Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: Characterization of interstitial concentration and regulation of gene expression by insulin

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 7, 2007, Pages 2688-2695

  Murdolo, Giuseppe ^a,b,e   Hammarstedt, Ann ^a   Sandqvist, Madeléne ^a   Schmelz, Martin ^c   Herder, Christian ^d   Smith, Ulf ^a   Jansson, Per Anders ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e Division of Endocrinology and Metabolism   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; INSULIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2;

ABDOMINAL FAT; ADULT; ARTERY COMPLIANCE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE CONTROL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; MALE; MICRODIALYSIS; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PULSE WAVE; SUBCUTANEOUS FAT; UPREGULATION;

EID: 34447114513     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2814     Document Type: Article

References (40)

1. Trayhurn P, Wood IS 2005 Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33:1078-1081
2. Murdolo G, Smith U 2006 The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis. Nutr Metab Cardiovasc Dis 16(Suppl 1):S35-S38
3. Gustafson B, Smith U 2006 Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281:9507-9516
4. Christiansen T, Richelsen B, Bruun JM 2005 Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) 29:146-150
5. Festa A, D'Agostino Jr R, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM 2001 The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 25:1407-1415
6. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H 2003 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
7. Rajala MW, Scherer PE 2003 Minireview: the adipocyte at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765-3773
8. Lonnroth P, Jansson P-A, Smith U 1987 A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol Endocrinol Metab 253:E228-E231
9. Sopasakis VR, Sandqvist M, Gustafson B, Hammarstedt A, Schmelz M, Yang X, Jansson P-A, Smith U 2004 High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. Obes Res 12:454-460
10. Rollins BJ 1997 Chemokines. Blood 90:909-928
11. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante Jr AW 2006 CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115-124
12. Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA 2005 Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54:2305-2313
13. Bruun JM, Lihn AS, Pedersen SB, Richelsen B 2005 Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 90:2282-2289
14. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa KI, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M 2006 MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505
15. Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T 2006 Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281:26602-26614
16. Gerhardt CC, Romero IA, Cancello R, Camoin L, Strosberg AD 2001 Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 175:81-92
17. Sartipy P, Loskutoff D 2003 Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 12:7265-7270
18. Sell H, Dietze-Schroeder D, Kaiser U, Eckel J 2006 Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. Endocrinology 147:2458-2467
19. Reape TJ, Groot PH 1999 Chemokines and atherosclerosis. Atherosclerosis 147:213-225
20. Piemonti L, Calori G, Mercalli A, Lattuada G, Monti P, Garancini MP, Costantino F, Ruotolo G, Luzi L, Perseghin G 2003 Fasting plasma leptin, tumor necrosis factor- receptor 2, and monocyte chemoattracting protein-1 concentration in a population of glucose-tolerant and glucose-intolerant women. Diabetes Care 26:2883-2889
21. Fain JN, Madan AK 2005 Regulation of monocyte chemoattractant protein 1 (MCP-1) release by explants of human visceral adipose tissue. Int J Obes (Lond) 29:1299-1307
22. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S 2001 Insulin inhibits intranuclear nuclear factor κB and stimulates IκB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 86:3257-3265
23. Smith U, Gogg S, Johansson A, Olausson T, Rotter V, Svalstedt B 2001 Thiazolidinediones (PPARγ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes. FASEB J 15:215-220
24. Sjostrand M, Holmang A, Lonnroth P 1999 Measurement of interstitial insulin in human muscle. Am J Physiol Endocrinol Metab 276:E151-E154
25. Jansson P-A, Fowelin JP, von Schenck HP, Smith U, Lonnroth PN 1993 Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin. Diabetes 42:1469-1473
26. De Fronzo R, Tobin JB, Anders R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
27. O'Rourke MF, Gallagher DE 1996 Pulse wave analysis. J Hypertens Suppl 14:S147-S157
28. Wilkinson IB, McCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ 2000 The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol 525:263-270
29. Dahlman I, Kaaman M, Olsson T, Tan GD, Bickerton AST, Wåhlén K, Andersson J, Arvidsson Nordström E, Blomqvist L, Sjögren A, Forsgren M, Attersand A, Arner P 2005 A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 90:5834-5840
30. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 82:4196-4200
31. Yudkin JS, Coppack SW, Bulmera K, Rawesha A, Mohamed-Ali V 1999 Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo. Thromb Res 96:1-9
32. Deo R, Khera A, McGuire DK, Murphy SA, Meo Neto JP, Morrow DA, De Lemos JA 2004 Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis. J Am Coll Cardiol 44:1812-1818
33. Herder C, Muller-Scholze S, Rating P, Koenig W, Thorand B, Haastert B, Holle R, Illig T, Rathmann W, Seissler J, Wichmann HE, Kolb H 2006 Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4). Eur J Endocrinol 154:311-317
34. Herder C, Baumert J, Thorand B, Martin S, Löwel H, Kolb H, Koenig W 2006 Chemokines and incident coronary heart disease: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002. Arterioscler Thromb Vasc Biol 26:2147-2152
35. Confalonieri P, Bernasconi P, Megna P, Galbiati S, Cornelio F, Mantegazza R 2000 Increased expression of β-chemokines in muscle of patients with inflammatory myopathies. J Neuropathol Exp Neurol 59:164-169
36. Bruun JM, Helge JW, Richelsen B, Stallknecht B 2006 Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 290:E961-E967
37. Smith U 2002 Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance. Is insulin resistance initiated in the adipose tissue? Int J Obes Relat Metab Disord 26:897-904
38. Nair S, Lee YH, Rousseau E, Cam M, Tataranni PA, Baier LJ, Bogardus C, Permana PA 2005 Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with nonobese Pima Indians. Diabetologia 48:1784-1788
39. Garg A 2004 Regional adiposity and insulin resistance. J Clin Endocrinol Metab 89:4206-4210
40. Fontana L, Eagon CJ, Trujillo ME, Scherer PE, Klein S 2007 Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013