PET-based reporter gene imaging

IEEE Engineering in Medicine and Biology Magazine

Volumn 23, Issue 4, 2004, Pages 38-50

  Doubrovin, Michael ^a   Ponomarev, Vladimir ^a,b   Blasberg, Ronald G ^c,d  

^a MSKCC   (United States)

^b Department of Radiology ^*

^c Memorial Hospital   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 FLUOROETHYL)SPIPERONE F 18; BIOLOGICAL MARKER; CYTOSINE DEAMINASE; FLUCYTOSINE; FLUORODEOXYGLUCOSE F 18; GANCICLOVIR; PENTETREOTIDE IN 111; PERTECHNETIC ACID TC 99M; PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; XANTHINE PHOSPHORIBOTRANSFERASE; XANTHOSINE 5 PHOSPHATE;

GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; HUMAN; IMAGING; ISOTOPE LABELING; MOLECULAR GENETICS; MOLECULAR IMAGING; MOLECULAR STABILITY; POSITRON EMISSION TOMOGRAPHY; PROTEIN PROTEIN INTERACTION; REPORTER GENE; REVIEW;

ANIMALS; BIOLOGICAL MARKERS; CELL PHYSIOLOGY; GENE EXPRESSION PROFILING; GENES, REPORTER; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; ISOTOPE LABELING; MOLECULAR BIOLOGY; POSITRON-EMISSION TOMOGRAPHY;

EID: 7044255078     PISSN: 07395175     EISSN: None     Source Type: Journal    
DOI: 10.1109/MEMB.2004.1337948     Document Type: Review

References (113)

1. K.J. Harrington, E. Linardakis, and R.G. Vile, "Transcriptional control: An essential component of cancer gene therapy strategies," Advanced Drug Delivery Reviews, vol. 44, pp. 167-184, Nov. 2000.
2. M. Fussenegger, "The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies," Biotechnology Progress, vol. 17, pp. 1-51, Jan.-Feb. 2001.
3. S. Nakagawa, B. Massie, and R.G. Hawley, "Tetracycline-regulatable adenovirus vectors: Pharmacologic properties and clinical potential," Eur. J. Pharmaceutical Sci., vol. 13, pp. 53-60, Apr. 2001.
4. R. Weissleder, P. Reimer, A.S. Lee, J. Wittenberg, and T.J. Brady, "MR receptor imaging: Ultrasmall iron oxide particles targeted to asialoglycoprotein receptors," Amer. J. Roentgenol., vol. 155, pp. 1161-1167, Dec. 1990.
5. R. Weissleder, A.S. Lee, A.J. Fischman, P. Reimer, T. Shen, R. Wilkinson, R.J. Callahan, and T.J. Brady, "Polyclonal human immunoglobulin G labeled with polymeric iron oxide: Antibody MR imaging," Radiology, vol. 181, pp. 245-249, Oct. 1991.
6. J.F. Kayyem, R.M. Kumar, S.E. Fraser, and T.J. Meade, "Receptor-targeted co-transport of DNA and magnetic resonance contrast agents," Chem. Biol., vol. 2, pp. 615-620, Sept. 1995.
7. R. Weissleder, M. Simonova, A. Bogdanova, S. Bredow, W.S. Enochs, and A. Bogdanov, "MR imaging and scintigraphy of gene expression through melanin induction," Radiology, vol. 204, pp. 425-429, Aug. 1997.
8. A.Y. Louie, M.M. Huber, E.T. Ahrens, U. Rothbacher, R. Moats, R.E. Jacobs, S.E. Fraser, and T.J. Meade, "In vivo visualization of gene expression using magnetic resonance imaging," Natl. Biotechnol., vol. 18, pp. 321-325, Mar. 2000.
9. J.G. Tjuvajev, G. Stockhammer, R. Desai, H. Uehara, H. Watanabe, B. Gansbacher, and R.G. Blasberg, "Imaging the expression of transfected genes in vivo," Cancer Res., vol. 55, pp. 6126-6132, Dec. 1995.
10. J.G. Tjuvajev, R. Finn, K. Watanabe, R. Joshi, T. Oku, J. Kennedy, B. Beattie, J. Koutcher, S. Larson, and R.G. Blasberg, "Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy," Cancer Res., vol. 56, pp. 4087-4095, Sept. 1996.
