Effect of refeed strategies and non-ammoniagenic medium on adenovirus production at high cell densities

Journal of Biotechnology

Volumn 119, Issue 3, 2005, Pages 272-280

  Ferreira, T B ^a   Ferreira, A L ^a   Carrondo, M J T ^a,b   Alves, P M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Adenovirus; High cell densities; Non ammoniagenic medium; Refeed

Indexed keywords

AMINO ACIDS; CELLS; DRUG DOSAGE; GENES; GLUCOSE; METABOLISM; PROTEINS; VACCINES; VECTORS; VIRUSES;

ADENOVIRUS; HIGH CELL DENSITIES; NON-AMMONIAGENIC MEDIUM; REFEED;

GENETIC ENGINEERING;

AMINO ACID; AMMONIA; GLUCOSE; GLUTAMINE; THREONINE;

ADENOVIRUS; AMMONIA FORMATION; ARTICLE; BIOREACTOR; CELL DENSITY; CELL METABOLISM; CELL SPECIFICITY; CELL SUSPENSION; DEPLETION; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS RECOMBINANT; VOLUMETRY; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; CULTURE TECHNIQUE; GENE VECTOR; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; TIME; VIRUS CULTURE;

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 5;

ADENOVIRIDAE; AMMONIA; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; GENETIC VECTORS; GLUCOSE; GLUTAMINE; HUMANS; THREONINE; TIME FACTORS; VIRUS CULTIVATION;

EID: 24344450870     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.03.009     Document Type: Article

References (24)

1. C. Altamirano, C. Paredes, J.J. Cairo, and F. Godia Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine Biotechnol. Prog. 16 2000 69 75
2. F. Blanche, B. Cameron, A. Barbot, L. Ferrero, T. Guillemin, S. Guyot, S. Somarriba, and D. Bisch An improved anion-exchange HPLC method for the detection and purification of adenoviral particles Gene Ther. 7 2000 1055 1062
3. A. Christie, and M. Butler The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium Biotechnol. Bioeng. 64 1999 298 309
4. H.J. Cruz, A.S. Ferreira, C.M. Freitas, J.L. Moreira, and M.J. Carrondo Metabolic responses to different glucose and glutamine levels in baby hamster kidney cell culture Appl. Microbiol. Biotechnol. 51 1999 579 585
5. H.J. Cruz, C.M. Freitas, P.M. Alves, J.L. Moreira, and M.J. Carrondo Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells Enzyme Microb. Technol. 27 2000 43 52
6. A.J. Darling, J.A. Boose, and J. Spaltro Virus assay methods: accuracy and validation Biologicals 26 1998 105 110
7. C.B. Elias, E. Carpentier, Y. Durocher, L. Bisson, R. Wagner, and A. Kamen Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme Biotechnol. Prog. 19 2003 90 97
8. M. Eloit, and M. Adam Isogenic adenoviruses type 5 expressing or not expressing the E1A gene: efficiency as virus vectors in the vaccination of permissive and non-permissive species J. Gen. Virol. 76 1995 1583 1589
9. A. Garnier, J. Cote, I. Nadeau, A. Kamen, and B. Massie Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells Cytotechnology 15 1994 145 155
10. O. Henry, E. Dormond, M. Perrier, and A. Kamen Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures Biotechnol. Bioeng. 86 2004 765 774
11. B.G. Huyghe, X. Liu, S. Sutjipto, B.J. Sugarman, M.T. Horn, H.M. Shepard, C.J. Scandella, and P. Shabram Purification of a type 5 recombinant adenovirus encoding human p53 by column chromatography Hum. Gene Ther. 6 1995 1403 1416
12. P. Iyer, J.M. Ostrove, and D. Vacante Comparison of manufacturing techniques for adenovirus production Cytotechnology 30 1999 169 172
13. M. Jardon, and A. Garnier pH, pCO2, and temperature effect on R-adenovirus production Biotechnol. Prog. 19 2003 202 208
14. A. Kamen, and O. Henry Development and optimization of an adenovirus production process J. Gene Med. 6 Suppl. 1 2004 184 192
15. P. Matsudaira Methods in Enzymology 1990 Academic Press San Diego
16. A. McQueen, and J.E. Bailey Growth inhibition of hybridoma cells by ammonium ion: correlation with effects on intracellular pH Bioprocess. Eng. 6 1991 49 61
17. A. Mountain Gene therapy: the first decade Trends Biotechnol. 18 2000 119 128
18. I. Nadeau, A. Garnier, J. Côté, B. Massie, C. Chavarie, and A. Kamen Improvement of recombinant protein production with human adenovirus/293S expression system using fed-batch strategies Biotechnol. Bioeng. 51 1996 613 623
19. I. Nadeau, P.A. Gilbert, D. Jacob, M. Perrier, and A. Kamen Low-protein medium affects the 293SF central metabolism during growth and infection with adenovirus Biotechnol. Bioeng. 77 2002 91 104
20. I. Nadeau, D. Jacob, M. Perrier, and A. Kamen 293SF metabolic flux analysis during cell growth and infection with an adenoviral vector Biotechnol. Prog. 16 2000 872 884
21. I. Nadeau, and A. Kamen Production of adenovirus vector for gene therapy Biotechnol. Adv. 20 2003 475 489
22. I. Nadeau, J. Sabatie, M. Koehl, M. Perrier, and A. Kamen Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis Metab. Eng. 2 2000 277 292
23. D. Rea, F.H. Schagen, R.C. Hoeben, M. Mehtali, M.J. Havenga, R.E. Toes, C.J. Melief, and R. Offringa Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset J. Virol. 73 1999 10245 10253
24. ® cells and recombinant adenovirus production under different pH conditions Biotechnol. Bioeng. 80 2002 569 579