메뉴 건너뛰기




Volumn 5, Issue 3, 2009, Pages 166-176

Iatrogenic QT abnormalities and fatal arrhythmias: Mechanisms and clinical significance

Author keywords

Drug induced; HERG potassium channels; Long QT; Torsades de pointe

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTIDEPRESSANT AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; AZITHROMYCIN; CALCIUM CHANNEL L TYPE; CIPROFLOXACIN; CLARITHROMYCIN; DOFETILIDE; ERYTHROMYCIN; FLUOXETINE; GATIFLOXACIN; GLYCOSIDE; GREPAFLOXACIN; KETOCONAZOLE; LEVOFLOXACIN; MACROLIDE; MOXIFLOXACIN; NEUROLEPTIC AGENT; NORFLUOXETINE; OFLOXACIN; PENTAMIDINE; POTASSIUM CHANNEL HERG; QUINIDINE DERIVATIVE; SOTALOL; SPARFLOXACIN; UNINDEXED DRUG;

EID: 70449623537     PISSN: 1573403X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340309788970397     Document Type: Review
Times cited : (50)

References (107)
  • 1
    • 0002455016 scopus 로고
    • Long QT syndrome and torsades de pointes: Basic and clinical aspects
    • El-Sherif, N, Samet P, Eds. WB Saunders Co, Philadelphia
    • Roden DM. Long QT syndrome and torsades de pointes: basic and clinical aspects. In: Cardiac Pacing and Electrophysiology. El-Sherif, N, Samet P, Eds. WB Saunders Co, Philadelphia 1991; 265-284
    • (1991) Cardiac Pacing and Electrophysiology , pp. 265-284
    • Roden, D.M.1
  • 2
    • 0034728805 scopus 로고    scopus 로고
    • Risk of torsades de pointes with non-cardiac drugs
    • Yap YG, Camm J. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause QT prolongation. BMJ 2000; 320: 1158-1159 (Pubitemid 30224261)
    • (2000) British Medical Journal , vol.320 , Issue.7243 , pp. 1158-1159
    • Yap, Y.G.1    Camm, J.2
  • 3
    • 2142660225 scopus 로고    scopus 로고
    • QT prolongation and fatal arrhythmias: A review of clinical implications and effects of drugs
    • Cubeddu LX. QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs. Am J Ther 2003; 10: 452-457
    • (2003) Am J Ther , vol.10 , pp. 452-457
    • Cubeddu, L.X.1
  • 4
    • 25844508334 scopus 로고    scopus 로고
    • Drug-induced long QT syndrome and torsade de pointes
    • Morissette P, Hreiche R, Turgeon J. Drug-induced long QT syndrome and torsade de pointes Can J Cardiol 2005; 21: 857-864
    • (2005) Can J Cardiol , vol.21 , pp. 857-864
    • Morissette, P.1    Hreiche, R.2    Turgeon, J.3
  • 5
    • 33845435347 scopus 로고    scopus 로고
    • Drug-induced long QT and torsade de pointes: Recent advances
    • Kannankeril J, Roden DM. Drug-induced long QT and torsade de pointes: recent advances. Curr Opin Cardiol 2007; 22: 39-43.
    • (2007) Curr Opin Cardiol , vol.22 , pp. 39-43
    • Kannankeril, J.1    Roden, D.M.2
  • 7
    • 17544389464 scopus 로고    scopus 로고
    • Warnings strengthened on tranquilizer inapsine [Droperidol]
    • SoRelle R. Warnings strengthened on tranquilizer inapsine [Droperidol]. Circulation 2001;104: E 9061-9062
    • (2001) Circulation , vol.104
    • SoRelle, R.1
  • 8
    • 0014976738 scopus 로고
    • The syndrome, "QT lengthening and syncope due to torsion of the points"
    • Slama R, Motte G, Coumel P, Dessertenne F. The syndrome, "QT lengthening and syncope due to torsion of the points". Laval Med 1971; 42: 353-366
    • (1971) Laval Med , vol.42 , pp. 353-366
    • Slama, R.1    Motte, G.2    Coumel, P.3    Dessertenne, F.4
  • 10
    • 0034805825 scopus 로고    scopus 로고
    • Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes
    • DOI 10.1016/S1520-765X(01)90009-4
    • Darpo B. Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. Eur Heart J 2001; 3: K70-K80. (Pubitemid 32910785)
    • (2001) European Heart Journal, Supplement , vol.3 , Issue.K
    • Darpo, B.1
  • 11
    • 34247397075 scopus 로고    scopus 로고
    • Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes
    • Lehtonen A, Fodstad H, Laitinen-Forsblom P, Toivonen L, Kontula K, Swan H. Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes. Heart Rhythm 2007; 4: 608-610
    • (2007) Heart Rhythm , vol.4 , pp. 608-610
    • Lehtonen, A.1    Fodstad, H.2    Laitinen-Forsblom, P.3    Toivonen, L.4    Kontula, K.5    Swan, H.6
  • 12
    • 0033404894 scopus 로고    scopus 로고
    • The QT interval and Torsades de Pointes
    • Moss AJ. The QT interval and Torsades de Pointes. Drug Saf 1999; 21: 5-10.
