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Volumn 23, Issue 6, 2009, Pages 1193-1211

Thrombopoietin and Platelet Production in Chronic Immune Thrombocytopenia

Author keywords

ITP; Platelets; Thrombocytopenia; Thrombopoietin; TPO

Indexed keywords

AKR 501; BUTYZAMIDE; CORTICOSTEROID; ELTROMBOPAG; IMMUNOGLOBULIN; LGD 4665; NIP 004; NIP 022; PEGYLATED RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; PLACEBO; PREDNISONE; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT THROMBOPOIETIN; RHESUS D ANTIBODY; ROMIPLOSTIM; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 70450043949     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2009.09.001     Document Type: Review
Times cited : (66)

References (91)
  • 1
    • 70450092060 scopus 로고
    • On pestilential feavers
    • Culpepper N. (Ed), Streator, London
    • Riverius L. On pestilential feavers. In: Culpepper N. (Ed). The practice of physick (1668), Streator, London 618
    • (1668) The practice of physick , pp. 618
    • Riverius, L.1
  • 2
    • 13044262797 scopus 로고
    • Opera omnia
    • Hanover, Helwig, 1775, 748. Major R. (Ed), CC Thomas, Springfield (IL)
    • Werlhof P.G. Opera omnia. Hanover, Helwig, 1775, 748. In: Major R. (Ed). Classical descriptions of disease. 3rd edition (1965), CC Thomas, Springfield (IL)
    • (1965) Classical descriptions of disease. 3rd edition
    • Werlhof, P.G.1
  • 4
    • 84980097238 scopus 로고
    • The histogenesis of the blood platelets
    • Wright J.H. The histogenesis of the blood platelets. J Morphol 21 (1910) 263
    • (1910) J Morphol , vol.21 , pp. 263
    • Wright, J.H.1
  • 5
    • 0000492422 scopus 로고
    • The origin and nature of blood plates
    • Wright J.H. The origin and nature of blood plates. Boston Med Surg J 154 (1906) 643
    • (1906) Boston Med Surg J , vol.154 , pp. 643
    • Wright, J.H.1
  • 6
    • 0000085062 scopus 로고
    • A rapid method for the differential staining of blood films and malarial parasites
    • Wright J.H. A rapid method for the differential staining of blood films and malarial parasites. J Med Res 7 (1902) 138
    • (1902) J Med Res , vol.7 , pp. 138
    • Wright, J.H.1
  • 7
    • 0347053372 scopus 로고
    • Studies on a case of idiopathic purpura hemorrhagica
    • Minot G. Studies on a case of idiopathic purpura hemorrhagica. Am J Med Sci 152 (1916) 48
    • (1916) Am J Med Sci , vol.152 , pp. 48
    • Minot, G.1
  • 8
    • 0007871320 scopus 로고
    • Die essentielle thrombopenie
    • [in German]
    • Frank E. Die essentielle thrombopenie. Berl Klin Wochenschr 52 (1915) 454 [in German]
    • (1915) Berl Klin Wochenschr , vol.52 , pp. 454
    • Frank, E.1
  • 9
    • 0001604269 scopus 로고
    • Verschwinden der hamorrhagische diathese bei einem falle von "essentieller thrombopene" (Frank) nach milzexstirpation. Splenogene thrombolytische purpura
    • [in German]
    • Kaznelson P. Verschwinden der hamorrhagische diathese bei einem falle von "essentieller thrombopene" (Frank) nach milzexstirpation. Splenogene thrombolytische purpura. Wien Klin Wochenschr 29 (1916) 1451 [in German]
    • (1916) Wien Klin Wochenschr , vol.29 , pp. 1451
    • Kaznelson, P.1
  • 10
    • 53549133356 scopus 로고    scopus 로고
    • Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology
    • Yoshida Y. Historical review. The light and shadow of Paul Kaznelson: his life and contribution to hematology. Ann Hematol 87 (2008) 877
    • (2008) Ann Hematol , vol.87 , pp. 877
    • Yoshida, Y.1
  • 11
    • 0011075765 scopus 로고
    • Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura
    • Harrington W.J., Minnich V., Hollingsworth J.W., et al. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 38 (1951) 1
    • (1951) J Lab Clin Med , vol.38 , pp. 1
    • Harrington, W.J.1    Minnich, V.2    Hollingsworth, J.W.3
  • 13
    • 0013855839 scopus 로고
    • Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies
    • Shulman N.R., Marder V.J., and Weinrach R.S. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies. Ann N Y Acad Sci 124 (1965) 499
