Epithelial-Mesenchymal Transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

Developmental Dynamics

Volumn 237, Issue 10, 2008, Pages 2755-2768

  Lou, Yuanmei ^a   Preobrazhenska, Olena ^a   Auf Dem Keller, Ulrich ^b   Sutcliffe, Margaret ^a   Barclay, Lorena ^a   McDonald, Paul C ^a   Roskelley, Calvin ^b   Overall, Christopher M ^b   Dedhar, Shoukat ^a,b  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Breast cancer; EMT; Imaging; Invasion; Migration; Spontaneous metastasis

Indexed keywords

NERVE CELL ADHESION MOLECULE; PROTEIN ZO1; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CELL MIGRATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENOTYPE; LUNG METASTASIS; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSPLANTATION; CHEMOTAXIS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; MESODERM; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS;

MURINAE;

EID: 54549108997     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21658     Document Type: Article

References (28)

1. Aslakson CJ, Miller FR. 1992. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 52:1399-1405.
2. Aslakson CJ, McEachern D, Conaway DH, Miller FR. 1991. Inhibition of lung colonization at two different steps in the metastatic sequence. Clin Exp Metastasis 9:139-150.
3. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. 2000. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2:84-89.
4. Brennan DJ, Jirstrom K, Kronblad A, Millikan RC, Landberg G, Duffy MJ, Ryden L, Gallagher WM, O'Brien SL. 2006. CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res 12:6421-6431.
5. Eckhardt BL, Parker BS, van Laar RK, Restall CM, Natoli AL, Tavaria MD, Stanley KL, Sloan EK, Moseley JM, Anderson RL. 2005. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol Cancer Res 3:1-13.
6. Hussain SA, Ganesan R, Reynolds G, Gross L, Stevens A, Pastorek J, Murray PG, Perunovic B, Anwar MS, Billingham L, James ND, Spooner D, Poole CJ, Rea DW, Palmer DH. 2007. Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. Br J Cancer 96:104-109.
7. Lee JM, Dedhar S, Kalluri R, Thompson EW. 2006. The epithelial- mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172:973-981.
8. Lee GY, Kenny PA, Lee EH, Bissell MJ. 2007. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 4:359-365.
9. Lelekakis M, Moseley JM, Martin TJ, Hards D, Williams E, Ho P, Lowen D, Javni J, Miller FR, Slavin J, Anderson RL. 1999. A novel orthotopic model of breast cancer metastasis to bone. Clin Exp Metastasis 17:163-170.
10. Locascio A, Nieto MA. 2001. Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr Opin Genet Dev 11:464-469.
11. Maeda M, Johnson KR, Wheelock MJ. 2005. Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci 118:873-887.
12. Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, Notorfrancesco KL, Cardiff RD, Chodosh LA. 2005. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8:197-209.
13. Nieto MA. 2002. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3:155-166.
14. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. 1998. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392:190-193.
15. Rainer J, Sanchez-Cabo F, Stocker G, Sturn A, Trajanoski Z. 2006. CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis. Nucleic Acids Res 34:W498-W503.
16. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE. 2006. Generation of a functional mammary gland from a single stem cell. Nature 439:84-88.
17. Somasiri A, Howarth A, Goswami D, Dedhar S, Roskelley CD. 2001. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci 114:1125-1136.
18. Talmadge JE. 2007. Clonal selection of metastasis within the life history of a tumor. Cancer Res 67:11471-11475.
19. Tarin D, Thompson EW, Newgreen DF. 2005. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 65:5996-6000; discussion 6000.
20. Thiery JP. 2002. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442-454.
21. Thiery JP, Sleeman JP. 2006. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131-142.
22. Thompson EW, Newgreen DF, Tarin D. 2005. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 65:5991-5995; discussion 5995.
23. Todaro GJ, Green H. 1963. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17:299-313.
24. Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J, Berra E. 2007. HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer 120:1451-1458.
25. Tusher VG, Tibshirani R, Chu G. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98:5116-5121.
26. Wu Q, Suo Z, Risberg B, Karlsson MG, Villman K, Nesland JM. 2004. Expression of Ephb2 and Ephb4 in breast carcinoma. Pathol Oncol Res 10:26-33.
27. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA. 2004. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117:927-939.
28. Yauch RL, Januario T, Eberhard DA, Cavet G, Zhu W, Fu L, Pham TQ, Soriano R, Stinson J, Seshagiri S, Modrusan Z, Lin CY, O'Neill V, Amler LC. 2005. Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res 11:8686-8698.