The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase

Biochemical Pharmacology

Volumn 72, Issue 7, 2006, Pages 806-815

  Tang, Baiqing ^a   Kadariya, Yuwaraj ^a   Murphy, Maureen E ^a   Kruger, Warren D ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Apoptosis; Keto acid; Methionine; Methylthioadenosine phosphorylase; Polyamines

Indexed keywords

4 METHYLTHIO 2 OXOBUTYRIC ACID; CASPASE 3; CASPASE 7; EFLORNITHINE; MESSENGER RNA; METHIONINE; ORNITHINE DECARBOXYLASE; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; WESTERN BLOTTING;

ADENOSINE; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CASPASES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EFLORNITHINE; ENZYME ACTIVATION; GROWTH INHIBITORS; HUMANS; METHIONINE; ORNITHINE DECARBOXYLASE; POLYAMINES; PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33748053658     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.018     Document Type: Article

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