    • (1965) Ann N Y Acad Sci , vol.124 , pp. 499
    • Shulman, N.R.1    Marder, V.J.2    Weinrach, R.S.3
  • 14
    • 0013831385 scopus 로고
    • The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura
    • Shulman N.R., Weinrach R.S., Libre E.P., et al. The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura. Trans Assoc Am Physicians 78 (1965) 374
    • (1965) Trans Assoc Am Physicians , vol.78 , pp. 374
    • Shulman, N.R.1    Weinrach, R.S.2    Libre, E.P.3
  • 15
    • 0014264397 scopus 로고
    • Kinetics of thrombopoiesis
    • Harker L.A. Kinetics of thrombopoiesis. J Clin Invest 47 (1968) 458
    • (1968) J Clin Invest , vol.47 , pp. 458
    • Harker, L.A.1
  • 16
    • 0014782039 scopus 로고
    • Regulation of thrombopoiesis
    • Harker L.A. Regulation of thrombopoiesis. Am J Phys 218 (1970) 1376
    • (1970) Am J Phys , vol.218 , pp. 1376
    • Harker, L.A.1
  • 18
    • 52449135494 scopus 로고    scopus 로고
    • Transcriptional regulation of bone marrow thrombopoietin by platelet proteins
    • McIntosh B., and Kaushansky K. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins. Exp Hematol 36 (2008) 799
    • (2008) Exp Hematol , vol.36 , pp. 799
    • McIntosh, B.1    Kaushansky, K.2
  • 19
    • 12944249537 scopus 로고    scopus 로고
    • Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production
    • Peck-Radosavljevic M., Wichlas M., Zacherl J., et al. Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production. Blood 95 (2000) 795
    • (2000) Blood , vol.95 , pp. 795
    • Peck-Radosavljevic, M.1    Wichlas, M.2    Zacherl, J.3
  • 20
    • 0030737715 scopus 로고    scopus 로고
    • Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?
    • Peck-Radosavljevic M., Zacherl J., Meng Y.G., et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver?. J Hepatol 27 (1997) 127
    • (1997) J Hepatol , vol.27 , pp. 127
    • Peck-Radosavljevic, M.1    Zacherl, J.2    Meng, Y.G.3
  • 21
    • 0028117771 scopus 로고
    • The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production
    • Kuter D.J., Beeler D.L., and Rosenberg R.D. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci U S A 91 (1994) 11104
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11104
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 22
    • 0032899072 scopus 로고    scopus 로고
    • The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat
    • Yang C., Li J., and Kuter D.J. The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Br J Haematol 105 (1999) 478
    • (1999) Br J Haematol , vol.105 , pp. 478
    • Yang, C.1    Li, J.2    Kuter, D.J.3
  • 23
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics
    • Li J., Xia Y., and Kuter D.J. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics. Br J Haematol 106 (1999) 345
    • (1999) Br J Haematol , vol.106 , pp. 345
    • Li, J.1    Xia, Y.2    Kuter, D.J.3
  • 24
    • 0036516690 scopus 로고    scopus 로고
    • Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo
    • Scheding S., Bergmann M., Shimosaka A., et al. Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo. Transfusion 42 (2002) 321
    • (2002) Transfusion , vol.42 , pp. 321
    • Scheding, S.1    Bergmann, M.2    Shimosaka, A.3
  • 25
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons R.V., Reid D.M., Cohen R.L., et al. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87 (1996) 4068
    • (1996) Blood , vol.87 , pp. 4068
    • Emmons, R.V.1    Reid, D.M.2    Cohen, R.L.3
  • 26
    • 0029943307 scopus 로고    scopus 로고
    • Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
    • Harker L.A., Marzec U.M., Hunt P., et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 88 (1996) 511
    • (1996) Blood , vol.88 , pp. 511
    • Harker, L.A.1    Marzec, U.M.2    Hunt, P.3
  • 27
    • 33646490285 scopus 로고    scopus 로고
    • Lineage-specific hematopoietic growth factors
    • Kaushansky K. Lineage-specific hematopoietic growth factors. N Engl J Med 354 (2006) 2034
    • (2006) N Engl J Med , vol.354 , pp. 2034
    • Kaushansky, K.1
