Macronutrient specific postprandial oxidative stress: Relevance to the development of insulin resistance

Current Diabetes Reviews

Volumn 5, Issue 4, 2009, Pages 228-238

  Fisher Wellman, Kelsey ^a   Bloomer, Richard J ^a  

^a UNIVERSITY OF MEMPHIS   (United States)

Author keywords

Free radicals; Hyperglycemia; Hypertriglyceridemia; Insulin resistance; Oxidative stress; Postprandial

Indexed keywords

ADENOSINE TRIPHOSPHATE; FREE RADICAL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

CALORIC INTAKE; CARBOHYDRATE INTAKE; CARDIOVASCULAR DISEASE; CITRIC ACID CYCLE; DNA SYNTHESIS; EXERCISE; FOOD INTAKE; GENE DISRUPTION; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLYCOLYSIS; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; MITOCHONDRIAL MEMBRANE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXIDATION; OXIDATIVE STRESS; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REVIEW; RNA SYNTHESIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS, TYPE 2; FOOD; HUMANS; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; OXIDATIVE STRESS;

EID: 70450198818     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339909789804369     Document Type: Review

References (109)

1. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb 2005; 12: 295-300.
2. Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Executive summary of the third report of the national cholesterol education program (NCEP). JAMA 2001; 285: 2486-2497
3. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004; 24: 816-823 (Pubitemid 38620857)
4. Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-948
5. O'Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 2007; 100: 899-904. (Pubitemid 47268287)
6. Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991; 91: 14S-22S.
7. Matsuo, M, Kaneko, T. The chemistry of reactive oxygen species and related free radicals. In: Radak Z, Eds. Free Radicals in exercise and aging Champaign, IL: Human Kinetics 2000; 1-33.
8. Miller DM, Buettner GR, Aust SD. Transition metals as catalysts of "autoxidation" reactions. Free Rad Biol Med 1990; 8: 95-108.
9. Bogdan C, Rollinghoff M, Diefenbach A. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr Opin Immunol 2000; 12: 64-76. (Pubitemid 30093452)
10. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84. (Pubitemid 44566469)
11. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001; 30: 1191-1212.
12. Lane N. A unifying view of ageing and disease: the double-agent theory. J Theor Biol 2003; 225: 531-540 (Pubitemid 37393283)
13. Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem 2006; 52: 601-623
14. Lee HC, Wei YH. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med 2007; 232: 592-606. (Pubitemid 46683384)
15. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev 2008; 8: 18-30.
16. Fisher-Wellman K, Bloomer RJ. Acute exercise and oxidative stress: a 30 year history. Dyn Med 2009; 8: 1.
17. Halliwell B, Cross CE. Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect 1994; 102(Suppl 10): 5-12.
18. Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P. Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am J Clin Nutr 2002; 75: 767-772 (Pubitemid 34250692)
19. Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J Clin Endocrinol Metab 2000; 85: 2970-2973 (Pubitemid 32269184)
20. Aljada A, Mohanty P, Ghanim H, et al. Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am J Clin Nutr 2004; 79: 682-690 (Pubitemid 41103915)
21. Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr 2005; 135: 969-972 (Pubitemid 40638292)
22. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005; 54: 1615-1625 (Pubitemid 40770750)
23. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295: 1681-1687
24. Bae JH, Bassenge E, Kim KB, et al. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis 2001; 155: 517-523 (Pubitemid 32209324)
25. Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment. Circulation 2002; 106: 1211-1218 (Pubitemid 34988638)
26. de Koning EJ, Rabelink TJ. Endothelial function in the post-prandial state. Atheroscler Suppl 2002; 3: 11-16
27. Rebolledo OR, Actis Dato SM. Postprandial hyperglycemia and hyperlipidemia-generated glycoxidative stress: its contribution to the pathogenesis of diabetes complications. Eur Rev Med Pharmacol Sci 2005; 9: 191-208.
28. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007; 298: 309-316 (Pubitemid 47080485)
29. O'Keefe JH, Gheewala NM, O'Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 2008; 51: 249-255
30. Cavalot F, Petrelli A, Traversa M, et al. Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study. J Clin Endocrinol Metab 2006; 91: 813-9.
31. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Non-fasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308. (Pubitemid 47080484)
32. Anderson EJ, Lustig ME, Boyle KE, et al. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 2009; 119: 573-581
33. Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 2008; 118: 789-800. (Pubitemid 351206566)
34. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7: 45-56.
35. Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787-790 (Pubitemid 30212409)
36. Liu Y, Fiskum G, Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J Neurochem 2002; 80: 780-787 (Pubitemid 34809230)
37. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 134: 707-716
38. Boveris A, Cadenas E, Stoppani AO. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem J 1976; 156: 435-444
39. 2 production. Free Radic Biol Med 2005; 39: 1249-1261
40. Knight JA. Free radicals: their history and current status in aging and disease. Ann Clin Lab Sci 1998; 28: 331-346 (Pubitemid 28541691)
41. Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 2006; 8: 243-270
42. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071 (Pubitemid 27163860)
43. Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. Am J Clin Nutr 2004; 80: 51-57 (Pubitemid 41115554)
44. Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 2004; 279: 41294-41301 (Pubitemid 39313568)
45. Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 2006; 116: 1071-1080
46. Ceriello A. New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care 2003; 26: 1589-1596
47. Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab 2007; 27: 435-451 (Pubitemid 46310424)
48. van Oostrom AJ, Sijmonsma TP, Verseyden C, et al. Postprandial recruitment of neutrophils may contribute to endothelial dysfunction. J Lipid Res 2003; 44: 576-583 (Pubitemid 37279707)
49. Aljada A, Friedman J, Ghanim H, et al. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism 2006; 55: 1177-1185 (Pubitemid 44215936)
50. Ceriello A, Quagliaro L, Piconi L, et al. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes 2004; 53: 701-710 (Pubitemid 38270640)
51. Khachigian LM, Lindner V, Williams AJ, Collins T. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 1996; 271: 1427-1431 (Pubitemid 26089480)
52. Rauch U, Nemerson Y. Circulating tissue factor and thrombosis. Curr Opin Hematol 2000; 7: 273-277
53. Engerman RL, Kern TS, Larson ME. Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs. Diabetologia 1994; 37: 141-144 (Pubitemid 24042881)
54. Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996; 272: 728-731 (Pubitemid 26000279)
55. Hammes HP, Martin S, Federlin K, Geisen K, Brownlee M. Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc Natl Acad Sci USA 1991; 88: 11555-11558 (Pubitemid 21916080)
56. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820 (Pubitemid 34000785)
57. Bloomer RJ, Cole BJ, Fisher-Wellman KH. Racial differences in postprandial oxidative stress with and without acute exercise. Int J Sport Nutr Exerc Metab [In Press].
58. Bloomer RJ, Ferebee DE, Fisher-Wellman KH, Quindry JC, Schilling BK. Postprandial oxidative stress: Influence of gender and exercise training status. Med Sci Sports Exerc [In Press].
59. Bloomer RJ, Fisher-Wellman KH. Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal. Med Cell Longevity 2009; 2: 1-7.
60. Bloomer RJ, Fisher-Wellman KH. Postprandial oxidative stress in exercise trained and untrained cigarette smokers. Int J Environ Res Public Health 2009; 6: 579-591
61. Bloomer RJ, Solis AD, Fisher-Wellman KH, Smith WA. Post-prandial oxidative stress is exacerbated in cigarette smokers. Br J Nutr 2008; 99: 1055-1060
62. Tsai WC, Li YH, Lin CC, Chao TH, Chen JH. Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci 2004; 106: 315-319 (Pubitemid 38365839)
63. Mc Clean CM, Mc Laughlin J, Burke G, et al. The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men. Eur J Appl Physiol 2007; 100: 225-234 (Pubitemid 46681642)
64. Schinkovitz A, Dittrich P, Wascher TC. Effects of a high-fat meal on resistance vessel reactivity and on indicators of oxidative stress in healthy volunteers. Clin Physiol 2001; 21: 404-410 (Pubitemid 32611278)
65. Anderson RA, Evans ML, Ellis GR, et al. The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes. Atherosclerosis 2001; 154: 475-483
66. Neri S, Signorelli SS, Torrisi B, et al. Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls. Clin Ther 2005; 27: 1764-1773 (Pubitemid 41815227)
67. Tushuizen ME, Nieuwland R, Scheffer PG, Sturk A, Heine RJ, Diamant M. Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost 2006; 4: 1003-1010
68. Bae JH, Schwemmer M, Lee IK, et al. Postprandial hypertriglyceridemia- induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int J Cardiol 2003; 87: 259-267 (Pubitemid 36135984)
69. Ceriello A, Assaloni R, Da Ros R, et al. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation 2005; 111: 2518-2524 (Pubitemid 40696141)
70. Sampson MJ, Gopaul N, Davies IR, Hughes DA, Carrier MJ. Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes. Diabetes Care 2002; 25: 537-541 (Pubitemid 41103349)
71. Serin O, Konukoglu D, Firtina S, Mavis O. Serum oxidized low density lipoprotein, paraoxonase 1 and lipid peroxidation levels during oral glucose tolerance test. Horm Metab Res 2007; 39: 207-211 (Pubitemid 46580620)
72. Miyazaki Y, Kawano H, Yoshida T, et al. Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia. Diabet Med 2007; 24: 154-160 (Pubitemid 46174938)
