Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and X-ray crystallography

Structure

Volumn 10, Issue 7, 2002, Pages 981-987

  Josephson, Kristopher ^a   Jones, Brandi C ^a   Walter, Leigh J ^a   DiGiacomo, Ruth ^a   Indelicato, Stephen R ^a   Walter, Mark R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Crystal structure; Cytokine; IL 10; Neutralizing antibody; Noncompetitive; Protein engineering

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN RECEPTOR;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; EPSTEIN BARR VIRUS; PRIORITY JOURNAL; PROTEIN ENGINEERING; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; MUTATION; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; CRYSTALLOGRAPHY, X-RAY; HERPESVIRUS 4, HUMAN; IMMUNOGLOBULINS, FAB; INTERLEUKIN-10; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECEPTORS, INTERLEUKIN; SUPPORT, U.S. GOV'T, P.H.S.; IMMUNOGLOBULIN FAB FRAGMENTS; RECEPTORS, INTERLEUKIN-10;

HUMAN HERPESVIRUS 4;

EID: 0036065431     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00791-8     Document Type: Article

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