    • (1999) Drug Saf , vol.21 , pp. 5-10
    • Moss, A.J.1
  • 13
    • 33747864799 scopus 로고    scopus 로고
    • Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval
    • DOI 10.1016/j.hrthm.2006.05.023, PII S1547527106015979
    • Indik JH, Pearson EC, Fried K, Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm 2006; 3: 1003-1007 (Pubitemid 44283697)
    • (2006) Heart Rhythm , vol.3 , Issue.9 , pp. 1003-1007
    • Indik, J.H.1    Pearson, E.C.2    Fried, K.3    Woosley, R.L.4
  • 14
    • 0027515633 scopus 로고
    • Female gender as a risk factors for torsades de pointes associated with cardiovascular drugs
    • Makkar RR, Fromm BS, Steinman RT, Meissner MD, Lehmann MH. Female gender as a risk factors for torsades de pointes associated with cardiovascular drugs. JAMA 1993; 270: 2590-2597
    • (1993) JAMA , vol.270 , pp. 2590-2597
    • Makkar, R.R.1    Fromm, B.S.2    Steinman, R.T.3    Meissner, M.D.4    Lehmann, M.H.5
  • 15
    • 35748985581 scopus 로고    scopus 로고
    • Genome-wide association study of electrocardiographic and heart rate variability traits: The Framingham Heart Study
    • Newton-Cheh C, Guo CY, Wang TJ, O'donnell CJ, Levy D, Larson MG. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet 2007; 8: S7.
    • (2007) BMC Med Genet , vol.8
    • Newton-Cheh, C.1    Guo, C.Y.2    Wang, T.J.3    O'Donnell, C.J.4    Levy, D.5    Larson, M.G.6
  • 17
    • 0036707486 scopus 로고    scopus 로고
    • 2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome
    • DOI 10.1113/jphysiol.2002.024570
    • Choi BR, Burton F, Salama G. Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 2002; 543: 615-631 (Pubitemid 35012214)
    • (2002) Journal of Physiology , vol.543 , Issue.2 , pp. 615-631
    • Choi, B.-R.1    Burton, F.2    Salama, G.3
  • 18
    • 0037065893 scopus 로고    scopus 로고
    • Early Afterdepolarizations, U Waves, and Torsades de Pointes
    • PhD; MD, MD
    • Jiashin Wu, PhD; Jianyi Wu, MD, Douglas P. Zipes, MD. Early Afterdepolarizations, U Waves, and Torsades de Pointes. Circulation 2002; 105: 770-774
    • (2002) Circulation , vol.105 , pp. 770-774
    • Wu, J.1    Wu, J.2    Zipes, D.P.3
  • 20
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the Ikr potassium channel
    • Sanguinetti MS, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the Ikr potassium channel. Cell 1995; 81: 299-307.
    • (1995) Cell , vol.81 , pp. 299-307
    • Sanguinetti, M.S.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 22
    • 84992827699 scopus 로고    scopus 로고
    • Amiodarone therapy after previous sotalol-induced torsade de pointes: Analysis of at dispersion to predict proarrhythmia
    • Van de Loo A, Klingenheben T, Hohnloser SH. Amiodarone therapy after previous sotalol-induced torsade de pointes: analysis of AT dispersion to predict proarrhythmia. J Cardiovasc Pharmacol Ther 1996; 1: 75-78
    • (1996) J Cardiovasc Pharmacol Ther , vol.1 , pp. 75-78
    • Van De Loo, A.1    Klingenheben, T.2    Hohnloser, S.H.3
  • 23
    • 0030984197 scopus 로고    scopus 로고
    • Amiodarone induced torsades de pointes with excessive QT dispersion following quinidine induced polymorphic ventricular tachycardia
    • Tran HT, Chow MS, Kluger J. Amiodarone induced torsades de pointes with excessive QT dispersion following quinidine induced polymorphic ventricular tachycardia. Pacing Clin Electrophysiol 1997; 9: 2275-2278
    • (1997) Pacing Clin Electrophysiol , vol.9 , pp. 2275-2278
    • Tran, H.T.1    Chow, M.S.2    Kluger, J.3
  • 24
    • 0036548891 scopus 로고    scopus 로고
    • Prevalence of Q-T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: The EURODIAB IDDM Complications Study Group
    • EURODIAB IDDM Complications Study Group
    • Veglio M, Giunti S, Stevens LK, Fuller JH, Perin PC, EURODIAB IDDM Complications Study Group. Prevalence of Q-T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: the EURODIAB IDDM Complications Study Group. Diabetes Care 2002; 25: 702-707
    • (2002) Diabetes Care , vol.25 , pp. 702-707
    • Veglio, M.1    Giunti, S.2    Stevens, L.K.3    Fuller, J.H.4    Perin, P.C.5
  • 25
    • 38849162370 scopus 로고    scopus 로고
    • Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes
    • Antzelevitch C. Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes Europace 2007; 9: 4-15.
