Novel graft copolymers enhance in vitro delivery of antisense oligonucleotides in the presence of serum

Journal of Controlled Release

Volumn 140, Issue 2, 2009, Pages 134-140

  Peddada, Lavanya Y ^a   Harris, Nicole K ^c   Devore, David I ^c   Roth, Charles M ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b The State University of New Jersey   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Delivery vector; Endosomal escape; Gene silencing; Graft copolymers; Poly(oxyalkylene amines)

Indexed keywords

ANTISENSE; ANTISENSE ACTIVITY; ANTISENSE OLIGODEOXYNUCLEOTIDES; ANTISENSE OLIGONUCLEOTIDES; ANTISENSE TECHNOLOGY; CARRIER SYSTEMS; CATIONIC LIPOSOMES; CELLULAR INTERNALIZATION; CLINICAL SETTINGS; DELIVERY SYSTEMS; DELIVERY VECTOR; ENDOSOMAL ESCAPE; EXTRACELLULAR; GENE SILENCING; GRAFTING ONTO; GREEN FLUORESCENT PROTEIN; IN-VITRO; JEFFAMINES; PH SENSITIVE; PH-DEPENDENT; POLY(OXYALKYLENE AMINES); SERUM-FREE CONDITIONS; SERUM-FREE MEDIA; THERAPEUTIC DELIVERY;

AMINATION; AMINES; BODY FLUIDS; COPOLYMERIZATION; ENZYME ACTIVITY; ETHYLENE; GENETIC ENGINEERING; GRAFT COPOLYMERS; HYDROPHOBICITY; OLIGONUCLEOTIDES; PLASTIC PRODUCTS; POLYETHYLENE OXIDES; PROPANE;

GRAFTING (CHEMICAL);

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ANTISENSE OLIGONUCLEOTIDE; COPOLYMER; DRUG CARRIER; GREEN FLUORESCENT PROTEIN; POLYPROPYLACRYLIC ACID; POLYPROPYLACRYLIC ACID JEFFAMINE COPOLYMER; POLYPROPYLACRYLIC ACID MACROGOL COPOLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTISENSE THERAPY; ARTICLE; CELL SURVIVAL; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GENE SILENCING; HYDROPHOBICITY; INTERNALIZATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM;

ACRYLATES; AMINES; ANIMALS; BIOLOGICAL TRANSPORT; CHO CELLS; CRICETINAE; CRICETULUS; ENDOSOMES; FATTY ACIDS, MONOUNSATURATED; GENE SILENCING; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEMOLYSIS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; OLIGONUCLEOTIDES, ANTISENSE; POLYETHYLENE GLYCOLS; POLYMERS; QUATERNARY AMMONIUM COMPOUNDS; SERUM; TRANSFECTION;

EID: 70449532192     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.08.008     Document Type: Article

References (29)