  • 28
    • 0030024685 scopus 로고    scopus 로고
    • Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
    • de Sauvage F.J., Carver-Moore K., Luoh S.M., et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183 (1996) 651
    • (1996) J Exp Med , vol.183 , pp. 651
    • de Sauvage, F.J.1    Carver-Moore, K.2    Luoh, S.M.3
  • 29
    • 0032102234 scopus 로고    scopus 로고
    • Regulation of megakaryocytopoiesis and platelet production: lessons from animal models
    • de Sauvage F.J., Villeval J.L., and Shivdasani R.A. Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med 131 (1998) 496
    • (1998) J Lab Clin Med , vol.131 , pp. 496
    • de Sauvage, F.J.1    Villeval, J.L.2    Shivdasani, R.A.3
  • 30
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    • Alexander W.S., Roberts A.W., Nicola N.A., et al. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87 (1996) 2162
    • (1996) Blood , vol.87 , pp. 2162
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3
  • 31
    • 0029684417 scopus 로고    scopus 로고
    • Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice
    • Carver-Moore K., Broxmeyer H.E., Luoh S.M., et al. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood 88 (1996) 803
    • (1996) Blood , vol.88 , pp. 803
    • Carver-Moore, K.1    Broxmeyer, H.E.2    Luoh, S.M.3
  • 32
    • 0035174334 scopus 로고    scopus 로고
    • c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
    • Ballmaier M., Germeshausen M., Schulze H., et al. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood 97 (2001) 139
    • (2001) Blood , vol.97 , pp. 139
    • Ballmaier, M.1    Germeshausen, M.2    Schulze, H.3
  • 33
    • 0033019932 scopus 로고    scopus 로고
    • Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia
    • Ihara K., Ishii E., Eguchi M., et al. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Proc Natl Acad Sci U S A 96 (1999) 3132
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3132
    • Ihara, K.1    Ishii, E.2    Eguchi, M.3
  • 34
    • 0033845012 scopus 로고    scopus 로고
    • Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia
    • van den Oudenrijn S., Bruin M., Folman C.C., et al. Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. Br J Haematol 110 (2000) 441
    • (2000) Br J Haematol , vol.110 , pp. 441
    • van den Oudenrijn, S.1    Bruin, M.2    Folman, C.C.3
  • 35
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    • McMillan R., Wang L., Tomer A., et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 103 (2004) 1364
    • (2004) Blood , vol.103 , pp. 1364
    • McMillan, R.1    Wang, L.2    Tomer, A.3
  • 36
    • 0031877979 scopus 로고    scopus 로고
    • Thrombopoietin levels after chemotherapy and in naturally occurring human diseases
    • Nichol J.L. Thrombopoietin levels after chemotherapy and in naturally occurring human diseases. Curr Opin Hematol 5 (1998) 203
    • (1998) Curr Opin Hematol , vol.5 , pp. 203
    • Nichol, J.L.1
  • 37
    • 0030307622 scopus 로고    scopus 로고
    • The physiology of platelet production
    • Kuter D.J. The physiology of platelet production. Stem Cells 14 (1996) 88
    • (1996) Stem Cells , vol.14 , pp. 88
    • Kuter, D.J.1
  • 38
    • 0008781796 scopus 로고
    • The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism
    • Dameshek W., and Miller E. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. Blood 1 (1946) 27
    • (1946) Blood , vol.1 , pp. 27
    • Dameshek, W.1    Miller, E.2
  • 39
    • 0343906556 scopus 로고
    • Platelet sequestration in man. I. Methods
    • Aster R.H., and Jandl J.H. Platelet sequestration in man. I. Methods. J Clin Invest 43 (1964) 843
    • (1964) J Clin Invest , vol.43 , pp. 843
    • Aster, R.H.1    Jandl, J.H.2
  • 40
    • 0014085221 scopus 로고
    • The platelet destruction site in thrombocytopenic purpuras
    • Najean Y., Ardaillou N., Dresch C., et al. The platelet destruction site in thrombocytopenic purpuras. Br J Haematol 13 (1967) 409
    • (1967) Br J Haematol , vol.13 , pp. 409
    • Najean, Y.1    Ardaillou, N.2    Dresch, C.3
