Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 11, 2009, Pages 4508-4516

  Murdolo, Giuseppe ^a,b   Hammarstedt, Ann ^a   Schmelz, Martin ^c   Jansson, Per Anders ^a   Smith, Ulf ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; INSULIN; MESSENGER RNA; OLIGOMER; PROTEIN; PROTEIN ERO1 L ALPHA; PROTEIN ERP44; UNCLASSIFIED DRUG;

ABDOMINAL SUBCUTANEOUS FAT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN RESISTANCE; INTERSTITIAL FLUID; MALE; MICRODIALYSIS; MOLECULAR WEIGHT; OBESITY; OLIGOMERIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 70449083221     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0431     Document Type: Article

References (46)

1. Hada Y, Yamauchi T, Waki H, Tsuchida A, Hara K, Yago H, Miyazaki O, Ebinuma H, Kadowaki T 2007 Selective purification and characterization of adiponectin multimer species from human plasma. Biochem Biophys Res Commun 356:487-493 (Pubitemid 46454397)
2. Basu R, Pajvani UB, Rizza RA, Scherer PE 2007 Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes 56:2174-2177 (Pubitemid 47195840)
3. Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT 2006 Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55:249-259 (Pubitemid 43343322)
4. Inoue T, Kotooka N, Morooka T, Komoda H, Uchida T, Aso Y, Inukai T, Okuno T, Node K 2007 High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am J Cardiol 100:569-574 (Pubitemid 47223129)
5. Wang Y, Lam KS, Yau MH, Xu A 2008 Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 409:623-633 (Pubitemid 351214189)
6. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K 2006 Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784-1792
7. Nakashima R, Kamei N, Yamane K, Nakanishi S, Nakashima A, Kohno N 2006 Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J Clin Endocrinol Metab 91:3873-3877 (Pubitemid 44536857)
8. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE 2004 Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279:12152-12162 (Pubitemid 38445780)
9. Schraw T, Wang ZV, Halberg N, Hawkins M, Scherer PE 2008 Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology 149:2270-2282 (Pubitemid 351574488)
10. Semple RK, Halberg NH, Burling K, Soos MA, Schraw T, Luan J, Cochran EK, Dunger DB, Wareham NJ, Scherer PE, Gorden P, O'Rahilly S 2007 Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes 56:1712-1717 (Pubitemid 46842611)
11. Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS 2005 Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem 280:18073-18080 (Pubitemid 41389052)
12. Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE 2007 Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 27:3716-3731 (Pubitemid 46726179)
13. Bogan JS, Lodish HF 1999 Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146:609-620
14. Qiang L, Wang H, Farmer SR 2007 Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα. Mol Cell Biol 27:4698-4707 (Pubitemid 47016124)
15. Hoffstedt J, Arvidsson E, Sjölin E, Wåhlén K, Arner P 2004 Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance. J Clin Endocrinol Metab 89:1391-1396 (Pubitemid 38368442)
16. Peake PW, Kriketos AD, Campbell LV, Shen Y, Charlesworth JA 2005 The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur J Endocrinol 153: 409-417 (Pubitemid 41410498)
17. Pasquali R 2006 Obesity and androgens: facts and perspectives. Fertil Steril 85:1319-1340
18. Abbasi F, Chu JW, Lamendola C, McLaughlin T, Hayden J, Reaven GM, Reaven PD 2004 Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 53:585-590 (Pubitemid 38270626)
19. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA 2001 Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935 (Pubitemid 32472900)
20. Koistinen HA, Forsgren M, Wallberg-Henriksson H, Zierath JR 2004 Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects. Obes Res 12:25-31 (Pubitemid 41137484)
21. Bodles AM, Banga A, Rasouli N, Ono F, Kern PA, Owens RJ 2006 Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab 291:E1100-E1105 (Pubitemid 44776763)
22. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y 2002 Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte- derived protein. Diabetes 51:2734-2741 (Pubitemid 34970926)
23. Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T 2004 Insulin/Foxo1 pathway regulates expression of adiponectin receptors and adiponectin sensitivity. J Biol Chem 279: 30817-30822 (Pubitemid 38938015)