    • (2007) Europace , vol.9 , pp. 4-15
    • Antzelevitch, C.1
  • 27
    • 30344485732 scopus 로고    scopus 로고
    • T-wave alternans and the susceptibility to ventricular arrhythmias
    • Narayan SM. T-wave alternans and the susceptibility to ventricular arrhythmias. J Am Coll Cardiol 2006; 47: 269-281
    • (2006) J Am Coll Cardiol , vol.47 , pp. 269-281
    • Narayan, S.M.1
  • 28
    • 0037426398 scopus 로고    scopus 로고
    • Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure
    • DOI 10.1161/01.CIR.0000057980.84624.95
    • Vrtovec B, Delgado R, Zewail A, Thomas CD, Richartz BM, Radovancevic B. Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure. Circulation 2003; 107: 1764-1769 (Pubitemid 36418357)
    • (2003) Circulation , vol.107 , Issue.13 , pp. 1764-1769
    • Vrtovec, B.1    Delgado, R.2    Zewail, A.3    Thomas, C.D.4    Richartz, B.M.5    Radovancevic, B.6
  • 30
    • 10844238024 scopus 로고    scopus 로고
    • QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests
    • Rana BS, Lim PO, Naas AA, Ogston SA, Newton RW, Jung RT, Morris AD, Struthers AD. QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests. Heart 2005; 91: 44-50.
    • (2005) Heart , vol.91 , pp. 44-50
    • Rana, B.S.1    Lim, P.O.2    Naas, A.A.3    Ogston, S.A.4    Newton, R.W.5    Jung, R.T.6    Morris, A.D.7    Struthers, A.D.8
  • 32
    • 28644443749 scopus 로고    scopus 로고
    • QTc interval prolongation in patients with HIV and AIDS
    • Sani MU, Okeahialam BN. QTc interval prolongation in patients with HIV and AIDS. J Natl Med Assoc 2005; 97: 1657-1661
    • (2005) J Natl Med Assoc , vol.97 , pp. 1657-1661
    • Sani, M.U.1    Okeahialam, B.N.2
  • 33
    • 0033378863 scopus 로고    scopus 로고
    • Inherited long QT syndromes: A paradigm for understanding arrhythmogenesis
    • Roden DM, Spooner PM. Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis. J Cardiovasc Electrophysiol 1999; 10: 1664-1683
    • (1999) J Cardiovasc Electrophysiol , vol.10 , pp. 1664-1683
    • Roden, D.M.1    Spooner, P.M.2
  • 34
    • 0033798205 scopus 로고    scopus 로고
    • Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current
    • Witchel HJ, Hancox JC. Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 2000; 27: 753-766
    • (2000) Clin Exp Pharmacol Physiol , vol.27 , pp. 753-766
    • Witchel, H.J.1    Hancox, J.C.2
  • 35
    • 0036141017 scopus 로고    scopus 로고
    • Long QT syndrome: Diagnosis and management
    • Kahn IA. Long QT syndrome: diagnosis and management. Am Heart J 2002; 143: 7-14.