  • 41
    • 0016229715 scopus 로고
    • Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP)
    • Branehog I., Kutti J., and Weinfeld A. Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP). Br J Haematol 27 (1974) 127
    • (1974) Br J Haematol , vol.27 , pp. 127
    • Branehog, I.1    Kutti, J.2    Weinfeld, A.3
  • 42
    • 0017102714 scopus 로고
    • Indium-LLL labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions
    • Thakur M.L., Welch M.J., Joist J.H., et al. Indium-LLL labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions. Thromb Res 9 (1976) 345
    • (1976) Thromb Res , vol.9 , pp. 345
    • Thakur, M.L.1    Welch, M.J.2    Joist, J.H.3
  • 43
    • 0023218341 scopus 로고
    • Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
    • Ballem P.J., Segal G.M., Stratton J.R., et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 80 (1987) 33
    • (1987) J Clin Invest , vol.80 , pp. 33
    • Ballem, P.J.1    Segal, G.M.2    Stratton, J.R.3
  • 45
    • 0022195188 scopus 로고
    • Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement
    • Hanson S.R., and Slichter S.J. Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement. Blood 66 (1985) 1105
    • (1985) Blood , vol.66 , pp. 1105
    • Hanson, S.R.1    Slichter, S.J.2
  • 46
    • 0024554747 scopus 로고
    • Mechanisms of response to treatment in autoimmune thrombocytopenic purpura
    • Gernsheimer T., Stratton J., Ballem P.J., et al. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. N Engl J Med 320 (1989) 974
    • (1989) N Engl J Med , vol.320 , pp. 974
    • Gernsheimer, T.1    Stratton, J.2    Ballem, P.J.3
  • 47
    • 0024361930 scopus 로고
    • Platelet destruction in autoimmune thrombocytopenic purpura: kinetics and clearance of indium-111-labeled autologous platelets
    • Stratton J.R., Ballem P.J., Gernsheimer T., et al. Platelet destruction in autoimmune thrombocytopenic purpura: kinetics and clearance of indium-111-labeled autologous platelets. J Nucl Med 30 (1989) 629
    • (1989) J Nucl Med , vol.30 , pp. 629
    • Stratton, J.R.1    Ballem, P.J.2    Gernsheimer, T.3
  • 48
    • 0035670010 scopus 로고    scopus 로고
    • Effects of prednisone and splenectomy in patients with idiopathic thrombocytopenic purpura: only splenectomy induces a complete remission
    • Louwes H., Vellenga E., Houwerzijl E.J., et al. Effects of prednisone and splenectomy in patients with idiopathic thrombocytopenic purpura: only splenectomy induces a complete remission. Ann Hematol 80 (2001) 728
    • (2001) Ann Hematol , vol.80 , pp. 728
    • Louwes, H.1    Vellenga, E.2    Houwerzijl, E.J.3
  • 49
    • 35748937316 scopus 로고    scopus 로고
    • CD8+ T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura
    • Li S., Wang L., Zhao C., et al. CD8+ T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura. Br J Haematol 139 (2007) 605
    • (2007) Br J Haematol , vol.139 , pp. 605
    • Li, S.1    Wang, L.2    Zhao, C.3
  • 50
    • 66749122752 scopus 로고    scopus 로고
    • Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia
    • Kuter D.J. Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med 60 (2009) 193
    • (2009) Annu Rev Med , vol.60 , pp. 193
    • Kuter, D.J.1
  • 51
    • 38649127253 scopus 로고    scopus 로고
    • New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura
    • Kuter D.J. New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura. Eur J Haematol Suppl 69 (2008) 9
    • (2008) Eur J Haematol Suppl , vol.69 , pp. 9
    • Kuter, D.J.1
  • 52
    • 34249733156 scopus 로고    scopus 로고
    • New thrombopoietic growth factors
    • Kuter D.J. New thrombopoietic growth factors. Blood 109 (2007) 4607
    • (2007) Blood , vol.109 , pp. 4607
    • Kuter, D.J.1
  • 53
    • 0029805293 scopus 로고    scopus 로고
    • Thrombopoietin: biology, clinical applications, role in the donor setting
    • Kuter D.J. Thrombopoietin: biology, clinical applications, role in the donor setting. J Clin Apheresis 11 (1996) 149
    • (1996) J Clin Apheresis , vol.11 , pp. 149
    • Kuter, D.J.1
