Aldehyde dehydrogenase inhibitors: α,β-Acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 906-916

  Quash, Gerard ^a   Fournet, Guy ^b   Courvoisier, Charlotte ^b   Martinez, Rosa M ^b   Chantepie, Jacqueline ^a   Paret, Marie Julie ^a   Pharaboz, Julie ^c   Joly Pharaboz, Marie Odile ^c   Goré, Jacques ^b   André, Jean ^c   Reichert, Uwe ^d  

^a UNIVERSITÉ LYON 1   (France)

^b CPE LYON   (France)

^c HÔPITAL DEBROUSSE   (France)

^d Galderma R and D   (France)

Author keywords

Acetylenic aminothiolesters; ALDH1 and ALDH3 inhibitors; Apoptosis; Human prostate cancer cells; Human prostate epithelial normal cells

Indexed keywords

4 (DIPROPYLAMINO) 4 METHYL 2 PENTYNETHIOIC ACID S METHYL ESTER; ALDEHYDE DEHYDROGENASE 3; ALDEHYDE DEHYDROGENASE INHIBITOR; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALPHA,BETA ACETYLENIC AMINOTHIOLESTER DERIVATIVE; CELL ENZYME; ISOENZYME; SUPEROXIDE; XENOBIOTIC AGENT;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INDUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNE DEFICIENCY; MALE; MITOCHONDRION; OXIDATION REDUCTION POTENTIAL; PROSTATE CANCER; PROSTATE EPITHELIUM; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; ESTERS; HUMANS; ISOENZYMES; MALE; MICE; MITOCHONDRIA; OXIDATION-REDUCTION; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; SUPEROXIDES; TRANSPLANTATION, HETEROLOGOUS;

EID: 42949130191     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.004     Document Type: Article

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