    • (2002) Am Heart J , vol.143 , pp. 7-14
    • Kahn, I.A.1
  • 36
    • 33645317063 scopus 로고    scopus 로고
    • hERG potassium channels and cardiac arrhythmia
    • Sanguinetti MC, Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 2006; 440: 463-469
    • (2006) Nature , vol.440 , pp. 463-469
    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
  • 37
    • 0031978985 scopus 로고    scopus 로고
    • The molecular genetics of the long QT syndrome: Genes causing fainting and sudden death
    • Vincent GM. The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. Annu Rev Med 1998; 49: 263-274
    • (1998) Annu Rev Med , vol.49 , pp. 263-274
    • Vincent, G.M.1
  • 38
    • 0031707743 scopus 로고    scopus 로고
    • The molecular basis of long QT syndrome and prospects for therapy
    • DOI 10.1016/S1357-4310(98)01320-3, PII S1357431098013203
    • Wang Q, Bowles NE, Towbin JA. The molecular basis of long QT syndrome and prospects for therapy. Mol Med Today 1998; 4: 382-388 (Pubitemid 28411032)
    • (1998) Molecular Medicine Today , vol.4 , Issue.9 , pp. 382-388
    • Wang, Q.1    Bowles, N.E.2    Towbin, J.A.3
  • 40
    • 18744395493 scopus 로고    scopus 로고
    • Protein trafficking abnormalities: A new mechanism in drug-induced long QT syndrome
    • DOI 10.1038/sj.bjp.0706143
    • Eckhardt LL, Rajamani S, January CT. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol 2005; 145: 3-4. (Pubitemid 40675542)
    • (2005) British Journal of Pharmacology , vol.145 , Issue.1 , pp. 3-4
    • Eckhardt, L.L.1    Rajamani, S.2    January, C.T.3
  • 41
    • 0032516934 scopus 로고    scopus 로고
    • HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects
    • DOI 10.1074/jbc.273.33.21061
    • Zhou Z, Gong O, Epstein ML, January CT. HERG Channel Dysfunction in Human Long QT Syndrome: intracellular transport and functional defects. J Biol Chem 1998; 273: 21061-21066 (Pubitemid 28385391)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.33 , pp. 21061-21066
    • Zhou, Z.1    Gong, Q.2    Epstein, M.L.3    January, C.T.4
  • 42
    • 0034646627 scopus 로고    scopus 로고
    • The Dominant Negative LQT2 Mutation A561V Reduces Wild-type HERG Expression
    • Anna K, Zhihui Yu, Glenn IF, Thomas V. McDonald. The Dominant Negative LQT2 Mutation A561V Reduces Wild-type HERG Expression. J Biol Chem 2000; 275: 11241-11248
    • (2000) J Biol Chem , vol.275 , pp. 11241-11248
    • Anna, K.1    Yu, Z.2    Glenn, I.F.3    McDonald, T.V.4
  • 43
    • 0033615646 scopus 로고    scopus 로고
    • Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome: Pharmacological and temperature effects
    • Zhou Z, Gong Q, January CT. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome: pharmacological and temperature effects. J Biol Chem 1999; 274: 31123-31126 (Pubitemid 129501552)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.44 , pp. 31123-31126
    • Zhou, Z.1    Gong, Q.2    January, C.T.3
  • 44
    • 0037085464 scopus 로고    scopus 로고
    • The binding site for channel blockers that rescue misprocessed human long QT síndrome type 2-ether-a-go-go-related gene [HERG]mutations
    • Ficker E, Obejero-Paz CA, Zhao S, Brown A. The binding site for channel blockers that rescue misprocessed human long QT síndrome type 2-ether-a-go-go-related gene [HERG]mutations. J Biol Chem 2002; 277: 4989-4998
    • (2002) J Biol Chem , vol.277 , pp. 4989-4998
    • Ficker, E.1    Obejero-Paz, C.A.2    Zhao, S.3    Brown, A.4
  • 45
    • 2442464375 scopus 로고    scopus 로고
    • Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG
    • Ficker E, Dennis AT, Wang L, Brown AM. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res 2003; 92: 87-100.
    • (2003) Circ Res , vol.92 , pp. 87-100
    • Ficker, E.1    Dennis, A.T.2    Wang, L.3    Brown, A.M.4
  • 46
    • 0030022457 scopus 로고    scopus 로고
    • Kr: Implications for Torsade de Pointes and Reverse Use-Dependence
    • Yang T, Roden DM. Extracellualr potassium modulation of drug blockade of IKr: implications for torsades de pointes and reverse use dependence. Circulation 1996; 93: 407-411 (Pubitemid 126425247)
    • (1996) Circulation , vol.93 , Issue.3 , pp. 407-411
    • Yang, T.1    Roden, D.M.2
  • 49
    • 0242713010 scopus 로고    scopus 로고
    • A New Oral Therapy for Long QT Syndrome: Long-Term Oral Potassium Improves Repolarization in Patients with HERG Mutations
    • DOI 10.1016/j.jacc.2003.07.006
    • Etheridge SP, Compton ST, Tristani-Firouzi M, Mason JW. A new oral therapy for long QT syndrome: log-term oral potassium supplementation improves repolarization in patients with HERG mutations. J Am Coll Cardiol 2003; 42: 1777-1782 (Pubitemid 37433657)
