Detection of molecular determinants and epitope mapping using MALDI-TOF mass spectrometry

Clinical Immunology and Immunopathology

Volumn 85, Issue 3, 1997, Pages 229-235

  Van De Water, Judy ^a   Deininger, Sören O ^b   Macht, Marcus ^b   Przybylski, Michael ^b   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Autoimmune; Epitope; Mass spectrometry; Primary biliary cirrhosis

Indexed keywords

ANTIGEN; AUTOANTIBODY; COMPLEMENTARY DNA; CYANOGEN BROMIDE; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; MYOGLOBIN; T LYMPHOCYTE RECEPTOR; TROPONIN T;

ANTIGEN ANTIBODY COMPLEX; AUTOIMMUNE DISEASE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN SITU HYBRIDIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SHORT SURVEY;

EID: 0031391256     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4434     Document Type: Review

References (47)

1. Strupat K., Karas M., Hillenkamp F. 2, 5-Dihydrobenzoic acid: A new matrix for laser desorption ionization mass spectrometry. Int. J. Spectrom. Ion Processes. 111:1991;89-93.
2. Beavis R. C., Bridson J. N. Epitaxial protein inclusion in sinpic acid crystals. J. Phys. D: Appl. Phys. 26:1993;442-447.
3. Karas M., Hillenkamp F. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem. 60:1988;2299-2301.
4. Karas M., Bahr U., Hillenkamp F. UV laser matrix laser desorption ionization mass spectrometry of proteins in the 100,000 dalton range. Int. J. Mass Spectrom. Ion Processes. 92:1989;231-242.
5. Beavis R. C., Chait B. T. Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins. Rapid Commun. Mass Spectrom. 3:1989;432-435.
6. Beavis R. C., Chait B. T. Matrix-assisted laser-desorption mass spectrometry using 355 nm radiation. Rapid Commun. Mass Spectrom. 3:1989;436-439.
7. Beavis R. C., Chaudhary T., Chait B. T. α-Cyano-4-hydroxycinnamic acid as a matrix for matrix-assisted laser desorption mass spectrometry. Org. Mass. Spectrom. 272:1991;156-158.
8. Hillenkamp F., Karas M., Beavis R. C., Chait B. T. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal. Chem. 63:1991;1193A-1203A.
9. Beavis R. C., Chait B. T. Rapid, sensitive analysis of protein mixtures by mass spectrometry. Proc. Natl. Acad. Sci. USA. 87:1990;6873-6877.
10. Hutchens T. W., Nelson R. W., Yip T. T. Recognition of transition metal ions by peptides. Identification of specific metal-binding peptides in proteolytic digest maps by UV laser desorption time-of-flight mass spectrometry. FEBS Lett. 296:1992;99-102.
11. Yip T. T., Hutchens T. W. Mapping and sequence-specific identification of phosphopeptides in unfractionated protein digest mixtures by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. FEBS Lett. 308:1992;149-153.
12. Karas M., Bahr U., Giessmann R. Matrix-assisted laser desorption ionization mass spectrometry. Mass Spectrom. Rev. 10:1991;335-357.
13. Chait B. T., Kent S. B. Weighing naked proteins: Practical, high-accuracy mass measurement of peptides and proteins. Science. 257:1992;1885-1894.
14. Hutchens T. W., Yip T. T. New desorption strategies for the mass spectrometric analysis of macromolecules. Rapid Commun. Mass Spectrom. 7:1993;576-580.
15. Hutchens T. W., Yip T. T. Affinity mass spectrometry: Probe element surfaces enhanced for affinity capture (SEAC). Protein Sci. 3:1994;81.
16. Huczko E. L., Bodnar W. M., Benjamin D., Sakaguchi K. Characteristics of edogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry. J. Immunol. 151:1993;2572-2587.
17. Hunt D. F., Michel H., Dickenson T. A., Shabanowitz J., Cox A. L., Sakaguchi K., Appella E., Grey H. M., Sette A. Peptides presented to the immune system by the murine Class-II major histocompatibility complex molecule-I-A(D). Science. 256:1992;1817-1820.
18. Hunt D. F., Henderson R. A., Shabanowitz J., Sakaguchi K., Michel H., Sevilir N., Cox A. L., Appella E., Engelhard V. H. Characterization of peptides bound to the class I MHC molecule HLA-A2.1. Science. 255:1992;1261-1266.
19. Suckau D., Kohl J., Karwath G., Schneider K., Casaretto M., Bitter-Suermann D., Przybylski M. Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping. Proc. Natl. Acad. Sci. USA. 87:1990;9848-9852.
20. Yip T. T., Van de Water J., Gershwin M. E., Coppel R. L., Hutchens T. W. Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry. J. Biol. Chem. 271:1996;32825-32833.
21. Benjamin D. C., Berzofsky J. A., East I. J., Gurd F. R. N., Hannum C., Leach S. J., Magroliash E., Michael J. G., Miller A., Prager E. M., Reichlin M., Sercarz E. E., Smith-Gill S. J., Todd P. E., Wilson A. C. The antigenic structure of proteins: A reappraisal. Annu. Rev. Immunol. 2:1984;67-101.
22. Berzofsky J. A. Intrinsic and extrinsic factors in protein antigenic structure. Science. 229:1985;932-940.
23. Eisenberg R. J., Long D., Pereira L., Hampar B., Zweig M., Cohen G. H. Effect of monoclonal antibodies on limited proteolysis of native glycoprotein gD of herpes simplex virus type 1. J. Virol. 41:1982;478-488.