  • 54
    • 0031824101 scopus 로고    scopus 로고
    • Thrombopoietins and thrombopoiesis: a clinical perspective
    • Kuter D.J. Thrombopoietins and thrombopoiesis: a clinical perspective. Vox Sang 74 (1998) 75
    • (1998) Vox Sang , vol.74 , pp. 75
    • Kuter, D.J.1
  • 55
    • 0031963996 scopus 로고    scopus 로고
    • Adenovector-mediated expression of human thrombopoietin cDNA in immune- compromised mice: insights into the pathophysiology of osteomyelofibrosis
    • Frey B.M., Rafii S., Teterson M., et al. Adenovector-mediated expression of human thrombopoietin cDNA in immune- compromised mice: insights into the pathophysiology of osteomyelofibrosis. J Immunol 160 (1998) 691
    • (1998) J Immunol , vol.160 , pp. 691
    • Frey, B.M.1    Rafii, S.2    Teterson, M.3
  • 56
    • 0030718597 scopus 로고    scopus 로고
    • High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
    • Villeval J.L., Cohen-Solal K., Tulliez M., et al. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 90 (1997) 4369
    • (1997) Blood , vol.90 , pp. 4369
    • Villeval, J.L.1    Cohen-Solal, K.2    Tulliez, M.3
  • 57
    • 0029956149 scopus 로고    scopus 로고
    • A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation
    • Yan X.Q., Lacey D., Hill D., et al. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 88 (1996) 402
    • (1996) Blood , vol.88 , pp. 402
    • Yan, X.Q.1    Lacey, D.2    Hill, D.3
  • 58
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • Basser R.L., Rasko J.E., Clarke K., et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 348 (1996) 1279
    • (1996) Lancet , vol.348 , pp. 1279
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 59
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M., Glaspy J., Crawford J., et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 336 (1997) 404
    • (1997) N Engl J Med , vol.336 , pp. 404
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 60
    • 70450059367 scopus 로고
    • Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates
    • Harker L.A., Hunt P., Marzec U.M., et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87 (1833) 1996
    • (1833) Blood , vol.87 , pp. 1996
    • Harker, L.A.1    Hunt, P.2    Marzec, U.M.3
  • 61
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
    • Kuter D.J., and Begley C.G. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100 (2002) 3457
    • (2002) Blood , vol.100 , pp. 3457
    • Kuter, D.J.1    Begley, C.G.2
  • 62
    • 0035469854 scopus 로고    scopus 로고
    • Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin
    • Goodnough L.T., Kuter D.J., McCullough J., et al. Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin. Blood 98 (2001) 1346
    • (2001) Blood , vol.98 , pp. 1346
    • Goodnough, L.T.1    Kuter, D.J.2    McCullough, J.3
  • 63
    • 0035469813 scopus 로고    scopus 로고
    • Thrombopoietin therapy increases platelet yields in healthy platelet donors
    • Kuter D.J., Goodnough L.T., Romo J., et al. Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 98 (2001) 1339
    • (2001) Blood , vol.98 , pp. 1339
    • Kuter, D.J.1    Goodnough, L.T.2    Romo, J.3
  • 64
    • 0037157612 scopus 로고    scopus 로고
    • Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study
    • Vadhan-Raj S., Kavanagh J.J., Freedman R.S., et al. Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study. Lancet 359 (2002) 2145
    • (2002) Lancet , vol.359 , pp. 2145
    • Vadhan-Raj, S.1    Kavanagh, J.J.2    Freedman, R.S.3
  • 65
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J., Yang C., Xia Y., et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98 (2001) 3241
    • (2001) Blood , vol.98 , pp. 3241
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 66
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla S.E., Balasubramanian P., Duffin D.J., et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 276 (1997) 1696
    • (1997) Science , vol.276 , pp. 1696
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 67
    • 33750035507 scopus 로고    scopus 로고
    • AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    • Bussel J.B., Kuter D.J., George J.N., et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 355 (2006) 1672
    • (2006) N Engl J Med , vol.355 , pp. 1672
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 68
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B., Nichol J.L., and Sullivan J.T. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 76 (2004) 628
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 69
    • 0346881171 scopus 로고    scopus 로고
    • AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
    • Broudy V.C., and Lin N.L. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokines 25 (2004) 52
    • (2004) Cytokines , vol.25 , pp. 52
    • Broudy, V.C.1    Lin, N.L.2
  • 70
    • 70449878045 scopus 로고    scopus 로고
    • Evaluation of bone marrow reticulin formation in romiplostim-treated adult patients with chronic ITP
    • Kuter D.J., Mufti G., Bain B., et al. Evaluation of bone marrow reticulin formation in romiplostim-treated adult patients with chronic ITP. Blood 112 (2008) 1171a
    • (2008) Blood , vol.112
    • Kuter, D.J.1    Mufti, G.2    Bain, B.3
  • 71
    • 70449983788 scopus 로고    scopus 로고
    • ODAC meeting briefing document. Available at:. Accessed November 5, 2008
    • ODAC meeting briefing document. Available at:http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4345b1-02-AMGEN. pdf. Accessed November 5, 2008.
  • 72
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
    • Kuter D.J., Bussel J.B., Lyons R.M., et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 371 (2008) 395
    • (2008) Lancet , vol.371 , pp. 395
    • Kuter, D.J.1    Bussel, J.B.2    Lyons, R.M.3
  • 73
    • 0035950101 scopus 로고    scopus 로고
    • Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
    • Duffy K.J., Darcy M.G., Delorme E., et al. Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem 44 (2001) 3730
    • (2001) J Med Chem , vol.44 , pp. 3730
    • Duffy, K.J.1    Darcy, M.G.2    Delorme, E.3
  • 74
    • 0037103160 scopus 로고    scopus 로고
    • Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics
    • Duffy K.J., Price A.T., Delorme E., et al. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics. J Med Chem 45 (2002) 3576
    • (2002) J Med Chem , vol.45 , pp. 3576
    • Duffy, K.J.1    Price, A.T.2    Delorme, E.3
  • 75
    • 34249719511 scopus 로고    scopus 로고
    • Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins J.M., Williams D., Deng Y., et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 109 (2007) 4739
    • (2007) Blood , vol.109 , pp. 4739
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 76
    • 34648847269 scopus 로고    scopus 로고
    • Single and multiple oral doses of AKR-501 (TM477) increase the platelet count in healthy volunteers
    • Desjardins R.E., Tempel D.L., Lucek R., et al. Single and multiple oral doses of AKR-501 (TM477) increase the platelet count in healthy volunteers. Blood 108 (2006) 145a
    • (2006) Blood , vol.108
    • Desjardins, R.E.1    Tempel, D.L.2    Lucek, R.3
  • 77
    • 40849150244 scopus 로고    scopus 로고
    • Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects
    • Dziewanowska Z.E., Matsumoto R.M., Zhang J.K., et al. Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects. Blood 110 (2007) 1298
    • (2007) Blood , vol.110 , pp. 1298
    • Dziewanowska, Z.E.1    Matsumoto, R.M.2    Zhang, J.K.3
  • 78
    • 33744456732 scopus 로고    scopus 로고
    • A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
    • Nakamura T., Miyakawa Y., Miyamura A., et al. A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 107 (2006) 4300
    • (2006) Blood , vol.107 , pp. 4300
    • Nakamura, T.1    Miyakawa, Y.2    Miyamura, A.3
  • 79
    • 54349089372 scopus 로고    scopus 로고
    • The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
    • Nogami W., Yoshida H., Koizumi K., et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93 (2008) 1495
    • (2008) Haematologica , vol.93 , pp. 1495