11. J.G. Tjuvajev, N. Avril, T. Oku, T. Sasajima, T. Miyagawa, R. Joshi, M. Safer, B. Beattie, G. DiResta, F. Daghighian, F. Augensen, J. Koutcher, J. Zweit, J. Humm, S.M. Larson, R. Finn, and R. Blasberg, "Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography," Cancer Res., vol. 58, pp. 4333-4341, Oct. 1998.
12. S.S. Gambhir, J.R. Barrio, L. Wu, M. Iyer, M. Namavari, N. Satyamurthy, E. Bauer, C. Parrish, D.C. MacLaren, A.R. Borghei, L.A. Green, S. Sharfstein, A.J. Berk, S.R. Cherry, M.E. Phelps, and H.R. Herschman, "Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir," J. Nucl. Med., vol. 39, pp. 2003-2011, Nov. 1998.
13. S.S. Gambhir, J.R. Barrio, M.E. Phelps, M. Iyer, M. Namavari, N. Satyamurthy, L. Wu, L.A. Green, E. Bauer, D.C. MacLaren, K. Nguyen, A.J. Berk, S.R. Cherry, and H.R. Herschman, "Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography," Proc. Natl. Acad. Sci. USA., vol. 96, pp. 2333-2338, Nov. 1998.
14. R. Mayerhofer, K. Araki, and A.A. Szalay, "Monitoring of spatial expression of firefly luciferase in transformed zebrafish," J. Biolumin. Chemilumin., vol. 10, pp. 271-275, Sept.-Oct. 1995.
15. J. Bennett, D. Duan, J.F. Engelhardt, and A.M. Maguire, "Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction," Investigative Ophthalmology & Visual Sci., vol. 38, pp. 2857-2863, Dec. 1997.
16. A. Rehemtulla, L.D. Stegman, S.J. Cardozo, S. Gupta, D.E. Hall, C.H. Contag, and B.D. Ross, "Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging," Neoplasia, vol. 2, pp. 491-495, Nov.-Dec. 2000.
17. F.A. Jaffer, C.H. Tung, R.E. Gerszten, and R. Weissleder, "In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe," Arterioscler Thromb. Vasc. Biol., vol. 22, pp. 1929-1935, Nov. 2002.
18. R. Haubner, H.J. Wester, W.A. Weber, C. Mang, S.I. Ziegler, S.L. Goodman, R. Senekowitsch-Schmidtke, H. Kessler, and M. Schwaiger, "Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography," Cancer Res., vol. 61, pp. 1781-1785, Mar. 2001.
19. M.K. Dewanjee, A.K. Ghafouripour, M. Kapadvanjwala, S. Dewanjee, A.N. Serafini, D.M. Lopez, and G.N. Sfakianakis, "Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model," J. Nucl. Med., vol. 35, pp. 1054-1063, Jun. 1994.
20. S. Cammilleri, S. Sangrajrang, B. Perdereau, F. Brixy, F. Calvo, H. Bazin, and H. Magdelenat, "Biodistribution of iodine-125 tyramine transforming growth factor alpha antisense oligonucleotide in athymic mice with a human mammary tumour xenograft following intratumoral injection," Eur. J. Nucl. Med., vol. 23, pp. 448-452, Apr. 1996.
21. J.A. Phillips, S.J. Craig, D. Bayley, R.A. Christian, R. Geary, and P.L. Nicklin, "Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A) after intravenous and subcutaneous administration," Biochem. Pharmacol., vol. 54, pp. 657-668, Sept. 1997.
22. B. Tavitian, S. Terrazzino, B. Kuhnast, S. Marzabal, O. Stettler, F. Dolle, J.R. Deverre, A. Jobert, F. Hinnen, B. Bendriem, C. Crouzel, and L. Di Giamberardino, "In vivo imaging of oligonucleotides with positron emission tomography," Natl. Med., vol. 4, pp. 467-471, Apr. 1998.
23. G.D. Demetri, M. von Mehren, C.D. Blanke, A.D. Van den Abbeele, B. Eisenberg, P.J. Roberts, M.C. Heinrich, D.A. Tuveson, S. Singer, M. Janicek, J.A. Fletcher, S.G. Silverman, S.L. Silberman, R. Capdeville, B. Kiese, B. Peng, S. Dimitrijevic, B.J. Druker, C. Corless, C.D. Fletcher, and H. Joensuu, "Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors," New Eng. J. Med., vol. 347, pp. 472-480, Aug. 2002.
