The importance of ATP as a regulator of glycolytic flux in Saccharomyces cerevisiae

Yeast

Volumn 16, Issue 9, 2000, Pages 797-809

  Larsson, Christer ^a   Påhlman, Inga Lill ^b   Gustafsson, Lena ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

ATP; Flux control; Glycolysis; Permeabilization; Saccharomyces

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ENOLASE; GLUCOSE; GLYCOLYTIC ENZYME; HEXOKINASE; NITROGEN; NYSTATIN; PYRUVATE KINASE; TREHALOSE;

ARTICLE; CELL CULTURE; CELL WALL; CHEMOSTAT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GLYCOLYSIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SPHEROPLAST; YEAST;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANAEROBIOSIS; CELL MEMBRANE PERMEABILITY; CULTURE MEDIA; GLUCOSE; GLYCOLYSIS; NAD; NITROGEN; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; SUGAR PHOSPHATES; TREHALOSE;

EID: 0343457972     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0061(20000630)16:9<797::AID-YEA553>3.0.CO;2-5     Document Type: Article

References (31)

1. Albers E, Larsson C, Lidén G, Niklasson C, Gustafsson L. 1996. Influence of the nitrogen source on Saccharomyces cerevisiae anaerobic growth and product formation. Appl Environ Microbiol J 62: 3187-3195.
2. Avéret N, Fitton V, Bunoust O, Rigoulet M, Guérin B. 1998. Yeast mitochondrial metabolism: from in vitro to in situ quantitative study. Mol Cell Biochem 184: 67-79.
3. Bergmeyer HU. 1974. Methods of Enzymatic Analysis, 2nd edn. Academic Press: New York.
4. Blazquez MA, Lagunas R, Gancedo C, Gancedo JM. 1993. Trehalose-6-phosphate, a new regulator of yeast glycolysis that inhibits hexokinases. FEBS Lett 329: 51-54.
5. Boles E, Goehlmann HWH, Zimmerman FK. 1996. Cloning of a second gene encoding 6-phospofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2.6-bisphosphate. Mol Microbiol 20: 65-76.
6. Campbell-Burk SL, Shulman RG. 1987. High resolution NMR studies of Saccharomyces cerevisiae. Ann Rev Microbiol 41: 595-616.
7. Cortassa S, Aon MA. 1997. Distributed control of the glycolytic flux in wild-type cells and catabolite repression mutants of Saccharomyces cerevisiae growing in carbon-limited chemostat cultures. Enzyme Microb Technol 21: 596-602.
8. Davies SEC; Brindle KM. 1992. Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae. Biochemistry 31: 4729-4735.
9. de Konig W, van Dam K. 1992. A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH. Anal Biochem 204: 118-123.
10. Ernandes JR, de Meirsman C, Rolland F, Winderickx J, de Winde J, Brandao RL, Thevelein JM. 1998. During the initiation of fermentation overexpression of hexokinase PII in yeast transiently causes a similar deregulation of glycolysis as deletion of Tps1. Yeast 14: 255-269.
11. Fell D. 1997. Understanding the Control of Metabolism. Portland Press: London.
12. Fitton V. 1996. Ph.D thesis, University of Bordeaux, Bordeaux, France.
13. Gancedo C, Serrano R. 1989. Energy-yielding metabolism. In The Yeasts, Rose AH, Harrison JS (Eds). Academic Press: New York; 206-259.
14. Gustafsson L. 1979, The ATP pool in relation to the production of glycerol and heat during growth of the halotolerant yeast Debaryomyces hansenii. Arch Microbiol 120: 15-23.
15. Heinisch J. 1986. Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast. Mol Gen Genet 202: 75-82.
16. Heinisch JJ, Boles E, Timpel C. 1996. A yeast phosphofructokinase insensitive to the allosteric activator fructose 2,6-bisphosphate. J Biol Chem 271: 15928-15933.
17. Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard B. 1988. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Struct Lond 6: 195-210.
18. Kopetzki E, Entian KE. 1985. Glucose repression and hexokinase isoenzymes in yeast. Eur J Biochem 146: 657-662.
19. Larsson C, Morales C, Gustafsson L, Adler L. 1990. Osmo-regulation of the salt-tolerant yeast Debaryomyces hansenii grown in a chemostat at different salinities. J Bacteriol 172: 1769-1774.
20. Larsson C, Nilsson A, Blomberg A, Gustafsson L. 1997. Glycolytic flux is conditionally correlated with ATP concentration in Saccharomyces cerevisiae: a chemostat study under carbon- or nitrogen-limiting conditions. J Bacteriol 179: 7243-7250.
21. Lloyd D, James CJ, Maitra PK. 1992. Mutations in phosphofructokinases alter the control characteristics of glycolysis in vivo in Saccharomyces cereviase. Yeast 8: 291-301.
22. Mesecar AD, Nowak T. 1997. Metal-ion-mediated allosteric triggering of yeast pyruvate kinase. 1. A multidimensional kinetic linked-function analysis. Biochem 36: 6792-6802.
23. Murcott THL, Gutfreund H, Muirhead H. 1992. The cooperative binding of fructose-1,6-bisphosphate to yeast pyruvate kinase. EMBO J 11: 3811-3814.
24. Müller S, Zimmermann FK, Boles E. 1997. Mutant studies of phosphofructo-2-kinases do not reveal an essential role of fructose-2,6-bisphosphate in the regulation of carbon fluxes in yeast cells. Microbiology 143: 3055-3061.
25. Oehlen LJWM, Scholte ME, de Konig W, van Dam K. 1994. Decrease in glycolytic flux in Saccharomyces cerevisiae ede35-1 cells at restrictive temperature correlates with a decrease in glucose transport. Microbiology 140: 1891-1898.
26. Reibstein D, den Hollander JA, Pilkis SJ, Shulman RG. 1986. Studies on the regulation of yeast phosphofructo-1-kinase: its role in aerobic and anaerobic glycolysis. Biochemistry 25: 219-227.
27. Rosenzweig RF. 1992. Regulation of fitness in yeast overexpressing glycolytic enzymes: parameters of growth and viability. Genet Res Camb 59: 35-48.
28. Schaaff I, Heinisch J, Zimmermann FK. 1989. Overproduction of glycolytic enzymes in yeast. Yeast 5: 285-290.
29. Sierkstra LN, Verbakel JMA, Verrips CT. 1992. Analysis of transcription and translation of glycolytic enzymes in glucose-limited continuous cultures of Saccharomyces cerevisiae. J Gen Microbiol 138: 2559-2566.
30. Teusink B, Diderich JA, Westerhoff HV, van Dam K, Walsh MC. 1998. lntracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50%. J Bacteriol 180: 556-562.
31. Thomas S, Fell DA. 1998. A control analysis exploration of the role of ATP utilisation in glycolytic-flux control and glycolytic-metabolite-concentration regulation. Eur J Biochem 258: 956-967.