Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells

Bone

Volumn 40, Issue 5, 2007, Pages 1389-1398

  Edgar, Cory M ^a   Chakravarthy, Vinay ^a   Barnes, George ^a   Kakar, Sanjeev ^a   Gerstenfeld, Louis C ^a   Einhorn, Thomas A ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BMP; Bone morphogenetic proteins; Marrow stromal stem cells; Noggin; Osteoinduction

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 6; BONE MORPHOGENETIC PROTEIN 8A; MESSENGER RNA; NOGGIN; OSTEOGENIC PROTEIN 1; OSTEOGENIN; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMUR; GENE EXPRESSION; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TIBIA;

ANIMALS; BONE MARROW; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE REGULATORY NETWORKS; MALE; MICE; MICE, INBRED C57BL; OSTEOGENESIS; STROMAL CELLS;

EID: 34047267341     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.01.001     Document Type: Article

References (33)

1. Urist M.R. Bone formation by autoinduction. Science 150 (1965) 893-899
2. Rosen V., and Thies R.S. The BMP proteins in bone formation and repair. Trends Genet. 8 (1992) 97-102
3. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., et al. Novel regulators of bone formation: molecular clones and activities. Science 242 (1988) 1528-1534
4. Valcourt U., Ronziere M.C., Winkler P., Rosen V., Herbage D., and Mallein-Gerin F. Different effects of bone morphogenetic proteins 2,4,12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line. Exp. Cell Res. 251 (1999) 264-274
5. Cho T.J., Gerstenfeld L.C., and Einhorn T.A. Differential temporal expression of members of the transforming growth factor-b superfamily during murine fracture healing. J. Bone Miner. Res. 17 (2002) 513-520
6. Lyons K.M., Hogan B.L., and Robertson E.J. Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev. 50 (1995) 71-83
7. Duprez D., Bell E.J., Richardson M.K., Archer C.W., Wolpert L., Brickell P.M., et al. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57 (1996) 145-157
8. Asahina I., Sampath TK., and Hauschka PV. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp. Cell Res. 222 (1996) 38-47
9. Shea C.M., Edgar C.M., Einhorn T.A., and Gerstenfeld L.C. BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J. Cell. Biochem. 90 (2003) 1112-1127
10. Rickard D.J., Sullivan T.A., Shenker B.J., Leboy P.S., and Kazhdan I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev. Biol. 161 (1994) 218-228
11. Macias D., Ganan Y., Sampath T.K., Piedra M.E., Ros M.A., and Hurle J.M. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development 124 (1997) 1109-1117
12. Kuznetsov S.A., Friendenstein A.J., and Robey P.G. Factors required for bone marrow stromal fibroblast colony formation in vitro. Br. J. Haematol. 97 (1997) 561-570
13. Kalajzic I., Kalajzic Z., Hurley M.M., Lichtler A.C., and Rowe D.W. Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin. J. Cell. Biochem. 88 (2003) 1168-1176
14. Gerstenfeld L.C., Chipman S.D., Glowacki J., and Lian J.B. Expression of differentiated function by mineralizing cultures of chicken osteoblasts. Dev. Biol. 122 (1987) 49-60
15. Aubin J. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J. Cell. Biochem. 72 (1999) 396-410
16. Gerstenfeld L.C., Cho T.J., Kon T., Aizawa T., Tsay A., Fitch J., et al. Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J. Bone Miner. Res. 18 (2003) 1584-1592
17. Aronow M.A., Gerstenfeld L.C., Owen T.A., Tassinari M.S., Stein G.S., and Lian J.B. Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells. J. Cell. Physiol. 143 (1990) 213-221
18. Aubin J.E. Regulation of osteoblast formation and function. Rev. Endocr. Metab. Disord. 1 (2001) 81-94
19. Yang X., and Karsenty G. Transcription factors in bone: developmental and pathological. Trends Mol. Med. 8 (2002) 340-345
20. Zimmerman L.B., De Jesus-Escobar J.M., and Harland R.M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86 (1996) 599-606
21. Miyazono K. Bone morphogenetic protein receptors and actions (Chapter 51). In: Bilezikian JP., Raisz LG., and Rodan GA. (Eds). Principles of Bone Biology. 2nd ed. (2002), Academic Press, San Diego, CA
22. Angley C., Kumar M., Dinsio K.J., Hall A.K., and Siegel R.E. Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. J. Neurosci. 23 (2003) 260-268
23. Einhorn T.A., Majeska R.J., Mohaideen A., Kagel E.M., Bouxsein M.L., Turek T.J., et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J. Bone Jt. Surg., Am. 85-A (2003) 1425-1435
24. Welch R.D., Jones A.L., Bucholz R.W., Reinert C.M., Tjia J.S., Pierce W.A., et al. Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J. Bone Miner. Res. 13 (1998) 1483-1490
25. Cook S.D., Wolfe M.W., Salkeld S.L., and Rueger D.C. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J. Bone J. Surg., Am. 77 (1995) 734-750
26. Gazzerro E., Du Z., Devlin R.D., Rydziel S., Priest L., Economides A.N., et al. Noggin arrests stromal cell differentiation in vitro. Bone 32 (2003) 111-119
27. Abe E., Yamamoto M., Taguchi Y., Lecka-Czernik B., O'Brien C.A., Economides A.N., et al. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J. Bone Miner. Res. 15 4 (2000) 663-673
28. Zhang H., and Bradley A. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122 (1996) 2977-2986
29. Phimphilai M., Zhao Z., Boules H., Roca H., and Franceschi R.T. BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J. Bone Miner. Res. 21 (2006) 637-646
30. Tsuji K., Bandyopadhyay A., Harfe B.D., Cox K., Kakar S., Gerstenfeld L., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat. Genet. 38 (2006) 1424-1429
31. Dosch R., Gawantka V., Delius H., Blumenstock C., and Niehrs C. BMP-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development 124 (1997) 2325-2334
32. Friedman M.S., Long M.W., and Hankenson K.D. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J. Cell. Biochem. 98 (2006) 538-554
33. Gamer L.W., Nove J., Michael Levin M., and Rosen V. BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos. Dev. Biol. 285 (2005) 156-168