24. A.D. Van den Abbeele (for the GIST Collaborative PET Study Group, Dana-Farber Cancer Institute, Boston, MA; OSU, Portland, OR; Helsinki University Central Hospital, Turku University Central Hospital, Finland; Novartis Oncology), "F18-FDG-PET provides early evidence of biological response to ST1571 patients with malignant gastrontestinal stromal tumors (GIST)," Proc. Amer. Soc. Clin. Oncol., vol. 20, p. 362a, 2001.
25. K.A. Frauwirth, J.L. Riley, M.H. Harris, R.V. Parry, J.C. Rathmell, D.R. Plas, R.L. Elstrom, C.H. June, and C.B. Thompson, "The CD28 signaling pathway regulates glucose metabolism," Immunity, vol. 16, pp. 769-777, Jun. 2002.
26. T. Peng, T.R. Golub, and D.M. Sabatini, "The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation," Mol. Cell. Biol., vol. 22, pp. 5575-5584, Aug. 2002.
27. J.G. Tjuvajev, A. Joshi, J. Callegari, L. Lindsley, R. Joshi, J. Balatoni, R. Finn, S.M. Larson, M. Sadelain, and R.G. Blasberg, "A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase," Neoplasia, vol. 1, pp. 315-320, Oct. 1999.
28. Y. Yu, A.J. Annala, J.R. Barrio, T. Toyokuni, N. Satyamurthy, M. Namavari, S.R. Cherry, M.E. Phelps, H.R. Herschman, and S.S. Gambhir, "Quantification of target gene expression by imaging reporter gene expression in living animals," Natl. Med., vol. 6, pp. 933-937, Aug. 2000.
29. M. Doubrovin, V. Ponomarev, T. Beresten, J. Balatoni, W. Bornmann, R. Finn, J. Humm, S. Larson, M. Sadelain, R. Blasberg, and J. Gelovani Tjuvajev, "Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo," Proc. Natl. Acad. Sci., USA, vol. 98, pp. 9300-9305, Jul. 2001.
30. V. Ponomarev, M. Doubrovin, C. Lyddane, T. Beresten, J. Balatoni, W. Bornman, R. Finn, T. Akhurst, S. Larson, R. Blasberg, M. Sadelain, and J.G. Tjuvajev, "Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo," Neoplasia, vol. 3, pp. 480-488, Nov.-Dec. 2001.
31. J.G. Tjuvajev, M. Doubrovin, T. Akhurst, S. Cai, J. Balatoni, M.M. Alauddin, R. Finn, W. Bornmann, H. Thaler, P.S. Conti, and R.G. Blasberg, "Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression," J. Nucl. Med., vol. 43, pp. 1072-1083, Aug. 2002.
32. J.J. Min, M. Iyer, and S.S. Gambhir, "Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: Adenoviral infection vs stable transfection," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, pp. 1547-1560, Nov. 2003.
33. S.S. Gambhir, E. Bauer, M.E. Black, Q. Liang, M.S. Kokoris, J.R. Barrio, M. Iyer, M. Namavari, M.E. Phelps, and H.R. Herschman, "A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography," Proc. Natl. Acad. Sci., USA, vol. 97, pp. 2785-2790, Mar. 2000.
34. J. Wang, C. Su, J. Neuhard, and S. Eriksson, "Expression of human mitochondrial thymidine kinase in Escherichia Coli: Correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth," Biochem. Pharmacol., vol. 53, pp. 1583-1588, Jun. 2000.
35. A. Jacobs, J. Voges, R. Reszka, M. Lercher, A. Gossmann, L. Kracht, C. Kaestle, R. Wagner, K. Wienhard, and W.D. Heiss, "Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas," Lancet, vol. 358, pp. 727-729, Sept. 2001.
36. 18F]FHBG: A reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression," J. Nucl. Med., vol. 42, pp. 1225-1234, Aug. 2001.
37. M. Doubrovin, V. Ponomarev, I. Serganova, S. Soghomoyan, T. Miyagawa, T. Beresten, L. Ageyeva, M. Sadelain, J. Koutcher, R.G. Blasberg, and J. Gelovani-Tjuyajev, "Development of a new reporter gene system-dsRed/Xanthne phosphoribosyltransferase-Xanthine for molecular imaging of processes behind the intact blood-brain barrier," Molecular Imaging, vol. 2, pp. 93-112, Apr. 2003.
38. D.C. MacLaren, S.S. Gambhir, N. Satyamurthy, J.R. Barrio, S. Sharfstein, T. Toyokuni, L. Wu, A.J. Berk, S.R. Cherry, M.E. Phelps, and H.R. Herschman, "Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals," Gene Ther., vol. 6, pp. 785-791, May 1999.
