Reduced repolarization reserve due to anthracycline therapy facilitates torsade de pointes induced by IKr blockers

Basic Research in Cardiology

Volumn 102, Issue 1, 2007, Pages 42-51

  Milberg, Peter ^a,b   Fleischer, Dirk ^a   Stypmann, Jörg ^a,c   Osada, Nani ^a   Mönnig, Gerold ^a   Engelen, Markus A ^a,e   Bruch, Christian ^a   Breithardt, Günter ^a   Haverkamp, Wilhelm ^d   Eckardt, Lars ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c Interdisciplinary Center for Clinical Research (IZKF)   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Anthracyclines; Electrophysiology; Proarrhythmia; Rabbit; Repolarization reserve

Indexed keywords

ANTHRACYCLINE DERIVATIVE; DOXORUBICIN; ERYTHROMYCIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG POTENTIATION; DRUG SENSITIVITY; ECHOCARDIOGRAPHY; HEART DEPOLARIZATION; HEART EJECTION FRACTION; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HYPOKALEMIA; ISOLATED HEART; MALE; NONHUMAN; POTASSIUM CURRENT; QT INTERVAL; QT PROLONGATION; RABBIT; SUDDEN DEATH; TORSADE DES POINTES;

ACTION POTENTIALS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DELAYED RECTIFIER POTASSIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ELECTROCARDIOGRAPHY; ERYTHROMYCIN; HEART CONDUCTION SYSTEM; MALE; RABBITS; STROKE VOLUME; TORSADES DE POINTES;

EID: 33845584834     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-006-0609-0     Document Type: Article

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