    • Nogami, W.1    Yoshida, H.2    Koizumi, K.3
  • 80
    • 65849148342 scopus 로고    scopus 로고
    • Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis
    • Yamane N., Takahashi K., Tanaka Y., et al. Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis. Biosci Rep 28 (2008) 275
    • (2008) Biosci Rep , vol.28 , pp. 275
    • Yamane, N.1    Takahashi, K.2    Tanaka, Y.3
  • 81
    • 43549086159 scopus 로고    scopus 로고
    • Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor
    • Yamane N., Tanaka Y., Ohyabu N., et al. Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor. Eur J Pharmacol 586 (2008) 44
    • (2008) Eur J Pharmacol , vol.586 , pp. 44
    • Yamane, N.1    Tanaka, Y.2    Ohyabu, N.3
  • 82
    • 22244475160 scopus 로고    scopus 로고
    • An oral, non-peptide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects
    • Jenkins J., Nicholl R., Williams D., et al. An oral, non-peptide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects. Blood 104 (2004) 797a
    • (2004) Blood , vol.104
    • Jenkins, J.1    Nicholl, R.2    Williams, D.3
  • 83
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel J.B., Cheng G., Saleh M.N., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 357 (2007) 2237
    • (2007) N Engl J Med , vol.357 , pp. 2237
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3
  • 84
    • 33744497342 scopus 로고    scopus 로고
    • Species specificity and receptor domain interaction of a small molecule TPO receptor agonist
    • Erickson-Miller C., Delorme E., Iskander M., et al. Species specificity and receptor domain interaction of a small molecule TPO receptor agonist. Blood 104 (2004) 795a
    • (2004) Blood , vol.104
    • Erickson-Miller, C.1    Delorme, E.2    Iskander, M.3
  • 85
    • 52249095318 scopus 로고    scopus 로고
    • AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis
    • Fukushima-Shintani M., Suzuki K., Iwatsuki Y., et al. AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis. Exp Hematol 36 (2008) 1337
    • (2008) Exp Hematol , vol.36 , pp. 1337
    • Fukushima-Shintani, M.1    Suzuki, K.2    Iwatsuki, Y.3
  • 86
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S., Dan K., Hotta T., et al. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 100 (2002) 728
    • (2002) Blood , vol.100 , pp. 728
    • Nomura, S.1    Dan, K.2    Hotta, T.3
  • 87
    • 0034781155 scopus 로고    scopus 로고
    • Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
    • Rice L., Nichol J.L., McMillan R., et al. Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am J Hematol 68 (2001) 210
    • (2001) Am J Hematol , vol.68 , pp. 210
    • Rice, L.1    Nichol, J.L.2    McMillan, R.3
  • 88
    • 0032079880 scopus 로고    scopus 로고
    • Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients
    • Cole J.L., Marzec U.M., Gunthel C.J., et al. Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients. Blood 91 (1998) 3239
    • (1998) Blood , vol.91 , pp. 3239
    • Cole, J.L.1    Marzec, U.M.2    Gunthel, C.J.3
  • 89
    • 4243219531 scopus 로고    scopus 로고
    • Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy
    • Harker L.A., Carter R.A., Marzec U.M., et al. Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy. Blood 92 (1998) 707a
    • (1998) Blood , vol.92
    • Harker, L.A.1    Carter, R.A.2    Marzec, U.M.3
  • 90
    • 0031810565 scopus 로고    scopus 로고
    • Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor
    • Harker L.A., Marzec U.M., Novembre F., et al. Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor. Blood 91 (1998) 4427
    • (1998) Blood , vol.91 , pp. 4427
    • Harker, L.A.1    Marzec, U.M.2    Novembre, F.3
  • 91
    • 0942287736 scopus 로고    scopus 로고
    • Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
    • Houwerzijl E.J., Blom N.R., van der Want J.J., et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 103 (2004) 500
    • (2004) Blood , vol.103 , pp. 500
    • Houwerzijl, E.J.1    Blom, N.R.2    van der Want, J.J.3


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