24. Murdolo G, Hammarstedt A, Sandqvist M, Schmelz M, Herder C, Smith U, Jansson PA 2007 Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin. J Clin Endocrinol Metab 92:2688-2695 (Pubitemid 47037377)
25. Murdolo G, Herder C, Wang Z, Rose B, Schmelz M, Jansson PA 2008 In situ profiling of adipokines in subcutaneous microdialysates from lean and obese individuals. Am J Physiol Endocrinol Metab 295:E1095-E1105
26. Sopasakis VR, Sandqvist M, Gustafson B, Hammarstedt A, Schmelz M, Yang X, Jansson PA, Smith U 2004 High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. Obes Res 12:454-460 (Pubitemid 41132524)
27. Højbjerre L, Rosenzweig M, Dela F, Bruun JM, Stallknecht B 2007 Acute exercise increase adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol 157:613-623 (Pubitemid 350187378)
28. Smith U, Gogg S, Johansson A, Olausson T, Rotter V, Svalstedt B 2001 Thiazolidinediones (PPAR-γ agonists) but not PPAR-α agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes FASEB J 15:215-220
29. DeFronzo R, Tobin JB, Anders R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223 (Pubitemid 9249478)
30. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T 2003 Impaired multimerization ofhumanadiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin J Biol Chem 278:40352-40363
31. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE 2003 Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 278:9073-9085 (Pubitemid 36800387)
32. Hammarstedt A, Sopasakis VR, Gogg S, Jansson PA, Smith U 2005 Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects. Diabetologia 48:96-104 (Pubitemid 40174661)
33. Bobbert T, Wegewitz U, Brechtel L, Freudenberg M, Mai K, Möhlig M, Diederich S, Ristow M, Rochlitz H, Pfeiffer AF, Spranger J 2007 Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulin sensitivity. Int J Sports Med 28:1-8 (Pubitemid 46381854)
34. Lihn AS, Bruun JM, He G, Pedersen SB, Jensen PF, Richelsen B 2004 Lower expression of adiponectinmRNAin visceral adipose tissue in lean and obese subjects. Mol Cell Endocrinol 219:9-15 (Pubitemid 38638516)
35. Phillips SA, Ciaraldi TP, Oh DK, Savu MK, Henry RR 2008 Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose tissue. Am J Physiol Endocrinol Metab 295:E842-E850
36. Yang WS, Chen MH, Lee WJ, Lee KC, Chao CL, Huang KC, Chen CL, Tai TY, Chaung LM 2003 Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women. Int J Obes 27: 896-900 (Pubitemid 36918610)
37. Körner A, Wabitsch M, Seidel B, Fischer-Posovszky P, Berthold A, Stumvoll M, Blüher M, Kratzsch J, Kiess W 2005 Adiponectin expression inhumansis dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight. Biochem Biophys Res Commun 337:540-550 (Pubitemid 41429319)
38. Kahn BB, Flie JS 2000 Obesity and insulin resistance. J Clin Invest 106:473-481
39. Aso Y, Yamamoto R, Wakabayashi S, Uchida T, Takayanagi K, Takebayashi K, Okuno T, Inoue T, Node K, Tobe T, Inukai T, Nakano Y 2006 Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme- linked immunosorbent assay to detect HMW adiponectin. Diabetes 55:1954-1960 (Pubitemid 44509967)
40. Nishimura R, Morimoto A, Matsudaira T, Miyashita Y, Sano H, Shirasawa T, Takahashi E, Tajima N 2007 Ratio of high-, medium-, and low-molecular weight serum adiponectin to the total adiponectin value in children. J Pediatr 151:545-547, 547.e1-2
41. Smith U 2002 Impaired ("diabetic") insulin signaling and action occur in fat cells long before glucose intolerance. Is insulin resistance initiated in the adipose tissue? Int J Obes 26:897-904
42. Yang X, Jansson PA, Nagaev I, Jack MM, Carvalho E, Sunnerhagen KS, Cam MC, Cushman SW, Smith U 2004 Evidence of impaired adipigenesis un insulin resistance. Biochem Biophys Res Commun 317:1045-1051 (Pubitemid 38496415)
43. Bluher M, Williams CJ, Kloting N, Hsi A, Ruschke K, Oberbach A, Fasshauer M, Berndt J, Schon MR, Wolk A, Stumvoll M, Mantzoros CS 2007 Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training. Diabetes Care 30:3110-3115 (Pubitemid 350255258)
44. Jansson PA, Fowelin J, von Schenck H, Smith U, Lonnroth P 1993 Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin Diabetes 42:1469-1473
45. Pachler C, Ikeoka D, Plank J, Weinhadl H, Suppan M, Mader J, Bodenlenz M, Regitting W, Mangge H, Pieber T, Ellmerer M 2007 Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans Am J Physiol Endocrinol Metab 293: E690-E696
46. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S 2007 Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013 (Pubitemid 46525079)