39. 18F]fluoroethyl)spiperone in vivo biochemical and kinetic characterization in rodents, non-human primates, and humans," J. Cerebral Blood Flow and Metabolism, vol. 9, pp. 830-839, Dec. 1989.
40. B.E. Rogers, S.F. McLean, R.L. Kirkman, D. Della Manna, S.J. Bright, C.C. Olsen, A.D. Myracle, M.S. Mayo, D.T. Curiel, and D.J. Buchsbaum, "In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector," Clin. Cancer Res., vol. 5, pp. 383-393, Feb. 1999.
41. B.E. Rogers, K.R. Zinn, and D.J. Buchsbaum, "Gene transfer strategies for improving radiolabeled peptide imaging and therapy," Q J. Nucl. Med., vol. 44, no. 3, pp. 208-223, Sept. 2000.
42. E. Ur, J. Bomanji, S.J. Mather, K.E. Britton, J.A. Wass, A.B. Grossman, and G.M. Besser, "Localization of neuroendocrine tumours and insulinomas using radiolabeled somatostatin analogues, 123I-Tyr3-octreotide and 111In-pentatreotide," Clin Endocrinol. (Oxf.), vol. 38, pp. 501-506, May 1993.
43. U. Haberkorn, M. Henze, Altmann, S. Jiang, I. Morr, M. Mahmut, P. Peschke, W. Kubler, J. Debus, and M. Eisenhut, "Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells," J. Nucl. Med., vol. 42, pp. 317-325, Feb. 2001.
44. A. Altmann, M. Kissel, S. Zitzmann, W. Kübler, M. Mahmut, P. Peschke, and U. Haberkorn, "Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma," J. Nucl. Med., vol. 44. pp. 973-980, Jun. 2003.
45. C.H. Contag, D. Jenkins, P.R. Contag, and R.S. Negrin, "Use of reporter genes for optical measurements of neoplastic disease in vivo" Neoplasia, vol. 2, pp. 41-52, Jan.-Apr. 2000.
46. J. Ellenberg, J. Lippincott Schwartz, and J.F. Presley, "Dual-colour imaging with GFP variants," Trends Cell Biol., vol. 9, pp. 52-56, Feb. 1999.
47. M.M. Falk and U. Lauf, "High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells," Microsc. Res. Tech., vol. 52, pp. 251-262, Feb. 2001.
48. A.K. Hadjantonakis and A. Nagy, "The color of mice: In the light of GFP-variant reporters," Histochem. Cell Biol., vol. 115, pp. 49-58, Jan. 2001.
49. A.K. Lalwani, J.J. Han, B.J. Walsh, S. Zolotukhin, N. Muzyczka, and A.N. Mhatre, "Green fluorescent protein as a reporter for gene transfer studies in the cochlea," Hear Res., vol. 114, pp. 139-147, Dec. 1997.
50. J.P. Levy, R.R. Muldoon, S. Zolotukhin, and C.J. Link, Jr., "Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells," Nat Biotechnol., vol. 14, pp. 610-614, May 1996.
51. Y.A. Labas, N.G. Gurskaya, Y.G. Yanushevich, A.F. Fradkov, K.A. Lukyanov, S.A. Lukyanov, and M.V. Matz, "Diversity and evolution of the green fluorescent protein family," Proc. Natl. Acad. Sci. USA., vol. 99, pp. 4256-4261, Apr. 2002.
52. M. Matz, M.V. Matz, A.F. Fradkov, Y.A. Labas, A.P. Savitsky, A.G. Zaraisky, M.L. Markelov, and S.A. Lukyanov, "Fluorescent proteins from nonbioluminescent Anthozoa species," Nat Biotechnol., vol. 17, no. 10, pp. 969-973, Oct. 1999; Erratum in: Nat Biotechnol., vol. 17, pp. 1227, Dec. 1999.
53. M. Matz, M.V. Matz, A.F. Fradkov, Y.A. Labas, A.P. Savitsky, A.G. Zaraisky, M.L. Markelov, and S.A. Lukyanov, "Fluorescent proteins from nonbioluminescent Anthozoa species," Nat Biotechnol., vol. 17, no. 10, pp. 969-973, Oct. 1999; Erratum in: Nat Biotechnol., vol. 17, pp. 1227, Dec. 1999.
