What's new in orthopaedic research

Journal of Bone and Joint Surgery

Volumn 91, Issue 11, 2009, Pages 2756-2770

  Hidaka, Chisa ^a   Maher, Suzanne ^a   Packer, John ^a   Gasinu, Selom ^a   Cunningham, Matthew E ^a   Rodeo, Scott ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BRAIN DERIVED NEUROTROPHIC FACTOR; CELL PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; FLUOXETINE; GELATINASE B; GLUTAMIC ACID; GREEN FLUORESCENT PROTEIN; HISTONE DEACETYLASE; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KRUPPEL LIKE FACTOR 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE; NEUROTROPHIN; NEXIN 19; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; OXYTOCIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; SEROTONIN; SOMATOMEDIN C; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN HYDROXYLASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

AGING; BIOSENSOR; BONE DENSITY; BONE DISEASE; CALCIUM HOMEOSTASIS; CARTILAGE CELL; CELL AGING; CELL CILIA; CELL ORGANELLE; CHONDROGENESIS; CHONDROPATHY; CILIARY MOTILITY; CLINICAL RESEARCH; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONNECTIVE TISSUE; DEGENERATIVE DISEASE; DIAGNOSTIC IMAGING; DISEASE MODEL; ENCHONDRAL OSSIFICATION; FRACTURE HEALING; FRACTURE NONUNION; GENE EXPRESSION; GENE IDENTIFICATION; GENE THERAPY; GENOTOXICITY; HEREDITY; HUMAN; IMAGING; INTERVERTEBRAL DISK DEGENERATION; LIGAMENT SURGERY; MENISCAL REPAIR; MESENCHYMAL STEM CELL; MUSCULOSKELETAL DISEASE; MUSCULOSKELETAL INJURY; NICK END LABELING; NONHUMAN; ORTHOPEDIC SURGERY; OSSIFICATION; OSTEOARTHRITIS; OSTEOCYTE; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REVIEW; SMALL INTESTINE; SPINE FUSION; STEM CELL TRANSPLANTATION; SUBMUCOSA; TENDON LESION; THROMBOCYTE RICH PLASMA; TISSUE REPAIR;

BIOMEDICAL RESEARCH; ORTHOPEDIC PROCEDURES;

EID: 70449748134     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.I.00865     Document Type: Review

References (75)

