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Volumn 83, Issue 6, 2007, Pages 741-746

The effect of FK778 on the progression of chronic allograft nephropathy in a rat model

Author keywords

Chronic allograft nephropathy; FK778; Rat

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 34147139494     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000255558.02582.ce     Document Type: Article
Times cited : (17)

References (38)
  • 1
    • 0028944029 scopus 로고
    • Both alloantigen-dependent and -independent factors influence chronic allograft rejection
    • Tullius SG, Tilney NL. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995; 59: 313.
    • (1995) Transplantation , vol.59 , pp. 313
    • Tullius, S.G.1    Tilney, N.L.2
  • 2
    • 4143082819 scopus 로고    scopus 로고
    • FK778: A powerful immunosuppressive, but will it really be good for you?
    • Fawcett J, Johnson DW. FK778: a powerful immunosuppressive, but will it really be good for you? Transplantation 2004; 78: 7.
    • (2004) Transplantation , vol.78 , pp. 7
    • Fawcett, J.1    Johnson, D.W.2
  • 3
    • 0029127555 scopus 로고
    • Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
    • Williamson RA, Yea CM, Robson PA, et al. Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J Biol Chem 1995; 270: 22467.
    • (1995) J Biol Chem , vol.270 , pp. 22467
    • Williamson, R.A.1    Yea, C.M.2    Robson, P.A.3
  • 4
    • 0030032806 scopus 로고    scopus 로고
    • The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
    • Davis JP, Cain GA, Pitts WJ, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 1996; 35: 1270.
    • (1996) Biochemistry , vol.35 , pp. 1270
    • Davis, J.P.1    Cain, G.A.2    Pitts, W.J.3
  • 5
    • 0031179645 scopus 로고    scopus 로고
    • The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
    • Elder RT, Xu X, Williams JW, et al. The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 1997; 159: 22.
    • (1997) J Immunol , vol.159 , pp. 22
    • Elder, R.T.1    Xu, X.2    Williams, J.W.3
  • 6
    • 0032519992 scopus 로고    scopus 로고
    • Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
    • Siemasko K, Chong AS, Jack HM, et al. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol 1998; 160: 1581.
    • (1998) J Immunol , vol.160 , pp. 1581
    • Siemasko, K.1    Chong, A.S.2    Jack, H.M.3
  • 7
    • 3142734960 scopus 로고    scopus 로고
    • The effects of FK778 in combination with tacrolimus and steroids: A phase II multicenter study in renal transplant patients
    • Vanrenterghem Y, van Hooff JP, Klinger M, et al. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. Transplantation 2004; 78: 9.
    • (2004) Transplantation , vol.78 , pp. 9
    • Vanrenterghem, Y.1    van Hooff, J.P.2    Klinger, M.3
  • 8
    • 0032910625 scopus 로고    scopus 로고
    • The Banff 97 working classification of renal allograft pathology
    • Racusen LC, Solez, K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
    • (1999) Kidney Int , vol.55 , pp. 713
    • Racusen, L.C.1    Solez, K.2    Colvin, R.B.3
  • 9
    • 0037469022 scopus 로고    scopus 로고
    • FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts
    • Pan F, Ebbs A, Wynn C, et al. FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts. Transplantation 2003; 75: 1110.
    • (2003) Transplantation , vol.75 , pp. 1110
    • Pan, F.1    Ebbs, A.2    Wynn, C.3
  • 10
    • 20344390044 scopus 로고    scopus 로고
    • Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats
    • Crews GM, Erickson L, Pan F, et al. Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats. Transplant Proc 2005; 37: 1926.
    • (2005) Transplant Proc , vol.37 , pp. 1926
    • Crews, G.M.1    Erickson, L.2    Pan, F.3
  • 11
    • 0042467489 scopus 로고    scopus 로고
    • Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: Potential applications for restenosis and chronic rejection
    • Savikko J, Von Willebrand E, Hayry P. Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Transplantation 2003; 76: 455.
    • (2003) Transplantation , vol.76 , pp. 455
    • Savikko, J.1    Von Willebrand, E.2    Hayry, P.3
  • 12
    • 27844594950 scopus 로고    scopus 로고
    • FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation
    • Deuse T, Schrepfer S, Koch-Nolte F, et al. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. J Heart Lung Transplant 2005; 24: 1844.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1844
    • Deuse, T.1    Schrepfer, S.2    Koch-Nolte, F.3
  • 13
    • 18144376604 scopus 로고    scopus 로고