54. R.E. Campbell, O. Tour, A.E. Palmer, P.A. Steinbach, G.S. Baird, D.A. Zacharias, and R.Y. Tsien, "A monomeric red fluorescent protein," PNAS, vol. 99, pp. 7877-7882, Jun. 2002.
55. S. Mathieu and A. El-Battari, "Monitoring E-selectin-mediated adhesion using green and red fluorescent proteins," J. Immunol Methods, vol. 272, pp. 81-92, Jan. 2003.
56. N.G. Gurskaya, A.F. Fradkov, A. Terskikh, M.V. Matz, Y.A. Labas, V.I. Martynov, Y.G. Yanushevich, K.A. Lukyanov, and S.A. Lukyanov, "GFP-like chromoproteins as a source of far-red fluorescent proteins," FEBS Lett., vol. 507, pp. 16-20, Oct. 2001.
57. M. Yang, E. Baranov, P. Jiang, F. Sun, X.M. Li, L.N. Li, S. Hasegawa, M. Bouvet, M. Al Tuwaijri, T. Chishima, H. Shimada, A.R. Moossa, S. Penman, and R.M. Hoffman, "Whole-body optical imaging of green fluorescent protein expressing tumors and metastases," PNAS, vol. 97, pp. 1206-1211, Feb. 2000.
58. Y.A. Yu, T. Timiryasova, Q. Zhang, R. Beltz, and A.A. Szalay, "Optical imaging: Bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals," Anal. Bioanal. Chem., vol. 377, pp. 964-972, Jul. 2003.
59. J.C. Wu, M. Inubushi, G. Sundaresan, H.R. Schelbert, and S.S. Gambhir, "Optical imaging of cardiac reporter gene expression in living rats," Circulation, vol. 105, pp. 1631-1634, Apr. 2002.
60. S. Bhaumik and S. Gambhir, "Optical imaging of renilla luciferase reporter gene expression in living mice," PNAS, vol. 99, pp. 377-382, Jan. 2002.
61. M. Vooijs, J. Jonkers, S. Lyons, and A. Berns, "Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice," Can. Res., vol. 62, pp. 1862-1867, Mar. 2002.
62. T. Wilson and J.W. Hastings, "Bioluminescence," Ann. Rev. Cell Dev. Biol., vol. 14, pp. 197-230, Nov. 1998.
63. S.V. Markova, E.S. Vysotski, J.R. Blinks, L.P. Burakova, B.C. Wang, and J. Lee, "Obelin from thebioluminescent marine hydroid Obelia geniculata: Cloning, expression, and comparison of some properties with those of other Ca2+-regulatedphotoproteins," Biochemistry, vol. 41, pp. 2227-2236, Feb. 2002.
64. M. Verhaegent and T.K. Christopoulos, "Recombinant Gaussia luciferase. Overexpression, purification, and analytical application of a bioluminescent reporter for DNA hybridization," Anal. Chem., vol. 74, pp. 4378-4385, Sept. 2002.
65. T. Wilson, "Comments on the mechanisms of chemi-and bioluminescence," Photochem Photbio, vol. 62, pp. 601-606, 1995.
66. A. Jacobs, M. Doubrovin, J. Hewett, M. Sena-Esteves, C.W. Tan, M. Slack, M. Sadelain, X.O. Breakefield, and J.G. Tjuvajev, "Functional co-expression of HSV-1 thymidine kinase and green fluorescent protein: Implications for noninvasive imaging of transgene expression," Neoplasia, vol. 1, pp. 154-161, Jun. 1999.
67. P. Ray, A.M. Wu, and S.S. Gambhir, "Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice," Cancer Res., vol. 63, pp. 1160-1165, Mar. 2003.
68. S. Hasegawa, M. Yang, T. Chishima, Y. Miyagi, H. Shimada, A.R. Moossa, and R.M. Hoffman, "In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis," Cancer Gene Therapy, vol. 7, pp. 1336-1334, Oct. 2000.
69. R.M. Hoffman, "Visualization of GFP-expressing tumors and metastasis in vivo," Biotechniques, vol. 30, pp. 1016-1022, May 2001.
70. V. Ponomarev, M. Doubrovin, I. Serganova, T. Beresten, J. Vider, A. Shavrin, L. Ageyeva, J. Balatoni, R. Blasberg, and J.G. Gelovani-Tjuvajev, "Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging," Neoplasia, vol. 5, pp. 245-254, May 2003.