24. Jemmerson R., Paterson Y. Mapping epitopes on a protein antigen by the proteolysis of antigen-antibody complexes. Science. 232:1986;1001-1004.
25. Moelling K., Scott A., Dittmann K. E. J., Owada M. Effect of p15-associated protease from an avian RNA tumor virus on avian virus-specific polyprotein precursors. J. Virol. 33:1980;680-688.
26. Schwyzer M., Weir R., Frank G., Zuber H. Amino acid sequence analysis of fragments generated by partial proteolysis from large simian virus 40 tumor antigen. J. Biol. Chem. 255:1980;5627-5634.
27. Sheshberadaran H., Payne L. G. Protein antigen-monoclonal antibody contact sites investigated by limited proteolysis of monoclonal antibody-bound antigen: Protein "footprinting" Proc. Natl. Acad. Sci. USA. 85:1988;1-5.
28. Glocker M. O., Borchers C., Fiedler W., Suckau D., Przybylski M. Molecular characterization of surface topology in protein tertiary structures by amino-acylation and mass spectrometric peptide mapping. Bioconjugate Chem. 5:1994;583-590.
29. Gauss C., Klein J., Post K., Suckau D., Schneider K., Thomas H., Oesch F., Przybylski M. Mass spectrometric peptide mapping analysis and structural characterization of dihydrodiol dehydrogenase isoenzymes. Environ. Health Perspect. 88:1990;57-62.
30. Svoboda M. M., Przybylski M., Schreurs J., Miyajima A., Hogeland K., Deinzer M. Mass spectrometric determination of glycosylation sites and oligosaccharide composition of insect-expressed interleukin-3. J. Chromat. 562:1991;403-419.
31. Macht M., Fiedler W., Kurzinger K., Przybylski M. Mass spectrometric mapping of protein epitope structures of myocardial infarct markers myoglobin and troponin T. Biochemistry. 35:1996;15633-15639.
32. Fiedler W., Borchers C., Macht M., Deininger S., Przybylski M. Molecular characterization of conformational epitopes of hen eggwhite lysozyme by differential chemical modification of immune complexes and mass spectrometric peptide mapping. Bioconjugate Chem. 1997.
33. Nag B., Mukku P. V., Arimilli S., Phan D., Deshpande S. V., Winkelhake J. L. Antigenic peptide binding to MHC class II molecules at increased peptide concentrations. Mol. Immunol. 31:1994;1161-1168.
34. Hunt D. F., Michel H., Dickinson T. A., Shabanowitz J., Cox A. L., Sakaguchi K., Appella E., Grey H. M., Sette A. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science. 256:1992;1817-1820.
35. Urban R. G., Chicz R. M., Lane W. S., Strominger J. L., Rehm A., Kenter M. J., UytdeHaag F. G., Ploegh H., Uchanska-Ziegler B., Ziegler A. A subset of HLA-B27 molecules contains peptides much longer than nonamers. Proc. Natl. Acad. Sci. USA. 91:1994;1534-1538.
36. Vignali D. A., Urban R. G., Chicz R. M., Strominger J. L. Minute quantities of a single immunodominant foreign epitope are presented as large nested sets by major histocompatibility complex class II molecules. Eur. J. Immunol. 23:1993;1602-1607.
37. Appella E., Padlan E. A., Hunt D. F. Analysis of the structure of naturally processed peptides bound by class I and class II major histocompatibility complex molecules. EXS. 73:1995;105-119.
38. Rammensee H. G., Friede T., Stevanoviic S. MHC ligands and peptide motifs: First listing. Immunogenetics. 41:1995;178-228.
39. Huczko E. L., Bodnar W. M., Benjamin D., Sakaguchi K., Zhu N. Z., Shabanowitz J., Henderson R. A., Appella E., Hunt D. F., Engelhard V. H. Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling. J. Immunol. 151:1993;2572-2587.
40. MacSween R. N., Sumithran E. Histopathology of primary biliary cirrhosis. Semin. Liver Disease. 1:1981;282-292.
41. Surh C. D., Ahmed-Ansari A., Gershwin M. E. Comparative epitope mapping of murine monoclonal and human autoantibodies to human PDH-E2, the major mitochondrial autoantigen of primary biliary cirrhosis. J. Immunol. 144:1990;2647-2652.
42. Coppel R. L., Gershwin M. E. Primary biliary cirrhosis: The molecule and the mimic. Immunol. Rev. 144:1995;17-49.
43. Van de Water J., Turchany J., Leung P. S., Lake J., Munoz S., Surh C. D., Coppel R., Ansari A., Nakanuma Y., Gershwin M. E. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J. Clin. Invest. 91:1993;2653-2664.
44. Cha S., Leung P. S., Gershwin M. E., Fletcher M. P., Ansari A. A., Coppel R. L. Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. Proc. Natl. Acad. Sci. USA. 90:1993;2527-2531.
45. Cha S., Leung P. S., Coppel R. L., Van de Water J., Ansari A. A., Gershwin M. E. Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. Hepatology. 20:1994;574-583.
46. Joplin R., Wallace L. L., Johnson G. D., Lindsay J. G., Yeaman S. J., Palmer J. M., Strain A. J., Neuberger J. M. Subcellular localization of pyruvate dehydrogenase dihydrolipoamide acetyltransferase in human intrahepatic biliary epithelial cells. J. Pathol. 176:1995;381-390.
47. Harada K., Van de Water J., Leung P. S. C., Coppel R. L., Nakanuma Y., Gershwin M. E. In situ nucleaic acid hybridization of PDC-E2 in primary biliary cirrhosis. Hepatology. 25:1997;27-32.