Cerebral vessel laminins and IFN-γ define Trypanosoma brucei brucei penetration of the blood-brain barrier

Journal of Clinical Investigation

Volumn 114, Issue 5, 2004, Pages 689-694

  Masocha, Willias ^a   Robertson, Brita ^a   Rottenberg, Martin E ^a   Mhlanga, Jama ^a   Sorokin, Lydia ^b   Kristensson, Krister ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; LAMININ; RAG1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN INFECTION; CONTROLLED STUDY; HOST RESISTANCE; INTERFERON PRODUCTION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS; VASCULAR ENDOTHELIUM; AFRICAN TRYPANOSOMIASIS; ANIMAL; ANIMAL DISEASE; BLOOD VESSEL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; TIME;

ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; FLUORESCENT ANTIBODY TECHNIQUE; INTERFERON TYPE II; LAMININ; MICE; TIME FACTORS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 85047690580     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI22104     Document Type: Article

References (43)

1. Dumas, M., and Bisser, S. 1999. Clinical aspects of human African trypanosomiasis. In Progress in human African trypanosomiasis, sleeping sickness. M. Dumas, B. Bouteille, and A. Buguet, editors. Springer. Paris, France. 215-233.
2. Schultzberg, M., Ambatsis, M., Samuelsson, E.B., Kristensson, K., and van Meirvenne, N. 1988. Spread of Trypanosoma brucei to the nervous system: early attack on circumventricular organs and sensory ganglia. J. Neurosci. Res. 21:56-61.
3. Mulenga, C., Mhlanga, J.D., Kristensson, K., and Robertson, B. 2001. Trypanosoma brucei brucei crosses the blood-brain barrier while tight junction proteins are preserved in a rat chronic disease model. Neuropathol. Appl. Neurobiol. 27:77-85.
4. Rubin, L.L., and Staddon, J.M. 1999. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 22:11-28.
5. Sixt, M., et al. 2001. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J. Cell Biol. 153:933-946.
6. Aumailley, M., and Smyth, N. 1998. The role of laminins in basement membranes. J. Anat. 193:1-21.
7. Timpl, R., and Brown, J. 1994. The laminins. Matrix Biol. 14:275-281.
8. Tunggal, P., Smyth, N., Paulsson, M., and Ott, M.C. 2000. Laminins: structure and genetic regulation. Micro. Res. Tech. 51:214-227.
9. Gloor, S.M., et al. 2001. Molecular and cellular permeability control at the blood-brain barrier. Brain Res. Brain Res. Rev. 36:258-264.
10. Owens, T., et al. 2001. Pathogenesis of encephalitis. In Neuroimmune biology. Vol. 1: New foundation of biology. I. Berczi and M. Gorczynski, editors. Elsevier. Amsterdam, The Netherlands. 387-397.
11. Eugenin, E.A., and Berman, J.W. 2003. Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier. Methods. 29:351-361.
12. Boehm, U., Klamp, T., Groot, M., and Howard, J.C. 1997. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15:749-795.
13. Ma, X., et al. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:147-157.
14. Wenner, C.A., Guler, M.L., Macatonia, S.E., O'Garra, A., and Murphy, K.M. 1996. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442-1447.
15. Smeltz, R.B., Chen, J., Ehrhardt, R., and Shevach, E.M. 2002. Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression. J Immunol. 168:6165-6172.
16. Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. 1997. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
17. Hertz, C.J., Filutowicz, H., and Mansfield, J.M. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J. Immunol. 161:6775-6783.
18. Namangala, B., Noel, W., De Baetselier, P., Brys, L., and Beschin, A. 2001. Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis. J. Infect. Dis. 183:1794-1800.
19. Darji, A., Sileghem, M., Heremans, H., Brys, L., and De Baetselier, P. 1993. Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma Interferon. Infect. Immun. 61:3098-3102.
20. Shi, M., Pan, W., and Tabel, H. 2003. Experimental African trypanosomiasis: IFN-gamma mediates early mortality. Eur. J. Immunol. 33:108-118.
21. Uzonna, J.E., Kaushik, R.S., Gordon, J.R., and Tabel, H. 1998. Experimental murine Trypanosoma congolense infections. I. Administration of anti-IFN-gamma antibodies alters trypanosome-susceptible mice to a resistant-like phenotype. J. Immunol. 161:5507-5515.
22. Olsson, T., et al. 1993. CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell. 72:715-727.
23. Sorokin, L.M., Pausch, F, Durbeej, M., and Ekblom, P. 1997. Differential expression of five laminin α (1-5) chains in developing and adult mouse kidney. Dev. Dyn. 210:446-462.
24. Strack, A., Asensio, V.C., Campbell, I.L., Schluter, D., and Deckert, M. 2002. Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma. Acta Neuropathol. (Berl.). 103:458-468.
25. Olsson, T., et al. 1991. Bidirectional activating signals between Trypanosoma brucei and CD8+ T cells: a trypanosome-released factor triggers interferon-gamma production that stimulates parasite growth. Eur. J. Immunol. 21:2447-2454.
26. Hua, S.B., and Wang, C.C. 1997. Interferon-gamma activation of a mitogen-activated protein kinase, KFR1, in the bloodstream form of Trypanosoma brucei. J. Biol. Chem. 272:10797-10803.
27. Rosenberg, G.A. 1995. Matrix metalloproteinases in brain injury. J. Neurotrauma. 12:833-842.
28. Trachtman, H., Futterweit, S., and Singhal, P. 1995. Nitric oxide modulates the synthesis of extracellular matrix proteins in cultured rat mesangial cells. Biochem. Biophys. Res. Commun. 207:120-125.
29. Rosenberg, G.A., et al. 1992. TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase. Brain Res. 576:203-207.
30. Cuzner, M.L., and Opdenakker, G. 1999. Plasminogen activators and matrix metalloproteases, mediators of extracellular ptoteolysis in inflammatory demyelination of the central nervous system. J. Neuroimmunol. 94:1-14.
31. Graesser, D., Mahooti, S., and Madri, J.A. 2000. Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 109:121-131.
32. Hartung, H.P., and Kieseier, B.C. 2000. The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system. J. Neuroimmunol. 107:140-147.
33. Hertz, C.J., and Mansfield, J.M. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol. 192:24-32.
34. Tran, E.H., Prince, E.N., and Owens, T. 2000. IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J. Immunol. 164:2759-2768.
35. Dalton, D.K., et al. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259:1739-1742.
36. Huang, S., et al. 1993. Immune response in mice that lack the interferon-gamma receptor. Science. 259:1742-1745.
37. Magram, J., et al. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity. 4:471-481.
38. Mombaerts, P., et al. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
39. Herbert, W.J., and Lumsden, W.H. 1976. Trypanosoma brucei: a rapid "matching" method for estimating the host's parasitemia. Exp. Parasitol. 40:427-431.
40. Ringelmann, B., et al. 1999. Expression of laminin α1, α2, α4 and α5 chains, fibronectin and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice. Exp. Cell Res. 246:165-182.
41. Sorokin, L.M., et al. 1997. Developmental regulation of the laminin α5 chain suggests a role in epithelial and endothelial cell maturation. Dev. Biol. 189:285-300.
42. Sorokin, L.M., et al. 1992. Monoclonal antibodies against the laminin A chain fragment E3 and their effects on cell- and heparin-binding and on kidney development. Exp. Cell Res. 201:137-144.
43. Livak, K.J., and Schmittgen, T.D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402-408.