Nerve growth factor improves ligament healing

Journal of Orthopaedic Research

Volumn 26, Issue 7, 2008, Pages 957-964

  Mammoto, Takeo ^a   Seerattan, Ruth A ^a   Paulson, Kent D ^a   Leonard, Catherine A ^a   Bray, Robert C ^a   Salo, Paul T ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Immunohistochemistry; Laser speckle perfusion imaging; Ligament healing; Mechanical testing; Nerve growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; GENE PRODUCT; NERVE GROWTH FACTOR BETA SUBUNIT; PHOSPHATE BUFFERED SALINE; THROMBOSPONDIN 2; VON WILLEBRAND FACTOR; NERVE GROWTH FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; HEALING; IMAGING; IMMUNOHISTOCHEMISTRY; KNEE LIGAMENT; LIGAMENT INJURY; MALE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REINNERVATION; TENSILE STRENGTH; VASCULARIZATION; ANIMAL; BIOMECHANICS; DRUG EFFECT; INJURY; INNERVATION; NERVE CELL; PHYSIOLOGY; SCAR; SPRAGUE DAWLEY RAT; WOUND HEALING;

ANIMALS; BIOMECHANICS; CICATRIX; IMMUNOHISTOCHEMISTRY; MALE; MEDIAL COLLATERAL LIGAMENT, KNEE; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE GROWTH FACTOR; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; WOUND HEALING;

EID: 46449139313     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20615     Document Type: Article

References (37)

1. Woo SLY, Hildebrand K, Watanabe N, et al. 1999. Tissue engineering of ligament and tendon healing. Clin Orthop 367:312-323.
2. Bray RC, Leonard CA, Salo PT. 2003. Correlation of healing capacity with vascular response in the anterior cruciate ligament and medial collateral ligaments of the rabbit. J Orthop Res. 21:1118-1123.
3. Salo PT, Seerattan RA, Leonard CA, et al. 2004. Proliferation and regression of peptidergic innervation in healing rabbit medial collateral ligament. Trans Orthop Res Soc 29:885.
4. Ivie TJ, Bray RC, Salo PT. 2002. Denervation impairs healing of the rabbit medial collateral ligament. J Orthop Res 20:990-995.
5. Beye JA, Hart DA, Bray RC, et al. 2005. Denervation alters mRNA levels of repair-associated genes in a rabbit medial collateral ligament injury model. J Orthop Res 24:1842-1853.
6. Molly T, Wang Y, Murrell GAC. 2003. The role of growth factors in tendon and ligament healing. Sports Med 33:381-394.
7. Creighton RA, Spang JT, Dahners LE. 2005. Basic science of ligament healing. Medial collateral ligament healing with and without treatment. Sports Med Arthrosc Rev 13:145-150.
8. Letson AK, Dahners LE. 1994. The effects of combinations of growth factors on ligament healing. Clin Orthop 308:207-212.
9. Hildebrand KA, Woo SLY, Smith DW, et al. 1998. The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament: an in vivo study. Am J Sports Med 26:549-554.
10. Spindler KP, Murray MM, Detwiler KB, et al. 2003. The biomechanical response to doses of TGF-â2 in the healing rabbit medial collateral ligament. J Orthop Res 21:245-249.
11. Tashiro T, Hiraoka H, Ikeda Y, et al. 2006. Effect of GDF-5 on ligament healing. J Orthop Res 24:71-79.
12. Levi-Montalcini R, Toso RD, Valle FD, et al. 1995. Update of the NGF saga. J Neurol Sci 130:119-127.
13. Matsuda H, Koyama H, Sawada J, et al. 1998. Role of nerve growth factor in cutaneous wound healing: accelerating effects in normal and healing-impaired diabetic mice. J Exp Med 187:297-306.
14. Muangman P, Muffley LA, Anthony JP, et al. 2004. Nerve growth factor accelerates wound healing in diabetic mice. Wound Rep Reg 12:44-52.
15. Nithya M, Suguna L, Rose C. 2003. The effect of nerve growth factor on the early responses during the process of wound healing. Biochem Biophys Acta 1620:25-31.
16. Lambiase A, Rama P, Bonini S, et al. 1998. Topical treatment with nerve growth factor for corneal neutrophic ulcer. N Engl J Med 338:1174-1180.
17. Bernabei R, Landi F, Bonini S, et al. 1999. Effect of topical application of nerve-growth factor on pressure ulcers. Lancet 354:307.
18. Tuveri M, Generini S, Matucci-Cerinic M, et al. 2000. NGF, a useful tool in the treatment of chronic vasculitic ulcers in rheumatoid arthritis. Lancet 356:1739-1740.
19. Forrester KR, Tulip J, Leonard C, et al. 2004. A laser speckle imaging technique for measuring tissue perfusion. IEEE Trans Biomed Eng 51:2074-2084.
20. Dahners LE, Gilbert JA, Lester GE, et al. 1988. The effect of a nonsteroidal anti-inflammatory drug on the healing of ligaments. Am J Sports Med 16:641-646.
21. Campbell RB, Wiggins ME, Cannistra LM, et al. 1996. Influence of steroid injection on ligament healing in the rat. Clin Orthop 332:242-253.
22. Grills BL, Shuijers JA, Ward AR. 1997. Topical application of nerve growth factor improves fracture healing in rats. J Orthop Res 15:235-242.
23. Ackermann PW, Ahmed M, Kreicbergs A. 2002. Early nerve regeneration after Achilles tendon rupture - a prerequisite for healing? A study in rat. J Orthop Res 20:849-856.
24. Kyriakides TR, Tam JWY, Borstein P. 1999. Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J Invest Dermatol 113:782-787.
25. Thornton GM, Leask GP, Shrive NG, et al. 2000. Early medial collateral ligament scars have inferior creep behavior. J Orthop Res 18:238-246.
26. Brain SD. 1997. Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology 37:133-152.
27. Schaffer M, Beiter T, Becker HD, et al. 1998. Neuropeptides: mediators of inflammation and tissue repair? Arch Surg 133:1107-1116.
28. Cantarella G, Lempereur L, Presta M, et al. 2002. Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J 16:1307-1309.
29. Raychaudhuri SK, Raychaudhuri SP, Weltman H, et al. 2001. Effect of nerve growth factor on endothelial cell biology: Proliferation and adherence molecule expression on human dermal microvascular endothelial cells. Arch Dermatol Res 293:291-295.
30. Mukouyama Y, Gerber HP, Ferrara N, et al. 2005. Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback. Development 132: 941-952.
31. Mukouyama Y, Shin D, Britsch S, et al. 2002. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109:693-705.
32. Bornstein P, Agah A, Kyriakides TR. 2004. The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury. Int J Biochem Cell Biol 36:1115-1125.
33. Armstrong LC, Bornstein P. 2003. Thrombospondin 1 and 2 function as inhibitors of angiogenesis. Matrix Biol 22:63-71.
34. Adams JC, Tucker RP. 2000. The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development. Dev Dyn 218:280-299.
35. Hoffman JR, O'Shea KS. 1999. Thrombospondin expression in nerve regeneration I. Comparison of sciatic nerve crush, transection and long term denervation. Brain Res Bull 48: 413-420.
36. Taria MA, Fusco M, Vantini G, et al. 1994. Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats. Exp Neurol 127:178-183.
37. Kilborn SH, Trudel G, Uhthoff H. 2002. Review of growth plate closure compared with age at sexual maturity and life-span in laboratory animals. Cont Top Lab Anim Sci 41:21-26.