Structural constraints and the importance of lipophilicity for the mitochondrial uncoupling activity of naturally occurring caffeic acid esters with potential for the treatment of insulin resistance

Biochemical Pharmacology

Volumn 79, Issue 3, 2010, Pages 444-454

  Eid, Hoda M ^a   Vallerand, Diane ^a   Muhammad, Asim ^b   Durst, Tony ^b   Haddad, Pierre S ^a   Martineau, Louis C ^a  

^a Montreal Diabetes Research Centre   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Adenosine monophosphate (AMP) activated protein kinase signaling pathway; Glucose uptake; Insulin resistance; Mitochondrial energy transduction; Naturally occurring phenolic compounds; Uncoupling of oxidative phosphorylation

Indexed keywords

4 (1 PROPENYL)CATECHOL; CAFFEIC ACID; CAFFEIC ACID 1,1 DIMETHYLALLYL ESTER; CAFFEIC ACID DERIVATIVE; CAFFEIC ACID DIHYDROETHYL ESTER; CAFFEIC ACID DIHYDROMETHYL ESTER; CAFFEIC ACID DIHYDROPHENETHYL ESTER; CAFFEIC ACID ETHYL ESTER; CAFFEIC ACID METHYL ESTER; CAFFEIC ACID N OCTYL ESTER; CAFFEIC ACID PHENETHYL ESTER; CHLOROGENIC ACID; CINNAMIC ACID; CINNAMIC ACID 2,4 DIHYDROXYMETHYL ESTER; CINNAMIC ACID 2,5 DIHYDROXYMETHYL ESTER; CINNAMIC ACID 4 HYDROXYMETHYL ESTER; CINNAMIC ACID METHYL ESTER; DIHYDROCAFFEIC ACID; FERULIC ACID; FERULIC ACID ETHYL ESTER; FERULIC ACID METHYL ESTER; FERULIC ACID PHENETHYL ESTER; GLUCOSE; LACTATE DEHYDROGENASE; ROSMARINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME RELEASE; GLUCOSE TRANSPORT; INSULIN RESISTANCE; LIPOPHILICITY; LIVER MITOCHONDRION; MALE; MOUSE; MYOBLAST; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PREDICTION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CAFFEIC ACIDS; CELLS, CULTURED; ESTERS; INSULIN RESISTANCE; MALE; MEMBRANE LIPIDS; MICE; MITOCHONDRIA, LIVER; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; UNCOUPLING AGENTS;

EID: 70449622770     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.08.026     Document Type: Article

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