Structure-based mechanism of ADP-ribosylation by sirtuins

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33654-33661

  Hawse, William F ^a   Wolberger, Cynthia ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADP-RIBOSYLATION; ADP-RIBOSYLTRANSFERASE; ARGININE PEPTIDES; DEACETYLATION; PREDOMINANT REACTIONS; REACTION INTERMEDIATE; REGULATION OF TRANSCRIPTION; SIRTUIN; STRUCTURAL STUDIES; STRUCTURE-BASED; TRANSCRIPTIONAL SILENCING;

ACETYLATION; AMINES; CATALYSTS; ENZYMES; PEPTIDES;

AMINO ACIDS;

ARGININE; LYSINE; SIRTUIN 2; SIRTUIN 2TM; UNCLASSIFIED DRUG;

ACETYLATION; ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; BACTERIUM; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEACETYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE;

ACETYLATION; ADENOSINE DIPHOSPHATE RIBOSE; ADP RIBOSE TRANSFERASES; AMINO ACID SEQUENCE; ARGININE; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMOTOGA MARITIMA; TUMOR SUPPRESSOR PROTEIN P53;

BACTERIA (MICROORGANISMS);

EID: 70450225307     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.024521     Document Type: Article

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