71. J.L. Cohen, O. Boyer, B. Salomon, R. Onclerco, D. Depetris, L. Lejeune, V. Dubus Bonnet, S. Bruel, F. Charlotte, M.G. Mattei, and D. Klatzmann, "Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene," Transgenic Res., vol. 7, pp. 321-330, Sept. 1998.
72. C. Cowsill, T.D. Southgate, G. Morrissey, R.A. Dewey, A.E. Morelli, T.C. Maleniak, Z. Forrest, D. Klatzmann, G.W. Wilkinson, P.R. Lowenstein, and M.G. Castro, "Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: Reduced cytotoxicity of a truncated HSV1-TK," Gene Ther., vol. 7, pp. 679-685, Apr. 2000.
73. B. Salomon, S. Maury, L. Loubiere, M. Caruso, R. Onclercq, and D. Klatzmann, "A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice," Mol. Cell Biol., vol. 15, pp. 5322-5328, Oct. 1995.
74. S. Pelletier, "Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA," Nature, vol. 334, pp. 320-325, 1988.
75. A.B. Sachs, P. Sarnow, and M.W. Hentze, "Starting at the Beginning, Middle, and End Translation Initiation in Eukaryotes," Cell, vol. 89, pp. 831-838, Jun. 1997.
76. B.E. Rogers, K.R. Zinn, and D.J. Buchsbaum, "Gene transfer strategies for improving radiolabeled peptide imaging and therapy," Q. J. Nucl. Med., vol. 44, pp. 208-223, Sept. 2000.
77. Y. Yu, A.J. Annala, J.R. Barrio, T. Toyokuni, N. Satyamurthy, M. Namavari, S.R. Cherry, M.E. Phelps, H.R. Herschman, and S.S. Gambhir, "Quantification of target gene expression by imaging reporter gene expression in living animals," Nat. Med., vol. 6, pp. 933-937, Aug. 2000.
78. V.A. Kolb, E.V. Makeyev, and A.S. Spirin, "Co-translational folding of an eukaryotic multidomain protein in a prokaryotic translation system," J. Biol. Chem., vol. 275, pp. 16597-16601, Jun. 2000.
79. J.F. Thompson, L.S. Hayes, and D.B. Lloyd, "Modulation of firefly luciferase stability and impact on studies of gene regulation," Gene, vol. 103, pp. 171-177, Jul. 1991.
80. R.N. Day, M. Kawecki, and D. Berry, "Dual function reporter protein for analysis of gene expression in living cells," Biotechnology, vol. 25, pp. 852-854, Nov. 1998.
81. V. Ponomarev, D. Doubrovin, I. Serganova, J. Vider, A. Shavrin, T. Beresten, A. Ivanova, L. Ageyeva, V. Tourkova, J. Balatoni, W. Bornmann, R. Blasberg, and J. Gelovani-Tjuvajev, "A novel triple modality reporter gene for whole body fluorescent, bioluminescent and nuclear non-invasive imaging, " Eur. J. Nuc. Med. (In press).
82. A. Bogdanov Jr. and R. Weissleder, "The development of in vivo imaging systems to study gene expression," Trends Biotechnol., vol. 16, pp. 5-10, Jan. 1998.
83. R. Weissleder and U. Mahmood, "Molecular imaging," Radiology, vol. 219, pp. 316-333, May 2001.
84. M. Rudin and R. Weissleder, "Molecular imaging in drug discovery and development," Nat. Rev. Drug. Discov., vol. 2, pp. 123-131, Feb. 2003.
85. L.D. Stegman, A. Rehemtulla, B. Beattie, E. Kievit, T.S. Lawrence, R.G. Blasberg, J.G. Tjuvajev, and B.D. Ross, "Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy," Proc. Natl. Acad. Sci. USA., vol. 96, pp. 9821-9826, Aug. 1999.
86. T. Hackman, M. Doubrovin, J. Balatoni, T. Beresten, V. Ponomarev, B. Beattie, R. Finn, W. Bornmann, R. Blasberg, and J.G. Tjuvajev, "Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET," Mol. Imaging, vol. 1, pp. 36-42, Jan.-Mar. 2002.
87. A. Rehemtulla, D.E. Hall, L.D. Stegman, U. Prasad, G. Chen, M.S. Bhojani, T.L. Chenevert, and B.D. Ross, "Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy," Mol. Imaging, vol. 1, pp. 43-55, Jan.-Mar. 2002.