    • (2003) Journal of the American College of Cardiology , vol.42 , Issue.10 , pp. 1777-1782
    • Etheridge, S.P.1    Compton, S.J.2    Tristani-Firouzi, M.3    Mason, J.W.4
  • 50
    • 17144366913 scopus 로고    scopus 로고
    • Molecular predictors of drug-induced prolongation of the QT interval
    • Dilaveris PE. Molecular predictors of drug-induced prolongation of the QT interval. Curr Med Chem Cardiovasc Hematol Agents 2005; 3: 105-118
    • (2005) Curr Med Chem Cardiovasc Hematol Agents , vol.3 , pp. 105-118
    • Dilaveris, P.E.1
  • 51
    • 0034774943 scopus 로고    scopus 로고
    • Kr: Model systems and relevance to human arrhythmias
    • DOI 10.1097/00005344-200111000-00010
    • Yang T, Snyders D, Roden DM. Drug block of I[Kr]: model systems and relevance to human arrhythmias. J Cardiovasc Pharmacol 2001; 38: 737-744 (Pubitemid 32983280)
    • (2001) Journal of Cardiovascular Pharmacology , vol.38 , Issue.5 , pp. 737-744
    • Yang, T.1    Snyders, D.2    Roden, D.M.3
  • 52
    • 0037378286 scopus 로고    scopus 로고
    • Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome - A case-control pilot study using i.v. sotalol
    • DOI 10.1016/S0195-668X(02)00806-0
    • Kääb S, Hinterseer M, Näbauer M, Steinbeck G. Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome-a case-control pilot study using i.v. sotalol. Eur Heart J 2003; 24: 649-657 (Pubitemid 36343198)
    • (2003) European Heart Journal , vol.24 , Issue.7 , pp. 649-657
    • Kaab, S.1    Hinterseer, M.2    Nabauer, M.3    Steinbeck, G.4
  • 53
    • 0036150473 scopus 로고    scopus 로고
    • Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d-Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes
    • Farkas A, Lepran I, Papp JG. Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d-Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes. J Cardiovasc Pharmacol 2002; 39: 287-297
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 287-297
    • Farkas, A.1    Lepran, I.2    Papp, J.G.3
  • 54
    • 22144484449 scopus 로고    scopus 로고
    • Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3
    • DOI 10.1007/s00395-005-0533-8
    • Milberg P, Reinsch N, Osada N, et al. Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3. Basic Res Cardiol 2005; 100: 365-371 (Pubitemid 40974087)
    • (2005) Basic Research in Cardiology , vol.100 , Issue.4 , pp. 365-371
    • Milberg, P.1    Reinsch, N.2    Osada, N.3    Wasmer, K.4    Monnig, G.5    Stypmann, J.6    Breithardt, G.7    Haverkamp, W.8    Eckardt, L.9
  • 55
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival with Oral d-Sotalol
    • Waldo AL, Camm AJ, de Ruyter H, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 1996; 348: 7-12.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    De Ruyter, H.3
  • 56
    • 0032990279 scopus 로고    scopus 로고
    • Recurrent torsades de pointes after sotalol therapy for symptomatic paroxysmal atrial fibrillation in a patient with end-stage renal disease
    • Rizza C, Valderrabano M, Singh BN. Recurrent torsades de pointes after sotalol therapy for symptomatic paroxysmal atrial fibrillation in a patient with end-stage renal disease. J Cardiovasc Pharmacol Ther 1999; 4: 129-134 (Pubitemid 29256917)
    • (1999) Journal of Cardiovascular Pharmacology and Therapeutics , vol.4 , Issue.2 , pp. 129-134
    • Rizza, C.1    Valderrabano, M.2    Singh, B.N.3
  • 57
    • 6444237997 scopus 로고    scopus 로고
    • Increased short-term variability of repolarization predicts D-sotalol-induced torsade de pointes in dogs
    • Thomsen MB, Verduyn SC, Stengl M, et al. Increased short-term variability of repolarization predicts D-sotalol-induced torsade de pointes in dogs. Circulation 2004; 110: 2456-2459
    • (2004) Circulation , vol.110 , pp. 2456-2459
    • Thomsen, M.B.1    Verduyn, S.C.2    Stengl, M.3
  • 58
    • 0035033684 scopus 로고    scopus 로고
    • Amiodarone-induced long QT and polymorphic ventricular tachycardia [7]
    • Nkomo VT, Shen WK. Amiodarone-induced long QT and polymorphic ventricular tachycardia. Am J Emerg Med 2001; 19: 246-248 (Pubitemid 32378676)
    • (2001) American Journal of Emergency Medicine , vol.19 , Issue.3 , pp. 246-248
    • Nkomo, V.T.1    Shen, W.-K.2
  • 60
    • 33846450657 scopus 로고    scopus 로고
    • Cardiac glycosides as novel inhibitors of human Ether-a-gogo-related gene channel trafficking
    • DOI 10.1124/jpet.106.113043
    • Wang L, Wible BA, Wan X, Ficker E. Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking. J Pharmacol Exp Ther 2007; 320: 525-534 (Pubitemid 46147930)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.2 , pp. 525-534
    • Wang, L.1    Wible, B.A.2    Wan, X.3    Ficker, E.4