73. Lee IK, Kim HS, Bae JH. Endothelial dysfunction: its relationship with acute hyperglycaemia and hyperlipidemia. Int J Clin Pract Suppl 2002; 129: 59-64. (Pubitemid 34839467)
74. Kawano H, Motoyama T, Hirashima O, et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999; 34: 146-154
75. Schindhelm RK, Alssema M, Scheffer PG, et al. Fasting and post-prandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes. Diabetes Care 2007; 30: 1789-1794 (Pubitemid 47036353)
76. Ceriello A, Bortolotti N, Motz E, et al. Meal-generated oxidative stress in type 2 diabetic patients. Diabetes Care 1998; 21: 1529-1533 (Pubitemid 28405209)
77. Ceriello A, Quagliaro L, Catone B, et al. Role of hyperglycemia in nitrotyrosine postprandial generation. Diabetes Care 2002; 25: 1439-1443 (Pubitemid 41071158)
78. Zhu W, Zhong C, Yu Y, Li K. Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men. Eur J Appl Physiol 2007; 99: 585-591 (Pubitemid 46404016)
79. Jenkins DJ, Kendall CW, Josse AR, et al. Almonds decrease post-prandial glycemia, insulinemia, and oxidative damage in healthy individuals. J Nutr 2006; 136: 2987-2992
80. Bartke A. Insulin and aging. Cell Cycle 2008; 7: 3338-3343
81. Oh-ishi S, Heinecke JW, Ookawara T, et al. Role of Lipid and Lipoprotein Oxidation. In: Radak Z, Ed. Free Radicals in Exercise and Aging Champaign, IL: Human Kinetics 2000; 211-258
82. Marfella R, Quagliaro L, Nappo F, Ceriello A, Giugliano D. Acute hyperglycemia induces an oxidative stress in healthy subjects. J Clin Invest 2001; 108: 635-636 (Pubitemid 32777744)
83. Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 2007; 30: 1406-1411 (Pubitemid 46871146)
84. Dandona P, Aljada A, Mohanty P, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001; 86: 3257-3265
85. Layman DK, Baum JI. Dietary protein impact on glycemic control during weight loss. J Nutr 2004; 134: 968S-73S.
86. Westphal S, Leodolter A, Kahl S, Dierkes J, Malfertheiner P, Luley C. Addition of glucose to a fatty meal delays chylomicrons and suppresses VLDL in healthy subjects. Eur J Clin Invest 2002; 32: 322-327 (Pubitemid 36228391)
87. Anderson EJ, Yamazaki H, Neufer PD. Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration. J Biol Chem 2007; 282: 31257-31266 (Pubitemid 350044867)
88. St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002; 277: 44784-44790 (Pubitemid 36159072)
89. Sul HS. Metabolism of Fatty Acids, Acylglycerols, and Sphingolipids. In: Stipanuk MH, Ed. Biochemical, Physiological, & Molecular Aspects of Human Nutrition. 2nd ed. St. Louis, Missouri: Elsevier 2006; 449-491
90. Pastromas S, Terzi AB, Tousoulis D, Koulouris S. Postprandial lipemia: An under-recognized atherogenic factor in patients with diabetes mellitus. Int J Cardiol 2007; 126: 3-12.
91. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95. (Pubitemid 34654215)
92. Kim JH, Kwak HB, Leeuwenburgh C, Lawler JM. Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Exp Gerontol 2008; 43: 317-329
93. Ceriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 2005; 54: 1-7.
94. Hivert MF, Sullivan LM, Fox CS, et al. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab 2008; 93: 3165-3172
95. Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev 2007; 21: 1443-1455 (Pubitemid 46955717)
96. Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307-312 (Pubitemid 32151228)
97. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-2415
98. Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev 2008; 7: 34-42.
99. Lichtenstein AH, Appel LJ. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114: 82-96.
100. Park Y, Harris WS. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 2003; 44: 455-463 (Pubitemid 37279692)
101. Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr 2007; 85: 1552-1556 (Pubitemid 46890423)
102. Ostman E, Granfeldt Y, Persson L, Bjorck I. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr 2005; 59: 983-988 (Pubitemid 43118157)
103. Brand-Miller JC, Fatema K, Middlemiss C, et al. Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults. Am J Clin Nutr 2007; 85: 1545-1551 (Pubitemid 46890422)
104. Jenkins DJ, Kendall CW, Josse AR, et al. Almonds decrease post-prandial glycemia, insulinemia, and oxidative damage in healthy individuals. J Nutr 2006; 136: 2987-2992
105. Dandona P, Mohanty P, Ghanim H, et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab 2001; 86: 355-362 (Pubitemid 32109818)
106. Dandona P, Mohanty P, Hamouda W, et al. Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab 2001; 86: 2899-2902 (Pubitemid 32545759)
107. Ervin RB. Healthy Eating Index scores among adults, 60 years of age and over, by sociodemographic and health characteristics: United States, 1999-2002. Adv Data 2008; 395: 1-16.
108. Kennedy ET, Bowman SA, Spence JT, Freedman M, King J. Popular diets: correlation to health, nutrition, and obesity. J Am Diet Assoc 2001; 101: 411-420 (Pubitemid 33712124)
109. Vitolins MZ, Tooze JA, Golden SL, et al. Older adults in the rural South are not meeting healthful eating guidelines. J Am Diet Assoc 2007; 107: 265-272