Synthesis and cytotoxic evaluation of novel 2-(4-(2,2,2-trifluoroethoxy)-3- methylpyridin-2-ylthio)-1H-benzo[d]imidazole derivatives

Archives of Pharmacal Research

Volumn 32, Issue 10, 2009, Pages 1335-1343

  Ranganatha, S R ^a   Kavitha, C V ^b   Vinaya, K ^a   Prasanna, D S ^a   Chandrappa, S ^a   Raghavan, Sathees C ^b   Rangappa, Kanchugarakoppal S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Amino acids; Benzimidazole; Chronic myelogenous leukemia; Cytotoxicity

Indexed keywords

1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 2 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINOPROPAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAOL 1 YL) 2 AMINO MERCAPTOPROPAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 ( 1H INDOL 3 YL)PROPAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 ( 4 HYDROXYPHENYL)PROPAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 METHYLBUTAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 METHYLPENTAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 PHENYLPROPAN 1 ONE; 1 ( 2 (( 4 ( 2,2,2 TRIFLUOROETHOXY) 3 METHYLPYRIDIN 2 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL)(PYRROLIDIN 2 YL)METHANONE; 1 ( 2 (( 5 ( 2,2,2 TRIFLUOROETHOXY) 4 METHYLPYRIDIN 3 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2 AMINO 3 METHYLBUTAN 1 ONE; 1 ( 2 (( 5 ( 2,2,2 TRIFLUOROETHOXY) 4 METHYLPYRIDIN 3 YL)METHYLTHIO) 1H BENZO[D]IMIDAZOL 1 YL) 2,6 DIAMINOHEXAN 1 ONE; AMINO ACID; AMINO ACID DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CYSTEINE; IMIDAZOLE DERIVATIVE; PYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN K 562; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFRARED RADIATION; LEUKEMIA CELL; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70450186691     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-2000-9     Document Type: Article

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