  • 63
    • 11144353696 scopus 로고    scopus 로고
    • Short QT syndrome: Pharmacological treatment
    • Gaita F, Giustetto C, Bianchi F, et al. Short QT syndrome: pharmacological treatment. J Am Coll Cardiol 2004; 43: 1494-1499
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1494-1499
    • Gaita, F.1    Giustetto, C.2    Bianchi, F.3
  • 65
    • 0037823364 scopus 로고    scopus 로고
    • Torsade de pointes due to noncardiac drugs: Most patients have easily identifiable risk factors
    • DOI 10.1097/00005792-200307000-00007
    • Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S. Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors. Medicine 2003; 82: 282-290 Review. (Pubitemid 36859224)
    • (2003) Medicine , vol.82 , Issue.4 , pp. 282-290
    • Zeltser, D.1    Justo, D.2    Halkin, A.3    Prokhorov, V.4    Heller, K.5    Viskin, S.6
  • 66
    • 0035293881 scopus 로고    scopus 로고
    • Risk assessment of antimicrobial agent-induced QTc interval prolongation and torsades de pointes
    • Owens RC. Risk assessment of antimicrobial agent-induced QTc interval prolongation and torsades de pointes. Pharmacotherapy 2001; 21: 301-319
    • (2001) Pharmacotherapy , vol.21 , pp. 301-319
    • Owens, R.C.1
  • 68
    • 0035212983 scopus 로고    scopus 로고
    • Rates of torsades de pointes associated with ciprofluoxazine, ofloxazin, levofloxazine, gatifluoxazine and moxifluoxazine
    • Frothinghan R. Rates of torsades de pointes associated with ciprofluoxazine, ofloxazin, levofloxazine, gatifluoxazine and moxifluoxazine. Pharmacotherapy 2001; 21: 1468-1472
    • (2001) Pharmacotherapy , vol.21 , pp. 1468-1472
    • Frothinghan, R.1
  • 71
    • 33645287541 scopus 로고    scopus 로고
    • Calmodulin antagonist W-7 prevents sparfloxacin-induced early after-depolarizations [EADs] in isolated rabbit prukinge fibers: Importance of beat-to-beat instability of the repolarization
    • Lu HR, Vlaminckx E, Van de Water A, Gallacher DJ. Calmodulin antagonist W-7 prevents sparfloxacin-induced early after-depolarizations [EADs] in isolated rabbit prukinge fibers: importance of beat-to-beat instability of the repolarization. J Cardiovasc Electrophysiol 2006; 17: 415-422
    • (2006) J Cardiovasc Electrophysiol , vol.17 , pp. 415-422
    • Lu, H.R.1    Vlaminckx, E.2    Van De Water, A.3    Gallacher, D.J.4
  • 72
    • 35748932057 scopus 로고    scopus 로고
    • Safety concerns with fluoroquinolones
    • Mehlhorn AJ, Brown DA. Safety concerns with fluoroquinolones. Ann Pharmacother 2007; 41: 1859-1866
    • (2007) Ann Pharmacother , vol.41 , pp. 1859-1866
    • Mehlhorn, A.J.1    Brown, D.A.2
  • 74
    • 0024261675 scopus 로고
    • Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity
    • Bibler MR, Chou TC, Toltzis RJ, Wade PA. Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity. Chest 1988; 94: 1303-1306 (Pubitemid 19002808)
    • (1988) Chest , vol.94 , Issue.6 , pp. 1303-1306
    • Bibler, M.R.1    Chou, T.-C.2    Toltzis, R.J.3    Wade, P.A.4
  • 75
    • 0028156730 scopus 로고
    • Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients
    • Eisenhauer MD, Eliasson AH, Taylor AJ, Coyne PE Jr, Wortham DC. Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. Chest 1994; 105: 389-394
    • (1994) Chest , vol.105 , pp. 389-394
    • Eisenhauer, M.D.1    Eliasson, A.H.2    Taylor, A.J.3    Coyne Jr., P.E.4    Wortham, D.C.5
  • 78
    • 0033428669 scopus 로고
    • Block of cardiac potassium and other channels by antihistaminics
    • Delpon E, Valenzuela C, Tamargo J. Block of cardiac potassium and other channels by antihistaminics. Drug Saf 1991; 21: 11-18
    • (1991) Drug Saf , vol.21 , pp. 11-18
    • Delpon, E.1    Valenzuela, C.2    Tamargo, J.3
  • 79
    • 33751008639 scopus 로고    scopus 로고
    • Spotlight on ranolazine in chronic stable angina pectoris
    • DOI 10.2165/00129784-200606050-00009
    • Siddiqui MA, Keam SJ. Spotlight on ranolazine in chronic stable angina pectoris. Am J Cardiovasc Drugs 2006; 6: 357-359 (Pubitemid 44749346)
    • (2006) American Journal of Cardiovascular Drugs , vol.6 , Issue.5 , pp. 357-359
    • Siddiqui, M.A.A.1    Keam, S.J.2
  • 80
    • 29544446899 scopus 로고    scopus 로고
    • QT interval prolongation associated with the oral use of domperidone in an infant
    • Rocha CM, Barbosa MM. QT interval prolongation associated with the oral use of domperidone in an infant. Pediatr Cardiol 2005; 26: 720-723
    • (2005) Pediatr Cardiol , vol.26 , pp. 720-723
    • Rocha, C.M.1    Barbosa, M.M.2
  • 81
    • 37849189834 scopus 로고    scopus 로고
    • Domperidone and sudden death
    • No authors
    • No authors. Domperidone and sudden death. Prescrire Int 2006; 15: 226.
