Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level

Gynecologic Oncology

Volumn 97, Issue 1, 2005, Pages 155-165

  Kurrey, N K ^a   Amit, K ^a   Bapat, S A ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Adherens junction; Desmosomal junction; EMT; Epithelial ovarian carcinoma; Hypoxia; Peritoneal dissemination; Slug; Snail; Tight junction

Indexed keywords

BETA CATENIN; OCCLUDIN; PROTEIN ZO1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENICITY; CELL ADHESION; CELL JUNCTION; CELL MIGRATION; CELL MOTILITY; CELL SURVIVAL; CONTROLLED STUDY; DESMOSOME; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TRANSCRIPTION INITIATION; UPREGULATION;

EID: 15544362735     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygyno.2004.12.043     Document Type: Article

References (37)

1. M. Daly, and G.I. Obrams Epidemiology and risk assessment for ovarian cancer Semin. Oncol. 25 1998 255 264
2. M. Schummer, P.J. Paley, L. Thompson, J. Stewart, M. Ford, and M. Crawford Analysis of ovarian tumor antigens reveals a bias antigens encoded on 17q Int. J. Cancer 184 2003 73 84
3. B. Boyer, A.M. Valles, and N. Edme Induction and regulation of epithelial-mesenchymal transitions Biochem. Pharmacol. 60 2000 1091 1099
4. P. Savagner Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition BioEssays 23 2001 912 923
5. G. Hennig, O. Lowrick, W. Birchmeier, and J. Behrens Mechanisms identified in the transcriptional control of epithelial gene expression J. Biol. Chem. 271 1996 595 602
6. X. Ji, A.S. Woodard, D.L. Rimm, and E.R. Fearon Transcriptional defects underlie loss of E-cadherin expression in breast cancer Cell. Growth Differ. 8 1997 773 778
7. K. Sugimachi, S. Tanaka, T. Kameyama, K. Taguchi, S. Aishima, and M. Shimada Transcriptional repressor snail and progression of human hepatocellular carcinoma Clin. Cancer Res. 9 2003 2657 2664
8. S.J. Grille, A. Bellacosa, J. Upson, A.J. Klein-Szanto, F. Van Roy, and W. Lee-Kwon The protein kinase Akt induces epithelial esenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines Cancer Res. 63 2003 2172 2178
9. M.J. Blanco, G. Moreno-Bueno, D. Sarrio, A. Locascio, A. Cano, and J. Palacios Correlation of snail expression with histological grade and lymph node status in breast carcinomas Oncogene 21 2002 3241 3246
10. K.M. Hajra, D.Y. Chen, and E.R. Fearon The SLUG zinc-finger protein represses E-cadherin in breast cancer Cancer Res. 62 2002 1613 1618
11. E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar, and J. Baulida The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nat. Cell Biol. 2 2000 84 89
12. V. Bolos, H. Peinado, M.A. Perez-Moreno, M.F. Fraga, M. Esteller, and A. Cano The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors J. Cell Sci. 116 2003 499 511
13. D. Dominguez, B. Montserrat-Sentis, A. Virgos-Soler, S. Guaita, J. Grueso, and M. Porta Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor Mol. Cell. Biol. 23 2003 5078 5089
14. H. Peinado, E. Ballestar, M. Esteller, and A. Cano Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex Mol. Cell. Biol. 24 2004 306 319
15. J. Ikenouchi, M. Matsuda, M. Furuse, and S. Tsukita Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail J. Cell Sci. 116 2003 1959 1967
16. T. Ohkubo, and M. Ozawa The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation J. Cell Sci. 117 2004 1675 1685
17. S. Guaita, I. Puig, C. Francí, M. Garrido, D. Domínguez, and E. Batlle Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression J. Biol. Chem. 277 2002 39209 39216
18. P. Savagner, K.M. Yamada, and J.P. Thiery The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition J. Cell. Biol. 137 1997 1403 1419
19. P. Savagner, D.F. Kusewitt, E.A. Carver, F. Magnino, C. Choi, and T. Gridley Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes J. Cell. Physiol. 202 2005 858 866
20. F. Valdes, A.M. Alvarez, A. Locascio, S. Vega, B. Herrera, and M. Fernandez The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes Mol. Cancer Res. 1 2002 68 78
21. S. Vega, A.V. Morales, O.H. Ocana, F. Valdes, I. Fabregat, and M.A. Nieto Snail blocks the cell cycle and confers resistance to cell death Genes Dev. 18 2004 1131 1143
22. J. Perez-Losada, M. Sanchez-Martin, M. Perez-Caro, P.A. Perez-Mancera, and I. Sanchez-Garcia The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug Oncogene 22 2003 4205 4211
23. J.J. Peluso, A. Pappalardo, and G. Fernandez E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity Biol. Reprod. 64 2001 1183 1190
24. A. Cano, M.A. Perez-Moreno, I. Rodrigo, A. Locascio, M.J. Blanco, and M.G. Del Barrio The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat. Cell Biol. 2 2000 76 83
25. R. Kalluri, and E.G. Neilson Epithelial-mesenchymal transition and its implications for fibrosis J. Clin. Invest. 112 2003 1776 1784
26. K. Kim, Z. Lu, and E.D. Hay Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT Cell Biol. Int. 26 2002 463 476
27. J. Perez-Losada, M. Sanchez-Martin, M. Perez-Caro, P.A. Perez-Mancera, and I. Sanchez-Garcia The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug Oncogene 22 2003 4205 4211
28. T. Imai, A. Horiuchi, C. Wang, K. Oka, S. Ohira, and T. Nikaido Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells Am. J. Pathol. 163 2003 1437 1447
29. K.R. Ward, K.X. Zhang, A.M. Somasiri, C.D. Roskelley, and J.W. Schrader Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis Oncogene 23 2004 1187 1196
30. P. Birner, M. Schindl, A. Obermair, G. Breitenecker, and G. Oberhuber Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy Clin. Cancer Res. 7 2001 1661 1668
31. P.J. Ratcliffe, J.F. O'Rourke, P.H. Maxwell, and C.W. Pugh Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression J. Exp. Biol. 201 1998 1153 1162
32. A. Horiuchi, T. Imai, M. Shimizu, K. Oka, C. Wang, and T. Nikaido Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells Anticancer Res. 22 2002 2697 2702
33. N. Auersperg, J. Pan, B.D. Grove, T. Peterson, J. Fisher, and S. Maines-Bandiera E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium Proc. Natl. Acad. Sci. U. S. A. 96 1999 6249 6254
34. A.S. Wong, S.L. Maines-Bandiera, B. Rosen, M.J. Wheelock, K.R. Johnson, and P.C. Leung Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer Int. J. Cancer 81 1999 180 188
35. M.J. Aybar, M.A. Nieto, and R. Mayor Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest Development 130 2003 483 494
36. M. Kajita, K.N. McClinic, and P.A. Wade Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress Mol. Cell. Biol. 24 2004 7559 7566
37. A. Locascio, M. Manzanares, M.J. Blanco, and M.A. Nieto Modularity and reshuffling of Snail and Slug expression during vertebrate evolution Proc. Natl. Acad. Sci. U. S. A. 99 2002 16841 16846