejection
26. Endothelial responses to immune injury
27. Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries
28. Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries
29. Site of influx of inflammatory white cells into a rejecting rat renal allograft
30. Characterization of high endothelial-like properties of peritubular capillary endothelium during acute renal allograft rejection
31. Postcapillary venule-like transformation of peritubular capillaries in acute renal allograft rejection. An ultrastructural study
32. Specific cell-adhesion mechanisms determining migration pathways of recirculating lymphocytes
33. Lymphocyte migration patterns in organ allograft recipients
34. Secondary membranoproliferative glomerulonephritis
35. Intertubular capillary changes in kidney allografts: An ultrastructural study in patients with transplant glomerulopathy
36. Electron-microscopic peritubular capillary lesion is a specific and useful diagnostic indicator for chronic rejection of renal allografts showing less specific morphologic lesions in the cyclosporine era
37. Electron microscopic peritubular capillary lesions: A new criterion for chronic rejection
38. Capillary basal lamina thickening: Its relationship to endothelial cell death and replacement
39. Loss of glomerular function and tubulointerstitial fibrosis: Cause or effect?
40. Progressive renal disease: The chronic hypoxia hypothesis
41. Renal fibrogenesis and progression
42. Molecular insights into renal interstitial fibrosis
43. Biology of fibroblasts
44. Tubulointerstitium as a predictor of progression of glomerular disease
45. Transdifferentiation: A new angle on renal fibrosis
46. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats