Synthesis and potent antibacterial activity against MRSA of some novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines

European Journal of Medicinal Chemistry

Volumn 40, Issue 10, 2005, Pages 1062-1069

  Göker, Hakan ^a   Özden, Seçkin ^a   Yildiz, Sulhiye ^a   Boykin, David W ^b  

^a ANKARA UNIVERSITY   (Turkey)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

1H benzimidazole carboxamidines; Antibacterial activity; Methicilline resistant S. aureus

Indexed keywords

AMIDINE; BENZIMIDAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; DILUTION; DRUG ACTIVITY; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ALKYLATION; AMIDINES; ANTI-BACTERIAL AGENTS; BENZENE; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHICILLIN RESISTANCE; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444457959     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.05.002     Document Type: Article

References (17)

1. H. Muroi, K. Nihei, K. Tsujimoto, and I. Kubo Bioorg. Med. Chem. 12 2004 583 587
2. S.W. Lemmen, H. Hafner, D. Zolldann, S. Stanzel, and R. Lütticken J. Hosp. Infect. 56 2004 191 197
3. H. Matsumura, N. Yoshizawa, A. Narumi, N. Harunari, A. Sugamata, and K. Watanabe Burns 22 1996 283 286
4. K. Hiramatsu, H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F.C. Tenover J. Antimicrob. Chemother. 40 1997 135 136
5. Anonymous Morb. Mortal. Wkly. Rep. 46 1997 765 766
6. M.A. Weidner-Wells, K.A. Ohemeng, V.N. Nguyen, S. Fraga-Spano, M.J. Macielag, H.M. Werblood, B.D. Foleno, G.C. Webb, J.F. Barrett, and D.J. Hlasta Bioorg. Med. Chem. Lett. 11 2001 1545 1548
7. R. Roger, and D. Neilson Chem. Rev. 61 1961 179
8. H.F. Ridley, R.G.W. Spickett, and G.M. Timmis J. Heterocyclic Chem. 2 1965 453 456
9. National Committee for Clinical Laboratory Standarts Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, fifth ed., Approved Standard (M7A5) 2000 National Committee for Clinical Laboratory Standards Wayne, PA
10. T.J.F. Mattaar Recueil des Travaux Chimiques des Pays-Bas et de la Belgique 41 1922 24
11. H. Göker, C. Kus, D.W. Boykin, S. Yildiz, and N. Altanlar Bioorg. Med. Chem. 10 2002 2589 2596
12. T. Naoki, M. Yoshiyuki, S. Hiroshi, M. Tsuyoshi, 2001, WO 01053272.
13. T.A. Fairley, R.R. Tidwell, I. Donkor, N.A. Naiman, K.A. Ohemeng, R.J. Lombardy, J.A. Bentley, and M. Cory J. Med. Chem. 36 1993 1746 1753
14. M. Hranjec, K. Starcevic, B. Zamola, S. Mutak, M. Derek, and K. Grace J. Antibiot. (Tokyo) 55 2002 308 314
15. D.G. Cleary, M. Cory, P.A. Sherman, 1995, WO 9508540.
16. R. Manfred, R. Wolfgang, 1980, DE 2839989.
17. E.F. Morand, M.N. Iskander, 2003, WO 03104203.