1. Gerdes JM, Davis EE, Katsanis N. The vertebrate primary cilium in development, homeostasis, and disease. Cell. 2009;137:32-45.
2. Kaushik AP, Martin JA, Zhang Q, Sheffield VC, Morcuende JA. Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice. J Orthop Res. 2009;27:1093-1099
3. McGlashan SR, Cluett EC, Jensen CG, Poole CA. Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn. 2008;237:2013-2020
4. Thomopoulos S, Zampiakis E, Das R, Silva MJ, Gelberman RH. The effect of muscle loading on flexor tendon-to-bone healing in a canine model. J Orthop Res. 2008;26:1611-1617
5. Glazebrook MA, Wright JR Jr, Langman M, Stanish WD, Lee JM. Histological analysis of Achilles tendons in an overuse rat model. J Orthop Res. 2008;26:840-846
6. Leigh DR, Abreu EL, Derwin KA. Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture. J Orthop Res. 2008;26:1306-1312
7. Willett TL, Labow RS, Lee JM. Mechanical overload decreases the thermal stability of collagen in an in vitro tensile overload tendon model. J Orthop Res. 2008;26:1605-1610
8. Niedernhofer LJ, Robbins PD. Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol. 2008;40:176-180 (Pubitemid 350137884)
9. Elliott DM, Yerramalli CS, Beckstein JC, Boxberger JI, Johannessen W, Vresilovic EJ. The effect of relative needle diameter in puncture and sham injection animal models of degeneration. Spine (Phila Pa 1976). 2008;33:588-596
10. Sowa G, Vadalà G, Studer R, Kompel J, Iucu C, Georgescu H, Gilbertson L, Kang J. Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine (Phila Pa 1976). 2008;33:1821-1828
11. Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res. 2009;24:251-264
12. Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem. 2008;283:24682-24689
13. Iwaniec UT, Wronski TJ, Turner RT. Histological analysis of bone. Methods Mol Biol. 2008;447:325-341
14. Han L, Dean D, Daher LA, Grodzinsky AJ, Ortiz C. Cartilage aggrecan can undergo self-adhesion. Biophys J. 2008;95:4862-4870
15. Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 2008;135:825-837
16. Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano M, Faccio R, Liu X, Li J, Usmani S, Bachar M, Bab I, Nishimori K, Young LJ, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A. Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci USA. 2009;106:7149-7154
17. Skerry TM. The role of glutamate in the regulation of bone mass and architecture. J Musculoskelet Neuronal Interact. 2008;8:166-173
18. Jean YH, Wen ZH, Chang YC, Hsieh SP, Lin JD, Tang CC, Chen WF, Chou AK, Wong CS. Increase in excitatory amino acid concentration and transporters expression in osteoarthritic knees of anterior cruciate ligament transected rabbits. Osteoarthritis Cartilage. 2008;16:1442-1449
19. Piepoli T, Mennuni L, Zerbi S, Lanza M, Rovati LC, Caselli G. Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression. Osteoarthritis Cartilage. 2009;17:1076-1083
20. Ramage L, Martel MA, Hardingham GE, Salter DM. NMDA receptor expression and activity in osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage. 2008;16:1576-1584
21. Scott A, Alfredson H, Forsgren S. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. J Orthop Res. 2008;26:685-692
22. Grimsholm O, Guo Y, Ny T, Forsgren S. Expression patterns of neurotrophins and neurotrophin receptors in articular chondrocytes and inflammatory infiltrates in knee joint arthritis. Cells Tissues Organs. 2008;188: 299-309.
23. Mammoto T, Seerattan RA, Paulson KD, Leonard CA, Bray RC, Salo PT. Nerve growth factor improves ligament healing. J Orthop Res. 2008;26:957-964
24. Lin EA, Kong L, Bai XH, Luan Y, Liu CJ. miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J Biol Chem. 2009;284:11326-11335
25. Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One. 2008;3:e3740.
26. Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006;38:1424-1429 (Pubitemid 44837565)
27. Tsuji K, Cox K, Bandyopadhyay A, Harfe BD, Tabin CJ, Rosen V. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am. 2008;90 Suppl 1:14-18 (Pubitemid 351329115)
28. Edgar CM, Chakravarthy V, Barnes G, Kakar S, Gerstenfeld LC, Einhorn TA. Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells. Bone. 2007; 40:1389-1398 (Pubitemid 46550983)
29. Little SC, Mullins MC. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol. 2009;11:637-643
30. Fu TS, Chen WJ, Chen LH, Lin SS, Liu SJ, Ueng SW. Enhancement of posterolateral lumbar spine fusion using low-dose rhBMP-2 and cultured marrow stromal cells. J Orthop Res. 2009;27:380-384