88. P. Mayer-Kuckuk, D. Banerjee, S. Malhotra, M. Doubrovin, M. Iwamoto, T. Akhurst, J. Balatoni, W. Bornmann, R. Finn, S. Larson, Y. Fong, J. Gelovani Tjuvajev, R. Blasberg, and J.R. Bertino, "Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression," PNAS, vol. 99, pp. 3400-3405, Mar. 2002.
89. P. Ray, H. Pimenta, R. Paulmurugan, F. Berger, M.E. Phelps, M. Iyer, and S.S. Gambhir, "Noninvasive quantitative imaging of protein-protein interactions in living subjects," Proc. Natl. Acad. Sci, vol. 99, pp. 3105-3110, Mar. 2002.
90. G.D. Luker, V. Sharma, C.M. Pica, J.L. Dahlheimer, W. Li, J. Ochesky, C.E. Ryan, H. Piwnica-Worms, and D. Piwnica-Worms, "Noninvasive imaging of protein-protein interactions in living animals," Proc. Natl. Acad. Sci., USA, vol. 99, pp. 6961-6966, May 2002.
91. G.D. Luker, V. Sharma, C.M. Pica, J.L. Prior, W. Li, and D. Piwnica-Worms, "Molecular imaging of protein-protein interactions: Controlled expression of p53 and large T-antigen fusion proteins in vivo," Cancer Res., vol. 63, pp. 1780-1788, Apr. 2003.
92. G.D. Luker, C.M. Pica, J. Song, K.E. Luker, and D. Piwnica-Worms, "Imaging 26S proteasome activity and inhibition in living mice," Nat. Med., vol. 9, no. 7, pp. 969-973, Jul. 2003.
93. B. Laxman, D.E. Hall, M.S. Bhojani, D.A. Hamstra, T.L. Chenevert, B.D. Ross, and A. Rehemtulla, "Noninvasive real-time imaging of apoptosis," Proc. Natl. Acad. Sci., USA, vol. 99, pp. 16551-16555, Dec. 2002.
94. S.S. Gambhir, J.R. Barrio, M.E. Phelps, M. Iyer, M. Namavari, N. Satyamurthy, L. Wu, L.A. Green, E. Bauer, D.C. MacLaren, K. Nguyen, A.J. Berk, S.R. Cherry, and H.R. Herschman, "Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography," Proc. Natl. Acad. Sci., USA., vol. 96, pp. 2333-2338, Mar. 1999.
95. J.G. Tjuvajev, S.H. Chen, A. Joshi, R. Joshi, Z.S. Guo, J. Balatoni, D. Ballon, J. Koutcher, R. Finn, S.L. Woo, and R.G. Blasberg, "Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo," Cancer Res., vol. 59, pp. 5186-5193, Oct. 1999.
96. J. Tjuvajev, R. Blasberg, X. Luo, L.M. Zheng, I. King, and D. Bermudes, "Salmonella-based tumor-targeted cancer therapy. Tumor amplified protein expression therapy (TAPET) for diagnostic imaging," J. Control Release, vol. 74, pp. 313-315, Jul. 2001.
97. G. Koehne, M. Doubrovin, E. Doubrovina, P. Zanzonico, H.F. Gallardo, A. Ivanova, J. Balatoni, J. Teruya-Feldstein, G. Heller, C. May, V. Ponomarev, S. Ruan, R. Finn, R.G. Blasberg, W. Bornmann, I. Riviere, M. Sadelain, R.J. O'Reilly, S.M. Larson, and J.G. Tjuvajev, "Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes," Nat. Biotechnol., vol. 21, pp. 405-413, Apr. 2003.
98. N.C. Krak, J.J. van der Hoeven, O.S. Hoekstra, J.W. Twisk, E. van der Wall, and A.A. Lammertsma, "Measuring [(18)F]FDG uptake in breast cancer during chemotherapy: Comparison of analytical methods," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, pp. 674-681, May 2003.
99. S. Stroobants, J. Goeminne, M. Seegers, S. Dimitrijevic, P. Dupont, J. Nuyts, M. Martens, B. van den Borne, P. Cole, R. Sciot, H. Dumez, S. Silberman, L. Mortelmans, and A. van Oosterom, "18FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Gleevec)," Eur. J. Cancer., vol. 39, pp. 2012-2020, Sept. 2003.
100. S. Froidevaux and A.N. Eberle, "Somatostatin analogs and radiopeptides in cancer therapy," Biopolymers, vol. 66, pp. 161-183, 2002. Review.
