Methionine-derived metabolites in apoptosis: Therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells

Current Medicinal Chemistry

Volumn 16, Issue 28, 2009, Pages 3686-3700

  Quash, G ^a,b   Fournet, G ^a  

^a UNIVERSITÉ LYON 1   (France)

^b CERMA   (France)

Author keywords

4 methylthio 2 oxobutanoate (MTOB); Acyl CoA; Aldehyde dehydrogenase inhibitors; Bcl2 chemoresistant cancers; Methional

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); 4 (DIMETHYLAMINO) 4 METHYL 2 PENTYNETHIOIC ACID METHYL ESTER; 4 AMINO 4 METHYL PENT 2 YNTHIOIC ACID METHYL ESTER; 4 HYDROXYNONENAL; 4 METHYL 4 (4 MORPHOLINYL) 2 PENTYNETHIOIC ACID; 4 METHYLTHIO 2 OXOBUTYRIC ACID; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3; ALDEHYDE DEHYDROGENASE INHIBITOR; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ANTINEOPLASTIC AGENT; CHOLINE; COENZYME A; DISULFIRAM; GLUTAMINE PHENYLPYRUVATE AMINOTRANSFERASE; MALONALDEHYDE; MALONIC SEMIALDEHYDE COENZYME A; METHIONAL; METHIONINE; METHIONINE DERIVATIVE; METHYLTHIOPROPANOATE LIPOATE CHOLINE; METHYLTHIOPROPANOYL COENZYME A; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE INHIBITOR; PALMITOYL COENZYME A HYDROLASE; PROTEIN BCL 2; THIOCTIC ACID; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BIOGENESIS; CANCER CELL; CANCER RESISTANCE; CELL PROLIFERATION; CONCENTRATION RESPONSE; DECARBOXYLATION; DNA CROSS LINKING; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; GROWTH INHIBITION; HOMEOSTASIS; HUMAN; INTESTINE CANCER; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN DNA INTERACTION; PROTEIN METABOLISM; PROTEIN TRANSPORT; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSAMINATION;

EID: 70450220242     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709789104966     Document Type: Review

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