    • FK778, a novel immunosuppressive agent, reduces early adhesion molecule upregulation and prolongs cardiac allograft survival
    • Schrepfer S, Deuse T, Schafer H, Reichenspurner H. FK778, a novel immunosuppressive agent, reduces early adhesion molecule upregulation and prolongs cardiac allograft survival. Transpl Int 2005; 18: 215.
    • (2005) Transpl Int , vol.18 , pp. 215
    • Schrepfer, S.1    Deuse, T.2    Schafer, H.3    Reichenspurner, H.4
  • 14
    • 0031603396 scopus 로고    scopus 로고
    • Synergism of the malononitrilamides 279 and 715 with cyclosporine A in the induction of long-term cardiac allograft survival
    • Lindner JK, Zantl N. Synergism of the malononitrilamides 279 and 715 with cyclosporine A in the induction of long-term cardiac allograft survival. Transpl Int 1998; 11: S303.
    • (1998) Transpl Int , vol.11
    • Lindner, J.K.1    Zantl, N.2
  • 15
    • 0026660308 scopus 로고
    • Progressive albuminuria and glomerulosclerosis in a rat model of chronic renal allograft rejection
    • Diamond JR, Tilney NL, Frye J, et al. Progressive albuminuria and glomerulosclerosis in a rat model of chronic renal allograft rejection. Transplantation 1992; 54: 710.
    • (1992) Transplantation , vol.54 , pp. 710
    • Diamond, J.R.1    Tilney, N.L.2    Frye, J.3
  • 16
    • 0027428113 scopus 로고
    • Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts
    • HancockWH,WhitleyWD,Tullius SG, et al. Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 1993; 56: 643.
    • (1993) Transplantation , vol.56 , pp. 643
    • Hancock, W.H.1    Whitley, W.D.2    Tullius, S.G.3
  • 17
    • 0030461540 scopus 로고    scopus 로고
    • Sequential cytokine expression in renal allografts in rats immunosuppressed with maintenance cyclosporine or mycophenolate mofetil
    • Nadeau KC, Azuma H, Tilney NL. Sequential cytokine expression in renal allografts in rats immunosuppressed with maintenance cyclosporine or mycophenolate mofetil. Transplantation 1996; 62: 1363.
    • (1996) Transplantation , vol.62 , pp. 1363
    • Nadeau, K.C.1    Azuma, H.2    Tilney, N.L.3
  • 18
    • 0037708567 scopus 로고    scopus 로고
    • Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat
    • Bilolo KK, Ouyang J, Wang X, et al. Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat. Transplantation 2003; 75: 1881.
    • (2003) Transplantation , vol.75 , pp. 1881
    • Bilolo, K.K.1    Ouyang, J.2    Wang, X.3
  • 19
    • 0013241476 scopus 로고    scopus 로고
    • Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts
    • Vu MD, Qi S, Wang X, et al. Combination therapy of malononitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts. Transplantation 2003; 75: 1455.
    • (2003) Transplantation , vol.75 , pp. 1455
    • Vu, M.D.1    Qi, S.2    Wang, X.3
  • 20
    • 0343090809 scopus 로고    scopus 로고
    • Histopathology of calcineurin inhibitor-induced nephrotoxicity
    • Davies DR, Bittmann I, Pardo J. Histopathology of calcineurin inhibitor-induced nephrotoxicity. Transplantation 2000; 69: SS11.
    • (2000) Transplantation , vol.69
    • Davies, D.R.1    Bittmann, I.2    Pardo, J.3
  • 21
    • 0028868941 scopus 로고
    • Cyclosporine-induced renal dysfunction in experimental animals and humans
    • Remuzzi G, Perico N. Cyclosporine-induced renal dysfunction in experimental animals and humans. Kidney Int 1995; 52: S70.
    • (1995) Kidney Int , vol.52
    • Remuzzi, G.1    Perico, N.2
  • 22
    • 0031659245 scopus 로고    scopus 로고
    • Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats
    • Qi Z, Simanaitis M, Ekberg H. Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats. Transpl Immunol 1998; 6: 94.
    • (1998) Transpl Immunol , vol.6 , pp. 94
    • Qi, Z.1    Simanaitis, M.2    Ekberg, H.3
  • 23
    • 0031614971 scopus 로고    scopus 로고
    • Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine
    • Schorlemmer HU, Ruuth E, Kurrle R. Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine. Transpl Int 1998; 11: S340.
    • (1998) Transpl Int , vol.11
    • Schorlemmer, H.U.1    Ruuth, E.2    Kurrle, R.3
  • 24
    • 0036076671 scopus 로고    scopus 로고
    • A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs
    • Jin MB, Nakayama M, Ogata T, et al. A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs. Surgery 2002; 132: 72.
    • (2002) Surgery , vol.132 , pp. 72
    • Jin, M.B.1    Nakayama, M.2    Ogata, T.3
  • 25
    • 0037469015 scopus 로고    scopus 로고
    • Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs
    • Kyles AE, Gregory CR, Griffey SM, et al. Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs. Transplantation 2003; 75: 1128.