31. Levicoff EA, Kim JS, Sobajima S, Wallach CJ, Larson JW 3rd, Robbins PD, Xiao X, Juan L, Vadala G, Gilbertson LG, Kang JD. Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice. Spine (Phila Pa 1976). 2008;33:1509-1517
32. Miyazaki M, Sugiyama O, Zou J, Yoon SH, Wei F, Morishita Y, Sintuu C, Virk MS, Lieberman JR, Wang JC. Comparison of lentiviral and adenoviral gene therapy for spinal fusion in rats. Spine (Phila Pa 1976). 2008;33:1410-1417
33. Hsu WK, Wang JC, Liu NQ, Krenek L, Zuk PA, Hedrick MH, Benhaim P, Lieberman JR. Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model. J Bone Joint Surg Am. 2008;90:1043-1052 (Pubitemid 351632649)
34. Miyazaki M, Zuk PA, Zou J, Yoon SH, Wei F, Morishita Y, Sintuu C, Wang JC. Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model. Spine (Phila Pa 1976). 2008;33:863-869
35. Arpornmaeklong P, Brown SE, Wang Z, Krebsbach PH. Phenotypic characterization, osteoblastic differentiation, and bone regeneration capacity of human embryonic stem cell-derived mesenchymal stem cells. Stem Cells Dev. 2009; 18:955-968
36. Brown SE, Tong W, Krebsbach PH. The derivation of mesenchymal stem cells from human embryonic stem cells. Cells Tissues Organs. 2009;189:256-260
37. Fecek C, Yao D, Kacxorri A, Vasquez A, Iqbal S, Sheikh H, Svinarich DM, Perez-Cruet M, Chaudhry GR. Chondrogenic derivatives of embryonic stem cells seeded into 3D polycaprolactone scaffolds generated cartilage tissue in vivo. Tissue Eng Part A. 2008;14:1403-1413
38. Hwang NS, Varghese S, Lee HJ, Zhang Z, Ye Z, Bae J, Cheng L, Elisseeff J. In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. Proc Natl Acad Sci USA. 2008;105:20641-20646
39. Hwang NS, Varghese S, Elisseeff J. Derivation of chondrogenically- committed cells from human embryonic cells for cartilage tissue regeneration. PLoS One. 2008;3:e2498.
40. Hwang YS, Cho J, Tay F, Heng JY, Ho R, Kazarian SG, Williams DR, Boccaccini AR, Polak JM, Mantalaris A. The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering. Biomaterials. 2009;30:499-507.
41. Jukes JM, Both SK, Leusink A, Sterk LM, van Blitterswijk CA, de Boer J. Endochondral bone tissue engineering using embryonic stem cells. Proc Natl Acad Sci USA. 2008;105:6840-6845 (Pubitemid 351754492)
42. Kärner E, Bäckesjö CM, Cedervall J, Sugars RV, Ahrlund-Richter L, Wendel M. Dynamics of gene expression during bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro. Biochim Biophys Acta. 2009; 1790:110-118
43. Lounev VY, Ramachandran R, Wosczyna MN, Yamamoto M, Maidment AD, Shore EM, Glaser DL, Goldhamer DJ, Kaplan FS. Identification of progenitor cells that contribute to heterotopic skeletogenesis. J Bone Joint Surg Am. 2009;91:652-663
44. Tempfer H, Wagner A, Gehwolf R, Lehner C, Tauber M, Resch H, Bauer HC. Perivascular cells of the supraspinatus tendon express both tendon- and stem cell-related markers. Histochem Cell Biol. 2009;131:733-741
45. Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell. 2009;4:324-335
46. Liu TM, Wu YN, Guo XM, Hui JH, Lee EH, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009;18:1013-1022
47. Kuo CK, Tuan RS. Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A. 2008;14:1615-1627
48. de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA, van Osch GJ. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med. 2008;36:1171-1178 (Pubitemid 351713047)
49. Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 2008; 215:837-845 (Pubitemid 351632705)
50. Murray MM, Spindler KP, Abreu E, Muller JA, Nedder A, Kelly M, Frino J, Zurakowski D, Valenza M, Snyder BD, Connolly SA. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res. 2007;25:81-91. (Pubitemid 46070734)
51. Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res. 2009;27:631-638
52. Torigoe I, Sotome S, Tsuchiya A, Yoshii T, Maehara H, Sugata Y, Ichinose S, Shinomiya K, Okawa A. Bone regeneration with autologous plasma, bone marrow stromal cells, and porous beta-tricalcium phosphate in nonhuman primates. Tissue Eng Part A. 2009;15:1489-1499
53. Rao RD, Gourab K, Bagaria VB, Shidham VB, Metkar U, Cooley BC. The effect of platelet-rich plasma and bone marrow on murine posterolateral lumbar spine arthrodesis with bone morphogenetic protein. J Bone Joint Surg Am. 2009;91:1199-1206
54. Han B, Woodell-May J, Ponticiello M, Yang Z, Nimni M. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009;91:1459-1470
