Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells

PLoS Neglected Tropical Diseases

Volumn 3, Issue 7, 2009, Pages

  Grab, Dennis J ^a   Garcia Garcia, Jose C ^a   Nikolskaia, Olga V ^a   Kim, Yuri V ^a,e   Brown, Amanda ^a   Pardo, Carlos A ^a   Zhang, Yongqing ^b   Becker, Kevin G ^b   Wilson, Brenda A ^c   De A Lima, Ana Paula C ^d   Scharfstein, Julio ^d   Dumler, J Stephen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN RELATED PROTEIN 2; BACTERIAL TOXIN; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CATHEPSIN L; CELL NUCLEUS RECEPTOR; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYSTEINE PROTEINASE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOCYTE ENHANCER FACTOR 2; MYOGENIC FACTOR; NUCLEAR FACTOR Y; P21 ACTIVATED KINASE 4; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; S6 KINASE; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT3; BACTERIAL PROTEIN; PASTEURELLA MULTOCIDA TOXIN; SMALL INTERFERING RNA;

AFRICAN TRYPANOSOMIASIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CALCIUM SIGNALING; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LASER CAPTURE MICRODISSECTION; MEMBRANE PERMEABILITY; MICROVASCULATURE; MONOLAYER CULTURE; NEUROPROTECTION; NONHUMAN; PARASITE TRANSMISSION; PASTEURELLA MULTOCIDA; PATHOPHYSIOLOGY; PERMEABILITY BARRIER; RECEPTOR BLOCKING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRYPANOSOMA; TRYPANOSOMA RHODESIENSE; VASCULAR ENDOTHELIUM; ANIMAL; CELL LINE; DRUG ANTAGONISM; GENE SILENCING; GENETICS; PARASITOLOGY; PATHOGENICITY; PHYSIOLOGY;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; RECEPTOR, PAR-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 70449601758     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000479     Document Type: Article

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