    • (2003) Transplantation , vol.75 , pp. 1128
    • Kyles, A.E.1    Gregory, C.R.2    Griffey, S.M.3
  • 26
    • 0036941129 scopus 로고    scopus 로고
    • The involvement of activated T cells and growth-factor production in the early and late phase of chronic kidney allograft nephropathy in rats
    • Hamar P, Szabo A, Muller V, Heemann U. The involvement of activated T cells and growth-factor production in the early and late phase of chronic kidney allograft nephropathy in rats. Transpl Int 2002; 15: 446.
    • (2002) Transpl Int , vol.15 , pp. 446
    • Hamar, P.1    Szabo, A.2    Muller, V.3    Heemann, U.4
  • 27
    • 0038037898 scopus 로고    scopus 로고
    • Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood from non-human primates and healthy human volunteers
    • Birsan T, Dambrin C, Klupp J, et al. Effects of the malononitrilamide FK778 on immune functions in vitro in whole blood from non-human primates and healthy human volunteers. Transpl Immunol 2003; 11: 163.
    • (2003) Transpl Immunol , vol.11 , pp. 163
    • Birsan, T.1    Dambrin, C.2    Klupp, J.3
  • 28
    • 0026597965 scopus 로고
    • Platelet-derived growth factor and mesangial cells
    • Abboud HE. Platelet-derived growth factor and mesangial cells. Kidney Int 1992; 41: 581.
    • (1992) Kidney Int , vol.41 , pp. 581
    • Abboud, H.E.1
  • 29
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286.
    • (1994) N Engl J Med , vol.331 , pp. 1286
    • Border, W.A.1    Noble, N.A.2
  • 30
    • 0029923855 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy
    • Shihab FS, Andoh TF, Tanner AM, et al. Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy. Kidney Int 1996; 49: 1141.
    • (1996) Kidney Int , vol.49 , pp. 1141
    • Shihab, F.S.1    Andoh, T.F.2    Tanner, A.M.3
  • 31
    • 0032747379 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in transplant rejection
    • Hutchinson IV. The role of transforming growth factor-beta in transplant rejection. Transplant Proc 1999; 31: 9S.
    • (1999) Transplant Proc , vol.31
    • Hutchinson, I.V.1
  • 32
    • 3142780623 scopus 로고    scopus 로고
    • Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats
    • Yao HW, Li J, Chen JQ, Xu SY. Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats. Acta Pharmacol Sin 2004; 25: 915.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 915
    • Yao, H.W.1    Li, J.2    Chen, J.Q.3    Xu, S.Y.4
  • 33
    • 0030811256 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide
    • Shawver LK, Schwartz DP, Mann E, et al. Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide. Clin Cancer Res 1997; 3: 1167.
    • (1997) Clin Cancer Res , vol.3 , pp. 1167
    • Shawver, L.K.1    Schwartz, D.P.2    Mann, E.3
  • 34
    • 0032845287 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: Mechanisms of action
    • Xu X, Shen J, Mall JW, et al. In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action. Biochem Pharmacol 1999; 58: 1405.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1405
    • Xu, X.1    Shen, J.2    Mall, J.W.3
  • 35
    • 33748423224 scopus 로고    scopus 로고
    • Angiotensin type 1 and type 2 receptor blockade in chronic allograft nephropathy
    • Lutz J, Risch K, Liu S, et al. Angiotensin type 1 and type 2 receptor blockade in chronic allograft nephropathy. Kidney Int 2006; 70: 1080.
    • (2006) Kidney Int , vol.70 , pp. 1080
    • Lutz, J.1    Risch, K.2    Liu, S.3
  • 36
    • 0032958019 scopus 로고    scopus 로고
    • The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the "Fisher to Lewis" model
    • Orth SR, Odoni G, Amann K, et al. The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the "Fisher to Lewis" model. J Am Soc Nephrol 1999; 10: 387.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 387
    • Orth, S.R.1    Odoni, G.2    Amann, K.3
  • 37
    • 0042968648 scopus 로고    scopus 로고
    • Apoptosis and treatment of chronic allograft nephropathy with everolimus
    • Lutz J, Zou H, Liu S, et al. Apoptosis and treatment of chronic allograft nephropathy with everolimus. Transplantation 2003; 76: 508.
    • (2003) Transplantation , vol.76 , pp. 508
    • Lutz, J.1    Zou, H.2    Liu, S.3
  • 38
    • 4344660143 scopus 로고    scopus 로고
    • Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration
    • Wang M, Liu S, Ouyang N, et al. Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration. Kidney Int 2004; 66: 1248.
    • (2004) Kidney Int , vol.66 , pp. 1248
    • Wang, M.1    Liu, S.2    Ouyang, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.