55. Nagata M, Messora M, Okamoto R, Campos N, Pola N, Esper L, Sbrana M, Fucini S, Garcia V, Bosco A. Influence of the proportion of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: an immunohistochemical analysis in rat calvaria. Bone. 2009;45:339-345
56. Griffin XL, Smith CM, Costa ML. The clinical use of platelet-rich plasma in the promotion of bone healing: a systematic review. Injury. 2009;40:158-162
57. Kim CW, Talac R, Lu L, Moore MJ, Currier BL, Yaszemski MJ. Characterization of porous injectable poly-(propylene fumarate)-based bone graft substitute. J Biomed Mater Res A. 2008;85:1114-1119 (Pubitemid 351717981)
58. Kim J, Yaszemski MJ, Lu L. Development of biodegradable and injectable macromers based on poly(ethylene glycol) and diacid monomers. J Biomed Mater Res A. 2009;90:1010-1020
59. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT. Tissue engineering of bone: material and matrix considerations. J Bone Joint Surg Am. 2008;90 Suppl 1: 36-42. (Pubitemid 351329119)
60. Badylak S, Liang A, Record R, Tullius R, Hodde J. Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold. Biomaterials. 1999;20: 2257-2263
61. Liang R, Woo SL, Nguyen TD, Liu PC, Almarza A. Effects of a bioscaffold on collagen fibrillogenesis in healing medial collateral ligament in rabbits. J Orthop Res. 2008;26:1098-1104
62. Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng. 2006;12:519-526 (Pubitemid 43673457)
63. Karaoglu S, M BF, Woo SL, Fu YC, Liang R, Abramowitch SD. Use of a bioscaffold to improve healing of a patellar tendon defect after graft harvest for ACL reconstruction: a study in rabbits. J Orthop Res. 2008;26:255-263 (Pubitemid 351220145)
64. Rodkey WG, DeHaven KE, Montgomery WH 3rd, Baker CL Jr, Beck CL Jr, Hormel SE, Steadman JR, Cole BJ, Briggs KK. Comparison of the collagen meniscus implant with partial meniscectomy. A prospective randomized trial. J Bone Joint Surg Am. 2008;90:1413-1426
65. Verdonk R, Huysse W, Almqvist KF, Verdonk P, Verstraete K. P17-803 imaging findings after meniscal repair with degradable polyurethane scaffold: preliminary results. Knee Surg Sports Traumatol Arthrosc. 2008;16:73.
66. Welsing RT, van Tienen TG, Ramrattan N, Heijkants R, Schouten AJ, Veth RP, Buma P. Effect on tissue differentiation and articular cartilage degradation of a polymer meniscus implant: a 2-year follow-up study in dogs. Am J Sports Med. 2008;36:1978-1989
67. Koskinen E, Paavolainen P, Eskelinen A, Pulkkinen P, Remes V. Unicondylar knee replacement for primary osteoarthritis: a prospective follow-up study of 1,819 patients from the Finnish Arthroplasty Register. Acta Orthop. 2007;78: 128-135 (Pubitemid 46570269)
68. Koskinen E, Eskelinen A, Paavolainen P, Pulkkinen P, Remes V. Comparison of survival and cost-effectiveness between unicondylar arthroplasty and total knee arthroplasty in patients with primary osteoarthritis: a follow-up study of 50,493 knee replacements from the Finnish Arthroplasty Register. Acta Orthop. 2008; 79:499-507.
69. Digas G, Kärrholm J, Thanner J, Herberts P. 5-year experience of highly cross-linked polyethylene in cemented and uncemented sockets: two randomized studies using radiostereometric analysis. Acta Orthop. 2007;78:746-754 (Pubitemid 351185595)
70. Bragdon CR, Kwon YM, Geller JA, Greene ME, Freiberg AA, Harris WH, Malchau H. Minimum 6-year followup of highly cross-linked polyethylene in THA. Clin Orthop Relat Res. 2007;465:122-127 (Pubitemid 350306503)
71. Gomez-Barrena E, Puertolas JA, Munuera L, Konttinen YT. Update on UHMWPE research: from the bench to the bedside. Acta Orthop. 2008;79:832-840
72. Garvin KL, Hartman CW, Mangla J, Murdoch N, Martell JM. Wear analysis in THA utilizing oxidized zirconium and crosslinked polyethylene. Clin Orthop Relat Res. 2009;467:141-145
73. Evangelista GT, Fulkerson E, Kummer F, Di Cesare PE. Surface damage to an Oxinium femoral head prosthesis after dislocation. J Bone Joint Surg Br. 2007;89: 535-537 (Pubitemid 46851137)
74. Lazarinis S, Milbrink J, Hailer NP. Avascular necrosis and subsequent femoral neck fracture 3.5 years after hip resurfacing: a highly unusual late complication in the absence of risk factors - a case report. Acta Orthop. 2008;79:763-768
75. Long JP, Santner TJ, Bartel DL. Hip resurfacing increases bone strains associated with short-term femoral neck fracture. J Orthop Res. 2009.