101. A.J. Pantuck, J. Matherly, A. Zisman, D. Nguyen, F. Berger, S.S. Gambhir, M.E. Black, A. Belldegrun, and L. Wu, "Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants," Hum Gene Ther., vol. 13, pp. 777-789, May 2002.
102. X. Wang, M. Rosol, S. Ge, D. Peterson, G. McNamara, H. Pollack, D.B. Kohn, M.D. Nelson, and G.M. Crooks, "Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging," Blood, vol. 102, pp. 3478-3482, Nov. 2003.
103. J.M. Hill, A.J. Dick, V.K. Raman, R.B. Thompson, Z.X. Yu, K.A. Hinds, B.S. Pessanha, M.A. Guttman, T.R. Varney, B.J. Martin, C.E. Dunbar, E.R. McVeigh, and R.J. Lederman, "Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells," Circulation, vol. 108, pp. 1009-1014, Aug. 2003.
104. J.M. Vose, P.J. Bierman, J.R. Anderson, K.A. Harrison, G.V. Dalrymple, K. Byar, A. Kessinger, and J.O. Armitage, "Single-photon emission computed tomography gallium imaging versus computed tomography. Predictive value in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation for non-Hodgkin's lymphoma," J. Clin. Oncol, vol. 14, pp. 2473-2479, Sept. 1996.
105. S.F. Gardner, H.M. Lazarus, E.M. Bednarczyk, R.J. Creger, F.D. Miraldi, G. Leisure, and J.A. Green, "High-dose cyclophosphamide-induced myocardial damage during BMT: Assessment by positron emission tomography," Bone Marrow Transplant, vol. 12, pp. 139-144, Aug. 1993.
106. E.B. Olasz, L. Lang, J. Seidel, M.V. Green, W.C. Eckelman, and S.I. Katz, "Fluorine-18 labeled mouse bone marrow-derived dendritic cells can be detected in vivo by high resolution projection imaging," J. Immunol. Methods., vol. 260, pp. 137-148, Feb. 2002.
107. P. Mayer-Kuckuk, M. Doubrovin, T. Budak-Alpdogan, V. Ponomarev, R. Blasberg, D. Banerjee, and J.G. Tjuvajev, "Non-invasive imaging of the transplanted bone marrow progenitor cells transfected with a triple gene reporter system in fusion with methotrexate resistant DHFR in vivo," Abstract #93, 50th Annual Meeting of The Society of Nuclear Medicine, New Orleans, LA, JNM, vol. 44, p. 29, May 2003.
108. S. Tomita, D.A.G. Mickle, R.D. Weisel, Z.Q. Jia, L.C. Tumiati, Y. Allidina, P. Liu, and R.K. Li, "Improved heart function with myogenesis and angiogenesis following autologous porcine bone marrow stromal cell transplantation," J. Thorac. Cardiovasc. Surg., vol. 123, pp. 1132-1140, Jun. 2002.
109. C. Stamm, B. Westphal, H.D. Kleine, M. Petzsch, C. Kittner, H. Klinge, C. Schumichen, C.A. Nienaber, M. Freund, and G. Steinhoff, "Autologous bone-marrow stem-cell transplantation for myocardial infarction," Lancet, vol. 361, pp. 45-46, Jan. 2003.
110. R.J. Brentjens, J.B. Latouche, E. Santos, F. Marti, M.C. Gong, C. Lyddane, P.D. King, S. Larson, M. Weiss, I. Riviere, and M. Sadelain, "Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15," Nat. Med., vol. 9, pp. 279-286, Mar. 2003.
111. R. Blasberg and J. Tjuvajev, "In vivo monitoring of gene therapy by radiotracer imaging," Ernst Shering Research Foundation Workshop 22: Impact of Molecular Biology and New Technical Developments on Diagnostic Imaging., Berlin, Germany: Springer Verlag, Berlin-Heidelberg, 1997, pp. 161-189.
112. G. Ortu, I. Ben-David, Y. Rozen, N.M. Freedman, R. Chisin, A. Levitzki, and E. Mishani, "Labeled EGFr-TK irreversible inhibitor (ML03): In vitro and in vivo properties, potential as PET biomarker for cancer and feasibility as anticancer drug," Int. J. Cancer, vol. 101, pp. 360-370, Oct. 2002.
113. J. Gelovani Tjuvajev and R.G. Blasberg, "In vivo imaging of molecular-genetic targets for cancer therapy," Cancer Cell, vol. 3, pp. 327-332, Apr. 2003.