    • (2006) Prescrire Int , vol.15 , pp. 226
  • 82
    • 79651475884 scopus 로고    scopus 로고
    • Interaction between ketoconazole and domperidone and the risk of QT prolongation - Important safety information
    • Medicines Control Council
    • Medicines Control Council. Interaction between ketoconazole and domperidone and the risk of QT prolongation - important safety information. S Afr Med J 2006; 96: 596.
    • (2006) S Afr Med J , vol.96 , pp. 596
  • 83
    • 0034712552 scopus 로고    scopus 로고
    • QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
    • Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SH. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 2000; 355: 1048-1052 (Pubitemid 30162807)
    • (2000) Lancet , vol.355 , Issue.9209 , pp. 1048-1052
    • Reilly, J.G.1    Ayis, S.A.2    Ferrier, I.N.3    Jones, S.J.4    Thomas, S.H.L.5
  • 84
    • 0035150202 scopus 로고    scopus 로고
    • Antipsychotic drugs: Prolonged QTc interval, torsades de pointes, and sudden death
    • Glassman AH, Bigger JT Jr. Antipsychotic drugs: prolonged QTc interval, torsades de pointes, and sudden death. Am J Psychiatry 2001; 158: 1774-1782
    • (2001) Am J Psychiatry , vol.158 , pp. 1774-1782
    • Glassman, A.H.1    Bigger Jr., J.T.2
  • 85
    • 23244462985 scopus 로고    scopus 로고
    • The phenothiazine drugs inhibit hERG potassium channels
    • Kim KS, Kim EJ. The phenothiazine drugs inhibit hERG potassium channels. Drug Chem Toxicol 2005; 28: 303-313
    • (2005) Drug Chem Toxicol , vol.28 , pp. 303-313
    • Kim, K.S.1    Kim, E.J.2
  • 86
    • 0032518968 scopus 로고    scopus 로고
    • Torsades de pointes associated with intravenous haloperidol in critically ill patients
    • DOI 10.1016/S0002-9149(97)00888-6, PII S0002914997008886
    • Sharma ND, Rosman HS, Padhi ID, Tisdale JE. Torsades de Pointes associated with intravenous haloperidol in critically ill patients. Am J Cardiol 1998; 81: 238-240 (Pubitemid 28057213)
    • (1998) American Journal of Cardiology , vol.81 , Issue.2 , pp. 238-240
    • Sharma, N.D.1    Rosman, H.S.2    Padhi, I.D.3    Tisdale, J.E.4
  • 87
    • 36349007027 scopus 로고    scopus 로고
    • Comparative evaluation of hERG potassium channel blockade by antipsychotics
    • Silvestre JS, Prous JR. Comparative evaluation of hERG potassium channel blockade by antipsychotics Methods Find Exp Clin Pharmacol 2007; 29: 457-465
    • (2007) Methods Find Exp Clin Pharmacol , vol.29 , pp. 457-465
    • Silvestre, J.S.1    Prous, J.R.2
  • 88
    • 30344486923 scopus 로고    scopus 로고
    • Tricyclic antidepressant poisoning: Cardiovascular toxicity
    • DOI 10.2165/00139709-200524030-00013
    • Thanacoody HK, Thomas SH. Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol Rev 2005; 24: 205-214 (Pubitemid 43060627)
    • (2005) Toxicological Reviews , vol.24 , Issue.3 , pp. 205-214
    • Thanacoody, H.K.R.1    Thomas, S.H.L.2
  • 90
    • 0034610263 scopus 로고    scopus 로고
    • Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia
    • Ohnishi K, Yoshida H, Shigeno K, et al. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 2000; 133: 881-885
    • (2000) Ann Intern Med , vol.133 , pp. 881-885
    • Ohnishi, K.1    Yoshida, H.2    Shigeno, K.3
  • 93
    • 33749448371 scopus 로고    scopus 로고
    • Torsade de pointes induced by systemic antifungal agents: Lessons from a retrospective analysis of published case reports
    • DOI 10.1111/j.1439-0507.2006.01278.x
    • Justo D, Zeltser D. Torsade de pointes induced by systemic antifungal agents: lessons from a retrospective analysis of published case reports. Mycoses 2006; 49: 463-470 (Pubitemid 44511096)
    • (2006) Mycoses , vol.49 , Issue.6 , pp. 463-470
    • Justo, D.1    Zeltser, D.2
  • 94
    • 38849139779 scopus 로고    scopus 로고
    • Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome
    • Takemasa H, Nagatomo T, Abe H, et al. Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. Br J Pharmacol 2008; 153(3): 439-537