1. Zamecnik P.C., and Stephenson M.L. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 280-284
2. Dove A. Antisense and sensibility. Nat. Biotechnol. 20 (2002) 121-124
3. Opalinska J.B., and Gewirtz A.M. Nucleic-acid therapeutics: basic principles and recent applications. Nat. Rev. Drug Discov. 1 (2002) 503-514
4. Gleave M.E., and Monia B.P. Antisense therapy for cancer. Nat. Rev. Cancer 5 (2005) 468-479
5. Potera C. Antisense-down, but not out. Nat. Biotechnol. 25 (2007) 497-499
6. Shi F., and Hoekstra D. Effective intracellular delivery of oligonucleotides in order to make sense of antisense. J. Control. Release 97 (2004) 189-209
7. Roth C.M., and Sundaram S. Engineering synthetic vectors for improved DNA delivery: insights from intracellular pathways. Annu. Rev. Biomed. Eng. 6 (2004) 397-426
8. Khalil I.A., Kogure K., Akita H., and Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev. 58 (2006) 32-45
9. Park T.G., Jeong J.H., and Kim S.W. Current status of polymeric gene delivery systems. Adv. Drug. Deliv. Rev. 58 (2006) 467-486
10. Fenske D.B., and Cullis P.R. Liposomal nanomedicines. Expert Opin. Drug Deliv. 5 (2008) 25-44
11. Kabanov A., Zhu J., and Alakhov V. Pluronic block copolymers for gene delivery. Adv. Genet. 53PA (2005) 231-261
12. Murthy N., Robichaud J.R., Tirrell D.A., Stayton P.S., and Hoffman A.S. The design and synthesis of polymers for eukaryotic membrane disruption. J. Control. Release 61 (1999) 137-143
13. Cheung C.Y., Murthy N., Stayton P.S., and Hoffman A.S. A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer. Bioconjug. Chem. 12 (2001) 906-910
14. Lee L.K., Williams C.L., Devore D., and Roth C.M. Poly(propylacrylic acid) enhances cationic lipid-mediated delivery of antisense oligonucleotides. Biomacromolecules 7 (2006) 1502-1508
15. Roux E., Passirani C., Scheffold S., Benoit J.P., and Leroux J.C. Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes. J. Control. Release 94 (2004) 447-451
16. Lee M., and Kim S.W. Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm. Res. 22 (2005) 1-10
17. Kim J.K., Choi S.H., Kim C.O., Park J.S., Ahn W.S., and Kim C.K. Enhancement of polyethylene glycol (PEG)-modified cationic liposome-mediated gene deliveries: effects on serum stability and transfection efficiency. J. Pharm. Pharmacol. 55 (2003) 453-460
18. Kabanov A.V., Batrakova E.V., Sriadibhatla S., Yang Z., Kelly D.L., and Alakov V.Y. Polymer genomics: shifting the gene and drug delivery paradigms. J. Control. Release 101 (2005) 259-271
19. Kabanov A., Zhu J., and Alakhov V. Pluronic block copolymers for gene delivery. Adv. Genet. 53 (2005) 231-261
20. Sundaram S., Lee L.K., and Roth C.M. Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity. Nucleic Acids Res. 35 (2007) 4396-4408
21. Moore S.S.I., and J S. Cleavage of aldehyde hydrazonium iodides under mild conditions - a convenient route to chiral nitriles of high enantiomeric purity. Macromolecules 23 (1990)
22. Moore J., and Stupp S.I. Cleavage of aldehyde hydrazonium iodides under mild conditions. A convenient route to chiral nitriles of high enantiomeric purity. J. Org. Chem. 55 (1990) 3374
23. Hourdet L.A.F., D, and Audebert R. Synthesis of thermoassociative copolymers. Polymer 38 (1997) 2535-2547
24. Kyriakides T.R., Cheung C.Y., Murthy N., Bornstein P., Stayton P.S., and Hoffman A.S. pH-sensitive polymers that enhance intracellular drug delivery in vivo. J. Control. Release 78 (2002) 295-303
25. Kusonwiriyawong C., van de Wetering P., Hubbell J.A., Merkle H.P., and Walter E. Evaluation of pH-dependent membrane-disruptive properties of poly(acrylic acid) derived polymers. Eur. J. Pharm. Biopharm. 56 (2003) 237-246
26. Sakaguchi N., Kojima C., Harada A., and Kono K. Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH. Bioconjug. Chem. 19 (2008) 1040-1048
27. Chirila T.V., Rakoczy P.E., Garrett K.L., Lou X., and Constable I.J. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 23 (2002) 321-342
28. Duncan R., and Izzo L. Dendrimer biocompatibility and toxicity. Adv. Drug Deliv. Rev. 57 (2005) 2215-2237
29. Nguyen H.K., Lemieux P., Vinogradov S.V., Gebhart C.L., Guerin N., Paradis G., Bronich T.K., Alakhov V.Y., and Kabanov A.V. Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther. 7 (2000) 126-138