High resolution NMR-based model for the structure of a scFv-IL-1β complex: Potential for NMR as a key tool in therapeutic antibody design and development

Journal of Biological Chemistry

Volumn 284, Issue 46, 2009, Pages 31928-31935

  Wilkinson, Ian C ^a   Hall, Catherine J ^a   Veverka, Vaclav ^a   Shi, Jiye Y ^b   Muskett, Frederick W ^a   Stephens, Paul E ^b   Taylor, Richard J ^b   Henry, Alistair J ^b   Carr, Mark D ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE DRUGS; ANTIGEN BINDING; BINDING INTERFACE; CYTOKINES; DESIGN AND DEVELOPMENT; EXPERIMENTAL DETERMINATION; FAB FRAGMENTS; HIGH RESOLUTION; HIGH-RESOLUTION MODELS; KNOWLEDGE-BASED APPROACH; NMR RESTRAINTS; NMR SPECTROSCOPY; RATIONAL DESIGN; REGULATORY PROTEIN; RELATIVE ORIENTATION; SINGLE CHAIN VARIABLE FRAGMENTS; STRUCTURAL INFORMATION; TARGET PROTEINS; THERAPEUTIC ANTIBODIES;

DRUG PRODUCTS; KNOWLEDGE BASED SYSTEMS; LAWS AND LEGISLATION; MONOCLONAL ANTIBODIES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TARGETS;

PROTEINS;

INTERLEUKIN 1BETA; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

ANTIBODIES, MONOCLONAL; DRUG DESIGN; EPITOPE MAPPING; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-1BETA; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 70450274968     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.025304     Document Type: Article

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