    • (2008) Br J Pharmacol , vol.153 , Issue.3 , pp. 439-537
    • Takemasa, H.1    Nagatomo, T.2    Abe, H.3
  • 95
    • 0034945769 scopus 로고    scopus 로고
    • Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome
    • Drici MD, Clement N: Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001; 24: 575-585
    • (2001) Drug Saf , vol.24 , pp. 575-585
    • Drici, M.D.1    Clement, N.2
  • 96
    • 18244370000 scopus 로고    scopus 로고
    • Gender-related differences in ventricular repolarization: Beyond gonadal steroids
    • Arya A. Gender-related differences in ventricular repolarization: beyond gonadal steroids. J Cardiovasc Elctrophysiol 2005; 16: 525-527
    • (2005) J Cardiovasc Elctrophysiol , vol.16 , pp. 525-527
    • Arya, A.1
  • 98
    • 0035038148 scopus 로고    scopus 로고
    • Non-invasive testing of acquired long QT syndrome: Evidence for multiple arrhythmogenic substrates
    • Chevalier P, Rodriguez C, Bontemps L, et al. Non-invasive testing of acquired long QT syndrome: evidence for multiple arrhythmogenic substrates. Cardiovasc Rest 2001; 50: 3486-3498
    • (2001) Cardiovasc Rest , vol.50 , pp. 3486-3498
    • Chevalier, P.1    Rodriguez, C.2    Bontemps, L.3
  • 100
    • 33749047246 scopus 로고    scopus 로고
    • Epinephrine QT stress testing in congenital long QT syndrome
    • Review
    • Vyas H, Ackerman MJ. Epinephrine QT stress testing in congenital long QT syndrome. J Electrocardiol 2006; 39: S107-13. Review.
    • (2006) J Electrocardiol , vol.39
    • Vyas, H.1    Ackerman, M.J.2
  • 101
    • 0023614027 scopus 로고
    • Effects of low potassium or magnesium concentrations on isolated cardiac tissue
    • DOI 10.1016/0002-9343(87)90128-8
    • Roden DM, Iansmith DH. Effects of low potassium or magnesium concentrations on isolated cardiac tissue. Am J Med 1987; 82: 18-23 (Pubitemid 18119216)
    • (1987) American Journal of Medicine , vol.82 , Issue.3 A , pp. 18-23
    • Roden, D.M.1    Iansmith, D.H.S.2
  • 102
    • 31144457511 scopus 로고    scopus 로고
    • Relation between severity of left ventricular systolic dysfunction and repolarisation abnormalities on the surface ECG: A report from the Euro heart failure survey
    • DOI 10.1136/hrt.2005.061200
    • Velavan P, Khan NK, Rigby AS, et al. Relation between severity of left ventricular systolic dysfunction and repolarisation abnormalities on the surface ECG: a report from the Euro heart failure survey. Heart 2006; 92: 255-256 (Pubitemid 43131974)
    • (2006) Heart , vol.92 , Issue.2 , pp. 255-256
    • Velavan, P.1    Khan, N.K.2    Rigby, A.S.3    Goode, K.4    Komajda, M.5    Follath, F.6    Swedberg, K.7    Madeira, H.8    Clark, A.L.9    Cleland, J.G.F.10
  • 104
    • 36749056453 scopus 로고    scopus 로고
    • HERG channel trafficking: Novel targets in drug-induced long QT syndrome
    • DOI 10.1042/BST0351060
    • Dennis A, Wang L, Wan X, Ficker E. hERG channel trafficking: novel targets in drug-induced long QT syndrome. Biochem Soc Trans 2007; 35: 1060-1063 (Pubitemid 350206429)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.5 , pp. 1060-1063
    • Dennis, A.1    Wang, L.2    Wan, X.3    Ficker, E.4
  • 106
    • 33644786245 scopus 로고    scopus 로고
    • Thorough QT/QTc not so thorough: Removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs
    • Hondeghem LM. Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs. J Cardiovasc Electrophysiol 2006; 17: 337-340
    • (2006) J Cardiovasc Electrophysiol , vol.17 , pp. 337-340
    • Hondeghem, L.M.1
  • 107
    • 36148991754 scopus 로고    scopus 로고
    • The 5-HT[4] agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene [hERG]-blocking activities
    • Toga T, Kohmura Y, Kawatsu R. The 5-HT[4] agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene [hERG]-blocking activities. J Pharmacol Sci 2007; 105: 207-210
    • (2007) J Pharmacol Sci , vol.105 , pp. 207-210
    • Toga, T.1    Kohmura, Y.2    Kawatsu, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.