Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): Restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF3 cells overexpressing bcl2

Biochemical Pharmacology

Volumn 64, Issue 8, 2002, Pages 1279-1292

  Quash, Gerard ^a   Fournet, Guy ^b   Chantepie, Jacqueline ^a   Gore, Jacques ^b   Ardiet, Claude ^c   Ardail, Dominique ^a   Michal, Yvonne ^a   Reichert, Uwe ^d  

^a INSERM   (France)

^b CPE LYON   (France)

^c CENTRE LÉON BÉRARD   (France)

^d Galderma R and D   (France)

Author keywords

ALDH1; Apoptosis; bcl2; Chemoresistance; Thiolester inhibitors

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE INHIBITOR; CYCLOPHOSPHAMIDE DERIVATIVE; DNA FRAGMENT; ESTERASE; HYDROPEROXYCYCLOPHOSPHAMIDE; METHANETHIOL; MORPHOLINE DERIVATIVE; PROTEIN BCL 2; THIOESTER; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG INHIBITION; EMBRYO; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; INCUBATION TIME; PRIORITY JOURNAL;

ALDEHYDE DEHYDROGENASE; ALKYNES; ANIMALS; APOPTOSIS; CYCLOPHOSPHAMIDE; DNA FRAGMENTATION; ESTERS; GLUTATHIONE; HUMANS; ISOENZYMES; LEUKEMIA L1210; LYMPHOCYTES; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; SACCHAROMYCES CEREVISIAE; SULFHYDRYL COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0037109302     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01294-7     Document Type: Article

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