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Volumn 27, Issue 4, 2009, Pages 327-337

Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: A SAR study

Author keywords

Cytotoxic activities; Diazaspiro bicyclo hydantoin; Leukemia; MTT assay; SAR; Trypan blue dye exclusion assay

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 8 (3 FLUOROBENZYL) 1' (2 METHOXYETHYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5 DIONE; 8 (3 FLUOROBENZYL) 1' (PENT 4 ENYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5' DIONE; 8 (3,4 CHLOROBENZYL) 1' (2 METHOXYETHYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5 DIONE; 8 (3,4 DICHLOROBENZYL) 1' (2 METHOXYETHYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5 DIONE; 8 (3,4 DICHLOROBENZYL) 1' (PENT 4 ENYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5' DIONE; 8 (3,4 DIFLUOROBENZYL) 1' (2 METHOXYETHYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5 DIONE; 8 (3,4 DIFLUOROBENZYL) 1' (PENT 4 ENYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5' DIONE; 8 (4 DICHLOROBENZYL) 1' (PENT 4 ENYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5' DIONE; 8 (4 FLUOROBENZYL) 1' (2 METHOXYETHYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5 DIONE; 8 (4 FLUOROBENZYL) 1' (PENT 4 ENYL) 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 2',5' DIONE; ALKENE; ANTINEOPLASTIC AGENT; BENZYL DERIVATIVE; DIAZASPIROBICYCLOHYDANTOIN DERIVATIVE; ESTER; ETHER; FUNCTIONAL GROUP; HYDANTOIN DERIVATIVE; PHENYL GROUP; PROPYL 2 [8 (3 FLUOROBENZYL) 2' 5' DIOXO 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 1' YL]ACETIC ACID; PROPYL 2 [8 (3,4 DICHLOROBENZYL) 2' 5' DIOXO 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 1' YL]ACETIC ACID; PROPYL 2 [8 (3,4 DIFLUOROBENZYL) 2' 5' DIOXO 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 1' YL]ACETIC ACID; PROPYL 2 [8 (4 CHLOROBENZYL) 2' 5' DIOXO 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 1' YL]ACETIC ACID; PROPYL 2 [8 (4 FLUOROBENZYL) 2' 5' DIOXO 8 AZASPIRO[BICYCLO[3.2.1]OCTANE 3,4' IMIDAZOLIDINE] 1' YL]ACETIC ACID; TRYPAN BLUE; UNCLASSIFIED DRUG;

EID: 67651160775     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9179-3     Document Type: Article
Times cited : (33)

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